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The map label for this gene is yxdK [H]

Identifier: 116495221

GI number: 116495221

Start: 1735182

End: 1736282

Strand: Direct

Name: yxdK [H]

Synonym: LSEI_1741

Alternate gene names: 116495221

Gene position: 1735182-1736282 (Clockwise)

Preceding gene: 116495220

Following gene: 116495242

Centisome position: 59.93

GC content: 47.87

Gene sequence:

>1101_bases
ATGCGGTTTCGTGATTATTTAAAGGATCATTTAAGCCCGATTGGTGGCTATATTCTTTGTGTTGGTCTGGCGGCCTTGAT
CATCTGGCTTGACCCGCAGCATCGCGTTAAGGCCATGACGCTTTGGTACGCTGTGTTGTTAGTGACACTATTGGCCAGCG
CTTTTTTGATCGCACGGTATTGGCGCGTACGGCGGTTCGCAGCTCGGCTTCAGGAACGGATCGATGCTCAGGAGGCTGCG
TTAGATTGGCCCTTGCCTGGCGGTGAATCCGCAACCGAACAACTTGTGACGAAAACGTACAATCAAATTTTGACCCAGCA
TCGCCAACAAGTAACTGCCCTGCTAGCACAACAGCAAGATCAAAAAGACTTCATTGATTCTTGGGTGCACGAAATCAAAG
TACCGCTCGCGGCAGTGACGTTGCTGGCCGAAAGTTTTGAGGGGCAAGTACCTGATGACAAACTGGATAATTTGAATCTG
CAATTGGATCAAATCGAATTTTATGTCGAGCAAGTCTTGTATTACTCGCGTCTCGACAGCTTTTCAAAGGATTATTTGCT
GCATGAGACATCATTGCGCCCGCTCATCAATGACGTAGTCGCCAACCAGCGGAACGGCTTTATCAATAAACGACTATCTT
TCAGACTGAATGGCACCGATCAAATCGTATTGACAGACAACAAGTGGCTTCGCTTTATTCTTGCTCAGCTCATCTCCAAT
GCGGTCAAATATACGCCAGAAGGAGGCCGAATCACGGCTCTCATTCGTAACACCGGGAAGGAAACGCAACTACAGATTAC
TGATACCGGTATCGGCATCCCCAAAGATGAGCAACATCGTGTTTTTGAGAAGGGATTCACGGGCAGTAATGGGCGCCTTT
CGAATCATAAGTCAACGGGATTAGGCTTGTTCTTGGCTGAAAAGTTAGCTGAAAAACTTGGCCATCACTTGTCGTTAACC
TCGGTAATCAATCAAGGTACCACGGTCACAATCCATTTTCCTTACGTGAGCTATTATGGTGAGGCCGATCAAACTGTGCA
CCATCCTGAATCCCACGCGATTGCTGTGCAAACCCAGACTAGGTCACATCCAGACAGCTGA

Upstream 100 bases:

>100_bases
ACATTAATCGCCTGCGCAAAAAAATCGAGGAAGCCGGGTTGAAAGATTATATTCAAACCAAGGTTGGACAAGGTTACATC
GTTCCTTAGGAGGCTGGCAG

Downstream 100 bases:

>100_bases
CGAATAAGATAGCATCAAGTAGTTGAATCAACCCTAGATCTCAAAATTGAGAGCCACCTATTCAACCAAATCGGCACCAG
AGGCAAGCAGCCTCTGATGC

Product: Signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 366; Mature: 366

Protein sequence:

>366_residues
MRFRDYLKDHLSPIGGYILCVGLAALIIWLDPQHRVKAMTLWYAVLLVTLLASAFLIARYWRVRRFAARLQERIDAQEAA
LDWPLPGGESATEQLVTKTYNQILTQHRQQVTALLAQQQDQKDFIDSWVHEIKVPLAAVTLLAESFEGQVPDDKLDNLNL
QLDQIEFYVEQVLYYSRLDSFSKDYLLHETSLRPLINDVVANQRNGFINKRLSFRLNGTDQIVLTDNKWLRFILAQLISN
AVKYTPEGGRITALIRNTGKETQLQITDTGIGIPKDEQHRVFEKGFTGSNGRLSNHKSTGLGLFLAEKLAEKLGHHLSLT
SVINQGTTVTIHFPYVSYYGEADQTVHHPESHAIAVQTQTRSHPDS

Sequences:

>Translated_366_residues
MRFRDYLKDHLSPIGGYILCVGLAALIIWLDPQHRVKAMTLWYAVLLVTLLASAFLIARYWRVRRFAARLQERIDAQEAA
LDWPLPGGESATEQLVTKTYNQILTQHRQQVTALLAQQQDQKDFIDSWVHEIKVPLAAVTLLAESFEGQVPDDKLDNLNL
QLDQIEFYVEQVLYYSRLDSFSKDYLLHETSLRPLINDVVANQRNGFINKRLSFRLNGTDQIVLTDNKWLRFILAQLISN
AVKYTPEGGRITALIRNTGKETQLQITDTGIGIPKDEQHRVFEKGFTGSNGRLSNHKSTGLGLFLAEKLAEKLGHHLSLT
SVINQGTTVTIHFPYVSYYGEADQTVHHPESHAIAVQTQTRSHPDS
>Mature_366_residues
MRFRDYLKDHLSPIGGYILCVGLAALIIWLDPQHRVKAMTLWYAVLLVTLLASAFLIARYWRVRRFAARLQERIDAQEAA
LDWPLPGGESATEQLVTKTYNQILTQHRQQVTALLAQQQDQKDFIDSWVHEIKVPLAAVTLLAESFEGQVPDDKLDNLNL
QLDQIEFYVEQVLYYSRLDSFSKDYLLHETSLRPLINDVVANQRNGFINKRLSFRLNGTDQIVLTDNKWLRFILAQLISN
AVKYTPEGGRITALIRNTGKETQLQITDTGIGIPKDEQHRVFEKGFTGSNGRLSNHKSTGLGLFLAEKLAEKLGHHLSLT
SVINQGTTVTIHFPYVSYYGEADQTVHHPESHAIAVQTQTRSHPDS

Specific function: Probable member of the two-component regulatory system yxdK/yxdJ. May activate yxdJ in response to the antibacterial protein LL-37 [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790861, Length=310, Percent_Identity=26.1290322580645, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1789149, Length=277, Percent_Identity=28.5198555956679, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI145693157, Length=223, Percent_Identity=26.457399103139, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI1786600, Length=247, Percent_Identity=23.4817813765182, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI48994928, Length=267, Percent_Identity=28.0898876404494, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI87082128, Length=221, Percent_Identity=28.9592760180996, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI87081816, Length=261, Percent_Identity=22.6053639846743, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1788713, Length=301, Percent_Identity=24.2524916943522, Blast_Score=61, Evalue=9e-11,
Organism=Escherichia coli, GI1788393, Length=230, Percent_Identity=22.1739130434783, Blast_Score=61, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467 [H]

Pfam domain/function: PF02518 HATPase_c [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 41571; Mature: 41571

Theoretical pI: Translated: 7.25; Mature: 7.25

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFRDYLKDHLSPIGGYILCVGLAALIIWLDPQHRVKAMTLWYAVLLVTLLASAFLIARY
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WRVRRFAARLQERIDAQEAALDWPLPGGESATEQLVTKTYNQILTQHRQQVTALLAQQQD
HHHHHHHHHHHHHHCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
QKDFIDSWVHEIKVPLAAVTLLAESFEGQVPDDKLDNLNLQLDQIEFYVEQVLYYSRLDS
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHC
FSKDYLLHETSLRPLINDVVANQRNGFINKRLSFRLNGTDQIVLTDNKWLRFILAQLISN
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCEEEEECCHHHHHHHHHHHHH
AVKYTPEGGRITALIRNTGKETQLQITDTGIGIPKDEQHRVFEKGFTGSNGRLSNHKSTG
HHHCCCCCCEEEEEEECCCCCCEEEEEECCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCC
LGLFLAEKLAEKLGHHLSLTSVINQGTTVTIHFPYVSYYGEADQTVHHPESHAIAVQTQT
HHHHHHHHHHHHHCCCEEHHHHHCCCCEEEEEECHHHHCCCCCCCCCCCCCCEEEEEECC
RSHPDS
CCCCCC
>Mature Secondary Structure
MRFRDYLKDHLSPIGGYILCVGLAALIIWLDPQHRVKAMTLWYAVLLVTLLASAFLIARY
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WRVRRFAARLQERIDAQEAALDWPLPGGESATEQLVTKTYNQILTQHRQQVTALLAQQQD
HHHHHHHHHHHHHHCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
QKDFIDSWVHEIKVPLAAVTLLAESFEGQVPDDKLDNLNLQLDQIEFYVEQVLYYSRLDS
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHC
FSKDYLLHETSLRPLINDVVANQRNGFINKRLSFRLNGTDQIVLTDNKWLRFILAQLISN
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCEEEEECCHHHHHHHHHHHHH
AVKYTPEGGRITALIRNTGKETQLQITDTGIGIPKDEQHRVFEKGFTGSNGRLSNHKSTG
HHHCCCCCCEEEEEEECCCCCCEEEEEECCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCC
LGLFLAEKLAEKLGHHLSLTSVINQGTTVTIHFPYVSYYGEADQTVHHPESHAIAVQTQT
HHHHHHHHHHHHHCCCEEHHHHHCCCCEEEEEECHHHHCCCCCCCCCCCCCCEEEEEECC
RSHPDS
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7952181; 9384377; 8867804 [H]