Click here to switch to the map view.

The map label for this gene is lysP [H]

Identifier: 116493952

GI number: 116493952

Start: 388964

End: 390418

Strand: Direct

Name: lysP [H]

Synonym: LSEI_0386

Alternate gene names: 116493952

Gene position: 388964-390418 (Clockwise)

Preceding gene: 116493951

Following gene: 116493955

Centisome position: 13.43

GC content: 49.21

Gene sequence:

>1455_bases
ATGGCCCAGATTGCCTCAACACAAGTTAAACGCGTGCTGAAAACACGCCATCTTTCAATGATCGCACTAGGCGGTAGTAT
TGGTACTGGTCTGTTTGTTGCCAGCGGCAGTGCGATTGCGACAGCAGGACCGGGTGGGGCAATTGCTGCCTATGTTGGAA
TTGGCCTGATGGTCTTTTTCCTGATGACCAGTCTTGGCGAGATGGCAACCTATGTGCCGGTTTCGGGATCATTTTCAGAA
TATGCAAGTCGCTTTGTGGATCCTGCATTTGGCTTTGCGCTGGGGTGGAATTATTGGCTCAATTGGGCCATTACCCTAGC
TGTCGATGTTTCAACAACGGCGATTGTGATGCACTTTTGGCTGCCAAATTTGCCAGGATGGTTGATTTCAGTGGGATTTT
TGGCCTTGATTTTTGTCATCAACGTTGTTTCGGCAAAATCTTTTGCAGAGACAGAGTACTGGCTGTCGCTGGTTAAGGTG
ATCACGGTCATTGTTTTCCTTGGAGTCGGATTACTGACGATTGCGGGCATTATGGGCGGCAGCCATCCAGTTGGGTTGAA
AAACTATACGACCGGTGCGGCACCATTTGTCGGTGGTTTGCCAGCGACATTGTCCGTGTTTGTGGTGGCTGGATTCTCCT
TCCAAGGAACGGAACTCATTGGCATTACGGCAGGCGAAAGCGAGACACCTGAAACCAGTATTCCTAAGGCGATTAAACAG
GTTTTCTGGCGAATTTTGTTGTTCTACATTTTGTCGATTGCGATCATCGCAGCGATTATTCCATATACCAGCCCTAACTT
GCTAGGGGCGTCAGTCAACAATGTGGCGATTTCAACGTTCACATTGGTTTTCAATCGCATCGGCATGGCTGGGGCCGCGA
GTCTGATGAATGCGGTGATCCTGACCTCGGTGCTATCTTCAGCCAATTCGGGGATGTATGCGTCAACGCGAATGCTGTGG
GCGATGGGAAGCTCTGGCTTTGCGCCACGCATATTCCAAAAAACCAACAACCGTGGTGTGCCAATCGCAGCCTTGCTCTT
AACCACCTTGGTCGGCGCAATGACCTTTTTGACCAGCATCATGGGTCCAAGTGTGTATCAATTATTGGTGGCAGCATCAG
GTTTGACCGGCTTTCTAGCCTGGCTGGGTATCGCCGTCTCACATTTACGTTTCCGGCGAGCCTTCATCAAACAAGGCCAC
TCGCTGGATGAATTGAAGTATCATGCAAAATGGTTCCCAATCGGTCCAATTCTAGCCATCATCATGAGTTTGATCGTGAT
CATTGGCCAAGACATTGGGTCACTTGCCAACTTTGCTTGGGGGCGCCTGTTGATCTCGTACATGTCGATCCCGTTATTCA
TCGTGTTGTTCGTTTACTACAAGGTCAAAAACAAAACGAAACTGATTCCACTCGACGAAATTGATCTATCTCCACATCGG
GATCATCGGTCGTAG

Upstream 100 bases:

>100_bases
GTTTAAGGTATGGTGACGTGGGTTTCGGCAATTGCTGAGGCCCACGTTAGCATATCAAAATGGTTCTCGATGGCAGAGCG
TACAAAAGGAGCAGGCGAAC

Downstream 100 bases:

>100_bases
CTTTATTGTCAGAACAGAGATTAGAACCCAATTCACAGTGACCGAATAAAAGCGAGTAACTTTCGATATTGAAAATTACT
TGCTTTTTGTTTTCGCATGG

Product: amino acid transporter

Products: Proton [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 484; Mature: 483

Protein sequence:

>484_residues
MAQIASTQVKRVLKTRHLSMIALGGSIGTGLFVASGSAIATAGPGGAIAAYVGIGLMVFFLMTSLGEMATYVPVSGSFSE
YASRFVDPAFGFALGWNYWLNWAITLAVDVSTTAIVMHFWLPNLPGWLISVGFLALIFVINVVSAKSFAETEYWLSLVKV
ITVIVFLGVGLLTIAGIMGGSHPVGLKNYTTGAAPFVGGLPATLSVFVVAGFSFQGTELIGITAGESETPETSIPKAIKQ
VFWRILLFYILSIAIIAAIIPYTSPNLLGASVNNVAISTFTLVFNRIGMAGAASLMNAVILTSVLSSANSGMYASTRMLW
AMGSSGFAPRIFQKTNNRGVPIAALLLTTLVGAMTFLTSIMGPSVYQLLVAASGLTGFLAWLGIAVSHLRFRRAFIKQGH
SLDELKYHAKWFPIGPILAIIMSLIVIIGQDIGSLANFAWGRLLISYMSIPLFIVLFVYYKVKNKTKLIPLDEIDLSPHR
DHRS

Sequences:

>Translated_484_residues
MAQIASTQVKRVLKTRHLSMIALGGSIGTGLFVASGSAIATAGPGGAIAAYVGIGLMVFFLMTSLGEMATYVPVSGSFSE
YASRFVDPAFGFALGWNYWLNWAITLAVDVSTTAIVMHFWLPNLPGWLISVGFLALIFVINVVSAKSFAETEYWLSLVKV
ITVIVFLGVGLLTIAGIMGGSHPVGLKNYTTGAAPFVGGLPATLSVFVVAGFSFQGTELIGITAGESETPETSIPKAIKQ
VFWRILLFYILSIAIIAAIIPYTSPNLLGASVNNVAISTFTLVFNRIGMAGAASLMNAVILTSVLSSANSGMYASTRMLW
AMGSSGFAPRIFQKTNNRGVPIAALLLTTLVGAMTFLTSIMGPSVYQLLVAASGLTGFLAWLGIAVSHLRFRRAFIKQGH
SLDELKYHAKWFPIGPILAIIMSLIVIIGQDIGSLANFAWGRLLISYMSIPLFIVLFVYYKVKNKTKLIPLDEIDLSPHR
DHRS
>Mature_483_residues
AQIASTQVKRVLKTRHLSMIALGGSIGTGLFVASGSAIATAGPGGAIAAYVGIGLMVFFLMTSLGEMATYVPVSGSFSEY
ASRFVDPAFGFALGWNYWLNWAITLAVDVSTTAIVMHFWLPNLPGWLISVGFLALIFVINVVSAKSFAETEYWLSLVKVI
TVIVFLGVGLLTIAGIMGGSHPVGLKNYTTGAAPFVGGLPATLSVFVVAGFSFQGTELIGITAGESETPETSIPKAIKQV
FWRILLFYILSIAIIAAIIPYTSPNLLGASVNNVAISTFTLVFNRIGMAGAASLMNAVILTSVLSSANSGMYASTRMLWA
MGSSGFAPRIFQKTNNRGVPIAALLLTTLVGAMTFLTSIMGPSVYQLLVAASGLTGFLAWLGIAVSHLRFRRAFIKQGHS
LDELKYHAKWFPIGPILAIIMSLIVIIGQDIGSLANFAWGRLLISYMSIPLFIVLFVYYKVKNKTKLIPLDEIDLSPHRD
HRS

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of lysine [H]

COG id: COG0833

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Escherichia coli, GI1788480, Length=478, Percent_Identity=53.9748953974895, Blast_Score=529, Evalue=1e-151,
Organism=Escherichia coli, GI87081708, Length=425, Percent_Identity=40.9411764705882, Blast_Score=322, Evalue=3e-89,
Organism=Escherichia coli, GI1786789, Length=420, Percent_Identity=37.3809523809524, Blast_Score=263, Evalue=1e-71,
Organism=Escherichia coli, GI1786302, Length=467, Percent_Identity=35.3319057815846, Blast_Score=259, Evalue=2e-70,
Organism=Escherichia coli, GI48994972, Length=391, Percent_Identity=36.8286445012788, Blast_Score=249, Evalue=3e-67,
Organism=Escherichia coli, GI1789017, Length=401, Percent_Identity=34.6633416458853, Blast_Score=244, Evalue=7e-66,
Organism=Escherichia coli, GI1790653, Length=436, Percent_Identity=33.256880733945, Blast_Score=236, Evalue=2e-63,
Organism=Escherichia coli, GI87081915, Length=402, Percent_Identity=34.3283582089552, Blast_Score=233, Evalue=2e-62,
Organism=Escherichia coli, GI1786602, Length=391, Percent_Identity=36.0613810741688, Blast_Score=221, Evalue=6e-59,
Organism=Saccharomyces cerevisiae, GI6320772, Length=492, Percent_Identity=36.7886178861789, Blast_Score=309, Evalue=5e-85,
Organism=Saccharomyces cerevisiae, GI6324061, Length=494, Percent_Identity=35.82995951417, Blast_Score=301, Evalue=1e-82,
Organism=Saccharomyces cerevisiae, GI6322892, Length=497, Percent_Identity=36.6197183098592, Blast_Score=295, Evalue=9e-81,
Organism=Saccharomyces cerevisiae, GI6320717, Length=494, Percent_Identity=32.5910931174089, Blast_Score=275, Evalue=1e-74,
Organism=Saccharomyces cerevisiae, GI6324990, Length=497, Percent_Identity=33.6016096579477, Blast_Score=273, Evalue=5e-74,
Organism=Saccharomyces cerevisiae, GI6321629, Length=498, Percent_Identity=33.9357429718875, Blast_Score=270, Evalue=4e-73,
Organism=Saccharomyces cerevisiae, GI6324059, Length=489, Percent_Identity=34.9693251533742, Blast_Score=261, Evalue=1e-70,
Organism=Saccharomyces cerevisiae, GI6324553, Length=493, Percent_Identity=34.8884381338742, Blast_Score=261, Evalue=2e-70,
Organism=Saccharomyces cerevisiae, GI6319824, Length=490, Percent_Identity=32.6530612244898, Blast_Score=257, Evalue=2e-69,
Organism=Saccharomyces cerevisiae, GI6320251, Length=491, Percent_Identity=31.3645621181263, Blast_Score=245, Evalue=1e-65,
Organism=Saccharomyces cerevisiae, GI6321053, Length=480, Percent_Identity=31.875, Blast_Score=244, Evalue=3e-65,
Organism=Saccharomyces cerevisiae, GI6322967, Length=478, Percent_Identity=30.9623430962343, Blast_Score=238, Evalue=1e-63,
Organism=Saccharomyces cerevisiae, GI6319542, Length=491, Percent_Identity=30.5498981670061, Blast_Score=238, Evalue=2e-63,
Organism=Saccharomyces cerevisiae, GI6319543, Length=490, Percent_Identity=31.0204081632653, Blast_Score=238, Evalue=2e-63,
Organism=Saccharomyces cerevisiae, GI6324981, Length=493, Percent_Identity=33.6713995943205, Blast_Score=227, Evalue=3e-60,
Organism=Saccharomyces cerevisiae, GI6324924, Length=499, Percent_Identity=29.4589178356713, Blast_Score=226, Evalue=8e-60,
Organism=Saccharomyces cerevisiae, GI6319608, Length=505, Percent_Identity=27.5247524752475, Blast_Score=189, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6320364, Length=549, Percent_Identity=25.8652094717668, Blast_Score=160, Evalue=4e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 51781; Mature: 51650

Theoretical pI: Translated: 10.21; Mature: 10.21

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQIASTQVKRVLKTRHLSMIALGGSIGTGLFVASGSAIATAGPGGAIAAYVGIGLMVFF
CCCHHHHHHHHHHHHHHHHHEEECCCCCCCEEEECCCEEEECCCCHHHHHHHHHHHHHHH
LMTSLGEMATYVPVSGSFSEYASRFVDPAFGFALGWNYWLNWAITLAVDVSTTAIVMHFW
HHHHHHHHHEECCCCCCHHHHHHHHCCHHHHHHHHHHHHEEEEEEEEEECCHHHHHHHHH
LPNLPGWLISVGFLALIFVINVVSAKSFAETEYWLSLVKVITVIVFLGVGLLTIAGIMGG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
SHPVGLKNYTTGAAPFVGGLPATLSVFVVAGFSFQGTELIGITAGESETPETSIPKAIKQ
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCHHHHHHHH
VFWRILLFYILSIAIIAAIIPYTSPNLLGASVNNVAISTFTLVFNRIGMAGAASLMNAVI
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHH
LTSVLSSANSGMYASTRMLWAMGSSGFAPRIFQKTNNRGVPIAALLLTTLVGAMTFLTSI
HHHHHHHCCCCCCHHHHHHHEECCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
MGPSVYQLLVAASGLTGFLAWLGIAVSHLRFRRAFIKQGHSLDELKYHAKWFPIGPILAI
HCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCHHHHHHH
IMSLIVIIGQDIGSLANFAWGRLLISYMSIPLFIVLFVYYKVKNKTKLIPLDEIDLSPHR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCC
DHRS
CCCC
>Mature Secondary Structure 
AQIASTQVKRVLKTRHLSMIALGGSIGTGLFVASGSAIATAGPGGAIAAYVGIGLMVFF
CCHHHHHHHHHHHHHHHHHEEECCCCCCCEEEECCCEEEECCCCHHHHHHHHHHHHHHH
LMTSLGEMATYVPVSGSFSEYASRFVDPAFGFALGWNYWLNWAITLAVDVSTTAIVMHFW
HHHHHHHHHEECCCCCCHHHHHHHHCCHHHHHHHHHHHHEEEEEEEEEECCHHHHHHHHH
LPNLPGWLISVGFLALIFVINVVSAKSFAETEYWLSLVKVITVIVFLGVGLLTIAGIMGG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
SHPVGLKNYTTGAAPFVGGLPATLSVFVVAGFSFQGTELIGITAGESETPETSIPKAIKQ
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCHHHHHHHH
VFWRILLFYILSIAIIAAIIPYTSPNLLGASVNNVAISTFTLVFNRIGMAGAASLMNAVI
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHH
LTSVLSSANSGMYASTRMLWAMGSSGFAPRIFQKTNNRGVPIAALLLTTLVGAMTFLTSI
HHHHHHHCCCCCCHHHHHHHEECCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
MGPSVYQLLVAASGLTGFLAWLGIAVSHLRFRRAFIKQGHSLDELKYHAKWFPIGPILAI
HCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCHHHHHHH
IMSLIVIIGQDIGSLANFAWGRLLISYMSIPLFIVLFVYYKVKNKTKLIPLDEIDLSPHR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCC
DHRS
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-lysine [Periplasm] = Proton [Cytoplasm] + L-lysine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1315732; 9278503; 7551055 [H]