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The map label for this gene is clpE [H]

Identifier: 116495242

GI number: 116495242

Start: 1756942

End: 1759038

Strand: Direct

Name: clpE [H]

Synonym: LSEI_1762

Alternate gene names: 116495242

Gene position: 1756942-1759038 (Clockwise)

Preceding gene: 116495221

Following gene: 116495243

Centisome position: 60.68

GC content: 46.4

Gene sequence:

>2097_bases
ATGAGACCAACTGATGCAACCGATCCATTTGGTTTCGGCAGCTTAGATGATATTTTCCGTGCGATGAATCAGGGAATGGA
TCAACCGCAACAACCAAATGCTCAGACCCCGCCAACTCAGGCAGGCCGTGGCGGCAATGGTAATAACGGCCGCAATGGCA
ACCGTGGCAAGGGACTGCTGGGACAATTCGGCGTTGATCTGACTGAACAAGCACGGAATGGTCAAATTGATCCGGTCATT
GGTCGTGACAAAGAAATTTCACGGGTGATCGAGATCTTAAACCGCCGAACAAAAAATAATCCAGTCCTGATTGGTGAAGC
CGGTGTCGGCAAGACTGCTGTTGTTGAGGGCTTGGCATTGAAGATCGCTAATGGCGATGTTCCGTCAAAACTTCAAGATC
GGCATGTCATCCGACTCGATGTCGTTTCACTAGTTCAAGGAACTGGCATTCGCGGTCAATTCGAACAACGTATGCAACAA
TTGATTGACGAACTTAAAAAGAATAAGAACATTATCTTATTTATTGATGAAATCCATGAAATCGTCGGCGCTGGCAATGC
TGAAGGCGGTATGGATGCCGGCAATGTTCTGAAGCCAGCATTAGCACGTGGCGAGTTGCAGCTCGTTGGTGCCACTACTA
GCAATGAATATCGTCAAATTGAAAAAGATTCAGCCCTTGCTCGTCGTCTGCAACCAGTCCTCGTTGAGGAGCCAACTGTA
GAAGAGACGATTAAGATTCTAAAAGGCCTGCAGCCGCGGTATCAAGATTTTCATCATGTTAAATATACAGATGCCGCCAT
TGAAGCAGCTGCAACTTTGAGCAATCGTTACATTCAAGATCGTTTCTTGCCTGACAAAGCGATTGACCTTCTGGATGAAT
CAGGTTCCCGGAAGAATCTGACCATTGCCACTGTCGATCCAGAAACGATCAAGACCAAGATTGACGACGCCGAGAAGCAA
AAGCAAGCTGCTCTGAAGCAGGAGGATTACGAAAAAGCTGCCTTCTATCGTGACCAAGTTACTAAGTTAGAAGATATGGC
TAAGAAACAGTCTAATCTGCCTGAAAATGAAATTCCGACTGTCACCGAAAAAGATATGGAACAGATTGTTGAAGAAAAAA
CCAACATTCCAGTTGGTGAACTGAAGGCGCAGGAGCAAGCACAGCTGAAGAATCTGGCTGGTGACCTTGAAAAGCATGTC
ATTGGTCAGAATGAAGCAGTTGATAAAGTTGCTCGCGCTATTCGTCGTAACCGGATCGGCTTTAACAAGTCCGGTCGGCC
GATTGGGTCCTTCCTATTCGTCGGCCCAACAGGTGTCGGCAAAACTGAACTGGCTAAACAGCTTGCCAAAGAGCTGTTTG
GTTCTGAAGACGCCATGATCCGGTTTGATATGTCGGAGTACATGGAGAAATTCAGTGTCTCCAAGCTTATCGGGTCACCG
CCAGGCTATGTCGGCTATGAGGAAGCCGGTCAATTAACTGAAAAAGTTCGCCGAAATCCTTATAGCCTCATCTTGTTAGA
TGAAATTGAAAAAGCCCATCCAGATGTGATGAATATGTTCTTGCAGATCTTGGATGACGGCCGATTGACTGATTCTCAAG
GCCGTACCGTTTCCTTCAAGGACACGATCATTATCATGACATCCAATGCTGGCTCAACCGATGCCGAAGCAAACGTTGGT
TTTGGCGCAGCTTTAAGCGGTAAGACGCACAGTGTGCTGGATCAGCTTGGTAATTACTTCAAGCCTGAATTCCTGAACCG
TTTTGATGACATCGTTGAATTCAAGTCATTGTCTAAAGACGACTTGTTGAAGATTGTGTCACTGATGATTCAAGATACCA
ACAATAACATCAAGGATCAGGGCTTGACGATTCATGTTACCGATCCGGTTAAGGAAAAGCTGGTTAATCTCGGTTACAAT
CCTGCCATGGGAGCTCGGCCGCTGCGTCGAGTCATTCAGGAACAGATTGAAGACCGCGTTGCTGACTTCTACCTTGACCA
TCCAAAGGCTAAGGAACTTGAAGCCCGCATCAGTAATGGTGAGATTACGGTTGGTGAACCTGCCAAGGCTGAAACCACTC
AAAAATCTAAAAAGTAA

Upstream 100 bases:

>100_bases
AGCCACTATTCATCTTTCAACCGTTGTTAATGGCACTCGACAGGAAATTAATCTCTGCCAAAACTGTTATCAATTACTCA
AGAACCAAGCAGGAGGAAAT

Downstream 100 bases:

>100_bases
TTTGTTTTAAGAAAGCCCTCGAACTTCATTGCGTTCGAGGGCTTTCAATTCACATATTATTATTTTCCGTTAAACTGTTT
TATAATAAAAACAGTAGGGA

Product: ATP-binding subunit of Clp protease and DnaK/DnaJ chaperones

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 698; Mature: 698

Protein sequence:

>698_residues
MRPTDATDPFGFGSLDDIFRAMNQGMDQPQQPNAQTPPTQAGRGGNGNNGRNGNRGKGLLGQFGVDLTEQARNGQIDPVI
GRDKEISRVIEILNRRTKNNPVLIGEAGVGKTAVVEGLALKIANGDVPSKLQDRHVIRLDVVSLVQGTGIRGQFEQRMQQ
LIDELKKNKNIILFIDEIHEIVGAGNAEGGMDAGNVLKPALARGELQLVGATTSNEYRQIEKDSALARRLQPVLVEEPTV
EETIKILKGLQPRYQDFHHVKYTDAAIEAAATLSNRYIQDRFLPDKAIDLLDESGSRKNLTIATVDPETIKTKIDDAEKQ
KQAALKQEDYEKAAFYRDQVTKLEDMAKKQSNLPENEIPTVTEKDMEQIVEEKTNIPVGELKAQEQAQLKNLAGDLEKHV
IGQNEAVDKVARAIRRNRIGFNKSGRPIGSFLFVGPTGVGKTELAKQLAKELFGSEDAMIRFDMSEYMEKFSVSKLIGSP
PGYVGYEEAGQLTEKVRRNPYSLILLDEIEKAHPDVMNMFLQILDDGRLTDSQGRTVSFKDTIIIMTSNAGSTDAEANVG
FGAALSGKTHSVLDQLGNYFKPEFLNRFDDIVEFKSLSKDDLLKIVSLMIQDTNNNIKDQGLTIHVTDPVKEKLVNLGYN
PAMGARPLRRVIQEQIEDRVADFYLDHPKAKELEARISNGEITVGEPAKAETTQKSKK

Sequences:

>Translated_698_residues
MRPTDATDPFGFGSLDDIFRAMNQGMDQPQQPNAQTPPTQAGRGGNGNNGRNGNRGKGLLGQFGVDLTEQARNGQIDPVI
GRDKEISRVIEILNRRTKNNPVLIGEAGVGKTAVVEGLALKIANGDVPSKLQDRHVIRLDVVSLVQGTGIRGQFEQRMQQ
LIDELKKNKNIILFIDEIHEIVGAGNAEGGMDAGNVLKPALARGELQLVGATTSNEYRQIEKDSALARRLQPVLVEEPTV
EETIKILKGLQPRYQDFHHVKYTDAAIEAAATLSNRYIQDRFLPDKAIDLLDESGSRKNLTIATVDPETIKTKIDDAEKQ
KQAALKQEDYEKAAFYRDQVTKLEDMAKKQSNLPENEIPTVTEKDMEQIVEEKTNIPVGELKAQEQAQLKNLAGDLEKHV
IGQNEAVDKVARAIRRNRIGFNKSGRPIGSFLFVGPTGVGKTELAKQLAKELFGSEDAMIRFDMSEYMEKFSVSKLIGSP
PGYVGYEEAGQLTEKVRRNPYSLILLDEIEKAHPDVMNMFLQILDDGRLTDSQGRTVSFKDTIIIMTSNAGSTDAEANVG
FGAALSGKTHSVLDQLGNYFKPEFLNRFDDIVEFKSLSKDDLLKIVSLMIQDTNNNIKDQGLTIHVTDPVKEKLVNLGYN
PAMGARPLRRVIQEQIEDRVADFYLDHPKAKELEARISNGEITVGEPAKAETTQKSKK
>Mature_698_residues
MRPTDATDPFGFGSLDDIFRAMNQGMDQPQQPNAQTPPTQAGRGGNGNNGRNGNRGKGLLGQFGVDLTEQARNGQIDPVI
GRDKEISRVIEILNRRTKNNPVLIGEAGVGKTAVVEGLALKIANGDVPSKLQDRHVIRLDVVSLVQGTGIRGQFEQRMQQ
LIDELKKNKNIILFIDEIHEIVGAGNAEGGMDAGNVLKPALARGELQLVGATTSNEYRQIEKDSALARRLQPVLVEEPTV
EETIKILKGLQPRYQDFHHVKYTDAAIEAAATLSNRYIQDRFLPDKAIDLLDESGSRKNLTIATVDPETIKTKIDDAEKQ
KQAALKQEDYEKAAFYRDQVTKLEDMAKKQSNLPENEIPTVTEKDMEQIVEEKTNIPVGELKAQEQAQLKNLAGDLEKHV
IGQNEAVDKVARAIRRNRIGFNKSGRPIGSFLFVGPTGVGKTELAKQLAKELFGSEDAMIRFDMSEYMEKFSVSKLIGSP
PGYVGYEEAGQLTEKVRRNPYSLILLDEIEKAHPDVMNMFLQILDDGRLTDSQGRTVSFKDTIIIMTSNAGSTDAEANVG
FGAALSGKTHSVLDQLGNYFKPEFLNRFDDIVEFKSLSKDDLLKIVSLMIQDTNNNIKDQGLTIHVTDPVKEKLVNLGYN
PAMGARPLRRVIQEQIEDRVADFYLDHPKAKELEARISNGEITVGEPAKAETTQKSKK

Specific function: Could be necessary for degrading proteins generated by certain types of stress [H]

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=298, Percent_Identity=37.248322147651, Blast_Score=189, Evalue=8e-48,
Organism=Escherichia coli, GI1788943, Length=719, Percent_Identity=46.5924895688456, Blast_Score=605, Evalue=1e-174,
Organism=Escherichia coli, GI1787109, Length=650, Percent_Identity=40.1538461538462, Blast_Score=491, Evalue=1e-140,
Organism=Saccharomyces cerevisiae, GI6320464, Length=702, Percent_Identity=42.5925925925926, Blast_Score=531, Evalue=1e-151,
Organism=Saccharomyces cerevisiae, GI6323002, Length=694, Percent_Identity=38.4726224783862, Blast_Score=452, Evalue=1e-128,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR001943
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF10431 ClpB_D2-small; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 77251; Mature: 77251

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: PS50151 UVR ; PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPTDATDPFGFGSLDDIFRAMNQGMDQPQQPNAQTPPTQAGRGGNGNNGRNGNRGKGLL
CCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCH
GQFGVDLTEQARNGQIDPVIGRDKEISRVIEILNRRTKNNPVLIGEAGVGKTAVVEGLAL
HHHCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHEE
KIANGDVPSKLQDRHVIRLDVVSLVQGTGIRGQFEQRMQQLIDELKKNKNIILFIDEIHE
EEECCCCCCHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCEEEEHHHHHH
IVGAGNAEGGMDAGNVLKPALARGELQLVGATTSNEYRQIEKDSALARRLQPVLVEEPTV
HHCCCCCCCCCCCCHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHCCHHHCCCCCH
EETIKILKGLQPRYQDFHHVKYTDAAIEAAATLSNRYIQDRFLPDKAIDLLDESGSRKNL
HHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCE
TIATVDPETIKTKIDDAEKQKQAALKQEDYEKAAFYRDQVTKLEDMAKKQSNLPENEIPT
EEEECCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
VTEKDMEQIVEEKTNIPVGELKAQEQAQLKNLAGDLEKHVIGQNEAVDKVARAIRRNRIG
CCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCC
FNKSGRPIGSFLFVGPTGVGKTELAKQLAKELFGSEDAMIRFDMSEYMEKFSVSKLIGSP
CCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHCCC
PGYVGYEEAGQLTEKVRRNPYSLILLDEIEKAHPDVMNMFLQILDDGRLTDSQGRTVSFK
CCCCCHHHHHHHHHHHHCCCCEEEEEHHHHHCCHHHHHHHHHHHCCCCEECCCCCEEEEC
DTIIIMTSNAGSTDAEANVGFGAALSGKTHSVLDQLGNYFKPEFLNRFDDIVEFKSLSKD
CEEEEEECCCCCCCCCCCCCCCEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHH
DLLKIVSLMIQDTNNNIKDQGLTIHVTDPVKEKLVNLGYNPAMGARPLRRVIQEQIEDRV
HHHHHHHHHHHCCCCCCCCCCEEEEECCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
ADFYLDHPKAKELEARISNGEITVGEPAKAETTQKSKK
HHHHCCCCCHHHHHHHHCCCCEEECCCCCCCCHHCCCC
>Mature Secondary Structure
MRPTDATDPFGFGSLDDIFRAMNQGMDQPQQPNAQTPPTQAGRGGNGNNGRNGNRGKGLL
CCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCH
GQFGVDLTEQARNGQIDPVIGRDKEISRVIEILNRRTKNNPVLIGEAGVGKTAVVEGLAL
HHHCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHEE
KIANGDVPSKLQDRHVIRLDVVSLVQGTGIRGQFEQRMQQLIDELKKNKNIILFIDEIHE
EEECCCCCCHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCEEEEHHHHHH
IVGAGNAEGGMDAGNVLKPALARGELQLVGATTSNEYRQIEKDSALARRLQPVLVEEPTV
HHCCCCCCCCCCCCHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHCCHHHCCCCCH
EETIKILKGLQPRYQDFHHVKYTDAAIEAAATLSNRYIQDRFLPDKAIDLLDESGSRKNL
HHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCE
TIATVDPETIKTKIDDAEKQKQAALKQEDYEKAAFYRDQVTKLEDMAKKQSNLPENEIPT
EEEECCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
VTEKDMEQIVEEKTNIPVGELKAQEQAQLKNLAGDLEKHVIGQNEAVDKVARAIRRNRIG
CCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCC
FNKSGRPIGSFLFVGPTGVGKTELAKQLAKELFGSEDAMIRFDMSEYMEKFSVSKLIGSP
CCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHCCC
PGYVGYEEAGQLTEKVRRNPYSLILLDEIEKAHPDVMNMFLQILDDGRLTDSQGRTVSFK
CCCCCHHHHHHHHHHHHCCCCEEEEEHHHHHCCHHHHHHHHHHHCCCCEECCCCCEEEEC
DTIIIMTSNAGSTDAEANVGFGAALSGKTHSVLDQLGNYFKPEFLNRFDDIVEFKSLSKD
CEEEEEECCCCCCCCCCCCCCCEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHH
DLLKIVSLMIQDTNNNIKDQGLTIHVTDPVKEKLVNLGYNPAMGARPLRRVIQEQIEDRV
HHHHHHHHHHHCCCCCCCCCCEEEEECCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
ADFYLDHPKAKELEARISNGEITVGEPAKAETTQKSKK
HHHHCCCCCHHHHHHHHCCCCEEECCCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]