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The map label for this gene is phoR [H]

Identifier: 116494442

GI number: 116494442

Start: 913770

End: 915437

Strand: Direct

Name: phoR [H]

Synonym: LSEI_0935

Alternate gene names: 116494442

Gene position: 913770-915437 (Clockwise)

Preceding gene: 116494441

Following gene: 116494443

Centisome position: 31.56

GC content: 48.38

Gene sequence:

>1668_bases
ATGAATAAACGAATCATTCGGCGTGCACTCATCATTAGTCTGCTATCATTGGCAGGCTTTTTTGTGCTCGTGACAACGGT
GAATCAACAAATTGTCCATCAACAAGCGCGTGATCTTCGGCGGGTCGGCCGGACGTATGCGGCCTCGAGTCATGATGGGG
TCAATCGGCAAGCATTGGCAGAGTCAGAGGCAGCCTTCATCACGGTCATTCCCAATAATCCGCGGACCACGCGTCAAAAA
GTGATGGCTGATGCCTTGCGTGGTAATCGGGATGCAGCGTTTGTAACAACCGTCAACGTGAATGGTCGAACAGAGCAAGC
GTATTTATTCCAAAATAAAGGGCAGTGGGTGGCAGTCAGCCGCTTTAAGTCAAGTGTCTGGACAACTGCACCAGAGCAAT
TCTGGCTCCTAACGCTTGCCTTTGCGGCATTGCTCGCTGCCATTCTCATTTGGCTTTTTCGATCTGAACATCGTTATCAA
GAAGCGATTGAAGTCATGAGCCATAATCTAGATCGCATCCGTCGAAAGAAAGACCCAGATCCGGTGATTTTAGCGCCTGA
TTCACCTTTTGTACCAGTTGCTCGCCGCATCAATGCATTGGCCGCTGAACAAGCCCATCTCCGTGAAAAAGTGGCGGTGC
GTCAATCAAGTTTTGATCGGTTGATTGATAACTTGCCATTGGGAGTCATGCTGATTGACACCGATAAAGATGTCATCTTG
CATAATCACGCCATGTCGCAGCTGCTAGGTCATCAAATCCCGCAGCCCCGACACAGCTATCTTGATGATGTTAAAACTTA
TGCCTTGGCGCGCATGATCGAACACACTTTTCGCCATGAAAAAACGCATCATCAGGAACTGACAATTTTGACCACGCAAA
AATCCGTTGATGCTTCGGTTATTCCTTTGAATCAAGGCATCAGTCGGTTGCAGGTGCTGGTGATTCTATATGATGTCACT
TACTTGCGACAGGTTGAAAAAATGCAACTGGACTTTGTCGGGAATGTCAGTCATGAATTGAAGACCCCAGTCACAGCTAT
TTCTGGATTTGCAGAGACTTTACTTGGCGGTGCGAAGAATGATCCGGCGACCTTGGACAGGTTCTTAGGGATTATTTATG
ACGAGAGCAAGCGATTAACACAATTAATTAATGACATTTTGACCTTGAGTCGACCGGATTCCAACCAAAATGTGGCTGCA
TCGGTTGCTTTGAAAAAATTGGTCGATGATGCATTGCATAATTTGGCCAAAGTGATTCAAGACAAGCAAGTTCGCGTTGA
AGTGGCAATTACCCCGGATCTATTGGTCGTGACTGACGAGCGCAAATTGACCCAAATCGTGCGCAACTTATTGAACAACG
CAGTCTTCTACAATCGCTTGGCTGGTCATGTCACGATCAGCGCTCAGGTTGTCGATCATCAGCTGTCACTGGCAGTTGCC
GACACTGGGATCGGGATTTCTGAGACGGAACAGGCCCGGATCTTCGAACGCTTTTACCGAGTAGATAAGGCTCGCAGTCG
TCACAATGGCGGTACCGGTCTCGGTTTAGCGATTGTGGCCGAACTGGTTAAGAGTATGGATGGTCATGTTGCGGTTCACA
GCCAAGTAGGGGTTGGGTCAACGTTTACGGTCACTTTGCCTGTGGGTGAGGGCCCGCACAGAGGATGA

Upstream 100 bases:

>100_bases
ATTCAGGTCAGCCATTTACGCGATAAAATTGAAACGGATCCGAAACATCCGGACTATTTAAAGACAGTTCGCGGTTTCGG
ATACCAAATGGAGGCACCCC

Downstream 100 bases:

>100_bases
AAAACCGCAGCCATCATGCCTTTACACAATCTTTACATTCAATGGCATGAACATTTACATGTAACTGATAAAATAATTGG
AGCTTGAAATGGAGGATTTC

Product: Signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 555; Mature: 555

Protein sequence:

>555_residues
MNKRIIRRALIISLLSLAGFFVLVTTVNQQIVHQQARDLRRVGRTYAASSHDGVNRQALAESEAAFITVIPNNPRTTRQK
VMADALRGNRDAAFVTTVNVNGRTEQAYLFQNKGQWVAVSRFKSSVWTTAPEQFWLLTLAFAALLAAILIWLFRSEHRYQ
EAIEVMSHNLDRIRRKKDPDPVILAPDSPFVPVARRINALAAEQAHLREKVAVRQSSFDRLIDNLPLGVMLIDTDKDVIL
HNHAMSQLLGHQIPQPRHSYLDDVKTYALARMIEHTFRHEKTHHQELTILTTQKSVDASVIPLNQGISRLQVLVILYDVT
YLRQVEKMQLDFVGNVSHELKTPVTAISGFAETLLGGAKNDPATLDRFLGIIYDESKRLTQLINDILTLSRPDSNQNVAA
SVALKKLVDDALHNLAKVIQDKQVRVEVAITPDLLVVTDERKLTQIVRNLLNNAVFYNRLAGHVTISAQVVDHQLSLAVA
DTGIGISETEQARIFERFYRVDKARSRHNGGTGLGLAIVAELVKSMDGHVAVHSQVGVGSTFTVTLPVGEGPHRG

Sequences:

>Translated_555_residues
MNKRIIRRALIISLLSLAGFFVLVTTVNQQIVHQQARDLRRVGRTYAASSHDGVNRQALAESEAAFITVIPNNPRTTRQK
VMADALRGNRDAAFVTTVNVNGRTEQAYLFQNKGQWVAVSRFKSSVWTTAPEQFWLLTLAFAALLAAILIWLFRSEHRYQ
EAIEVMSHNLDRIRRKKDPDPVILAPDSPFVPVARRINALAAEQAHLREKVAVRQSSFDRLIDNLPLGVMLIDTDKDVIL
HNHAMSQLLGHQIPQPRHSYLDDVKTYALARMIEHTFRHEKTHHQELTILTTQKSVDASVIPLNQGISRLQVLVILYDVT
YLRQVEKMQLDFVGNVSHELKTPVTAISGFAETLLGGAKNDPATLDRFLGIIYDESKRLTQLINDILTLSRPDSNQNVAA
SVALKKLVDDALHNLAKVIQDKQVRVEVAITPDLLVVTDERKLTQIVRNLLNNAVFYNRLAGHVTISAQVVDHQLSLAVA
DTGIGISETEQARIFERFYRVDKARSRHNGGTGLGLAIVAELVKSMDGHVAVHSQVGVGSTFTVTLPVGEGPHRG
>Mature_555_residues
MNKRIIRRALIISLLSLAGFFVLVTTVNQQIVHQQARDLRRVGRTYAASSHDGVNRQALAESEAAFITVIPNNPRTTRQK
VMADALRGNRDAAFVTTVNVNGRTEQAYLFQNKGQWVAVSRFKSSVWTTAPEQFWLLTLAFAALLAAILIWLFRSEHRYQ
EAIEVMSHNLDRIRRKKDPDPVILAPDSPFVPVARRINALAAEQAHLREKVAVRQSSFDRLIDNLPLGVMLIDTDKDVIL
HNHAMSQLLGHQIPQPRHSYLDDVKTYALARMIEHTFRHEKTHHQELTILTTQKSVDASVIPLNQGISRLQVLVILYDVT
YLRQVEKMQLDFVGNVSHELKTPVTAISGFAETLLGGAKNDPATLDRFLGIIYDESKRLTQLINDILTLSRPDSNQNVAA
SVALKKLVDDALHNLAKVIQDKQVRVEVAITPDLLVVTDERKLTQIVRNLLNNAVFYNRLAGHVTISAQVVDHQLSLAVA
DTGIGISETEQARIFERFYRVDKARSRHNGGTGLGLAIVAELVKSMDGHVAVHSQVGVGSTFTVTLPVGEGPHRG

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=357, Percent_Identity=29.4117647058824, Blast_Score=142, Evalue=7e-35,
Organism=Escherichia coli, GI1789149, Length=271, Percent_Identity=30.6273062730627, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI145693157, Length=221, Percent_Identity=33.9366515837104, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1788713, Length=476, Percent_Identity=23.9495798319328, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI1788393, Length=233, Percent_Identity=32.1888412017167, Blast_Score=117, Evalue=3e-27,
Organism=Escherichia coli, GI48994928, Length=364, Percent_Identity=31.043956043956, Blast_Score=108, Evalue=6e-25,
Organism=Escherichia coli, GI1788549, Length=388, Percent_Identity=27.8350515463918, Blast_Score=105, Evalue=5e-24,
Organism=Escherichia coli, GI1786783, Length=260, Percent_Identity=29.2307692307692, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI87081816, Length=224, Percent_Identity=31.25, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1790861, Length=208, Percent_Identity=32.2115384615385, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1790346, Length=232, Percent_Identity=29.3103448275862, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI1787894, Length=221, Percent_Identity=28.9592760180996, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1790436, Length=223, Percent_Identity=30.9417040358744, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI87082128, Length=238, Percent_Identity=27.3109243697479, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1788279, Length=249, Percent_Identity=26.1044176706827, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1786912, Length=292, Percent_Identity=25.6849315068493, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1787374, Length=207, Percent_Identity=28.0193236714976, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1790300, Length=231, Percent_Identity=29.4372294372294, Blast_Score=62, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6322044, Length=76, Percent_Identity=46.0526315789474, Blast_Score=73, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 61901; Mature: 61901

Theoretical pI: Translated: 10.04; Mature: 10.04

Prosite motif: PS50112 PAS ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKRIIRRALIISLLSLAGFFVLVTTVNQQIVHQQARDLRRVGRTYAASSHDGVNRQALA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
ESEAAFITVIPNNPRTTRQKVMADALRGNRDAAFVTTVNVNGRTEQAYLFQNKGQWVAVS
CCCCEEEEEECCCCCHHHHHHHHHHHCCCCCEEEEEEEECCCCCCEEEEEECCCCEEEEE
RFKSSVWTTAPEQFWLLTLAFAALLAAILIWLFRSEHRYQEAIEVMSHNLDRIRRKKDPD
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCHHHHHHCCCCC
PVILAPDSPFVPVARRINALAAEQAHLREKVAVRQSSFDRLIDNLPLGVMLIDTDKDVIL
CEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEE
HNHAMSQLLGHQIPQPRHSYLDDVKTYALARMIEHTFRHEKTHHQELTILTTQKSVDASV
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCEE
IPLNQGISRLQVLVILYDVTYLRQVEKMQLDFVGNVSHELKTPVTAISGFAETLLGGAKN
EEHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCHHHHHHHHHHHHHCCCCC
DPATLDRFLGIIYDESKRLTQLINDILTLSRPDSNQNVAASVALKKLVDDALHNLAKVIQ
CHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHC
DKQVRVEVAITPDLLVVTDERKLTQIVRNLLNNAVFYNRLAGHVTISAQVVDHQLSLAVA
CCCEEEEEEECCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEECHHHEEEEE
DTGIGISETEQARIFERFYRVDKARSRHNGGTGLGLAIVAELVKSMDGHVAVHSQVGVGS
ECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCC
TFTVTLPVGEGPHRG
EEEEEEECCCCCCCC
>Mature Secondary Structure
MNKRIIRRALIISLLSLAGFFVLVTTVNQQIVHQQARDLRRVGRTYAASSHDGVNRQALA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
ESEAAFITVIPNNPRTTRQKVMADALRGNRDAAFVTTVNVNGRTEQAYLFQNKGQWVAVS
CCCCEEEEEECCCCCHHHHHHHHHHHCCCCCEEEEEEEECCCCCCEEEEEECCCCEEEEE
RFKSSVWTTAPEQFWLLTLAFAALLAAILIWLFRSEHRYQEAIEVMSHNLDRIRRKKDPD
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCHHHHHHCCCCC
PVILAPDSPFVPVARRINALAAEQAHLREKVAVRQSSFDRLIDNLPLGVMLIDTDKDVIL
CEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEE
HNHAMSQLLGHQIPQPRHSYLDDVKTYALARMIEHTFRHEKTHHQELTILTTQKSVDASV
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCEE
IPLNQGISRLQVLVILYDVTYLRQVEKMQLDFVGNVSHELKTPVTAISGFAETLLGGAKN
EEHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCHHHHHHHHHHHHHCCCCC
DPATLDRFLGIIYDESKRLTQLINDILTLSRPDSNQNVAASVALKKLVDDALHNLAKVIQ
CHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHC
DKQVRVEVAITPDLLVVTDERKLTQIVRNLLNNAVFYNRLAGHVTISAQVVDHQLSLAVA
CCCEEEEEEECCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEECHHHEEEEE
DTGIGISETEQARIFERFYRVDKARSRHNGGTGLGLAIVAELVKSMDGHVAVHSQVGVGS
ECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCC
TFTVTLPVGEGPHRG
EEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]