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The map label for this gene is purK [H]

Identifier: 116493118

GI number: 116493118

Start: 1362401

End: 1363540

Strand: Reverse

Name: purK [H]

Synonym: PEPE_1373

Alternate gene names: 116493118

Gene position: 1363540-1362401 (Counterclockwise)

Preceding gene: 116493119

Following gene: 116493117

Centisome position: 74.41

GC content: 34.91

Gene sequence:

>1140_bases
GTGGAGAGTGAAGTAATTACCTCTAGAAAAATTATTTATCCAGGGGACATAATTGGTATTATTGGAGAAGGACGTTCAAG
TGTACAACTCGTTGCTACTGCAAAGTCAATGGGTTTTAAGGTTGCTACATACGTTACTTCTGAGAAAAATGGCGTGAATC
AATATGCGGACATTAGTTTTGTCGGTAGTATTCATGATGGGGAAAAATTACAACGCTTTGCAGAACGTTGTAAAATTGTT
CTATACGAATCAGAACTAATTGATATTAAAACAATTCAATATTTACAACAATTTGTTTCAATTCCACAAGGAGTTAAATT
ACTTGAATTAAATCAAGATCGAATCCTAGAACGAGCAACTCTAGAACAAACAGGGATTAAGGGAACGCCCTATGTTACAG
TTGTAGATTTAGACGATTTATATGAGTCAATTAATGAAATTGGATATCCGGCTATTCTTCGTCCAATCTTAAAGGATGCT
ATGACTGAAAAAGAGTTAATTCTTAAGAGTGAGATAGATATTCCAAAGGCCAGCGTACTATTAGAACGTGGAACTTATAT
GCTTCAACCAGTTATGACCGGTGGAAAAGAAATCGCGGTAAGTATTGTTAAAGATCAAAATAATCGACAAAAAATGTTCC
CAATGGTCGAGAATGTTTACGAAAACCATTTTCTAAAAGAAACTAAAGTTCCAGTTGATTTAGATTCAAAAGTTCAAAAT
TCAGTATTAGAAGCAGCAACTAAAATTGCTGGTTTAGTAGAGTACGTAGGTGTATTTTCAATCGTCTTCTATGTTGATGG
TGAGGACATCTATTTTGAACAATTAATACCTGGAATTCGTGATGAACAAAACGTATTTAATCTAGCGTCAAACACCACGG
TCTATGAAGAAATGCTCCGGGCCTTGAGTGGAATGATGATTAGTGACATCCGGCTCCAAGTACCAACCATCATGTTAAAC
ATTACGGATGAACAAATGAAGAAAATCAAAACACAGTGGTTAATTAAATCAAATTGGCATTTCCACTTCTATCCACAAGT
AGATGAAGCAGATGCTAAACAGCATATCGGATATATCTTGGCAGATGGTGATGATGTCAAACAAATTCAAGAACAAATTG
ATAACACTGATATTTGGTAA

Upstream 100 bases:

>100_bases
AGTTAGAATCTTTAGCAAGAATTAAGGCGCTAACGGATGATGGTCAAGTTGAATTTGAATAAATAAGTAAGAAGATTGAT
GAACAGGCGGGATGATTTAA

Downstream 100 bases:

>100_bases
AACTCTGTTAAAGTCGGTAAATAAACCGGCTTTTTTTGATATAATGGTTTGTGGTTATTTTTTAGTTACGTAGATAGAGA
GGATTGAACAAATTGCCAGA

Product: phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)

Products: NA

Alternate protein names: N5-CAIR synthase; 5-(carboxyamino)imidazole ribonucleotide synthetase [H]

Number of amino acids: Translated: 379; Mature: 379

Protein sequence:

>379_residues
MESEVITSRKIIYPGDIIGIIGEGRSSVQLVATAKSMGFKVATYVTSEKNGVNQYADISFVGSIHDGEKLQRFAERCKIV
LYESELIDIKTIQYLQQFVSIPQGVKLLELNQDRILERATLEQTGIKGTPYVTVVDLDDLYESINEIGYPAILRPILKDA
MTEKELILKSEIDIPKASVLLERGTYMLQPVMTGGKEIAVSIVKDQNNRQKMFPMVENVYENHFLKETKVPVDLDSKVQN
SVLEAATKIAGLVEYVGVFSIVFYVDGEDIYFEQLIPGIRDEQNVFNLASNTTVYEEMLRALSGMMISDIRLQVPTIMLN
ITDEQMKKIKTQWLIKSNWHFHFYPQVDEADAKQHIGYILADGDDVKQIQEQIDNTDIW

Sequences:

>Translated_379_residues
MESEVITSRKIIYPGDIIGIIGEGRSSVQLVATAKSMGFKVATYVTSEKNGVNQYADISFVGSIHDGEKLQRFAERCKIV
LYESELIDIKTIQYLQQFVSIPQGVKLLELNQDRILERATLEQTGIKGTPYVTVVDLDDLYESINEIGYPAILRPILKDA
MTEKELILKSEIDIPKASVLLERGTYMLQPVMTGGKEIAVSIVKDQNNRQKMFPMVENVYENHFLKETKVPVDLDSKVQN
SVLEAATKIAGLVEYVGVFSIVFYVDGEDIYFEQLIPGIRDEQNVFNLASNTTVYEEMLRALSGMMISDIRLQVPTIMLN
ITDEQMKKIKTQWLIKSNWHFHFYPQVDEADAKQHIGYILADGDDVKQIQEQIDNTDIW
>Mature_379_residues
MESEVITSRKIIYPGDIIGIIGEGRSSVQLVATAKSMGFKVATYVTSEKNGVNQYADISFVGSIHDGEKLQRFAERCKIV
LYESELIDIKTIQYLQQFVSIPQGVKLLELNQDRILERATLEQTGIKGTPYVTVVDLDDLYESINEIGYPAILRPILKDA
MTEKELILKSEIDIPKASVLLERGTYMLQPVMTGGKEIAVSIVKDQNNRQKMFPMVENVYENHFLKETKVPVDLDSKVQN
SVLEAATKIAGLVEYVGVFSIVFYVDGEDIYFEQLIPGIRDEQNVFNLASNTTVYEEMLRALSGMMISDIRLQVPTIMLN
ITDEQMKKIKTQWLIKSNWHFHFYPQVDEADAKQHIGYILADGDDVKQIQEQIDNTDIW

Specific function: Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) [H]

COG id: COG0026

COG function: function code F; Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006115
- InterPro:   IPR005875
- InterPro:   IPR011761
- InterPro:   IPR003135
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02222 ATP-grasp; PF03446 NAD_binding_2 [H]

EC number: =6.3.4.18 [H]

Molecular weight: Translated: 43032; Mature: 43032

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESEVITSRKIIYPGDIIGIIGEGRSSVQLVATAKSMGFKVATYVTSEKNGVNQYADISF
CCCCCCCCCEEECCCCEEEEECCCCCCEEEEEEHHHCCEEEEEEEECCCCCCCCCCCEEE
VGSIHDGEKLQRFAERCKIVLYESELIDIKTIQYLQQFVSIPQGVKLLELNQDRILERAT
EECCCCCHHHHHHHHHCEEEEEECCCCHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHH
LEQTGIKGTPYVTVVDLDDLYESINEIGYPAILRPILKDAMTEKELILKSEIDIPKASVL
HHHCCCCCCCEEEEEEHHHHHHHHHHCCCHHHHHHHHHHHHCHHHHHHHHCCCCCHHHHH
LERGTYMLQPVMTGGKEIAVSIVKDQNNRQKMFPMVENVYENHFLKETKVPVDLDSKVQN
HHCCCEEEEHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHCHHHCCCCCCCCHHHHH
SVLEAATKIAGLVEYVGVFSIVFYVDGEDIYFEQLIPGIRDEQNVFNLASNTTVYEEMLR
HHHHHHHHHHHHHHHHHHHEEEEEECCCCEEHHHHCCCCCCCHHHHHHHCCCHHHHHHHH
ALSGMMISDIRLQVPTIMLNITDEQMKKIKTQWLIKSNWHFHFYPQVDEADAKQHIGYIL
HHCCCCHHHHEEEEEEEEEEECHHHHHHHHHHHEEECCCEEEEECCCCCCCHHHHCCEEE
ADGDDVKQIQEQIDNTDIW
ECCHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MESEVITSRKIIYPGDIIGIIGEGRSSVQLVATAKSMGFKVATYVTSEKNGVNQYADISF
CCCCCCCCCEEECCCCEEEEECCCCCCEEEEEEHHHCCEEEEEEEECCCCCCCCCCCEEE
VGSIHDGEKLQRFAERCKIVLYESELIDIKTIQYLQQFVSIPQGVKLLELNQDRILERAT
EECCCCCHHHHHHHHHCEEEEEECCCCHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHH
LEQTGIKGTPYVTVVDLDDLYESINEIGYPAILRPILKDAMTEKELILKSEIDIPKASVL
HHHCCCCCCCEEEEEEHHHHHHHHHHCCCHHHHHHHHHHHHCHHHHHHHHCCCCCHHHHH
LERGTYMLQPVMTGGKEIAVSIVKDQNNRQKMFPMVENVYENHFLKETKVPVDLDSKVQN
HHCCCEEEEHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHCHHHCCCCCCCCHHHHH
SVLEAATKIAGLVEYVGVFSIVFYVDGEDIYFEQLIPGIRDEQNVFNLASNTTVYEEMLR
HHHHHHHHHHHHHHHHHHHEEEEEECCCCEEHHHHCCCCCCCHHHHHHHCCCHHHHHHHH
ALSGMMISDIRLQVPTIMLNITDEQMKKIKTQWLIKSNWHFHFYPQVDEADAKQHIGYIL
HHCCCCHHHHEEEEEEEEEEECHHHHHHHHHHHEEECCCEEEEECCCCCCCHHHHCCEEE
ADGDDVKQIQEQIDNTDIW
ECCHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3036807; 9384377 [H]