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The map label for this gene is moaC [H]

Identifier: 116620526

GI number: 116620526

Start: 1730422

End: 1730892

Strand: Reverse

Name: moaC [H]

Synonym: Acid_1404

Alternate gene names: 116620526

Gene position: 1730892-1730422 (Counterclockwise)

Preceding gene: 116620527

Following gene: 116620525

Centisome position: 17.37

GC content: 59.66

Gene sequence:

>471_bases
ATGAAAAAACTCTCGCATTTCGATTCCACCGGTAGTCCACGCATGGTCGATGTCTCCGCCAAGCAGGAGACGCGCCGCAC
CGCACGCGCGCACGCGTTTGTGCGCATCGCAGCCGGCGTGCTCGAAAAACTGCCGCAGAACCCGAAAGGCAATCCGCTCG
AGATCGCGCGCATCGCCGGCATCTCCGCCGCCAAGCGAACCAGTGAACTGATTCCATTGTGCCACCCGCTCATGCTGACC
CACGCCGATCTCGAAGTCACGGTGGAGAAGGAGGGGGTGCGCATCATCGCGACGGCCGCCACCACGGGTCCGACAGGGGT
AGAAATGGAGGCGCTGACCGCCGCCGGAGTCGCCGCCCTCACGGTTTACGATATGACCAAAGCTCTCGATAAATCGATTG
AAATTCAAGACCTCTATCTGCTGGAAAAAACCGGTGGCAAAAGCGGAGACTTTGTACGGGGGAAACGATGA

Upstream 100 bases:

>100_bases
CCGCCGACATGCCCGCCCTGACGCAGGCCAACGCCTATCTGGTTGCCGACCCCGACCGCGCCGTGTACGCGCGCGGCGAG
CTTATCCGGGTACTCTACAA

Downstream 100 bases:

>100_bases
CCAAAGCCGCAGTCTTGACGATCAGCGATTCCGTTAGCGCCGGAACCCGGGCTGACCGCTCGGGTCCGGCGGTGCGTGAA
CGCCTGGAACAGCTGGGCTG

Product: GTP cyclohydrolase subunit MoaC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 156; Mature: 156

Protein sequence:

>156_residues
MKKLSHFDSTGSPRMVDVSAKQETRRTARAHAFVRIAAGVLEKLPQNPKGNPLEIARIAGISAAKRTSELIPLCHPLMLT
HADLEVTVEKEGVRIIATAATTGPTGVEMEALTAAGVAALTVYDMTKALDKSIEIQDLYLLEKTGGKSGDFVRGKR

Sequences:

>Translated_156_residues
MKKLSHFDSTGSPRMVDVSAKQETRRTARAHAFVRIAAGVLEKLPQNPKGNPLEIARIAGISAAKRTSELIPLCHPLMLT
HADLEVTVEKEGVRIIATAATTGPTGVEMEALTAAGVAALTVYDMTKALDKSIEIQDLYLLEKTGGKSGDFVRGKR
>Mature_156_residues
MKKLSHFDSTGSPRMVDVSAKQETRRTARAHAFVRIAAGVLEKLPQNPKGNPLEIARIAGISAAKRTSELIPLCHPLMLT
HADLEVTVEKEGVRIIATAATTGPTGVEMEALTAAGVAALTVYDMTKALDKSIEIQDLYLLEKTGGKSGDFVRGKR

Specific function: Together with moaA, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG0315

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moaC family [H]

Homologues:

Organism=Escherichia coli, GI1787001, Length=155, Percent_Identity=54.1935483870968, Blast_Score=149, Evalue=7e-38,
Organism=Caenorhabditis elegans, GI32566331, Length=149, Percent_Identity=42.2818791946309, Blast_Score=118, Evalue=1e-27,
Organism=Drosophila melanogaster, GI28574490, Length=155, Percent_Identity=49.6774193548387, Blast_Score=132, Evalue=1e-31,
Organism=Drosophila melanogaster, GI28574492, Length=143, Percent_Identity=51.0489510489511, Blast_Score=124, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023045
- InterPro:   IPR023046
- InterPro:   IPR002820 [H]

Pfam domain/function: PF01967 MoaC [H]

EC number: NA

Molecular weight: Translated: 16737; Mature: 16737

Theoretical pI: Translated: 9.89; Mature: 9.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKLSHFDSTGSPRMVDVSAKQETRRTARAHAFVRIAAGVLEKLPQNPKGNPLEIARIAG
CCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECC
ISAAKRTSELIPLCHPLMLTHADLEVTVEKEGVRIIATAATTGPTGVEMEALTAAGVAAL
CHHHHHHHHHHHHHHHHHEECCCEEEEEECCCEEEEEEECCCCCCCCCHHHHHHHHHHHH
TVYDMTKALDKSIEIQDLYLLEKTGGKSGDFVRGKR
HHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MKKLSHFDSTGSPRMVDVSAKQETRRTARAHAFVRIAAGVLEKLPQNPKGNPLEIARIAG
CCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECC
ISAAKRTSELIPLCHPLMLTHADLEVTVEKEGVRIIATAATTGPTGVEMEALTAAGVAAL
CHHHHHHHHHHHHHHHHHEECCCEEEEEECCCEEEEEEECCCCCCCCCHHHHHHHHHHHH
TVYDMTKALDKSIEIQDLYLLEKTGGKSGDFVRGKR
HHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Involved in molybdopterin biosynthesis [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA