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The map label for this gene is aroE [H]

Identifier: 116494035

GI number: 116494035

Start: 493536

End: 494426

Strand: Direct

Name: aroE [H]

Synonym: LSEI_0476

Alternate gene names: 116494035

Gene position: 493536-494426 (Clockwise)

Preceding gene: 116494034

Following gene: 116494036

Centisome position: 17.05

GC content: 49.38

Gene sequence:

>891_bases
ATGGAGACGTGGATTTCTGGAACGACTGGTTTGTTGTGTTTGCTGGGCAGTCCGGTTGGCCATTCTGGCTCGCCAGCAAT
GTATAACTTCAGTTTTCAAAAACAAAAAATTGATGCAGCTTATGTGGCGTTTGACGTGACCAAGGAGCAGATGCCAGAAG
CACTGAATGCCATGCGCCTTTTCAAAATGCGCGGCGGCAACGTCACGATGCCGTGTAAAAATGTAGCAGCAACTTTGATG
GACGAGTTATCGCCAGCTGCCAAGATCATTGGTGCGGTGAATGTCGTTGTGAATGATGATGGCAAATTGATCGGTCACAT
CACGGATGGCATCGGATTTGTTCGGAATTTGCAGGAACACGGGATTGATATCAAAGGCAAGCATTTGGTGGTATTAGGTG
CTGGTGGCGCCGCGACTGCCATTCAAGTCCAAGCGGCGCTAGATGGTGCCAAACAGATTACCATCTTTAATCGGCAGGAT
GAATTCTATTCACGTGCTGAATCGACTGCCAAAAAGTTGGCCGAGGCAGCACCTGCTGTCAAAGTAGATGTGGTTCAGTT
GGAAAATACTGACAGGCTCAAAGCAGCGATTGCGGACGCCGATATTCTTGTCAACGCAACTACTGTCGGCATGAAACCAG
ACGATGGGGTTTCCCTTGTTGATCCGAGTTTCCTACGCGCAGATTTGGTGGTGGCTGACACGGTATACAATCCGTTGAAG
ACAAAGTTGATTGAAGATGCTGAAAAAGCTGGCGCAAAAACAGCCCCGGGTAAAGGCATGCTACTTTGGCAAGGCGCAGC
CGGATATCAATTGTGGACTGGTCAGGACATGCCGGTGAAGGCATATCAGGCATTTGAAGAAGAGCGTGAACCAGACCGGT
CTCTGGTGTAG

Upstream 100 bases:

>100_bases
GTAATTTGCAATATTGATAGAAGCAACTTGATCGCACCTTGGGTCAGGTTCTTCTTTTCAAAATGCTCGTGAAAATATGA
ACTTAATGGAGGCACTGAAC

Downstream 100 bases:

>100_bases
GGAACACGTTTAAAAACGGAGGCAACTTGAACGATGAAAACCAAACGTAATCATTTTTTGCCGGGTGCACTGGCACTGTA
TTTTTCCTATGCGATGCTGG

Product: shikimate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
METWISGTTGLLCLLGSPVGHSGSPAMYNFSFQKQKIDAAYVAFDVTKEQMPEALNAMRLFKMRGGNVTMPCKNVAATLM
DELSPAAKIIGAVNVVVNDDGKLIGHITDGIGFVRNLQEHGIDIKGKHLVVLGAGGAATAIQVQAALDGAKQITIFNRQD
EFYSRAESTAKKLAEAAPAVKVDVVQLENTDRLKAAIADADILVNATTVGMKPDDGVSLVDPSFLRADLVVADTVYNPLK
TKLIEDAEKAGAKTAPGKGMLLWQGAAGYQLWTGQDMPVKAYQAFEEEREPDRSLV

Sequences:

>Translated_296_residues
METWISGTTGLLCLLGSPVGHSGSPAMYNFSFQKQKIDAAYVAFDVTKEQMPEALNAMRLFKMRGGNVTMPCKNVAATLM
DELSPAAKIIGAVNVVVNDDGKLIGHITDGIGFVRNLQEHGIDIKGKHLVVLGAGGAATAIQVQAALDGAKQITIFNRQD
EFYSRAESTAKKLAEAAPAVKVDVVQLENTDRLKAAIADADILVNATTVGMKPDDGVSLVDPSFLRADLVVADTVYNPLK
TKLIEDAEKAGAKTAPGKGMLLWQGAAGYQLWTGQDMPVKAYQAFEEEREPDRSLV
>Mature_296_residues
METWISGTTGLLCLLGSPVGHSGSPAMYNFSFQKQKIDAAYVAFDVTKEQMPEALNAMRLFKMRGGNVTMPCKNVAATLM
DELSPAAKIIGAVNVVVNDDGKLIGHITDGIGFVRNLQEHGIDIKGKHLVVLGAGGAATAIQVQAALDGAKQITIFNRQD
EFYSRAESTAKKLAEAAPAVKVDVVQLENTDRLKAAIADADILVNATTVGMKPDDGVSLVDPSFLRADLVVADTVYNPLK
TKLIEDAEKAGAKTAPGKGMLLWQGAAGYQLWTGQDMPVKAYQAFEEEREPDRSLV

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1787983, Length=271, Percent_Identity=47.9704797047971, Blast_Score=257, Evalue=5e-70,
Organism=Escherichia coli, GI1789675, Length=277, Percent_Identity=30.6859205776173, Blast_Score=107, Evalue=7e-25,
Organism=Saccharomyces cerevisiae, GI6320332, Length=282, Percent_Identity=29.0780141843972, Blast_Score=88, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151 [H]

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N [H]

EC number: =1.1.1.25 [H]

Molecular weight: Translated: 31634; Mature: 31634

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METWISGTTGLLCLLGSPVGHSGSPAMYNFSFQKQKIDAAYVAFDVTKEQMPEALNAMRL
CCCCCCCCCEEEEEECCCCCCCCCCCEEEEEHHHHHCCEEEEEEECCHHHHHHHHHHHHH
FKMRGGNVTMPCKNVAATLMDELSPAAKIIGAVNVVVNDDGKLIGHITDGIGFVRNLQEH
HEECCCCEECCHHHHHHHHHHHHCHHHHHHEEEEEEECCCCCEEEEEHHHHHHHHHHHHC
GIDIKGKHLVVLGAGGAATAIQVQAALDGAKQITIFNRQDEFYSRAESTAKKLAEAAPAV
CCCCCCCEEEEEECCCCCEEEEEEEHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCE
KVDVVQLENTDRLKAAIADADILVNATTVGMKPDDGVSLVDPSFLRADLVVADTVYNPLK
EEEEEEECCCCHHHHHHCCCEEEEEEEEECCCCCCCCEECCCHHHHHHEEEEHHHHHHHH
TKLIEDAEKAGAKTAPGKGMLLWQGAAGYQLWTGQDMPVKAYQAFEEEREPDRSLV
HHHHHHHHHCCCCCCCCCEEEEEECCCCCEEECCCCCCHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
METWISGTTGLLCLLGSPVGHSGSPAMYNFSFQKQKIDAAYVAFDVTKEQMPEALNAMRL
CCCCCCCCCEEEEEECCCCCCCCCCCEEEEEHHHHHCCEEEEEEECCHHHHHHHHHHHHH
FKMRGGNVTMPCKNVAATLMDELSPAAKIIGAVNVVVNDDGKLIGHITDGIGFVRNLQEH
HEECCCCEECCHHHHHHHHHHHHCHHHHHHEEEEEEECCCCCEEEEEHHHHHHHHHHHHC
GIDIKGKHLVVLGAGGAATAIQVQAALDGAKQITIFNRQDEFYSRAESTAKKLAEAAPAV
CCCCCCCEEEEEECCCCCEEEEEEEHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCE
KVDVVQLENTDRLKAAIADADILVNATTVGMKPDDGVSLVDPSFLRADLVVADTVYNPLK
EEEEEEECCCCHHHHHHCCCEEEEEEEEECCCCCCCCEECCCHHHHHHEEEEHHHHHHHH
TKLIEDAEKAGAKTAPGKGMLLWQGAAGYQLWTGQDMPVKAYQAFEEEREPDRSLV
HHHHHHHHHCCCCCCCCCEEEEEECCCCCEEECCCCCCHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]