BacMap

Definition	Lactobacillus casei ATCC 334, complete genome.
Accession	NC_008526
Length	2,895,264

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The map label for this gene is idnO [H]

Identifier: 116494034

GI number: 116494034

Start: 492606

End: 493439

Strand: Direct

Name: idnO [H]

Synonym: LSEI_0475

Alternate gene names: 116494034

Gene position: 492606-493439 (Clockwise)

Preceding gene: 116494033

Following gene: 116494035

Centisome position: 17.01

GC content: 48.44

Gene sequence:

>834_bases
ATGGCTGATTGGTTAGGTTTGAAAGACAAAGTTGTCGTTGTCACTGGTGCTGTTGGCGGTATGGGCACTCATTTTTGCGA
AGCCTTTGCAGAGCATGGGGCGAAGCTTGTCTTGGTTGATATTAAGAAAGATGCGATTCAGACAGCAGCTAAGAAGTTAG
CTGATCAATATGGCGTTCAAACATTAGCAGTGGCAACCGATACGACAGATGAAGATGAAGTCGATGCTACGGTGCAAGCG
GTTGTGGCTGAGTTTGGCAAAGTGGATATTCTCGTGAACACGGCCGCTATCTTGCGTTTTTCACCGTTTGAGGATTTGCG
TTTGGATGAGTGGAAGACGGCTGTGAATATTAATTTGACTGGTTATTTCTTGATGTCACAACGATTTGGTCGGCAAATGA
TTGCCCAACATCATGGGACGATGGTGCATATTTCAACGGTTGCGGCTGATTTCCCAGAGACATACAGCGGGGCGTACAGC
ACAACCAAAGCTGCGGTCAATATGTTATCGAAGCAAATGGCCGCTGAATGGGGACAGTTTGGGATTCGCAGCAACTGTGT
CATGCCATGTCTGGTGAAGACACCAATGTCGGCCGATTTTTACAAGGATCCTAACGTGTTGGACGGCCGTGAGCACTTAG
TTGCCAGTCGCCGGATTGGCAACTTGGATGACATCGCTAATGCTGTCCTTTACTTGAGCAGTGACCGTTCCGATTACACA
AACGGTGATGAACTGCGAGTTGATGGCGGGCTGGGCATCATGATGCAAGATATGATTCCGAAGCCGGGTGGTCGGCGTGA
ATACGCAATTAAAGCGCACCAAGCTGCCAAGTAA

Upstream 100 bases:

>100_bases
GCCAAATATACTTACGACACCACGGTGAAAACCTTGCAGGCGGCATGGCCGGAAATTTTGAAGGAAACTGTTGCGACACA
CTAAAAGGAGCGTAATTTTT

Downstream 100 bases:

>100_bases
TTTGCAATATTGATAGAAGCAACTTGATCGCACCTTGGGTCAGGTTCTTCTTTTCAAAATGCTCGTGAAAATATGAACTT
AATGGAGGCACTGAACATGG

Product: Short-chain alcohol dehydrogenase

Products: NA

Alternate protein names: 5-keto-D-gluconate 5-reductase [H]

Number of amino acids: Translated: 277; Mature: 276

Protein sequence:

>277_residues
MADWLGLKDKVVVVTGAVGGMGTHFCEAFAEHGAKLVLVDIKKDAIQTAAKKLADQYGVQTLAVATDTTDEDEVDATVQA
VVAEFGKVDILVNTAAILRFSPFEDLRLDEWKTAVNINLTGYFLMSQRFGRQMIAQHHGTMVHISTVAADFPETYSGAYS
TTKAAVNMLSKQMAAEWGQFGIRSNCVMPCLVKTPMSADFYKDPNVLDGREHLVASRRIGNLDDIANAVLYLSSDRSDYT
NGDELRVDGGLGIMMQDMIPKPGGRREYAIKAHQAAK

Sequences:

>Translated_277_residues
MADWLGLKDKVVVVTGAVGGMGTHFCEAFAEHGAKLVLVDIKKDAIQTAAKKLADQYGVQTLAVATDTTDEDEVDATVQA
VVAEFGKVDILVNTAAILRFSPFEDLRLDEWKTAVNINLTGYFLMSQRFGRQMIAQHHGTMVHISTVAADFPETYSGAYS
TTKAAVNMLSKQMAAEWGQFGIRSNCVMPCLVKTPMSADFYKDPNVLDGREHLVASRRIGNLDDIANAVLYLSSDRSDYT
NGDELRVDGGLGIMMQDMIPKPGGRREYAIKAHQAAK
>Mature_276_residues
ADWLGLKDKVVVVTGAVGGMGTHFCEAFAEHGAKLVLVDIKKDAIQTAAKKLADQYGVQTLAVATDTTDEDEVDATVQAV
VAEFGKVDILVNTAAILRFSPFEDLRLDEWKTAVNINLTGYFLMSQRFGRQMIAQHHGTMVHISTVAADFPETYSGAYST
TKAAVNMLSKQMAAEWGQFGIRSNCVMPCLVKTPMSADFYKDPNVLDGREHLVASRRIGNLDDIANAVLYLSSDRSDYTN
GDELRVDGGLGIMMQDMIPKPGGRREYAIKAHQAAK

Specific function: Catalyzes a reversible reduction of 5-ketoglutanate to form D-gluconate. Dependent on NADP, almost inactive with NAD [H]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI10190704, Length=245, Percent_Identity=31.0204081632653, Blast_Score=122, Evalue=2e-28,
Organism=Homo sapiens, GI4503301, Length=227, Percent_Identity=30.8370044052863, Blast_Score=118, Evalue=6e-27,
Organism=Homo sapiens, GI19923817, Length=252, Percent_Identity=28.1746031746032, Blast_Score=115, Evalue=5e-26,
Organism=Homo sapiens, GI66933014, Length=249, Percent_Identity=32.1285140562249, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI7705925, Length=248, Percent_Identity=30.6451612903226, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI32483357, Length=245, Percent_Identity=27.7551020408163, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI15277342, Length=253, Percent_Identity=25.6916996047431, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI40254992, Length=250, Percent_Identity=28, Blast_Score=91, Evalue=8e-19,
Organism=Homo sapiens, GI5031737, Length=248, Percent_Identity=26.6129032258064, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI31542939, Length=270, Percent_Identity=28.8888888888889, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI4758504, Length=258, Percent_Identity=26.3565891472868, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI59889578, Length=231, Percent_Identity=26.4069264069264, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI226371731, Length=220, Percent_Identity=26.8181818181818, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI20149619, Length=198, Percent_Identity=29.2929292929293, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI210032110, Length=199, Percent_Identity=26.1306532663317, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI7705855, Length=189, Percent_Identity=28.5714285714286, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI4504505, Length=196, Percent_Identity=28.5714285714286, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI142976729, Length=271, Percent_Identity=23.9852398523985, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI126723750, Length=248, Percent_Identity=24.5967741935484, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI33667109, Length=253, Percent_Identity=24.5059288537549, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI109715829, Length=251, Percent_Identity=23.9043824701195, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI83715985, Length=257, Percent_Identity=25.2918287937743, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI310128830, Length=241, Percent_Identity=26.1410788381743, Blast_Score=68, Evalue=7e-12,
Organism=Homo sapiens, GI310115468, Length=241, Percent_Identity=26.1410788381743, Blast_Score=68, Evalue=7e-12,
Organism=Homo sapiens, GI7706318, Length=174, Percent_Identity=26.4367816091954, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI40807363, Length=190, Percent_Identity=27.8947368421053, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI224922801, Length=174, Percent_Identity=29.8850574712644, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1790717, Length=251, Percent_Identity=30.2788844621514, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI87082100, Length=254, Percent_Identity=32.6771653543307, Blast_Score=134, Evalue=8e-33,
Organism=Escherichia coli, GI1787335, Length=247, Percent_Identity=30.7692307692308, Blast_Score=127, Evalue=8e-31,
Organism=Escherichia coli, GI87082160, Length=248, Percent_Identity=30.6451612903226, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1788459, Length=246, Percent_Identity=30.4878048780488, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1789208, Length=249, Percent_Identity=28.9156626506024, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1787905, Length=252, Percent_Identity=32.1428571428571, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1789057, Length=255, Percent_Identity=27.0588235294118, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1786812, Length=249, Percent_Identity=28.9156626506024, Blast_Score=91, Evalue=8e-20,
Organism=Escherichia coli, GI2367175, Length=247, Percent_Identity=27.1255060728745, Blast_Score=84, Evalue=9e-18,
Organism=Escherichia coli, GI1787820, Length=183, Percent_Identity=25.1366120218579, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI2367365, Length=244, Percent_Identity=29.0983606557377, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1787526, Length=206, Percent_Identity=22.8155339805825, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI1789378, Length=247, Percent_Identity=23.8866396761134, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17555706, Length=249, Percent_Identity=34.5381526104418, Blast_Score=142, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI25147288, Length=247, Percent_Identity=31.5789473684211, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI71994600, Length=251, Percent_Identity=29.0836653386454, Blast_Score=108, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI71994604, Length=254, Percent_Identity=30.7086614173228, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI115534694, Length=245, Percent_Identity=29.3877551020408, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17560676, Length=250, Percent_Identity=27.6, Blast_Score=98, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17562904, Length=270, Percent_Identity=26.6666666666667, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17536651, Length=251, Percent_Identity=27.0916334661355, Blast_Score=88, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17544670, Length=266, Percent_Identity=30.0751879699248, Blast_Score=88, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17536025, Length=249, Percent_Identity=27.710843373494, Blast_Score=87, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17562906, Length=270, Percent_Identity=26.6666666666667, Blast_Score=84, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17560150, Length=271, Percent_Identity=26.9372693726937, Blast_Score=84, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17538182, Length=265, Percent_Identity=26.7924528301887, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17562990, Length=272, Percent_Identity=25.7352941176471, Blast_Score=81, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17561272, Length=229, Percent_Identity=27.5109170305677, Blast_Score=81, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17561402, Length=251, Percent_Identity=25.0996015936255, Blast_Score=81, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17559104, Length=270, Percent_Identity=26.6666666666667, Blast_Score=80, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17538480, Length=266, Percent_Identity=26.6917293233083, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17562910, Length=271, Percent_Identity=24.3542435424354, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17563726, Length=260, Percent_Identity=26.5384615384615, Blast_Score=77, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17562908, Length=262, Percent_Identity=25.9541984732824, Blast_Score=77, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17551412, Length=277, Percent_Identity=25.2707581227437, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI72000259, Length=261, Percent_Identity=25.6704980842912, Blast_Score=74, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17560332, Length=268, Percent_Identity=26.4925373134328, Blast_Score=74, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17508895, Length=193, Percent_Identity=27.979274611399, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17567345, Length=194, Percent_Identity=27.319587628866, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17568967, Length=187, Percent_Identity=28.3422459893048, Blast_Score=70, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17538486, Length=274, Percent_Identity=25.5474452554745, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI193203115, Length=209, Percent_Identity=26.7942583732057, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17565030, Length=269, Percent_Identity=24.907063197026, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI193204405, Length=274, Percent_Identity=25.1824817518248, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17560220, Length=273, Percent_Identity=25.2747252747253, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI193203117, Length=194, Percent_Identity=26.2886597938144, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324126, Length=255, Percent_Identity=27.843137254902, Blast_Score=94, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6322861, Length=247, Percent_Identity=27.9352226720648, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6322226, Length=204, Percent_Identity=26.4705882352941, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24639444, Length=252, Percent_Identity=31.7460317460317, Blast_Score=124, Evalue=5e-29,
Organism=Drosophila melanogaster, GI23397609, Length=254, Percent_Identity=30.7086614173228, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI21357041, Length=250, Percent_Identity=30, Blast_Score=115, Evalue=4e-26,
Organism=Drosophila melanogaster, GI28571526, Length=254, Percent_Identity=29.9212598425197, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24643142, Length=252, Percent_Identity=28.5714285714286, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24644339, Length=249, Percent_Identity=28.1124497991968, Blast_Score=98, Evalue=8e-21,
Organism=Drosophila melanogaster, GI17737361, Length=260, Percent_Identity=28.8461538461538, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI21355319, Length=249, Percent_Identity=25.3012048192771, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24640442, Length=204, Percent_Identity=29.9019607843137, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21355631, Length=177, Percent_Identity=29.3785310734463, Blast_Score=85, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24644337, Length=258, Percent_Identity=27.906976744186, Blast_Score=84, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24649181, Length=188, Percent_Identity=30.3191489361702, Blast_Score=81, Evalue=6e-16,
Organism=Drosophila melanogaster, GI21357673, Length=230, Percent_Identity=24.7826086956522, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24584744, Length=189, Percent_Identity=28.042328042328, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24640492, Length=203, Percent_Identity=24.6305418719212, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI28574402, Length=189, Percent_Identity=28.042328042328, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI18859837, Length=188, Percent_Identity=28.1914893617021, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24584748, Length=187, Percent_Identity=25.668449197861, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI161076933, Length=187, Percent_Identity=25.668449197861, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21358495, Length=205, Percent_Identity=25.8536585365854, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.69 [H]

Molecular weight: Translated: 30227; Mature: 30096

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADWLGLKDKVVVVTGAVGGMGTHFCEAFAEHGAKLVLVDIKKDAIQTAAKKLADQYGVQ
CCCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHCCE
TLAVATDTTDEDEVDATVQAVVAEFGKVDILVNTAAILRFSPFEDLRLDEWKTAVNINLT
EEEEEECCCCCHHHHHHHHHHHHHHCCEEEEEEEEEHEEECCCCCCCCCCCCEEEEEEEE
GYFLMSQRFGRQMIAQHHGTMVHISTVAADFPETYSGAYSTTKAAVNMLSKQMAAEWGQF
EEEEHHHHHHHHHHHHHCCCEEEEEEHHCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHC
GIRSNCVMPCLVKTPMSADFYKDPNVLDGREHLVASRRIGNLDDIANAVLYLSSDRSDYT
CCCCCCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHEEEEEECCCCCCC
NGDELRVDGGLGIMMQDMIPKPGGRREYAIKAHQAAK
CCCEEEECCCCCEEEHHHCCCCCCCCEEEEECCCCCC
>Mature Secondary Structure 
ADWLGLKDKVVVVTGAVGGMGTHFCEAFAEHGAKLVLVDIKKDAIQTAAKKLADQYGVQ
CCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHCCE
TLAVATDTTDEDEVDATVQAVVAEFGKVDILVNTAAILRFSPFEDLRLDEWKTAVNINLT
EEEEEECCCCCHHHHHHHHHHHHHHCCEEEEEEEEEHEEECCCCCCCCCCCCEEEEEEEE
GYFLMSQRFGRQMIAQHHGTMVHISTVAADFPETYSGAYSTTKAAVNMLSKQMAAEWGQF
EEEEHHHHHHHHHHHHHCCCEEEEEEHHCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHC
GIRSNCVMPCLVKTPMSADFYKDPNVLDGREHLVASRRIGNLDDIANAVLYLSSDRSDYT
CCCCCCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHEEEEEECCCCCCC
NGDELRVDGGLGIMMQDMIPKPGGRREYAIKAHQAAK
CCCEEEECCCCCEEEHHHCCCCCCCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]