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The map label for this gene is ygcA [C]

Identifier: 116493111

GI number: 116493111

Start: 1353073

End: 1354440

Strand: Reverse

Name: ygcA [C]

Synonym: PEPE_1366

Alternate gene names: 116493111

Gene position: 1354440-1353073 (Counterclockwise)

Preceding gene: 116493112

Following gene: 116493110

Centisome position: 73.92

GC content: 36.7

Gene sequence:

>1368_bases
ATGAAGAGTACAGCACCTGTTGAAAAAAATTTAGTATATACGGTAGAAATTGAAGATTTAACATATCAAGGCATGGGAGT
TGCTAAGATTGAACATTTTCCAATTTTTATCGCTGATAGTATTCCTGGTGAAAAGATTGAAACTAAGATTATTAAGGTTC
AAAAGAATTTTGCTTTTGGACGTGTAGAAAAGGTCCTAGAAGAAAGTCCAGATCGTGTAGAAAGTAATGATGCGGCTTAT
ACCCAAACTGGAATTGCGCCATTACAACACATCACGTATGATGCACAACTAAAATTCAAACAAAATCAAATTAAAAACTT
ATTGAAAAAATCACATCTAGAAGATTTAGAAGTGGCGGATACAGTTGGAATGGAAAATCCAACCGGTTATCGTAACAAGG
CTCAAATTCCAGTACGTAAAATTAAAGGAAAACTTCAAACTGGCTTTTTCAAGCGAAACAGCCATGATTTAGTTCCTATC
GAAGATTTTTATATTCAAGATCCAGTAATTGATAAGGTAATCGTTGAAGTACGCGATATTTTACGTGAATTTTATATTGA
TCCATATCGTGAAGCCGAAAATAAGGGAATTATTCGAAATATTATGGTCCGTCGTGGACGTCGTTCAGGACAGATTATGG
TAGTTTTGATTACGCGTACTAAAGATGTTCCTCATCTAGCAGAAATTACAGAAGCAATTGCTGCTATTGATGGAGTTGTT
AGTGTAATTCAAAATATTAATTACAAACAAACTAACGTCATTATGGGAGATGAAGACCGAGTTCTTGCTGGTGAATCAGT
TATTCATGATGAACTTTTAGGACTGGATTTCATTATTTCAGCTCATTCTTTCTATCAAGTTAACCCTATCCAAACTGAAA
AACTTTATCAACTTGCTATCGATAAAGCTGGATTAACTGGAGAAGAAACTGTGATTGATGTTTATAGCGGAATCGGTACA
ATTTCGCTTGCGATGGCAAAAGCTGCTAAAAAAGTTTATGGCGTAGAAATTGTTAAGGAAGCTGTCCAAGACGCTAAAAT
CAACGCCTTCCAAAATAACGCAAGTAATACTGAATTTGTTGTTGGTAAAGCCGAAGAACAAATGCAAAAATGGCAAGAAG
ATGGCTTGAAACCGGACGTTGTTGTTGTTGATCCTCCACGAAAAGGACTTGACCAAAGTGTTATTGATGCAACTGTTGGT
ATGAAGCCAAAACGGGTTGTTTATGTAAGCTGTAACCCTGCAACCCTTGTGCGTGATATTGACCGTTTTGGCGAACAAGG
CTATGTAGTAAATCAACCAATCGTTCCCGTGGACCAATTTCCGCAAACACCACATGTAGAAAGCGTTACGGTGTTAGAAC
GAGCTTAG

Upstream 100 bases:

>100_bases
CGCTGAAATGCGTTACAGTTCTTGAGTAGCACACGAGAATAAAACAGGCTGGTATTAATGTGCCAGCCTGTTTTTATCAG
TAAATAGATAGGGGAAATAA

Downstream 100 bases:

>100_bases
ATAAAAATAAATTTTAAATTTCGTTGATTAAAAAGTGTACTACTTATTCGAAAATAAGTAGTACGCTTTTTTATTAAAAT
TATGATAAGAAACGGATTAA

Product: tRNA (uracil-5-)-methyltransferase related enzyme

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MKSTAPVEKNLVYTVEIEDLTYQGMGVAKIEHFPIFIADSIPGEKIETKIIKVQKNFAFGRVEKVLEESPDRVESNDAAY
TQTGIAPLQHITYDAQLKFKQNQIKNLLKKSHLEDLEVADTVGMENPTGYRNKAQIPVRKIKGKLQTGFFKRNSHDLVPI
EDFYIQDPVIDKVIVEVRDILREFYIDPYREAENKGIIRNIMVRRGRRSGQIMVVLITRTKDVPHLAEITEAIAAIDGVV
SVIQNINYKQTNVIMGDEDRVLAGESVIHDELLGLDFIISAHSFYQVNPIQTEKLYQLAIDKAGLTGEETVIDVYSGIGT
ISLAMAKAAKKVYGVEIVKEAVQDAKINAFQNNASNTEFVVGKAEEQMQKWQEDGLKPDVVVVDPPRKGLDQSVIDATVG
MKPKRVVYVSCNPATLVRDIDRFGEQGYVVNQPIVPVDQFPQTPHVESVTVLERA

Sequences:

>Translated_455_residues
MKSTAPVEKNLVYTVEIEDLTYQGMGVAKIEHFPIFIADSIPGEKIETKIIKVQKNFAFGRVEKVLEESPDRVESNDAAY
TQTGIAPLQHITYDAQLKFKQNQIKNLLKKSHLEDLEVADTVGMENPTGYRNKAQIPVRKIKGKLQTGFFKRNSHDLVPI
EDFYIQDPVIDKVIVEVRDILREFYIDPYREAENKGIIRNIMVRRGRRSGQIMVVLITRTKDVPHLAEITEAIAAIDGVV
SVIQNINYKQTNVIMGDEDRVLAGESVIHDELLGLDFIISAHSFYQVNPIQTEKLYQLAIDKAGLTGEETVIDVYSGIGT
ISLAMAKAAKKVYGVEIVKEAVQDAKINAFQNNASNTEFVVGKAEEQMQKWQEDGLKPDVVVVDPPRKGLDQSVIDATVG
MKPKRVVYVSCNPATLVRDIDRFGEQGYVVNQPIVPVDQFPQTPHVESVTVLERA
>Mature_455_residues
MKSTAPVEKNLVYTVEIEDLTYQGMGVAKIEHFPIFIADSIPGEKIETKIIKVQKNFAFGRVEKVLEESPDRVESNDAAY
TQTGIAPLQHITYDAQLKFKQNQIKNLLKKSHLEDLEVADTVGMENPTGYRNKAQIPVRKIKGKLQTGFFKRNSHDLVPI
EDFYIQDPVIDKVIVEVRDILREFYIDPYREAENKGIIRNIMVRRGRRSGQIMVVLITRTKDVPHLAEITEAIAAIDGVV
SVIQNINYKQTNVIMGDEDRVLAGESVIHDELLGLDFIISAHSFYQVNPIQTEKLYQLAIDKAGLTGEETVIDVYSGIGT
ISLAMAKAAKKVYGVEIVKEAVQDAKINAFQNNASNTEFVVGKAEEQMQKWQEDGLKPDVVVVDPPRKGLDQSVIDATVG
MKPKRVVYVSCNPATLVRDIDRFGEQGYVVNQPIVPVDQFPQTPHVESVTVLERA

Specific function: Could Be A 23s rRNA (Uracil-5-)-Methyltransferase. [C]

COG id: COG2265

COG function: function code J; SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 TRAM domain [H]

Homologues:

Organism=Homo sapiens, GI34222389, Length=429, Percent_Identity=29.6037296037296, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI51173878, Length=429, Percent_Identity=29.6037296037296, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI269784680, Length=462, Percent_Identity=25.974025974026, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI269784676, Length=462, Percent_Identity=25.974025974026, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI20149688, Length=462, Percent_Identity=25.974025974026, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI269784678, Length=357, Percent_Identity=27.7310924369748, Blast_Score=116, Evalue=3e-26,
Organism=Escherichia coli, GI1789148, Length=451, Percent_Identity=27.0509977827051, Blast_Score=154, Evalue=2e-38,
Organism=Escherichia coli, GI1787083, Length=363, Percent_Identity=25.3443526170799, Blast_Score=119, Evalue=5e-28,
Organism=Escherichia coli, GI1790403, Length=209, Percent_Identity=29.1866028708134, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71997438, Length=166, Percent_Identity=33.1325301204819, Blast_Score=79, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6322909, Length=426, Percent_Identity=25.8215962441315, Blast_Score=80, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24666579, Length=416, Percent_Identity=29.8076923076923, Blast_Score=158, Evalue=7e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016027
- InterPro:   IPR001566
- InterPro:   IPR002792
- InterPro:   IPR010280 [H]

Pfam domain/function: PF01938 TRAM; PF05958 tRNA_U5-meth_tr [H]

EC number: NA

Molecular weight: Translated: 50988; Mature: 50988

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS50926 TRAM ; PS01230 TRMA_1 ; PS01231 TRMA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSTAPVEKNLVYTVEIEDLTYQGMGVAKIEHFPIFIADSIPGEKIETKIIKVQKNFAFG
CCCCCCCCCCEEEEEEEECEEECCCCEEEEEECCEEEECCCCCCCHHEEEEEEECCCCHH
RVEKVLEESPDRVESNDAAYTQTGIAPLQHITYDAQLKFKQNQIKNLLKKSHLEDLEVAD
HHHHHHHCCCCCCCCCCCCEEHHCCCHHHHCEECEEEEEHHHHHHHHHHHCCCCHHHHHH
TVGMENPTGYRNKAQIPVRKIKGKLQTGFFKRNSHDLVPIEDFYIQDPVIDKVIVEVRDI
HCCCCCCCCCCCCCCCCHHHHHCHHHHCEEECCCCCCCCCHHHEECCHHHHHHHHHHHHH
LREFYIDPYREAENKGIIRNIMVRRGRRSGQIMVVLITRTKDVPHLAEITEAIAAIDGVV
HHHHCCCCHHHCCCCCHHHHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHH
SVIQNINYKQTNVIMGDEDRVLAGESVIHDELLGLDFIISAHSFYQVNPIQTEKLYQLAI
HHHHCCCCCCCEEEECCCCCEEECCHHHHHHHHCHHHEEECCCEEEECCCCHHHHHHHHH
DKAGLTGEETVIDVYSGIGTISLAMAKAAKKVYGVEIVKEAVQDAKINAFQNNASNTEFV
HCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCEEE
VGKAEEQMQKWQEDGLKPDVVVVDPPRKGLDQSVIDATVGMKPKRVVYVSCNPATLVRDI
EECHHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHCCCCCCEEEEEECCHHHHHHHH
DRFGEQGYVVNQPIVPVDQFPQTPHVESVTVLERA
HHHCCCCEEECCCCCCHHCCCCCCCCCEEEHEECC
>Mature Secondary Structure
MKSTAPVEKNLVYTVEIEDLTYQGMGVAKIEHFPIFIADSIPGEKIETKIIKVQKNFAFG
CCCCCCCCCCEEEEEEEECEEECCCCEEEEEECCEEEECCCCCCCHHEEEEEEECCCCHH
RVEKVLEESPDRVESNDAAYTQTGIAPLQHITYDAQLKFKQNQIKNLLKKSHLEDLEVAD
HHHHHHHCCCCCCCCCCCCEEHHCCCHHHHCEECEEEEEHHHHHHHHHHHCCCCHHHHHH
TVGMENPTGYRNKAQIPVRKIKGKLQTGFFKRNSHDLVPIEDFYIQDPVIDKVIVEVRDI
HCCCCCCCCCCCCCCCCHHHHHCHHHHCEEECCCCCCCCCHHHEECCHHHHHHHHHHHHH
LREFYIDPYREAENKGIIRNIMVRRGRRSGQIMVVLITRTKDVPHLAEITEAIAAIDGVV
HHHHCCCCHHHCCCCCHHHHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHH
SVIQNINYKQTNVIMGDEDRVLAGESVIHDELLGLDFIISAHSFYQVNPIQTEKLYQLAI
HHHHCCCCCCCEEEECCCCCEEECCHHHHHHHHCHHHEEECCCEEEECCCCHHHHHHHHH
DKAGLTGEETVIDVYSGIGTISLAMAKAAKKVYGVEIVKEAVQDAKINAFQNNASNTEFV
HCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCEEE
VGKAEEQMQKWQEDGLKPDVVVVDPPRKGLDQSVIDATVGMKPKRVVYVSCNPATLVRDI
EECHHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHCCCCCCEEEEEECCHHHHHHHH
DRFGEQGYVVNQPIVPVDQFPQTPHVESVTVLERA
HHHCCCCEEECCCCCCHHCCCCCCCCCEEEHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12566566 [H]