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The map label for this gene is odhL [H]

Identifier: 116620040

GI number: 116620040

Start: 1139777

End: 1141171

Strand: Direct

Name: odhL [H]

Synonym: Acid_0912

Alternate gene names: 116620040

Gene position: 1139777-1141171 (Clockwise)

Preceding gene: 116620037

Following gene: 116620041

Centisome position: 11.44

GC content: 61.36

Gene sequence:

>1395_bases
GTGCCCTACGATCTGATCGTCATCGGGAGTGGTCCCGGCGGCTACTCCGCAGCCATACGCGCCGGCCAGTACGGACTCAA
GACAGCGCTCATCGAAAAGCAGCCCAGACTCGGCGGAACCTGTCTTTTAGTGGGATGTATCCCGACCAAAAGCCTGCTCC
ACACCGCCGATGTCTGGGATCATTTCGTGCACGCCGAAGCCGATGGCATAGTAGCCGAGAACCCGCGCCTCGACTTTCCC
AAGGTGCAGGCGCGCAAGGATGGCATCGTCAGCAAGCACTCCAAAGGCGTGGAGTTCCTGTTGAAACGCGCCAAGGTGGA
GCGCATTTCGGGCTACGCCACCATCAAAGGCGGCGGCAAGATCGAAGTCAAGACCGATGCCGGCGTGCAGACCCTGGAAG
CCAGGAACATCATCATCGCCACCGGCAGCGAAGCGCGCATGCTTCCCGGTATGCAGCCCGACCCCGAATTCATCCTCACC
AACATCGAAATCCTGAACCTTGCGGCGGTTCCGAAAAGCCTGATCATTATCGGCGCGGGCGCTGTCGGCGTGGAGTTTGC
CTCCATTTTCAAGCGCTTCGGCACCGACGTCACCGTGATCGAAATGCTGCCGCGCATTGTGCCGGTGGAAGACGAAGACA
TCTCCAAGGAACTGGAGCGGGTCTTCAAGAAGCAAAAGATCCGCGTGGAAACCGGCGCGCGTGCTGAGAACATCCAGAAG
ACCGGCACGGGCGTCAAACTGACCCTCACCACCAAAGATGGGAAACAGGAGCAGCTCGAAGCCGAGAAGTTGCTGGTCGC
GGTGGGCCGCAAGCCCAACACCGACGCCATCGGTTTGGAGAACACGAAGGTCCAGCTGGACCGCGGTTTTATCAAGGTGG
ATCAGTACCAGCAGACCGGCGAGCCCGGCGTCTATGCCATCGGCGACGTGGTGGCCGGCACTCCGCAGCTGGCTCATGTG
GCCACCCGGGAAGGGATGATCGCGGTGGCGCACATGGCCGGCAAGCCCGCGGTTCCGATCAACAAGAACCGTATTCCGGG
CGCGACCTACACCACTCCCGGCATCGGCAGCGTCGGCCTCACCGAAGCCCAGGCGCGCGCCCAAGGCTACCAGGTAAAGG
TCGGCAAGTTCCCCTTCGCCGGCGATAGCCGGGCCACCATACTCGGCCAGCACGAGGGCTTCATCAAGGTAGTGGCCGAC
GAAAAATACGGCGAGATTCTTGGCGTCCACATCATCGGGCCCGATGGCTTCGAGTTGATCGCCGAAGCCGTCGCGGCGAT
GGAAGCCGAGGCTACCGTCGATGTCATGATGCAGACCATTCACGCCCATCCCACGCTCTACGAAGCGGTGGGCGAGGCCT
TCAACGCCGTTTACGGTCTCTCCATCAATGCGTAA

Upstream 100 bases:

>100_bases
CCGTGGCTGCTGGATTACGCGGGTATTACTTTGAGATCGGCGCTCTCGAAAAAGCACGCGCGATTCAGCATTTCGCCATT
CGTCCGCTAGAATAAAAAAA

Downstream 100 bases:

>100_bases
TTGCTGCCTGCGCCAACTCGGGCGGATTGACTACGCGAGCGCGCTGGAAATCCAGGAGCAGCTCGCCGCAAGCCGCAAAC
AGGGCACGGCCGCCGATCAC

Product: dihydrolipoamide dehydrogenase

Products: NA

Alternate protein names: Dihydrolipoamide dehydrogenase; E3 component of 2-oxoglutarate dehydrogenase complex [H]

Number of amino acids: Translated: 464; Mature: 463

Protein sequence:

>464_residues
MPYDLIVIGSGPGGYSAAIRAGQYGLKTALIEKQPRLGGTCLLVGCIPTKSLLHTADVWDHFVHAEADGIVAENPRLDFP
KVQARKDGIVSKHSKGVEFLLKRAKVERISGYATIKGGGKIEVKTDAGVQTLEARNIIIATGSEARMLPGMQPDPEFILT
NIEILNLAAVPKSLIIIGAGAVGVEFASIFKRFGTDVTVIEMLPRIVPVEDEDISKELERVFKKQKIRVETGARAENIQK
TGTGVKLTLTTKDGKQEQLEAEKLLVAVGRKPNTDAIGLENTKVQLDRGFIKVDQYQQTGEPGVYAIGDVVAGTPQLAHV
ATREGMIAVAHMAGKPAVPINKNRIPGATYTTPGIGSVGLTEAQARAQGYQVKVGKFPFAGDSRATILGQHEGFIKVVAD
EKYGEILGVHIIGPDGFELIAEAVAAMEAEATVDVMMQTIHAHPTLYEAVGEAFNAVYGLSINA

Sequences:

>Translated_464_residues
MPYDLIVIGSGPGGYSAAIRAGQYGLKTALIEKQPRLGGTCLLVGCIPTKSLLHTADVWDHFVHAEADGIVAENPRLDFP
KVQARKDGIVSKHSKGVEFLLKRAKVERISGYATIKGGGKIEVKTDAGVQTLEARNIIIATGSEARMLPGMQPDPEFILT
NIEILNLAAVPKSLIIIGAGAVGVEFASIFKRFGTDVTVIEMLPRIVPVEDEDISKELERVFKKQKIRVETGARAENIQK
TGTGVKLTLTTKDGKQEQLEAEKLLVAVGRKPNTDAIGLENTKVQLDRGFIKVDQYQQTGEPGVYAIGDVVAGTPQLAHV
ATREGMIAVAHMAGKPAVPINKNRIPGATYTTPGIGSVGLTEAQARAQGYQVKVGKFPFAGDSRATILGQHEGFIKVVAD
EKYGEILGVHIIGPDGFELIAEAVAAMEAEATVDVMMQTIHAHPTLYEAVGEAFNAVYGLSINA
>Mature_463_residues
PYDLIVIGSGPGGYSAAIRAGQYGLKTALIEKQPRLGGTCLLVGCIPTKSLLHTADVWDHFVHAEADGIVAENPRLDFPK
VQARKDGIVSKHSKGVEFLLKRAKVERISGYATIKGGGKIEVKTDAGVQTLEARNIIIATGSEARMLPGMQPDPEFILTN
IEILNLAAVPKSLIIIGAGAVGVEFASIFKRFGTDVTVIEMLPRIVPVEDEDISKELERVFKKQKIRVETGARAENIQKT
GTGVKLTLTTKDGKQEQLEAEKLLVAVGRKPNTDAIGLENTKVQLDRGFIKVDQYQQTGEPGVYAIGDVVAGTPQLAHVA
TREGMIAVAHMAGKPAVPINKNRIPGATYTTPGIGSVGLTEAQARAQGYQVKVGKFPFAGDSRATILGQHEGFIKVVADE
KYGEILGVHIIGPDGFELIAEAVAAMEAEATVDVMMQTIHAHPTLYEAVGEAFNAVYGLSINA

Specific function: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of 3 enzymatic components:branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransfer

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=470, Percent_Identity=41.4893617021277, Blast_Score=333, Evalue=1e-91,
Organism=Homo sapiens, GI50301238, Length=459, Percent_Identity=29.1938997821351, Blast_Score=152, Evalue=8e-37,
Organism=Homo sapiens, GI22035672, Length=472, Percent_Identity=27.5423728813559, Blast_Score=132, Evalue=7e-31,
Organism=Homo sapiens, GI291045266, Length=440, Percent_Identity=25.9090909090909, Blast_Score=129, Evalue=8e-30,
Organism=Homo sapiens, GI33519430, Length=457, Percent_Identity=25.382932166302, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI33519428, Length=457, Percent_Identity=25.382932166302, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI33519426, Length=457, Percent_Identity=25.382932166302, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI148277065, Length=457, Percent_Identity=25.382932166302, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI148277071, Length=457, Percent_Identity=25.382932166302, Blast_Score=123, Evalue=4e-28,
Organism=Homo sapiens, GI291045268, Length=433, Percent_Identity=24.9422632794457, Blast_Score=112, Evalue=7e-25,
Organism=Escherichia coli, GI1786307, Length=451, Percent_Identity=34.8115299334812, Blast_Score=268, Evalue=5e-73,
Organism=Escherichia coli, GI87082354, Length=459, Percent_Identity=32.4618736383442, Blast_Score=209, Evalue=3e-55,
Organism=Escherichia coli, GI87081717, Length=461, Percent_Identity=28.8503253796095, Blast_Score=186, Evalue=3e-48,
Organism=Escherichia coli, GI1789915, Length=455, Percent_Identity=30.989010989011, Blast_Score=156, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI32565766, Length=469, Percent_Identity=41.5778251599147, Blast_Score=348, Evalue=4e-96,
Organism=Caenorhabditis elegans, GI17557007, Length=469, Percent_Identity=27.7185501066098, Blast_Score=153, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI71983429, Length=369, Percent_Identity=29.810298102981, Blast_Score=122, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI71983419, Length=369, Percent_Identity=29.810298102981, Blast_Score=122, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI71982272, Length=485, Percent_Identity=27.8350515463918, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17559934, Length=295, Percent_Identity=27.1186440677966, Blast_Score=71, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6321091, Length=476, Percent_Identity=39.2857142857143, Blast_Score=297, Evalue=2e-81,
Organism=Saccharomyces cerevisiae, GI6325240, Length=480, Percent_Identity=31.25, Blast_Score=166, Evalue=5e-42,
Organism=Saccharomyces cerevisiae, GI6325166, Length=456, Percent_Identity=27.6315789473684, Blast_Score=157, Evalue=5e-39,
Organism=Drosophila melanogaster, GI21358499, Length=468, Percent_Identity=42.3076923076923, Blast_Score=348, Evalue=3e-96,
Organism=Drosophila melanogaster, GI24640553, Length=481, Percent_Identity=28.4823284823285, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24640549, Length=481, Percent_Identity=28.4823284823285, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24640551, Length=481, Percent_Identity=28.4823284823285, Blast_Score=139, Evalue=5e-33,
Organism=Drosophila melanogaster, GI17737741, Length=476, Percent_Identity=26.4705882352941, Blast_Score=115, Evalue=5e-26,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.4 [H]

Molecular weight: Translated: 49530; Mature: 49399

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPYDLIVIGSGPGGYSAAIRAGQYGLKTALIEKQPRLGGTCLLVGCIPTKSLLHTADVWD
CCEEEEEEECCCCCHHHHHCCCCCCHHHHHHCCCCCCCCEEEEEEECCCHHHHHHHHHHH
HFVHAEADGIVAENPRLDFPKVQARKDGIVSKHSKGVEFLLKRAKVERISGYATIKGGGK
HHHHCCCCCEEECCCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCEEEEECCCE
IEVKTDAGVQTLEARNIIIATGSEARMLPGMQPDPEFILTNIEILNLAAVPKSLIIIGAG
EEEEECCCCEEEECCEEEEEECCCCEECCCCCCCCCEEEEEEEEEEEECCCCEEEEEECC
AVGVEFASIFKRFGTDVTVIEMLPRIVPVEDEDISKELERVFKKQKIRVETGARAENIQK
HHHHHHHHHHHHHCCCEEHHHHHHHHCCCCCHHHHHHHHHHHHHCEEEEECCCCHHHHHH
TGTGVKLTLTTKDGKQEQLEAEKLLVAVGRKPNTDAIGLENTKVQLDRGFIKVDQYQQTG
CCCCEEEEEEECCCCHHHHHHHHHHEEECCCCCCCCCCCCCCEEEEECCEEEEECHHCCC
EPGVYAIGDVVAGTPQLAHVATREGMIAVAHMAGKPAVPINKNRIPGATYTTPGIGSVGL
CCCEEEECHHHCCCCHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCC
TEAQARAQGYQVKVGKFPFAGDSRATILGQHEGFIKVVADEKYGEILGVHIIGPDGFELI
CHHHHHHCCCEEEECCCCCCCCCCEEEEECCCCEEEEEECCCCCCEEEEEEECCCHHHHH
AEAVAAMEAEATVDVMMQTIHAHPTLYEAVGEAFNAVYGLSINA
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHEEEEEEECC
>Mature Secondary Structure 
PYDLIVIGSGPGGYSAAIRAGQYGLKTALIEKQPRLGGTCLLVGCIPTKSLLHTADVWD
CEEEEEEECCCCCHHHHHCCCCCCHHHHHHCCCCCCCCEEEEEEECCCHHHHHHHHHHH
HFVHAEADGIVAENPRLDFPKVQARKDGIVSKHSKGVEFLLKRAKVERISGYATIKGGGK
HHHHCCCCCEEECCCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCEEEEECCCE
IEVKTDAGVQTLEARNIIIATGSEARMLPGMQPDPEFILTNIEILNLAAVPKSLIIIGAG
EEEEECCCCEEEECCEEEEEECCCCEECCCCCCCCCEEEEEEEEEEEECCCCEEEEEECC
AVGVEFASIFKRFGTDVTVIEMLPRIVPVEDEDISKELERVFKKQKIRVETGARAENIQK
HHHHHHHHHHHHHCCCEEHHHHHHHHCCCCCHHHHHHHHHHHHHCEEEEECCCCHHHHHH
TGTGVKLTLTTKDGKQEQLEAEKLLVAVGRKPNTDAIGLENTKVQLDRGFIKVDQYQQTG
CCCCEEEEEEECCCCHHHHHHHHHHEEECCCCCCCCCCCCCCEEEEECCEEEEECHHCCC
EPGVYAIGDVVAGTPQLAHVATREGMIAVAHMAGKPAVPINKNRIPGATYTTPGIGSVGL
CCCEEEECHHHCCCCHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCC
TEAQARAQGYQVKVGKFPFAGDSRATILGQHEGFIKVVADEKYGEILGVHIIGPDGFELI
CHHHHHHCCCEEEECCCCCCCCCCEEEEECCCCEEEEEECCCCCCEEEEEEECCCHHHHH
AEAVAAMEAEATVDVMMQTIHAHPTLYEAVGEAFNAVYGLSINA
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8867378 [H]