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The map label for this gene is nuoD1

Identifier: 116619255

GI number: 116619255

Start: 149042

End: 150271

Strand: Direct

Name: nuoD1

Synonym: Acid_0111

Alternate gene names: 116619255

Gene position: 149042-150271 (Clockwise)

Preceding gene: 116619254

Following gene: 116619256

Centisome position: 1.5

GC content: 60.49

Gene sequence:

>1230_bases
ATGAGCGAATCGGAAATTCCGGGACAGGTAGTGGTGGACCTGGAGGCGGATCAATCCGCTGAGGGCGGACGCCGCATGGT
TCTCAACATGGGGCCGCAGCACCCCTCTACCCACGGCGTGCTGCGTCTGCTGATGGAGCTCGATGGCGAGAACATCATGA
AGTGCGTGCCGGATATCGGCTTCCTGCACACCGGCATCGAAAAGGAATTCGAGGAGAAGTTCTACCAGCAGGCCGTCACG
CTGACCGACCGCGTGGATTACCTGGCGCCCCTCTCCAACAATCTGGGCTGGTGCCTGGCGGTGGAGAAACTGCTGCAGCT
GGAAATTCCGCCGCAGGCGCAGTGGATGCGCGTGATGCTCACCGAGCTCACCCGCCTCAACAGCCACCTGGTGTGGCTCG
GTACGCACGCGCTCGATATCGGCGCGATGAGCGTGTTCCTCTACTGCTTCCGTGAGCGCGAGGAAATCCTCAAAATCTTC
GAATTGTTCAGCGGCCAGCGCATGATGACCAGCTACTTCCGCATAGGCGGGCTGGCTCTGGAGCCGCCACGCGGCTGGCA
GCAGCGCGTCAAGAAGTTCCTCGACGTCTTTCCGAGCCGCATCGACGAATACGAGAATCTGCTGACCAATAACCGCATCT
GGACCGGCCGGACCAAGGGCATCGGGTTTATTTCGCTGGAAGACATGCTCGATCTGGGCATCACGGGACCCATGCTCCGG
GCCGCAGGGCTCAAGATCGACGCCCGTAAGGACGCGCCCTACAGCAGCTACGAGAAGTTCGATTTCGAAGTCCCGACCAG
CACCGATAACGATGTGTTCGCCCGTTACCAGGTGCGCGTCGAGGAAATGCGCCAGAGCACAAAGATTGTCCGCCAGGCGA
TGGAAGGGATGCCGGCGGGAGCGTGGAAAGCGGATGCTCCCCACGTGGTGCTGCCCGACCGCGAGAAAATGAAGACCCAG
ATGGAAGCCCTGATCTTCCATTTCAAAATCGTCACCGAAGGCTTCCGGGTGCCCGAGGGTGAGGTCTACCAGGTGATCGA
ATCGCCGCGCGGGGAACTCGGATACTACGTGGTCAGCGACGGCACCACCAAGCCGTACCGCGTGCACATGCGCACGCCGA
GTTTCGGCAATTTGCAGGCCGTGCCTAAAATGGTAGAAGGCTCCTTGATCGCAGACGTCATCGCCTCCATCGGCAGCATG
GATTTCGTTCTGGGCGACACGGACAGGTAA

Upstream 100 bases:

>100_bases
TCTCAATCATCCGGACCTGCGGCGCATCTTAATGCCGGACGATTGGGAGGGCTACCCTTTGCGCAAAGACTACCCCGTGA
CGGGGACGAGAGTTTAAGCG

Downstream 100 bases:

>100_bases
GAACTCCGGCAGGCCAGGCAGCCTGCCAAACCGAACATAAATGACTCTTTCTCCACAACTGGAAGCCAGGTTTGAAAAAC
TGCTGACAAGCTATCCGCCG

Product: NADH dehydrogenase I subunit D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit D 1; NDH-1 subunit D 1

Number of amino acids: Translated: 409; Mature: 408

Protein sequence:

>409_residues
MSESEIPGQVVVDLEADQSAEGGRRMVLNMGPQHPSTHGVLRLLMELDGENIMKCVPDIGFLHTGIEKEFEEKFYQQAVT
LTDRVDYLAPLSNNLGWCLAVEKLLQLEIPPQAQWMRVMLTELTRLNSHLVWLGTHALDIGAMSVFLYCFREREEILKIF
ELFSGQRMMTSYFRIGGLALEPPRGWQQRVKKFLDVFPSRIDEYENLLTNNRIWTGRTKGIGFISLEDMLDLGITGPMLR
AAGLKIDARKDAPYSSYEKFDFEVPTSTDNDVFARYQVRVEEMRQSTKIVRQAMEGMPAGAWKADAPHVVLPDREKMKTQ
MEALIFHFKIVTEGFRVPEGEVYQVIESPRGELGYYVVSDGTTKPYRVHMRTPSFGNLQAVPKMVEGSLIADVIASIGSM
DFVLGDTDR

Sequences:

>Translated_409_residues
MSESEIPGQVVVDLEADQSAEGGRRMVLNMGPQHPSTHGVLRLLMELDGENIMKCVPDIGFLHTGIEKEFEEKFYQQAVT
LTDRVDYLAPLSNNLGWCLAVEKLLQLEIPPQAQWMRVMLTELTRLNSHLVWLGTHALDIGAMSVFLYCFREREEILKIF
ELFSGQRMMTSYFRIGGLALEPPRGWQQRVKKFLDVFPSRIDEYENLLTNNRIWTGRTKGIGFISLEDMLDLGITGPMLR
AAGLKIDARKDAPYSSYEKFDFEVPTSTDNDVFARYQVRVEEMRQSTKIVRQAMEGMPAGAWKADAPHVVLPDREKMKTQ
MEALIFHFKIVTEGFRVPEGEVYQVIESPRGELGYYVVSDGTTKPYRVHMRTPSFGNLQAVPKMVEGSLIADVIASIGSM
DFVLGDTDR
>Mature_408_residues
SESEIPGQVVVDLEADQSAEGGRRMVLNMGPQHPSTHGVLRLLMELDGENIMKCVPDIGFLHTGIEKEFEEKFYQQAVTL
TDRVDYLAPLSNNLGWCLAVEKLLQLEIPPQAQWMRVMLTELTRLNSHLVWLGTHALDIGAMSVFLYCFREREEILKIFE
LFSGQRMMTSYFRIGGLALEPPRGWQQRVKKFLDVFPSRIDEYENLLTNNRIWTGRTKGIGFISLEDMLDLGITGPMLRA
AGLKIDARKDAPYSSYEKFDFEVPTSTDNDVFARYQVRVEEMRQSTKIVRQAMEGMPAGAWKADAPHVVLPDREKMKTQM
EALIFHFKIVTEGFRVPEGEVYQVIESPRGELGYYVVSDGTTKPYRVHMRTPSFGNLQAVPKMVEGSLIADVIASIGSMD
FVLGDTDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family

Homologues:

Organism=Homo sapiens, GI4758786, Length=386, Percent_Identity=47.9274611398964, Blast_Score=377, Evalue=1e-105,
Organism=Homo sapiens, GI260898743, Length=380, Percent_Identity=47.6315789473684, Blast_Score=367, Evalue=1e-101,
Organism=Escherichia coli, GI145693162, Length=385, Percent_Identity=43.3766233766234, Blast_Score=353, Evalue=2e-98,
Organism=Escherichia coli, GI1789076, Length=385, Percent_Identity=26.2337662337662, Blast_Score=145, Evalue=5e-36,
Organism=Escherichia coli, GI1788832, Length=385, Percent_Identity=26.4935064935065, Blast_Score=125, Evalue=6e-30,
Organism=Caenorhabditis elegans, GI17568379, Length=384, Percent_Identity=48.9583333333333, Blast_Score=395, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI17555284, Length=397, Percent_Identity=47.103274559194, Blast_Score=394, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24638644, Length=386, Percent_Identity=46.6321243523316, Blast_Score=395, Evalue=1e-110,
Organism=Drosophila melanogaster, GI221459469, Length=386, Percent_Identity=44.8186528497409, Blast_Score=376, Evalue=1e-104,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOD1_SOLUE (Q02CU0)

Other databases:

- EMBL:   CP000473
- RefSeq:   YP_821411.1
- ProteinModelPortal:   Q02CU0
- SMR:   Q02CU0
- STRING:   Q02CU0
- GeneID:   4424023
- GenomeReviews:   CP000473_GR
- KEGG:   sus:Acid_0111
- NMPDR:   fig|234267.9.peg.105
- eggNOG:   COG0649
- HOGENOM:   HBG459705
- OMA:   FRARTIG
- PhylomeDB:   Q02CU0
- ProtClustDB:   CLSK846533
- GO:   GO:0006810
- HAMAP:   MF_01358
- InterPro:   IPR010219
- InterPro:   IPR001135
- InterPro:   IPR022885
- TIGRFAMs:   TIGR01962

Pfam domain/function: PF00346 Complex1_49kDa

EC number: =1.6.99.5

Molecular weight: Translated: 46441; Mature: 46310

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS00535 COMPLEX1_49K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSESEIPGQVVVDLEADQSAEGGRRMVLNMGPQHPSTHGVLRLLMELDGENIMKCVPDIG
CCCCCCCCEEEEEECCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCHHHHHCCCCH
FLHTGIEKEFEEKFYQQAVTLTDRVDYLAPLSNNLGWCLAVEKLLQLEIPPQAQWMRVML
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHH
TELTRLNSHLVWLGTHALDIGAMSVFLYCFREREEILKIFELFSGQRMMTSYFRIGGLAL
HHHHHHCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCEEE
EPPRGWQQRVKKFLDVFPSRIDEYENLLTNNRIWTGRTKGIGFISLEDMLDLGITGPMLR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCEEEEEHHHHHHCCCCCHHHH
AAGLKIDARKDAPYSSYEKFDFEVPTSTDNDVFARYQVRVEEMRQSTKIVRQAMEGMPAG
HCCCEEECCCCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
AWKADAPHVVLPDREKMKTQMEALIFHFKIVTEGFRVPEGEVYQVIESPRGELGYYVVSD
CCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCEEEEEC
GTTKPYRVHMRTPSFGNLQAVPKMVEGSLIADVIASIGSMDFVLGDTDR
CCCCCEEEEECCCCCCCHHHHHHHHCCHHHHHHHHHHCCCEEEECCCCC
>Mature Secondary Structure 
SESEIPGQVVVDLEADQSAEGGRRMVLNMGPQHPSTHGVLRLLMELDGENIMKCVPDIG
CCCCCCCEEEEEECCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCHHHHHCCCCH
FLHTGIEKEFEEKFYQQAVTLTDRVDYLAPLSNNLGWCLAVEKLLQLEIPPQAQWMRVML
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHH
TELTRLNSHLVWLGTHALDIGAMSVFLYCFREREEILKIFELFSGQRMMTSYFRIGGLAL
HHHHHHCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCEEE
EPPRGWQQRVKKFLDVFPSRIDEYENLLTNNRIWTGRTKGIGFISLEDMLDLGITGPMLR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCEEEEEHHHHHHCCCCCHHHH
AAGLKIDARKDAPYSSYEKFDFEVPTSTDNDVFARYQVRVEEMRQSTKIVRQAMEGMPAG
HCCCEEECCCCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
AWKADAPHVVLPDREKMKTQMEALIFHFKIVTEGFRVPEGEVYQVIESPRGELGYYVVSD
CCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCEEEEEC
GTTKPYRVHMRTPSFGNLQAVPKMVEGSLIADVIASIGSMDFVLGDTDR
CCCCCEEEEECCCCCCCHHHHHHHHCCHHHHHHHHHHCCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA