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The map label for this gene is yusP [H]

Identifier: 116494387

GI number: 116494387

Start: 853335

End: 854828

Strand: Direct

Name: yusP [H]

Synonym: LSEI_0878

Alternate gene names: 116494387

Gene position: 853335-854828 (Clockwise)

Preceding gene: 116494386

Following gene: 116494389

Centisome position: 29.47

GC content: 46.85

Gene sequence:

>1494_bases
ATGAAGCAAAGGAAAACCAATGTCGCACTCGTAACGGCGGCAATTTTTATTGGCACTTTTATGACGGCGATTGAAGGCAC
GATTGTGTCAACGGCTATGCCAACCATTATCGGCAGTTTACATGGGGTTCATTTAATGAACTGGGTCTTTTCCATTTTTC
TGTTGACTAATGCGATGGCGACGCCGATTTACGGCAAACTGAGTGACAAAATTGGTCGCAAACCAGTTTTTCTCATTGGA
CTAACGATATTTGTCATTGGTTCGTTGCTATCCGGTTTGTCACAATCCATGGAAATGCTAATTATTTTCCGCGCAATTCA
AGGGATTGGTGCTGGGGCTATTATGCCAGTGACATTTACGATTATCGCCGATATTTATCCATTCGAAAAACGAGCAAAAA
TGCTCGGTTTTAATGGCTCGATGTGGGGAATCGCTTCGGTAATTGCACCGTTATTGGGCGGTTTTATCGTTGATCAGTTA
AGTTGGCACTGGATTTTCTTTATTAACGTACCGTTGGGTATTTTCACGTTTGGCCTTGTGTGGTTCTTTTTGCAGGAAGA
TCGGCGCAGTGTCCGGCAGCCGCTTGACATGCGCGGGACGGTTTGGCTGCTGGTGGCCTTGTTGGCGATGATGTATGGCT
TTCAGACATTAGCTGAGCCCAACGGCATCTGGCAGTTAGTTGCCATGGCAATTGTGGCTACGCTGGGCTTTTGGCGTTTT
TGGCAGGCAGAACGGCGTGCAGTCGATCCGATCATTGACTTGAAACTATTTGAAAATCGTACTTTTGTGATTCATAATTT
GATCGCCGCTTTGATTTCGGGGTTCGTGATTGGATTTGAAGTCTACATGCCTATGTGGATTCAAGGAATTCGCGGCATGG
ATGCTTCCCTTGGCGGCTTTGCAGTGACCCCTAGTTCTTTGATGTGGGTCGTTGGCTCTTTTGTTGCTGGCAAGTTATTG
GGCCGGTTCCAACCTAAGCCGATTCTGACAGGGGCCATGATTTGGCTGCTTGGCGGCAGTCTTGTGCTGGCATTAGTGCC
GCAATCGACACCGTATTTTGTCTTTCTGCTAGTTGCCGGCGCCTTAGGATTCGGCTTTGGTTTGGTGATTACGATTACTA
CGGTAACAGCCCAGGCCGTTGTGGCGCCTGATCAGGTTGGCGTGGCAACGAGTTTCAATACCTTGTCTCGAACGTTGGGG
CAAACACTGATGGTCTCGGTTTATGGGATTGTTTTGAATCTGCGTCTGACTCAAGGTATCGCGGCAGATAGCCGGCTGAA
TAGCAATATGCTCAACGAACTGATTAATCCACATACCGCCAAAAATTTACCCGCAGCAGTGTTGCCAACGCTTCGGCAAA
TTTTGTATGAAGGTCTGCACAACATTTACTTTTTCTCGATTATCATCGTGGCGTTGGCGATTCTAGCCAATCATTTTGAA
GCAAAAAGGGTGCTGACAAAAGAAACAATTCAGGAGTCGAATGAAGAAAGCTGA

Upstream 100 bases:

>100_bases
GGCCTTAGTCGAGAATTATTCTCGGCTGGGTCGTTTTTTCGTGCTTATGAGGGGCTTCTCAAGACTAACAACATCGCCTG
GCAACTCAGAAGGGATATTT

Downstream 100 bases:

>100_bases
ATCAACTGAAATATCATACAAAAAACCGGATTCTATTTAAGAATCCGGTTTTTTGTACGCTGATATCGCTCTCGTTTGCC
GATAAATAGCTGAAGTTAAA

Product: major facilitator superfamily permease

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 497; Mature: 497

Protein sequence:

>497_residues
MKQRKTNVALVTAAIFIGTFMTAIEGTIVSTAMPTIIGSLHGVHLMNWVFSIFLLTNAMATPIYGKLSDKIGRKPVFLIG
LTIFVIGSLLSGLSQSMEMLIIFRAIQGIGAGAIMPVTFTIIADIYPFEKRAKMLGFNGSMWGIASVIAPLLGGFIVDQL
SWHWIFFINVPLGIFTFGLVWFFLQEDRRSVRQPLDMRGTVWLLVALLAMMYGFQTLAEPNGIWQLVAMAIVATLGFWRF
WQAERRAVDPIIDLKLFENRTFVIHNLIAALISGFVIGFEVYMPMWIQGIRGMDASLGGFAVTPSSLMWVVGSFVAGKLL
GRFQPKPILTGAMIWLLGGSLVLALVPQSTPYFVFLLVAGALGFGFGLVITITTVTAQAVVAPDQVGVATSFNTLSRTLG
QTLMVSVYGIVLNLRLTQGIAADSRLNSNMLNELINPHTAKNLPAAVLPTLRQILYEGLHNIYFFSIIIVALAILANHFE
AKRVLTKETIQESNEES

Sequences:

>Translated_497_residues
MKQRKTNVALVTAAIFIGTFMTAIEGTIVSTAMPTIIGSLHGVHLMNWVFSIFLLTNAMATPIYGKLSDKIGRKPVFLIG
LTIFVIGSLLSGLSQSMEMLIIFRAIQGIGAGAIMPVTFTIIADIYPFEKRAKMLGFNGSMWGIASVIAPLLGGFIVDQL
SWHWIFFINVPLGIFTFGLVWFFLQEDRRSVRQPLDMRGTVWLLVALLAMMYGFQTLAEPNGIWQLVAMAIVATLGFWRF
WQAERRAVDPIIDLKLFENRTFVIHNLIAALISGFVIGFEVYMPMWIQGIRGMDASLGGFAVTPSSLMWVVGSFVAGKLL
GRFQPKPILTGAMIWLLGGSLVLALVPQSTPYFVFLLVAGALGFGFGLVITITTVTAQAVVAPDQVGVATSFNTLSRTLG
QTLMVSVYGIVLNLRLTQGIAADSRLNSNMLNELINPHTAKNLPAAVLPTLRQILYEGLHNIYFFSIIIVALAILANHFE
AKRVLTKETIQESNEES
>Mature_497_residues
MKQRKTNVALVTAAIFIGTFMTAIEGTIVSTAMPTIIGSLHGVHLMNWVFSIFLLTNAMATPIYGKLSDKIGRKPVFLIG
LTIFVIGSLLSGLSQSMEMLIIFRAIQGIGAGAIMPVTFTIIADIYPFEKRAKMLGFNGSMWGIASVIAPLLGGFIVDQL
SWHWIFFINVPLGIFTFGLVWFFLQEDRRSVRQPLDMRGTVWLLVALLAMMYGFQTLAEPNGIWQLVAMAIVATLGFWRF
WQAERRAVDPIIDLKLFENRTFVIHNLIAALISGFVIGFEVYMPMWIQGIRGMDASLGGFAVTPSSLMWVVGSFVAGKLL
GRFQPKPILTGAMIWLLGGSLVLALVPQSTPYFVFLLVAGALGFGFGLVITITTVTAQAVVAPDQVGVATSFNTLSRTLG
QTLMVSVYGIVLNLRLTQGIAADSRLNSNMLNELINPHTAKNLPAAVLPTLRQILYEGLHNIYFFSIIIVALAILANHFE
AKRVLTKETIQESNEES

Specific function: Translocase That Confers Resistance To Substances Of High Hydrophobicity. [C]

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1789042, Length=347, Percent_Identity=30.2593659942363, Blast_Score=142, Evalue=6e-35,
Organism=Escherichia coli, GI1788710, Length=324, Percent_Identity=32.0987654320988, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI1790195, Length=409, Percent_Identity=28.361858190709, Blast_Score=136, Evalue=4e-33,
Organism=Escherichia coli, GI87081983, Length=403, Percent_Identity=25.3101736972705, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1788392, Length=254, Percent_Identity=33.4645669291339, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI1790146, Length=165, Percent_Identity=31.5151515151515, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI1788509, Length=152, Percent_Identity=33.5526315789474, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI48994889, Length=117, Percent_Identity=36.7521367521368, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI87081738, Length=117, Percent_Identity=37.6068376068376, Blast_Score=73, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI32564663, Length=154, Percent_Identity=29.8701298701299, Blast_Score=72, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6323735, Length=452, Percent_Identity=23.6725663716814, Blast_Score=102, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6322958, Length=567, Percent_Identity=21.1640211640212, Blast_Score=98, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6321663, Length=146, Percent_Identity=34.2465753424658, Blast_Score=95, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6319770, Length=460, Percent_Identity=22.8260869565217, Blast_Score=91, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6325455, Length=150, Percent_Identity=34, Blast_Score=87, Evalue=7e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 54513; Mature: 54513

Theoretical pI: Translated: 10.08; Mature: 10.08

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHCCCCCC
>Mature Secondary Structure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HHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]