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The map label for this gene is nox [C]

Identifier: 116516669

GI number: 116516669

Start: 1316926

End: 1318305

Strand: Reverse

Name: nox [C]

Synonym: SPD_1298

Alternate gene names: 116516669

Gene position: 1318305-1316926 (Counterclockwise)

Preceding gene: 116517108

Following gene: 116515752

Centisome position: 64.43

GC content: 40.72

Gene sequence:

>1380_bases
ATGAGTAAAATCGTTGTAGTCGGTGCTAACCACGCTGGTACAGCATGTATCAATACCATGTTGGATAATTTTGGAAATGA
GAACGAAATTGTTGTATTTGACCAAAACTCTAACATCTCTTTCCTAGGATGTGGAATGGCTCTTTGGATTGGTGAACAAA
TTGACGGTGCTGAAGGCTTGTTCTATTCTGATAAAGAAAAATTGGAAGCTAAAGGTGCTAAAGTTTACATGAACTCACCT
GTTCTTTCAATCGACTATGATAACAAAGTAGTTACAGCGGAAGTTGAAGGAAAAGAGCACAAAGAATCATACGAAAAATT
GATTTTCGCTACAGGTTCTACACCAATCTTGCCACCAATCGAAGGTGTTGAAATTGTTAAAGGAAACCGCGAATTTAAAG
CAACTCTTGAAAACGTACAATTCGTGAAATTGTACCAAAATGCTGAAGAAGTTATCAATAAACTTTCTGACAAGAGCCAA
CACCTCGACCGTATCGCCGTTGTTGGTGGTGGTTACATCGGTGTTGAACTTGCTGAAGCCTTTGAACGTCTTGGAAAAGA
AGTTGTCCTTGTTGATATCGTTGATACTGTCTTGAACGGTTACTATGACAAAGACTTCACACAAATGATGGCGAAGAACT
TGGAAGATCACAACATCCGCTTGGCTCTAGGTCAAACTGTTAAAGCAATCGAAGGTGACGGTAAAGTTGAACGCTTGATT
ACTGACAAAGAAAGCTTTGACGTGGATATGGTTATCCTTGCAGTTGGTTTCCGTCCAAACACAGCCCTTGCAGATGGTAA
GATCGAACTCTTCCGCAACGGTGCCTTCCTTGTAGACAAGAAACAAGAAACATCTATCCCAGGCGTTTACGCTGTTGGTG
ACTGTGCGACTGTTTATGACAATGCTCGTAAAGATACAAGCTATATCGCTCTTGCTTCAAATGCTGTTCGCACTGGTATC
GTTGGTGCCTACAACGCTTGTGGACATGAATTGGAAGGAATCGGTGTTCAAGGTTCAAATGGTATCTCAATCTACGGTCT
TCACATGGTTTCAACTGGTTTGACTCTTGAAAAAGCGAAAGCTGCTGGTTACAACGCAACTGAAACAGGCTTTAACGATC
TTCAAAAACCAGAATTCATGAAACATGACAACCATGAAGTAGCAATTAAGATTGTCTTTGACAAAGATAGCCGTGAAATT
CTTGGTGCCCAAATGGTTTCACATGATATTGCAATTAGCATGGGAATCCACATGTTCTCACTTGCTATCCAAGAGCATGT
GACAATTGATAAATTGGCATTGACAGACCTCTTCTTCTTGCCACACTTCAACAAACCATACAACTACATCACAATGGCTG
CCCTTACGGCTGAAAAATAA

Upstream 100 bases:

>100_bases
TTTTGATAAAAAATGCTGAAATAATAGTACCCCCCTTGTAAACGCTAACGGTAAATGGTATACTAGTAAGGTAAATTTAG
AATGAAGGCAGGAAATTTTT

Downstream 100 bases:

>100_bases
AAATGAATGAGCTATCTGGCCTTAAGTTAAGGTCAGATAGTTTTTAGCTAATCTGTCCCCATACAATTATAGTTTTTTTA
TCTTGTGCTTCATTCTGTTC

Product: NADH oxidase

Products: NA

Alternate protein names: NOXase [H]

Number of amino acids: Translated: 459; Mature: 458

Protein sequence:

>459_residues
MSKIVVVGANHAGTACINTMLDNFGNENEIVVFDQNSNISFLGCGMALWIGEQIDGAEGLFYSDKEKLEAKGAKVYMNSP
VLSIDYDNKVVTAEVEGKEHKESYEKLIFATGSTPILPPIEGVEIVKGNREFKATLENVQFVKLYQNAEEVINKLSDKSQ
HLDRIAVVGGGYIGVELAEAFERLGKEVVLVDIVDTVLNGYYDKDFTQMMAKNLEDHNIRLALGQTVKAIEGDGKVERLI
TDKESFDVDMVILAVGFRPNTALADGKIELFRNGAFLVDKKQETSIPGVYAVGDCATVYDNARKDTSYIALASNAVRTGI
VGAYNACGHELEGIGVQGSNGISIYGLHMVSTGLTLEKAKAAGYNATETGFNDLQKPEFMKHDNHEVAIKIVFDKDSREI
LGAQMVSHDIAISMGIHMFSLAIQEHVTIDKLALTDLFFLPHFNKPYNYITMAALTAEK

Sequences:

>Translated_459_residues
MSKIVVVGANHAGTACINTMLDNFGNENEIVVFDQNSNISFLGCGMALWIGEQIDGAEGLFYSDKEKLEAKGAKVYMNSP
VLSIDYDNKVVTAEVEGKEHKESYEKLIFATGSTPILPPIEGVEIVKGNREFKATLENVQFVKLYQNAEEVINKLSDKSQ
HLDRIAVVGGGYIGVELAEAFERLGKEVVLVDIVDTVLNGYYDKDFTQMMAKNLEDHNIRLALGQTVKAIEGDGKVERLI
TDKESFDVDMVILAVGFRPNTALADGKIELFRNGAFLVDKKQETSIPGVYAVGDCATVYDNARKDTSYIALASNAVRTGI
VGAYNACGHELEGIGVQGSNGISIYGLHMVSTGLTLEKAKAAGYNATETGFNDLQKPEFMKHDNHEVAIKIVFDKDSREI
LGAQMVSHDIAISMGIHMFSLAIQEHVTIDKLALTDLFFLPHFNKPYNYITMAALTAEK
>Mature_458_residues
SKIVVVGANHAGTACINTMLDNFGNENEIVVFDQNSNISFLGCGMALWIGEQIDGAEGLFYSDKEKLEAKGAKVYMNSPV
LSIDYDNKVVTAEVEGKEHKESYEKLIFATGSTPILPPIEGVEIVKGNREFKATLENVQFVKLYQNAEEVINKLSDKSQH
LDRIAVVGGGYIGVELAEAFERLGKEVVLVDIVDTVLNGYYDKDFTQMMAKNLEDHNIRLALGQTVKAIEGDGKVERLIT
DKESFDVDMVILAVGFRPNTALADGKIELFRNGAFLVDKKQETSIPGVYAVGDCATVYDNARKDTSYIALASNAVRTGIV
GAYNACGHELEGIGVQGSNGISIYGLHMVSTGLTLEKAKAAGYNATETGFNDLQKPEFMKHDNHEVAIKIVFDKDSREIL
GAQMVSHDIAISMGIHMFSLAIQEHVTIDKLALTDLFFLPHFNKPYNYITMAALTAEK

Specific function: Catalyzes the four-electron reduction of molecular oxygen to water [H]

COG id: COG0446

COG function: function code R; Uncharacterized NAD(FAD)-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI21389617, Length=337, Percent_Identity=24.9258160237389, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI226437568, Length=337, Percent_Identity=24.9258160237389, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI65787454, Length=337, Percent_Identity=24.9258160237389, Blast_Score=82, Evalue=1e-15,
Organism=Escherichia coli, GI1789065, Length=225, Percent_Identity=31.1111111111111, Blast_Score=99, Evalue=7e-22,
Organism=Escherichia coli, GI1789765, Length=304, Percent_Identity=25.3289473684211, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1786307, Length=362, Percent_Identity=26.2430939226519, Blast_Score=68, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24639257, Length=230, Percent_Identity=27.3913043478261, Blast_Score=72, Evalue=9e-13,
Organism=Drosophila melanogaster, GI281359715, Length=230, Percent_Identity=27.3913043478261, Blast_Score=72, Evalue=9e-13,
Organism=Drosophila melanogaster, GI281359713, Length=230, Percent_Identity=27.3913043478261, Blast_Score=72, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24639250, Length=230, Percent_Identity=27.3913043478261, Blast_Score=72, Evalue=9e-13,
Organism=Drosophila melanogaster, GI18543267, Length=230, Percent_Identity=27.3913043478261, Blast_Score=72, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24639252, Length=230, Percent_Identity=27.3913043478261, Blast_Score=72, Evalue=9e-13,
Organism=Drosophila melanogaster, GI21358499, Length=151, Percent_Identity=30.4635761589404, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.6.99.3 [H]

Molecular weight: Translated: 50256; Mature: 50125

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKIVVVGANHAGTACINTMLDNFGNENEIVVFDQNSNISFLGCGMALWIGEQIDGAEGL
CCEEEEEECCCCCHHHHHHHHHHCCCCCEEEEEECCCCEEEEECCEEEEECCCCCCCCCC
FYSDKEKLEAKGAKVYMNSPVLSIDYDNKVVTAEVEGKEHKESYEKLIFATGSTPILPPI
EECCHHHHHCCCCEEEECCCEEEEECCCEEEEEEECCCHHHHHHHEEEEECCCCCCCCCC
EGVEIVKGNREFKATLENVQFVKLYQNAEEVINKLSDKSQHLDRIAVVGGGYIGVELAEA
CCEEEEECCCHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHCCEEEEECCCEEHHHHHHH
FERLGKEVVLVDIVDTVLNGYYDKDFTQMMAKNLEDHNIRLALGQTVKAIEGDGKVERLI
HHHCCCEEEEEEHHHHHHCCCCCHHHHHHHHCCCCCCEEEEEECCEEEECCCCCCEEEEE
TDKESFDVDMVILAVGFRPNTALADGKIELFRNGAFLVDKKQETSIPGVYAVGDCATVYD
CCCCCCCEEEEEEEECCCCCCEECCCEEEEEECCEEEEECCCCCCCCCEEEECCHHHHHC
NARKDTSYIALASNAVRTGIVGAYNACGHELEGIGVQGSNGISIYGLHMVSTGLTLEKAK
CCCCCCCEEEEECCCHHHCCCCCHHHCCCCCCCCCEECCCCEEEEEEEEEECCCEEEHHH
AAGYNATETGFNDLQKPEFMKHDNHEVAIKIVFDKDSREILGAQMVSHDIAISMGIHMFS
CCCCCCCCCCCCCCCCCHHHCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
LAIQEHVTIDKLALTDLFFLPHFNKPYNYITMAALTAEK
HHHHHCCCHHHHHHHHHHCCCCCCCCCCEEEEEEEECCC
>Mature Secondary Structure 
SKIVVVGANHAGTACINTMLDNFGNENEIVVFDQNSNISFLGCGMALWIGEQIDGAEGL
CEEEEEECCCCCHHHHHHHHHHCCCCCEEEEEECCCCEEEEECCEEEEECCCCCCCCCC
FYSDKEKLEAKGAKVYMNSPVLSIDYDNKVVTAEVEGKEHKESYEKLIFATGSTPILPPI
EECCHHHHHCCCCEEEECCCEEEEECCCEEEEEEECCCHHHHHHHEEEEECCCCCCCCCC
EGVEIVKGNREFKATLENVQFVKLYQNAEEVINKLSDKSQHLDRIAVVGGGYIGVELAEA
CCEEEEECCCHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHCCEEEEECCCEEHHHHHHH
FERLGKEVVLVDIVDTVLNGYYDKDFTQMMAKNLEDHNIRLALGQTVKAIEGDGKVERLI
HHHCCCEEEEEEHHHHHHCCCCCHHHHHHHHCCCCCCEEEEEECCEEEECCCCCCEEEEE
TDKESFDVDMVILAVGFRPNTALADGKIELFRNGAFLVDKKQETSIPGVYAVGDCATVYD
CCCCCCCEEEEEEEECCCCCCEECCCEEEEEECCEEEEECCCCCCCCCEEEECCHHHHHC
NARKDTSYIALASNAVRTGIVGAYNACGHELEGIGVQGSNGISIYGLHMVSTGLTLEKAK
CCCCCCCEEEEECCCHHHCCCCCHHHCCCCCCCCCEECCCCEEEEEEEEEECCCEEEHHH
AAGYNATETGFNDLQKPEFMKHDNHEVAIKIVFDKDSREILGAQMVSHDIAISMGIHMFS
CCCCCCCCCCCCCCCCCHHHCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
LAIQEHVTIDKLALTDLFFLPHFNKPYNYITMAALTAEK
HHHHHCCCHHHHHHHHHHCCCCCCCCCCEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA