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The map label for this gene is aroE [H]

Identifier: 116494037

GI number: 116494037

Start: 495696

End: 496595

Strand: Direct

Name: aroE [H]

Synonym: LSEI_0478

Alternate gene names: 116494037

Gene position: 495696-496595 (Clockwise)

Preceding gene: 116494036

Following gene: 116494038

Centisome position: 17.12

GC content: 50.22

Gene sequence:

>900_bases
ATGTCATTAAAAGATGAAATTGACGGTCACACCGTTTTAGCTGGCTTACTGGCGCATCCTGCTGGCCACTCGATGTCGCC
GGCAATGTATAACGCAACATTTGAAAAACTTGGGTTAAATGATGCTTACCTGTCCTTTGATGTTGATGCACCTGAATTGG
CACACGCCTTGCAAGCTATGCGCAGCCTGCATTTTCTGGGTGGTAATTTGTCGATGCCGAATAAGCAAAAGGCCATACCG
TTGTTGGACAAACTATCGCCGGCCGCAAAATTGATCGGTGCCGTAAATACCATTGTCAATGACCACGGGGTGCTGACCGG
CCATATCACCGATGGCACAGGCTTCATGCAAGCACTGAGCAACGATGGCTTGGATATTCGCGGCGAGAAAATGACACTGG
CAGGAGCTGGCGGTGCGGGGACAGCGATTGCGATTCAAGCAGCTTTGGACGGTGTCCGGGAAATCAATATTTTTAATCGT
CGTGATGCTTCGTGGCAAAATGCCGAACGTAATGTGGCCATCATTAATGACCAAACGCAAGGCCATGCGACATTGTTTGC
ACTCGATGATCAACCGGCGTTAAAGGCTAGCATTTCGGATTCAGTGATCTATGTTGATGCGACACCCGCGGGGATGAAGC
CGCTAGAAACTGTTAGTAATGTGCCTGATGGCGATTGGTTTACGCCAGAGACGATCGTGTTTGATACGGTCTATGCACCG
CGCGAAACCAAGCTTATGCAGCTCGCTAAAGAAGCCGGTGTGAACCACGTGTATAACGGCATTAACATGCTGATCAATCA
AGGCGCCGCCGCCTTCCATCTGTGGACAGGCTTACAAATGCCAGTTGATTATATTCGCGAGACGGTGTTTGGTGAACCGG
CGGCAGTCGCGCACTCGTAA

Upstream 100 bases:

>100_bases
CATCACGATTGTCGGCATCGGTTTAGCACTGGTCGTGAAGACGCAGGAAAAGCACGTCCTAGCAGTTTCACAAGTCCATT
AGCAAAAAGGAGTTCGGAAC

Downstream 100 bases:

>100_bases
GCAAGAAGACGAATTCAAGCAGTCAGCCACGCGCTTAAAATCGTCATTTCGACAAATCAAAAAAGAAGATAATCTTGTAA
AAAAGCCCTGATGCCAGTGG

Product: shikimate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 299; Mature: 298

Protein sequence:

>299_residues
MSLKDEIDGHTVLAGLLAHPAGHSMSPAMYNATFEKLGLNDAYLSFDVDAPELAHALQAMRSLHFLGGNLSMPNKQKAIP
LLDKLSPAAKLIGAVNTIVNDHGVLTGHITDGTGFMQALSNDGLDIRGEKMTLAGAGGAGTAIAIQAALDGVREINIFNR
RDASWQNAERNVAIINDQTQGHATLFALDDQPALKASISDSVIYVDATPAGMKPLETVSNVPDGDWFTPETIVFDTVYAP
RETKLMQLAKEAGVNHVYNGINMLINQGAAAFHLWTGLQMPVDYIRETVFGEPAAVAHS

Sequences:

>Translated_299_residues
MSLKDEIDGHTVLAGLLAHPAGHSMSPAMYNATFEKLGLNDAYLSFDVDAPELAHALQAMRSLHFLGGNLSMPNKQKAIP
LLDKLSPAAKLIGAVNTIVNDHGVLTGHITDGTGFMQALSNDGLDIRGEKMTLAGAGGAGTAIAIQAALDGVREINIFNR
RDASWQNAERNVAIINDQTQGHATLFALDDQPALKASISDSVIYVDATPAGMKPLETVSNVPDGDWFTPETIVFDTVYAP
RETKLMQLAKEAGVNHVYNGINMLINQGAAAFHLWTGLQMPVDYIRETVFGEPAAVAHS
>Mature_298_residues
SLKDEIDGHTVLAGLLAHPAGHSMSPAMYNATFEKLGLNDAYLSFDVDAPELAHALQAMRSLHFLGGNLSMPNKQKAIPL
LDKLSPAAKLIGAVNTIVNDHGVLTGHITDGTGFMQALSNDGLDIRGEKMTLAGAGGAGTAIAIQAALDGVREINIFNRR
DASWQNAERNVAIINDQTQGHATLFALDDQPALKASISDSVIYVDATPAGMKPLETVSNVPDGDWFTPETIVFDTVYAPR
ETKLMQLAKEAGVNHVYNGINMLINQGAAAFHLWTGLQMPVDYIRETVFGEPAAVAHS

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1787983, Length=280, Percent_Identity=43.9285714285714, Blast_Score=236, Evalue=2e-63,
Organism=Escherichia coli, GI1789675, Length=265, Percent_Identity=26.0377358490566, Blast_Score=72, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6320332, Length=288, Percent_Identity=27.0833333333333, Blast_Score=87, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151 [H]

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N [H]

EC number: =1.1.1.25 [H]

Molecular weight: Translated: 31896; Mature: 31764

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLKDEIDGHTVLAGLLAHPAGHSMSPAMYNATFEKLGLNDAYLSFDVDAPELAHALQAM
CCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHH
RSLHFLGGNLSMPNKQKAIPLLDKLSPAAKLIGAVNTIVNDHGVLTGHITDGTGFMQALS
HHHHHHCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHC
NDGLDIRGEKMTLAGAGGAGTAIAIQAALDGVREINIFNRRDASWQNAERNVAIINDQTQ
CCCCEECCCEEEEEECCCCCHHEEEHHHHCCHHEEEEECCCCCCCCCCCCCEEEEECCCC
GHATLFALDDQPALKASISDSVIYVDATPAGMKPLETVSNVPDGDWFTPETIVFDTVYAP
CCEEEEEECCCCCCEEECCCCEEEEECCCCCCCHHHHHHCCCCCCCCCCCEEEEEEECCC
RETKLMQLAKEAGVNHVYNGINMLINQGAAAFHLWTGLQMPVDYIRETVFGEPAAVAHS
CHHHHHHHHHHHCHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
SLKDEIDGHTVLAGLLAHPAGHSMSPAMYNATFEKLGLNDAYLSFDVDAPELAHALQAM
CCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHH
RSLHFLGGNLSMPNKQKAIPLLDKLSPAAKLIGAVNTIVNDHGVLTGHITDGTGFMQALS
HHHHHHCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHC
NDGLDIRGEKMTLAGAGGAGTAIAIQAALDGVREINIFNRRDASWQNAERNVAIINDQTQ
CCCCEECCCEEEEEECCCCCHHEEEHHHHCCHHEEEEECCCCCCCCCCCCCEEEEECCCC
GHATLFALDDQPALKASISDSVIYVDATPAGMKPLETVSNVPDGDWFTPETIVFDTVYAP
CCEEEEEECCCCCCEEECCCCEEEEECCCCCCCHHHHHHCCCCCCCCCCCEEEEEEECCC
RETKLMQLAKEAGVNHVYNGINMLINQGAAAFHLWTGLQMPVDYIRETVFGEPAAVAHS
CHHHHHHHHHHHCHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]