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The map label for this gene is argH

Identifier: 116496234

GI number: 116496234

Start: 2795748

End: 2797130

Strand: Direct

Name: argH

Synonym: LSEI_2812

Alternate gene names: 116496234

Gene position: 2795748-2797130 (Clockwise)

Preceding gene: 116496233

Following gene: 116496239

Centisome position: 96.56

GC content: 49.46

Gene sequence:

>1383_bases
ATGACTGATAAGTTATGGGGCGGTCGGTTTACTGAAAAAGCGGCACACTGGGTTGATGCTTTTGGAGCCTCCATCGGTTT
TGATCAGCAAATGGCCCAAGAAGATTTGGAGGGGTCGCTTGCACATGTCAAGATGCTGGGCAAAACCGGCATCATCCCCC
AAGCCGATGCCGACACGATCACGGCGGGTTTGCAGCATCTGCAGAAGGAATTGGCTGCTGGCAAACTGCACTTCACGGTT
GAAAATGAGGATATCCATCTTAATATGGAAGCCCTGTTGACCGCTGAAATCGGCCCCGTTGCTGGCAAACTGCACACTGC
CCGCTCGCGCAATGATCAAGTCGCAACCGATCTGCACCTCTGGCTGAAACATCGCCTACCAACAATCAAAGAAGCTTTGA
CCAACCTGCAAACCGTGTTGGTTGGTCAAGCCAAGGTCCACGCAGCAACAATCATGCCCGGTTATACCCATATGCAACAC
GCCCAGCCGATCACTTATGGTCATTATTTGTTGGCGTATTTCGAAATGTTCCAGCGCGATTGGGAACGTTTCGACTTTAC
CCAAAAGCACACCGACATTTTGCCATTAGGGGCAGCCGCCCTCGCTGGTACGACCTTCCCGATTGACCGGACGCTGGTTG
CTCAAGAGCTGGGATTTGACCAAATTTATCACAACAGCCTCGATGCTGTTTCAGACCGCGACTTTGCGCTTGAGTTTCTC
AGCAATAGTGCCATTTTGATGCAGCACTTGAGTCGCATGGCAGAAGAGCTCATTCTTTGGTCCACTTACGAGTTTAATTA
CATTGAACTCGGCGATGATTTTTCAACCGGTAGCTCAATTATGCCGCAAAAAAAGAATCCTGATTTTGCGGAACTTATTC
GTGGCAAAACTGGCCGTGTTTATGGCGCCTTAATGGGCTTGTTGACAACGATGAAGGCAATCCCGTTGGCTTACAACAAA
GATATGCAAGAAGATAAAGAACCCATTTTCGATGCTTATAACACTATTCTTGGCTCTTTGCACATTTTCACTGGCATGTT
AAGCGACCTGACCGTTCACGAAAAACGGATGGCAGAGGCAACCACGCATGACTTCAGCAATGCAACGGAGTTAGCGGATT
ACCTCGCGACAAAGGGTGTGCCATTCCGGCAGGCACATGCCATTGTTGGTGAGTTGGTACTCAAGGGGATCAAAACCAAC
ACTGCCTTGCAGGAAATGCCGTTAAGCGAGTTGCAAGCAGCCGCACCGCAAATTCAGCAGGATGTTTACGCTGAATTAAC
GTCAAAGGCCGCCGTAGATCGCCGGACTTCGTTAGGTGGTACTGCGGTTAGTAATGTGTTGAAAGAAGTTGCTCGCGATG
AGGAAATGATTGCTTCCCACTAG

Upstream 100 bases:

>100_bases
TCCTTCGATCAAGAAGCAGCAGCTGGCTTTATCAAACTCTGGACCTTGCCGACAACCGTTTTCGAGCAAGTCAACCATGT
GCACTCCGAGGAAAAACAAC

Downstream 100 bases:

>100_bases
CGGCATTTGCTCGTTATAGCGCGGTTGCAAACGTTCTTTGCCGTGCCAAACTCCGCAATCTCCGGCCAGCTGGGTGGCGA
CGCACAGCTAGAGCGGAGAT

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase

Number of amino acids: Translated: 460; Mature: 459

Protein sequence:

>460_residues
MTDKLWGGRFTEKAAHWVDAFGASIGFDQQMAQEDLEGSLAHVKMLGKTGIIPQADADTITAGLQHLQKELAAGKLHFTV
ENEDIHLNMEALLTAEIGPVAGKLHTARSRNDQVATDLHLWLKHRLPTIKEALTNLQTVLVGQAKVHAATIMPGYTHMQH
AQPITYGHYLLAYFEMFQRDWERFDFTQKHTDILPLGAAALAGTTFPIDRTLVAQELGFDQIYHNSLDAVSDRDFALEFL
SNSAILMQHLSRMAEELILWSTYEFNYIELGDDFSTGSSIMPQKKNPDFAELIRGKTGRVYGALMGLLTTMKAIPLAYNK
DMQEDKEPIFDAYNTILGSLHIFTGMLSDLTVHEKRMAEATTHDFSNATELADYLATKGVPFRQAHAIVGELVLKGIKTN
TALQEMPLSELQAAAPQIQQDVYAELTSKAAVDRRTSLGGTAVSNVLKEVARDEEMIASH

Sequences:

>Translated_460_residues
MTDKLWGGRFTEKAAHWVDAFGASIGFDQQMAQEDLEGSLAHVKMLGKTGIIPQADADTITAGLQHLQKELAAGKLHFTV
ENEDIHLNMEALLTAEIGPVAGKLHTARSRNDQVATDLHLWLKHRLPTIKEALTNLQTVLVGQAKVHAATIMPGYTHMQH
AQPITYGHYLLAYFEMFQRDWERFDFTQKHTDILPLGAAALAGTTFPIDRTLVAQELGFDQIYHNSLDAVSDRDFALEFL
SNSAILMQHLSRMAEELILWSTYEFNYIELGDDFSTGSSIMPQKKNPDFAELIRGKTGRVYGALMGLLTTMKAIPLAYNK
DMQEDKEPIFDAYNTILGSLHIFTGMLSDLTVHEKRMAEATTHDFSNATELADYLATKGVPFRQAHAIVGELVLKGIKTN
TALQEMPLSELQAAAPQIQQDVYAELTSKAAVDRRTSLGGTAVSNVLKEVARDEEMIASH
>Mature_459_residues
TDKLWGGRFTEKAAHWVDAFGASIGFDQQMAQEDLEGSLAHVKMLGKTGIIPQADADTITAGLQHLQKELAAGKLHFTVE
NEDIHLNMEALLTAEIGPVAGKLHTARSRNDQVATDLHLWLKHRLPTIKEALTNLQTVLVGQAKVHAATIMPGYTHMQHA
QPITYGHYLLAYFEMFQRDWERFDFTQKHTDILPLGAAALAGTTFPIDRTLVAQELGFDQIYHNSLDAVSDRDFALEFLS
NSAILMQHLSRMAEELILWSTYEFNYIELGDDFSTGSSIMPQKKNPDFAELIRGKTGRVYGALMGLLTTMKAIPLAYNKD
MQEDKEPIFDAYNTILGSLHIFTGMLSDLTVHEKRMAEATTHDFSNATELADYLATKGVPFRQAHAIVGELVLKGIKTNT
ALQEMPLSELQAAAPQIQQDVYAELTSKAAVDRRTSLGGTAVSNVLKEVARDEEMIASH

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily

Homologues:

Organism=Homo sapiens, GI31541964, Length=445, Percent_Identity=44.2696629213483, Blast_Score=386, Evalue=1e-107,
Organism=Homo sapiens, GI68303542, Length=445, Percent_Identity=44.2696629213483, Blast_Score=386, Evalue=1e-107,
Organism=Homo sapiens, GI68303549, Length=445, Percent_Identity=42.247191011236, Blast_Score=356, Evalue=2e-98,
Organism=Homo sapiens, GI68303547, Length=445, Percent_Identity=41.7977528089888, Blast_Score=351, Evalue=8e-97,
Organism=Escherichia coli, GI1790398, Length=448, Percent_Identity=47.3214285714286, Blast_Score=410, Evalue=1e-115,
Organism=Saccharomyces cerevisiae, GI6321806, Length=452, Percent_Identity=44.0265486725664, Blast_Score=367, Evalue=1e-102,
Organism=Drosophila melanogaster, GI221473854, Length=459, Percent_Identity=38.9978213507625, Blast_Score=341, Evalue=7e-94,
Organism=Drosophila melanogaster, GI78706858, Length=459, Percent_Identity=38.9978213507625, Blast_Score=341, Evalue=7e-94,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARLY_LACC3 (Q033U6)

Other databases:

- EMBL:   CP000423
- RefSeq:   YP_807968.1
- ProteinModelPortal:   Q033U6
- SMR:   Q033U6
- STRING:   Q033U6
- GeneID:   4421382
- GenomeReviews:   CP000423_GR
- KEGG:   lca:LSEI_2812
- eggNOG:   COG0165
- HOGENOM:   HBG539632
- OMA:   MAEDLIF
- PhylomeDB:   Q033U6
- ProtClustDB:   PRK00855
- BioCyc:   LCAS321967:LSEI_2812-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00006
- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761
- PANTHER:   PTHR11444:SF3
- PRINTS:   PR00145
- PRINTS:   PR00149
- TIGRFAMs:   TIGR00838

Pfam domain/function: PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.3.2.1

Molecular weight: Translated: 51024; Mature: 50892

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDKLWGGRFTEKAAHWVDAFGASIGFDQQMAQEDLEGSLAHVKMLGKTGIIPQADADTI
CCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHCCCCCCCCCCHHHH
TAGLQHLQKELAAGKLHFTVENEDIHLNMEALLTAEIGPVAGKLHTARSRNDQVATDLHL
HHHHHHHHHHHHCCEEEEEEECCCEEEEHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHH
WLKHRLPTIKEALTNLQTVLVGQAKVHAATIMPGYTHMQHAQPITYGHYLLAYFEMFQRD
HHHHCCCHHHHHHHHHHHHHHCHHHHEEEEECCCCHHHHHCCCCHHHHHHHHHHHHHHHH
WERFDFTQKHTDILPLGAAALAGTTFPIDRTLVAQELGFDQIYHNSLDAVSDRDFALEFL
HHHCCCCHHCCCCCCCCHHHHCCCCCCCHHHHHHHHHCHHHHHHCCHHHCCCHHHHHHHH
SNSAILMQHLSRMAEELILWSTYEFNYIELGDDFSTGSSIMPQKKNPDFAELIRGKTGRV
CCCHHHHHHHHHHHHHHHHHEECCCCEEEECCCCCCCCCCCCCCCCCCHHHHHCCCCCHH
YGALMGLLTTMKAIPLAYNKDMQEDKEPIFDAYNTILGSLHIFTGMLSDLTVHEKRMAEA
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TTHDFSNATELADYLATKGVPFRQAHAIVGELVLKGIKTNTALQEMPLSELQAAAPQIQQ
HHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHH
DVYAELTSKAAVDRRTSLGGTAVSNVLKEVARDEEMIASH
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHCCC
>Mature Secondary Structure 
TDKLWGGRFTEKAAHWVDAFGASIGFDQQMAQEDLEGSLAHVKMLGKTGIIPQADADTI
CCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHCCCCCCCCCCHHHH
TAGLQHLQKELAAGKLHFTVENEDIHLNMEALLTAEIGPVAGKLHTARSRNDQVATDLHL
HHHHHHHHHHHHCCEEEEEEECCCEEEEHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHH
WLKHRLPTIKEALTNLQTVLVGQAKVHAATIMPGYTHMQHAQPITYGHYLLAYFEMFQRD
HHHHCCCHHHHHHHHHHHHHHCHHHHEEEEECCCCHHHHHCCCCHHHHHHHHHHHHHHHH
WERFDFTQKHTDILPLGAAALAGTTFPIDRTLVAQELGFDQIYHNSLDAVSDRDFALEFL
HHHCCCCHHCCCCCCCCHHHHCCCCCCCHHHHHHHHHCHHHHHHCCHHHCCCHHHHHHHH
SNSAILMQHLSRMAEELILWSTYEFNYIELGDDFSTGSSIMPQKKNPDFAELIRGKTGRV
CCCHHHHHHHHHHHHHHHHHEECCCCEEEECCCCCCCCCCCCCCCCCCHHHHHCCCCCHH
YGALMGLLTTMKAIPLAYNKDMQEDKEPIFDAYNTILGSLHIFTGMLSDLTVHEKRMAEA
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TTHDFSNATELADYLATKGVPFRQAHAIVGELVLKGIKTNTALQEMPLSELQAAAPQIQQ
HHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHH
DVYAELTSKAAVDRRTSLGGTAVSNVLKEVARDEEMIASH
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA