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The map label for this gene is glcD [H]

Identifier: 116620182

GI number: 116620182

Start: 1304342

End: 1305775

Strand: Direct

Name: glcD [H]

Synonym: Acid_1055

Alternate gene names: 116620182

Gene position: 1304342-1305775 (Clockwise)

Preceding gene: 116620181

Following gene: 116620183

Centisome position: 13.09

GC content: 64.5

Gene sequence:

>1434_bases
ATGATCCCCGACGGCCTGACGAAACGCGTGCATGCGCTGCTTGGCCCGCGCGGGTATCTCGATCTTCCGGAAGACCTTAA
GCTTTACGAGTACGATGGCGGCATAGACAAGCACGCGCCCGAACTGGTGGCATTTCCGCGCACTACGGAAGAGGTCGCCG
CGCTGGTCAAACTGGCCCAGGAATTCGGGGTGCCGTTTGTGGGGCGGGGCGCAGGGACGGGACTGTCGGGTGGTGCAATC
CCGCGCGAGGGCGGCGTCATGATCGCGTTCGCGCGCATGAACCGGATCCTCGAAATCGATCTGGAGAATGAACGCGCGGT
GGTGCAACCGGGCGTGGTCAATCTGGACATCACGGTGGCGGTGGAGGGCAGCGGCTTTTTCTACGCGCCGGATCCTTCCA
GCCAGCGCGCCTGCACGATCGGCGGCAATGTCGCGGAGAATGCCGGCGGACCGCATACGCTGGCGTACGGGGTCACGACC
AATCATGTGCTCGGACTGGAAGTGGTGCTGGCCGATGGGAGCGTGGTCGAGATCGGAGGTAAGGGGCAGGATTTGCCAGG
GTACGACCTGACCGGGCTGCTCACGGGCAGCGAAGGCACGATGGCGCTGGTGACCAAGGCCATCGTGCGGTTGATGCGCA
AGCCGGAACTGGTGAAGACGATTCTGGCGATTTACGAGTCGAGTGAAGACGCCGGGCGGACGGTCGCGGAGATCACGTCG
CGCGCAATCACGCCGGTGGCGGTGGAGATGCTGGATGGAGTGATGCTGCGCATGGTGGAGGAGGCGACGCACGCGGGCTA
TCCGATGGATGCGGCGGCCGTCCTGCTGATCGAACTGGAGGGGTTGCGCGAGGCGGTGGAAGAGCAGGTGGAGCAGGTGC
GCGAGGCCTGCATGGTCTGCGGCGCGCGCGAGTTCCGCGTGGCGCGGACGGCGGAGGAGCGCGACCTGCTGTGGAAGGGG
CGCAAGAATGCGTTTGGCGCGGTGGGGCGGGTCAGCCCGACATATTACGTACAAGATGGCGTGGTGCCGCGCACCAAGAT
CGCGCCCACCCTGCACTATATCGGCGAAGTGGCCGAACGCTTCGGGCTGATCATCAGCAATATCTTCCACGCGGGCGATG
GCAACATGCACCCGATTATTCTCTTCGACCCGCGCAAGCCCGGCGATATGGAGAAGGCGCGCGCGGCCGGGGAAGAGATT
CTCAAGTGGTGCATCGATTGCGGCGGATCAATTACGGGCGAGCACGGTGTCGGAATGGAAAAGAACGAGCTGATGGCGCG
GCTGTTTCCGGCGGCGACGCTGGAGACGATACTGGCGTTGAAGTTGCTGTTCGACGCCGAGGCGCGGCTCAATCCGGGTA
AGGTGCTGCCGACGGGGCGGGGGTGCCTGGAGATCCGGCAGGCGCCGATCACTACGGACTCCGTCGTGTATTGA

Upstream 100 bases:

>100_bases
CGGAGACCGTGAACCAGGAATGGTTCGCGGTAGTGAAGGCGATCAACGGAGACGACATTCTAGGGGTGGCGAGGGCGTTG
GCGGCGCTACACTATACAAG

Downstream 100 bases:

>100_bases
GCGTGGCCCCTACTCAAAAACCGAAATCTGCCGATTAGGCAGATATGAAATGGCTGCGGATGGCCGCAGGGGCGGCATGG
CTCATCGGCAATCTCGGCGC

Product: FAD linked oxidase domain-containing protein

Products: 2-oxo acid; H2O2

Alternate protein names: NA

Number of amino acids: Translated: 477; Mature: 477

Protein sequence:

>477_residues
MIPDGLTKRVHALLGPRGYLDLPEDLKLYEYDGGIDKHAPELVAFPRTTEEVAALVKLAQEFGVPFVGRGAGTGLSGGAI
PREGGVMIAFARMNRILEIDLENERAVVQPGVVNLDITVAVEGSGFFYAPDPSSQRACTIGGNVAENAGGPHTLAYGVTT
NHVLGLEVVLADGSVVEIGGKGQDLPGYDLTGLLTGSEGTMALVTKAIVRLMRKPELVKTILAIYESSEDAGRTVAEITS
RAITPVAVEMLDGVMLRMVEEATHAGYPMDAAAVLLIELEGLREAVEEQVEQVREACMVCGAREFRVARTAEERDLLWKG
RKNAFGAVGRVSPTYYVQDGVVPRTKIAPTLHYIGEVAERFGLIISNIFHAGDGNMHPIILFDPRKPGDMEKARAAGEEI
LKWCIDCGGSITGEHGVGMEKNELMARLFPAATLETILALKLLFDAEARLNPGKVLPTGRGCLEIRQAPITTDSVVY

Sequences:

>Translated_477_residues
MIPDGLTKRVHALLGPRGYLDLPEDLKLYEYDGGIDKHAPELVAFPRTTEEVAALVKLAQEFGVPFVGRGAGTGLSGGAI
PREGGVMIAFARMNRILEIDLENERAVVQPGVVNLDITVAVEGSGFFYAPDPSSQRACTIGGNVAENAGGPHTLAYGVTT
NHVLGLEVVLADGSVVEIGGKGQDLPGYDLTGLLTGSEGTMALVTKAIVRLMRKPELVKTILAIYESSEDAGRTVAEITS
RAITPVAVEMLDGVMLRMVEEATHAGYPMDAAAVLLIELEGLREAVEEQVEQVREACMVCGAREFRVARTAEERDLLWKG
RKNAFGAVGRVSPTYYVQDGVVPRTKIAPTLHYIGEVAERFGLIISNIFHAGDGNMHPIILFDPRKPGDMEKARAAGEEI
LKWCIDCGGSITGEHGVGMEKNELMARLFPAATLETILALKLLFDAEARLNPGKVLPTGRGCLEIRQAPITTDSVVY
>Mature_477_residues
MIPDGLTKRVHALLGPRGYLDLPEDLKLYEYDGGIDKHAPELVAFPRTTEEVAALVKLAQEFGVPFVGRGAGTGLSGGAI
PREGGVMIAFARMNRILEIDLENERAVVQPGVVNLDITVAVEGSGFFYAPDPSSQRACTIGGNVAENAGGPHTLAYGVTT
NHVLGLEVVLADGSVVEIGGKGQDLPGYDLTGLLTGSEGTMALVTKAIVRLMRKPELVKTILAIYESSEDAGRTVAEITS
RAITPVAVEMLDGVMLRMVEEATHAGYPMDAAAVLLIELEGLREAVEEQVEQVREACMVCGAREFRVARTAEERDLLWKG
RKNAFGAVGRVSPTYYVQDGVVPRTKIAPTLHYIGEVAERFGLIISNIFHAGDGNMHPIILFDPRKPGDMEKARAAGEEI
LKWCIDCGGSITGEHGVGMEKNELMARLFPAATLETILALKLLFDAEARLNPGKVLPTGRGCLEIRQAPITTDSVVY

Specific function: Unknown

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI37595756, Length=423, Percent_Identity=33.806146572104, Blast_Score=235, Evalue=8e-62,
Organism=Homo sapiens, GI37595754, Length=446, Percent_Identity=32.2869955156951, Blast_Score=226, Evalue=4e-59,
Organism=Homo sapiens, GI119964728, Length=427, Percent_Identity=29.2740046838407, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI4501993, Length=256, Percent_Identity=25.390625, Blast_Score=88, Evalue=2e-17,
Organism=Escherichia coli, GI1789351, Length=443, Percent_Identity=46.0496613995485, Blast_Score=403, Evalue=1e-113,
Organism=Escherichia coli, GI1787977, Length=504, Percent_Identity=25.7936507936508, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI48994907, Length=435, Percent_Identity=22.9885057471264, Blast_Score=80, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71992373, Length=425, Percent_Identity=27.7647058823529, Blast_Score=190, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI71992381, Length=429, Percent_Identity=26.1072261072261, Blast_Score=168, Evalue=7e-42,
Organism=Caenorhabditis elegans, GI71992392, Length=357, Percent_Identity=27.7310924369748, Blast_Score=162, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17534361, Length=437, Percent_Identity=27.6887871853547, Blast_Score=127, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17556096, Length=466, Percent_Identity=21.244635193133, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320027, Length=476, Percent_Identity=26.4705882352941, Blast_Score=178, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6320023, Length=455, Percent_Identity=26.1538461538462, Blast_Score=115, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6320764, Length=460, Percent_Identity=24.1304347826087, Blast_Score=114, Evalue=4e-26,
Organism=Drosophila melanogaster, GI18921117, Length=433, Percent_Identity=27.0207852193995, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24639277, Length=433, Percent_Identity=27.0207852193995, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24639275, Length=433, Percent_Identity=27.0207852193995, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24653753, Length=221, Percent_Identity=27.6018099547511, Blast_Score=92, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR004113
- InterPro:   IPR004490
- InterPro:   IPR006094
- InterPro:   IPR016171 [H]

Pfam domain/function: PF02913 FAD-oxidase_C; PF01565 FAD_binding_4 [H]

EC number: 1.1.3.15

Molecular weight: Translated: 51169; Mature: 51169

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPDGLTKRVHALLGPRGYLDLPEDLKLYEYDGGIDKHAPELVAFPRTTEEVAALVKLAQ
CCCCHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCCEEECCCCHHHHHHHHHHHH
EFGVPFVGRGAGTGLSGGAIPREGGVMIAFARMNRILEIDLENERAVVQPGVVNLDITVA
HHCCCEEECCCCCCCCCCCCCCCCCEEEEEECCCCEEEEEECCCCEEECCCEEEEEEEEE
VEGSGFFYAPDPSSQRACTIGGNVAENAGGPHTLAYGVTTNHVLGLEVVLADGSVVEIGG
EECCEEEECCCCCCCCEEEECCCCCCCCCCCCEEEECCCCCCEEEEEEEEECCCEEEECC
KGQDLPGYDLTGLLTGSEGTMALVTKAIVRLMRKPELVKTILAIYESSEDAGRTVAEITS
CCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHCHHHHHHHH
RAITPVAVEMLDGVMLRMVEEATHAGYPMDAAAVLLIELEGLREAVEEQVEQVREACMVC
HCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHEEEEEHHHHHHHHHHHHHHHHHHHHHC
GAREFRVARTAEERDLLWKGRKNAFGAVGRVSPTYYVQDGVVPRTKIAPTLHYIGEVAER
CCHHHHHHHCCHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHH
FGLIISNIFHAGDGNMHPIILFDPRKPGDMEKARAAGEEILKWCIDCGGSITGEHGVGME
HHHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
KNELMARLFPAATLETILALKLLFDAEARLNPGKVLPTGRGCLEIRQAPITTDSVVY
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MIPDGLTKRVHALLGPRGYLDLPEDLKLYEYDGGIDKHAPELVAFPRTTEEVAALVKLAQ
CCCCHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCCEEECCCCHHHHHHHHHHHH
EFGVPFVGRGAGTGLSGGAIPREGGVMIAFARMNRILEIDLENERAVVQPGVVNLDITVA
HHCCCEEECCCCCCCCCCCCCCCCCEEEEEECCCCEEEEEECCCCEEECCCEEEEEEEEE
VEGSGFFYAPDPSSQRACTIGGNVAENAGGPHTLAYGVTTNHVLGLEVVLADGSVVEIGG
EECCEEEECCCCCCCCEEEECCCCCCCCCCCCEEEECCCCCCEEEEEEEEECCCEEEECC
KGQDLPGYDLTGLLTGSEGTMALVTKAIVRLMRKPELVKTILAIYESSEDAGRTVAEITS
CCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHCHHHHHHHH
RAITPVAVEMLDGVMLRMVEEATHAGYPMDAAAVLLIELEGLREAVEEQVEQVREACMVC
HCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHEEEEEHHHHHHHHHHHHHHHHHHHHHC
GAREFRVARTAEERDLLWKGRKNAFGAVGRVSPTYYVQDGVVPRTKIAPTLHYIGEVAER
CCHHHHHHHCCHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHH
FGLIISNIFHAGDGNMHPIILFDPRKPGDMEKARAAGEEILKWCIDCGGSITGEHGVGME
HHHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
KNELMARLFPAATLETILALKLLFDAEARLNPGKVLPTGRGCLEIRQAPITTDSVVY
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-2-hydroxy acid; O2

Specific reaction: (S)-2-hydroxy acid + O2 = 2-oxo acid + H2O2

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]