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The map label for this gene is phoP [H]

Identifier: 116494441

GI number: 116494441

Start: 913070

End: 913777

Strand: Direct

Name: phoP [H]

Synonym: LSEI_0934

Alternate gene names: 116494441

Gene position: 913070-913777 (Clockwise)

Preceding gene: 116494440

Following gene: 116494442

Centisome position: 31.54

GC content: 46.19

Gene sequence:

>708_bases
ATGAAGAAGATCTTGATTGTTGATGACGAACCTGCGATTTTGACGTTGCTGCAATATAATTTGGAAGCTGAACACTATCA
GGTCGAAACAGCGACAGATGGTCAGGAGGCTTTGGATAAAGTACGCAACGAGCCATTTGACTTTATCATCCTCGATTTAA
TGCTGCCGAGTCTGAGCGGCTTGGATGTTACCCGCAAAATTCGTGAAGATAAAATTCAGACGCCGATTATGATCTTGACT
GCCAAAGACAATGAAACCGATAAAATTGTTGGCCTAGAACTCGGAGCAGATGACTATGTGACTAAGCCGTTTTCGCCGCG
GGAGATCATTGCTCGGATCAAGGCGATTGAACGACGGAGTCAGAGTCAGCCGCAAACCAGTCAAAAACCGGGCAACAGTG
ATCAGATCACAGTTGGCCAGATCGCGATTGATCCAGAAAATTATAAGGCCAGCAAGGGTGGCAAACGTCTGCAGTTGACG
CCAAAAGAATTTGAGCTACTGGTTTACTTTGCTCAACGTGTTGGCAAGACCTTGTCTCGAGATGCTTTATTGAACGGGGT
TTGGGGATTCGACTATCCCGCAGAGACGCGAATGGTGGATATTCAGGTCAGCCATTTACGCGATAAAATTGAAACGGATC
CGAAACATCCGGACTATTTAAAGACAGTTCGCGGTTTCGGATACCAAATGGAGGCACCCCATGAATAA

Upstream 100 bases:

>100_bases
GGCTTCGACAGGCAGATGGTGAGCTGCGATTAGCTGAGACGGCCATTTTTGCCGGTGCCCCACACGAACTTGGTATGATT
TTATTTCCGGAGGAGACAGC

Downstream 100 bases:

>100_bases
ACGAATCATTCGGCGTGCACTCATCATTAGTCTGCTATCATTGGCAGGCTTTTTTGTGCTCGTGACAACGGTGAATCAAC
AAATTGTCCATCAACAAGCG

Product: DNA-binding response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 235; Mature: 235

Protein sequence:

>235_residues
MKKILIVDDEPAILTLLQYNLEAEHYQVETATDGQEALDKVRNEPFDFIILDLMLPSLSGLDVTRKIREDKIQTPIMILT
AKDNETDKIVGLELGADDYVTKPFSPREIIARIKAIERRSQSQPQTSQKPGNSDQITVGQIAIDPENYKASKGGKRLQLT
PKEFELLVYFAQRVGKTLSRDALLNGVWGFDYPAETRMVDIQVSHLRDKIETDPKHPDYLKTVRGFGYQMEAPHE

Sequences:

>Translated_235_residues
MKKILIVDDEPAILTLLQYNLEAEHYQVETATDGQEALDKVRNEPFDFIILDLMLPSLSGLDVTRKIREDKIQTPIMILT
AKDNETDKIVGLELGADDYVTKPFSPREIIARIKAIERRSQSQPQTSQKPGNSDQITVGQIAIDPENYKASKGGKRLQLT
PKEFELLVYFAQRVGKTLSRDALLNGVWGFDYPAETRMVDIQVSHLRDKIETDPKHPDYLKTVRGFGYQMEAPHE
>Mature_235_residues
MKKILIVDDEPAILTLLQYNLEAEHYQVETATDGQEALDKVRNEPFDFIILDLMLPSLSGLDVTRKIREDKIQTPIMILT
AKDNETDKIVGLELGADDYVTKPFSPREIIARIKAIERRSQSQPQTSQKPGNSDQITVGQIAIDPENYKASKGGKRLQLT
PKEFELLVYFAQRVGKTLSRDALLNGVWGFDYPAETRMVDIQVSHLRDKIETDPKHPDYLKTVRGFGYQMEAPHE

Specific function: Member of the two-component regulatory system phoP/phoR involved in the regulation of alkaline phosphatase genes phoA and phoB and of phosphodiesterase [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789809, Length=230, Percent_Identity=38.695652173913, Blast_Score=167, Evalue=5e-43,
Organism=Escherichia coli, GI1788394, Length=231, Percent_Identity=41.991341991342, Blast_Score=163, Evalue=7e-42,
Organism=Escherichia coli, GI1786599, Length=232, Percent_Identity=36.6379310344828, Blast_Score=154, Evalue=7e-39,
Organism=Escherichia coli, GI2367329, Length=231, Percent_Identity=39.8268398268398, Blast_Score=151, Evalue=4e-38,
Organism=Escherichia coli, GI1786784, Length=231, Percent_Identity=35.4978354978355, Blast_Score=149, Evalue=1e-37,
Organism=Escherichia coli, GI1790552, Length=233, Percent_Identity=34.7639484978541, Blast_Score=146, Evalue=1e-36,
Organism=Escherichia coli, GI1789402, Length=228, Percent_Identity=33.3333333333333, Blast_Score=143, Evalue=8e-36,
Organism=Escherichia coli, GI87082012, Length=230, Percent_Identity=31.7391304347826, Blast_Score=136, Evalue=1e-33,
Organism=Escherichia coli, GI1790863, Length=229, Percent_Identity=34.4978165938865, Blast_Score=135, Evalue=2e-33,
Organism=Escherichia coli, GI1786911, Length=230, Percent_Identity=34.7826086956522, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1790860, Length=231, Percent_Identity=34.6320346320346, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1787229, Length=235, Percent_Identity=33.6170212765957, Blast_Score=117, Evalue=6e-28,
Organism=Escherichia coli, GI145693140, Length=240, Percent_Identity=31.25, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1787375, Length=231, Percent_Identity=31.6017316017316, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI1788713, Length=123, Percent_Identity=33.3333333333333, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1790437, Length=101, Percent_Identity=32.6732673267327, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1788550, Length=104, Percent_Identity=28.8461538461538, Blast_Score=64, Evalue=8e-12,
Organism=Escherichia coli, GI1788521, Length=115, Percent_Identity=33.0434782608696, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI145693157, Length=102, Percent_Identity=33.3333333333333, Blast_Score=62, Evalue=2e-11,
Organism=Escherichia coli, GI1790576, Length=99, Percent_Identity=34.3434343434343, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1787487, Length=102, Percent_Identity=33.3333333333333, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1788191, Length=117, Percent_Identity=30.7692307692308, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI1790299, Length=129, Percent_Identity=27.1317829457364, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26712; Mature: 26712

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKILIVDDEPAILTLLQYNLEAEHYQVETATDGQEALDKVRNEPFDFIILDLMLPSLSG
CCEEEEECCCCCEEEEEHHCCCCCEEEEEECCCHHHHHHHHHCCCCCEEEHHHHHCCCCC
LDVTRKIREDKIQTPIMILTAKDNETDKIVGLELGADDYVTKPFSPREIIARIKAIERRS
CHHHHHHHHHHCCCCEEEEEECCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHH
QSQPQTSQKPGNSDQITVGQIAIDPENYKASKGGKRLQLTPKEFELLVYFAQRVGKTLSR
CCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHH
DALLNGVWGFDYPAETRMVDIQVSHLRDKIETDPKHPDYLKTVRGFGYQMEAPHE
HHHHCCCCCCCCCCCCEEEEEEHHHHHHHHHCCCCCCHHHHHHHCCCEECCCCCC
>Mature Secondary Structure
MKKILIVDDEPAILTLLQYNLEAEHYQVETATDGQEALDKVRNEPFDFIILDLMLPSLSG
CCEEEEECCCCCEEEEEHHCCCCCEEEEEECCCHHHHHHHHHCCCCCEEEHHHHHCCCCC
LDVTRKIREDKIQTPIMILTAKDNETDKIVGLELGADDYVTKPFSPREIIARIKAIERRS
CHHHHHHHHHHCCCCEEEEEECCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHH
QSQPQTSQKPGNSDQITVGQIAIDPENYKASKGGKRLQLTPKEFELLVYFAQRVGKTLSR
CCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHH
DALLNGVWGFDYPAETRMVDIQVSHLRDKIETDPKHPDYLKTVRGFGYQMEAPHE
HHHHCCCCCCCCCCCCEEEEEEHHHHHHHHHCCCCCCHHHHHHHCCCEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1454550; 3036763; 9387221; 9384377; 8045898; 3142862 [H]