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The map label for this gene is nuoC [H]

Identifier: 116619254

GI number: 116619254

Start: 148565

End: 149038

Strand: Direct

Name: nuoC [H]

Synonym: Acid_0110

Alternate gene names: 116619254

Gene position: 148565-149038 (Clockwise)

Preceding gene: 116619253

Following gene: 116619255

Centisome position: 1.49

GC content: 59.92

Gene sequence:

>474_bases
ATGCTACCCGAGAATCTGAAAGAGAATGCCGTGGCCGCCGCGGTGGAGGCCTTTGACGCCGATGCCGTGCGCGGTGGTAA
GGTGACGTTCGGCGAGTTGACGCTCGAAATCGCCGTCCCGAAGATCGCCAGCATTTGCGGCTTCCTCAAATACGACCAGA
AATTTGTCCGCGTGAGCACGGTGACCGCGGTCGATCGGTATCCGGCCGAACCGCGCTTTGAAATTGTCTACCACCTGCAT
TCCATCGAACGCAATCAGCGTGTACGCCTGAAGGCATTGCTGCCGGGCGCGGACCCCGTGATCGAGTCGGTTACAGGCGT
CTGGCGGGGAGCGGGTTGGTACGAACGCGAGGTTTTCGACCTCTTCGGCGTCCGCTTTCTCAATCATCCGGACCTGCGGC
GCATCTTAATGCCGGACGATTGGGAGGGCTACCCTTTGCGCAAAGACTACCCCGTGACGGGGACGAGAGTTTAA

Upstream 100 bases:

>100_bases
CGTGATCCTCATCCTTTCGGGATTCTTCTACATCTGGAAGAAAGGCGCGTTGGACTGGGGCGAGCCCACCGCTCGGCCGG
GGCGGAAGTAAGGAAACAAA

Downstream 100 bases:

>100_bases
GCGATGAGCGAATCGGAAATTCCGGGACAGGTAGTGGTGGACCTGGAGGCGGATCAATCCGCTGAGGGCGGACGCCGCAT
GGTTCTCAACATGGGGCCGC

Product: NADH (or F420H2) dehydrogenase subunit C

Products: NA

Alternate protein names: NADH dehydrogenase I subunit C; NDH-1 subunit C [H]

Number of amino acids: Translated: 157; Mature: 157

Protein sequence:

>157_residues
MLPENLKENAVAAAVEAFDADAVRGGKVTFGELTLEIAVPKIASICGFLKYDQKFVRVSTVTAVDRYPAEPRFEIVYHLH
SIERNQRVRLKALLPGADPVIESVTGVWRGAGWYEREVFDLFGVRFLNHPDLRRILMPDDWEGYPLRKDYPVTGTRV

Sequences:

>Translated_157_residues
MLPENLKENAVAAAVEAFDADAVRGGKVTFGELTLEIAVPKIASICGFLKYDQKFVRVSTVTAVDRYPAEPRFEIVYHLH
SIERNQRVRLKALLPGADPVIESVTGVWRGAGWYEREVFDLFGVRFLNHPDLRRILMPDDWEGYPLRKDYPVTGTRV
>Mature_157_residues
MLPENLKENAVAAAVEAFDADAVRGGKVTFGELTLEIAVPKIASICGFLKYDQKFVRVSTVTAVDRYPAEPRFEIVYHLH
SIERNQRVRLKALLPGADPVIESVTGVWRGAGWYEREVFDLFGVRFLNHPDLRRILMPDDWEGYPLRKDYPVTGTRV

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0852

COG function: function code C; NADH:ubiquinone oxidoreductase 27 kD subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 30 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI4758788, Length=128, Percent_Identity=43.75, Blast_Score=103, Evalue=5e-23,
Organism=Escherichia coli, GI145693162, Length=83, Percent_Identity=50.6024096385542, Blast_Score=94, Evalue=3e-21,
Organism=Escherichia coli, GI1789076, Length=153, Percent_Identity=32.0261437908497, Blast_Score=62, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71990788, Length=133, Percent_Identity=42.1052631578947, Blast_Score=103, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI32563621, Length=133, Percent_Identity=42.1052631578947, Blast_Score=103, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24656494, Length=135, Percent_Identity=39.2592592592593, Blast_Score=96, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010218
- InterPro:   IPR001268
- InterPro:   IPR020396
- ProDom:   PD001581 [H]

Pfam domain/function: PF00329 Complex1_30kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 17818; Mature: 17818

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00542 COMPLEX1_30K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPENLKENAVAAAVEAFDADAVRGGKVTFGELTLEIAVPKIASICGFLKYDQKFVRVST
CCCCCCHHHHHHHHHHHHCCCCCCCCCEEEHEEEEEEEHHHHHHHHHHHHHCCEEEEEEE
VTAVDRYPAEPRFEIVYHLHSIERNQRVRLKALLPGADPVIESVTGVWRGAGWYEREVFD
EEHHHCCCCCCCHHHEEEEHHCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCHHHHHHH
LFGVRFLNHPDLRRILMPDDWEGYPLRKDYPVTGTRV
HHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MLPENLKENAVAAAVEAFDADAVRGGKVTFGELTLEIAVPKIASICGFLKYDQKFVRVST
CCCCCCHHHHHHHHHHHHCCCCCCCCCEEEHEEEEEEEHHHHHHHHHHHHHCCEEEEEEE
VTAVDRYPAEPRFEIVYHLHSIERNQRVRLKALLPGADPVIESVTGVWRGAGWYEREVFD
EEHHHCCCCCCCHHHEEEEHHCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCHHHHHHH
LFGVRFLNHPDLRRILMPDDWEGYPLRKDYPVTGTRV
HHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA