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The map label for this gene is csd [H]

Identifier: 116494677

GI number: 116494677

Start: 1164135

End: 1165331

Strand: Direct

Name: csd [H]

Synonym: LSEI_1182

Alternate gene names: 116494677

Gene position: 1164135-1165331 (Clockwise)

Preceding gene: 116494676

Following gene: 116494678

Centisome position: 40.21

GC content: 50.29

Gene sequence:

>1197_bases
ATGCGTGAACAATTTCCATTTTTTAAAGCTCATCCCGAGCTGGTCTATCTAGATACGGCGGCGACTTCTCAGAAACCGCA
AGCTTTACTAGATGCTATTCAAAATTACTATGTCAATGATAATGCCAATGTTCATCGTGGCTTGTATAAATTGGCTTATG
ACACCACCGAGGCTTATGAAAACGTACGCCAACAAGTGGCCGGCTTTTTAGGTGCGGCGAGTGCTGACGAGATTATTTTT
ACTCGCGGGACCACTGATAGCTTGAACTTGGTTGCTAGTGCTTATGGGCCGCAAGTCGTCGCGGCTGGGTCACAAATTGT
TGTGACGGGTGCAGAGCATCACAGTAATTTCATTCCTTGGCAGCAATTAGCCAAGCGCCAGCAGGCTACGTTCACAGTGA
CGCCGGTAAAGCCGGATGGCACGGTGGATATTGCTGCCTTATTAGCGGCCATCACGCCTCAGACGAAGGTGGTTGCGGTG
GCGCAAGTGACGAATGTTGCAGGTGATACGTTACCGATTGCCAAAATTGCGGCCAAAGCCCATGCAGTTGGTGCTGTTGT
CGTTGTTGATGGCGCGCAGGCGGTAGCCCATCTGGCAGTTGATGTTCAAGCTATGGGGGCGGATTTCTATGCATTTTCTG
GGCATAAAATTTATGGCCCAACTGGCATTGGCGCCCTCTATGGCCGCGCTGATTTATTGCAGCACATGCCGCCGATTCAG
TTTGGCGGTGAAATGATTTCAGAAGTCCGCGATGATGTCAGTACTTGGGCAGACGGCCCAATTAAGTATGAGGCTGGCAC
GCCGCACATTGCTGGCGTGATCGGATTAGGCGCTGCTTTAACGTGGTTTAATCAGTCTGTGAATGCAGCAGCATTTGACA
ACGAACATCAATTGGCAGATCAGTTACGCGCTGGCTTGGCAGCGATTCCAGATGTGACCGTGTATGGTAATCAAGCAAGT
TTGGCGACTGTGTCGTTTAACTTAACTGGGATTCACCCGCATGATCTTGCGACTTTCTTAGATGAGCAGCAAATTGCGGT
TCGTGCGGGGCATCATTGTGCACAACCGCTGATGGCGCGACTAGGGGTGCCAGCTACGGTTCGTGCTAGTTTCGGCGTTT
ACAACAATGCTGACGATGTTGAACGATTGATTCAGGCAGTTCAGGCGGCAAGGAGGTATTTCCATGGCATTGACTAA

Upstream 100 bases:

>100_bases
GTCATTCGCGGTTTCCTTGAAGGCGGCTTGGCTGAAATTGATGATGTCCGACTGAAGAAAGAACTCTTCGCAACGATTGA
TCGAACGCTGGTGGCTGAAG

Downstream 100 bases:

>100_bases
GCTGGACCAGATGTATCGGGCGGTCATTTTGGATGAAGCACAACACCCGCGACATCACGGGGTTTTGCCAGCTTTTGACC
ATGAAATTACGGTTCGCAAT

Product: cysteine sulfinate desulfinase/cysteine desulfurase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MREQFPFFKAHPELVYLDTAATSQKPQALLDAIQNYYVNDNANVHRGLYKLAYDTTEAYENVRQQVAGFLGAASADEIIF
TRGTTDSLNLVASAYGPQVVAAGSQIVVTGAEHHSNFIPWQQLAKRQQATFTVTPVKPDGTVDIAALLAAITPQTKVVAV
AQVTNVAGDTLPIAKIAAKAHAVGAVVVVDGAQAVAHLAVDVQAMGADFYAFSGHKIYGPTGIGALYGRADLLQHMPPIQ
FGGEMISEVRDDVSTWADGPIKYEAGTPHIAGVIGLGAALTWFNQSVNAAAFDNEHQLADQLRAGLAAIPDVTVYGNQAS
LATVSFNLTGIHPHDLATFLDEQQIAVRAGHHCAQPLMARLGVPATVRASFGVYNNADDVERLIQAVQAARRYFHGID

Sequences:

>Translated_398_residues
MREQFPFFKAHPELVYLDTAATSQKPQALLDAIQNYYVNDNANVHRGLYKLAYDTTEAYENVRQQVAGFLGAASADEIIF
TRGTTDSLNLVASAYGPQVVAAGSQIVVTGAEHHSNFIPWQQLAKRQQATFTVTPVKPDGTVDIAALLAAITPQTKVVAV
AQVTNVAGDTLPIAKIAAKAHAVGAVVVVDGAQAVAHLAVDVQAMGADFYAFSGHKIYGPTGIGALYGRADLLQHMPPIQ
FGGEMISEVRDDVSTWADGPIKYEAGTPHIAGVIGLGAALTWFNQSVNAAAFDNEHQLADQLRAGLAAIPDVTVYGNQAS
LATVSFNLTGIHPHDLATFLDEQQIAVRAGHHCAQPLMARLGVPATVRASFGVYNNADDVERLIQAVQAARRYFHGID
>Mature_398_residues
MREQFPFFKAHPELVYLDTAATSQKPQALLDAIQNYYVNDNANVHRGLYKLAYDTTEAYENVRQQVAGFLGAASADEIIF
TRGTTDSLNLVASAYGPQVVAAGSQIVVTGAEHHSNFIPWQQLAKRQQATFTVTPVKPDGTVDIAALLAAITPQTKVVAV
AQVTNVAGDTLPIAKIAAKAHAVGAVVVVDGAQAVAHLAVDVQAMGADFYAFSGHKIYGPTGIGALYGRADLLQHMPPIQ
FGGEMISEVRDDVSTWADGPIKYEAGTPHIAGVIGLGAALTWFNQSVNAAAFDNEHQLADQLRAGLAAIPDVTVYGNQAS
LATVSFNLTGIHPHDLATFLDEQQIAVRAGHHCAQPLMARLGVPATVRASFGVYNNADDVERLIQAVQAARRYFHGID

Specific function: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine [H]

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=397, Percent_Identity=28.2115869017632, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI156713448, Length=425, Percent_Identity=26.3529411764706, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI1787970, Length=402, Percent_Identity=44.7761194029851, Blast_Score=355, Evalue=3e-99,
Organism=Escherichia coli, GI1789175, Length=390, Percent_Identity=43.3333333333333, Blast_Score=310, Evalue=8e-86,
Organism=Escherichia coli, GI48994898, Length=395, Percent_Identity=26.3291139240506, Blast_Score=117, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI25143064, Length=345, Percent_Identity=27.2463768115942, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17533177, Length=326, Percent_Identity=23.3128834355828, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI193211090, Length=374, Percent_Identity=22.192513368984, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6319831, Length=398, Percent_Identity=25.8793969849246, Blast_Score=121, Evalue=2e-28,
Organism=Drosophila melanogaster, GI20129463, Length=351, Percent_Identity=29.9145299145299, Blast_Score=129, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 42375; Mature: 42375

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREQFPFFKAHPELVYLDTAATSQKPQALLDAIQNYYVNDNANVHRGLYKLAYDTTEAYE
CCCCCCCEECCCCEEEEECCCCCCCHHHHHHHHHHCEECCCCCHHHHHHHHHHHHHHHHH
NVRQQVAGFLGAASADEIIFTRGTTDSLNLVASAYGPQVVAAGSQIVVTGAEHHSNFIPW
HHHHHHHHHHCCCCCCCEEEECCCCCCHHHHHHCCCCEEEECCCEEEEECCHHCCCCCCH
QQLAKRQQATFTVTPVKPDGTVDIAALLAAITPQTKVVAVAQVTNVAGDTLPIAKIAAKA
HHHHHHCCCEEEEEECCCCCCHHHHHHHHHHCCCCEEEEEEHHHHCCCCCCHHHHHHHHH
HAVGAVVVVDGAQAVAHLAVDVQAMGADFYAFSGHKIYGPTGIGALYGRADLLQHMPPIQ
HHCEEEEEECCHHHHHHHHHHHHHHCCCEEEECCCEEECCCCHHHHHHHHHHHHCCCCHH
FGGEMISEVRDDVSTWADGPIKYEAGTPHIAGVIGLGAALTWFNQSVNAAAFDNEHQLAD
HHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
QLRAGLAAIPDVTVYGNQASLATVSFNLTGIHPHDLATFLDEQQIAVRAGHHCAQPLMAR
HHHHHHHHCCCEEEECCCCEEEEEEEEEECCCHHHHHHHHHHHHHHHHHCHHHHHHHHHH
LGVPATVRASFGVYNNADDVERLIQAVQAARRYFHGID
CCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MREQFPFFKAHPELVYLDTAATSQKPQALLDAIQNYYVNDNANVHRGLYKLAYDTTEAYE
CCCCCCCEECCCCEEEEECCCCCCCHHHHHHHHHHCEECCCCCHHHHHHHHHHHHHHHHH
NVRQQVAGFLGAASADEIIFTRGTTDSLNLVASAYGPQVVAAGSQIVVTGAEHHSNFIPW
HHHHHHHHHHCCCCCCCEEEECCCCCCHHHHHHCCCCEEEECCCEEEEECCHHCCCCCCH
QQLAKRQQATFTVTPVKPDGTVDIAALLAAITPQTKVVAVAQVTNVAGDTLPIAKIAAKA
HHHHHHCCCEEEEEECCCCCCHHHHHHHHHHCCCCEEEEEEHHHHCCCCCCHHHHHHHHH
HAVGAVVVVDGAQAVAHLAVDVQAMGADFYAFSGHKIYGPTGIGALYGRADLLQHMPPIQ
HHCEEEEEECCHHHHHHHHHHHHHHCCCEEEECCCEEECCCCHHHHHHHHHHHHCCCCHH
FGGEMISEVRDDVSTWADGPIKYEAGTPHIAGVIGLGAALTWFNQSVNAAAFDNEHQLAD
HHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
QLRAGLAAIPDVTVYGNQASLATVSFNLTGIHPHDLATFLDEQQIAVRAGHHCAQPLMAR
HHHHHHHHCCCEEEECCCCEEEEEEEEEECCCHHHHHHHHHHHHHHHHHCHHHHHHHHHH
LGVPATVRASFGVYNNADDVERLIQAVQAARRYFHGID
CCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]