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The map label for this gene is fruA [H]

Identifier: 116492925

GI number: 116492925

Start: 1162903

End: 1164816

Strand: Reverse

Name: fruA [H]

Synonym: PEPE_1164

Alternate gene names: 116492925

Gene position: 1164816-1162903 (Counterclockwise)

Preceding gene: 116492926

Following gene: 116492924

Centisome position: 63.57

GC content: 39.71

Gene sequence:

>1914_bases
ATGGAGATTAAAGATTTACTCAAGAAAAACTTAATGATTATGGATCTAAAAGCAGATTCAAAATCGGATGCAATTAACGA
AATGATTGATAAATACGTTAGTGAAGGAATTGTTGCCGATCGTGCGACCTATCTTAAAGGTATTCTAGATCGTGAAGCTG
AATCAACAACTGGTATTGGTGATGAGATTGCGATGCCTCATGCTAAGACTAATGCTGTTAATGAGGCAGCGGTGTTATTT
GCTAAAAGTAGTAATGGGGTGGATTTTGATGCCTTGGATGGAAAACCTGTAAAATTATTCTTCATGATTGCTGCTCCAGA
GGGGGCGAATAACGCGCATCTACAGGCCTTAGCTAAACTATCTAGTTTGCTGATTGACCCAGAGTTGGTAGGAAAATTGA
AGAACGCTGAAACTCCAGCGGATGTCTTAGCATTATTTGAAGCTGCAGAAGCAGCAAAAGATGTAGAAGATTCACATGAT
GCTGAAACAACTGAACCAGTCGATTCAGATAAAAAGTCCTTTATTGTTGCGGTTTCAGCTTGTCCTAATGGGATTGCTCA
TACTTATATGGCTGAGGCTGCTTTGAAAAAGGCGGCTAAGGAAAAAGGAATCGAGATCAAAGTTGAAACAAATGGTTCCG
AAGGTGTAAAGCATCGTTTAACTAATGAAGATATTGAACGAGCTGATGGAGTTATCATTACAGCAGATAAAAAAGTTGAA
ATGGCGCGTTTCGATGGTAAACCACTTTTAAATCGACCAGTCATTGATGGGATTAATAAAGCTGATGAATTAATTGACTT
GGTTGAAGCTAATCAGGCTACTACATTCCATTCTACTGGAAATGAAGCGTCAGAATCTGAATCATCAAACGGTGGTTTTT
GGAATGAAATTTATAAAGATTTAATGAACGGTATTTCTCATATGCTACCATTTGTAGTTGGTGGTGGGATTATCATGGCT
CTTTCGTTCTTTATTGAGCGATATACGTCAGCAACTAGTTTGTGGTTTACTTTCCCTAATGGAATTGGTAATTATGCCTT
TTCATTCTTGATCCCAATTCTTGCCGGTTTTATTGCTCAATCAATTGGTGATTTACCAGCGTTAATGCCTGGGGTTGTGG
GTGGTTATATGGCAACCCAGTCAGCTGCGAGCGTAATGCATACAACAAGTGTTTCAGGATTTATTGGTGGATTAATTGCT
GGTTTTGCAGCTGGTTTGATTGTCAACGGTTTGAAAAAGTTATTCAAATTTGTTCCTAAGACACTTGAAGGTTTAAAACC
AATGTTGATTTATCCAATCTTGAGTTTACTTTTGGTTGGCGCATTAATGTTCTTTGCAGTTAACCCCGTGTTTGCGGCCG
TTAATGCATGGGTAACTGGTGTGCTAGAAGGCATGGGAACCGGAAACGCGGTTCTCTTAGGTGCTGTACTGGCAGCGATG
ATGTCAATTGATATGGGTGGTCCATTTAATAAGGCTGCTTATGCGTTTGCGATTGCAGCGTTTACTTCAACTAAAAATGG
TGATTTGATGGCTGCTGTAATGGTGGGTGGGATGATTCCACCTTTAGCTACAGCAATTGCCACAACATTTTGGCCTAAGA
AATTTACGGCACAAGAACGTGAAGCTGGAATTTCAAACTGGGTTCTGGGACTATCATTTATTACTGAAGGTGCCATTCCA
TTCGCAACTGCTGATCCTCTTCGTGTAATTGGATCAAGTATTATTGGTTCAGCAATCGGTGGTGGACTAAGTCAACTTTG
GAAGGTTAGTGTTCCGGCTCCTCATGGTGGTATATGGGTAATTGCGTTAGCTGATCATAAATTATTCTACGTTCTATCTG
TAGTAATTGGTGCGGTAATAGCCGGTGTAATTATGGGATTATGGAAACCAGTAAAGAATTCAAAAAATGCATAA

Upstream 100 bases:

>100_bases
GTGGAAGTGCCACAGCATTTTCACTGGATATTGCAACTAATAAAAAAATTGACGAGATTTTTAACGAAATTGATGTCTTT
GAAAAGTAAGGGGTAAAATT

Downstream 100 bases:

>100_bases
AAATTCATTTTTATGTATAAAAAATATGGTTTAACTTGGGAGTATTGTTACATTCTTTGTAACAATACTCTTTTTTTGTA
ATATTGGTGTAACATTAGAT

Product: fusion of IIA, IIB and IIC component of mannitol/fructose-specific phosphotransferase system mannitol/fructose-specific

Products: NA

Alternate protein names: EIIABC-Fru; Fructose-specific phosphotransferase enzyme IIA component; EII-Fru; PTS system fructose-specific EIIA component; Fructose-specific phosphotransferase enzyme IIB component; EIII-Fru; PTS system fructose-specific EIIB component; Fructose permease IIC component; PTS system fructose-specific EIIC component [H]

Number of amino acids: Translated: 637; Mature: 637

Protein sequence:

>637_residues
MEIKDLLKKNLMIMDLKADSKSDAINEMIDKYVSEGIVADRATYLKGILDREAESTTGIGDEIAMPHAKTNAVNEAAVLF
AKSSNGVDFDALDGKPVKLFFMIAAPEGANNAHLQALAKLSSLLIDPELVGKLKNAETPADVLALFEAAEAAKDVEDSHD
AETTEPVDSDKKSFIVAVSACPNGIAHTYMAEAALKKAAKEKGIEIKVETNGSEGVKHRLTNEDIERADGVIITADKKVE
MARFDGKPLLNRPVIDGINKADELIDLVEANQATTFHSTGNEASESESSNGGFWNEIYKDLMNGISHMLPFVVGGGIIMA
LSFFIERYTSATSLWFTFPNGIGNYAFSFLIPILAGFIAQSIGDLPALMPGVVGGYMATQSAASVMHTTSVSGFIGGLIA
GFAAGLIVNGLKKLFKFVPKTLEGLKPMLIYPILSLLLVGALMFFAVNPVFAAVNAWVTGVLEGMGTGNAVLLGAVLAAM
MSIDMGGPFNKAAYAFAIAAFTSTKNGDLMAAVMVGGMIPPLATAIATTFWPKKFTAQEREAGISNWVLGLSFITEGAIP
FATADPLRVIGSSIIGSAIGGGLSQLWKVSVPAPHGGIWVIALADHKLFYVLSVVIGAVIAGVIMGLWKPVKNSKNA

Sequences:

>Translated_637_residues
MEIKDLLKKNLMIMDLKADSKSDAINEMIDKYVSEGIVADRATYLKGILDREAESTTGIGDEIAMPHAKTNAVNEAAVLF
AKSSNGVDFDALDGKPVKLFFMIAAPEGANNAHLQALAKLSSLLIDPELVGKLKNAETPADVLALFEAAEAAKDVEDSHD
AETTEPVDSDKKSFIVAVSACPNGIAHTYMAEAALKKAAKEKGIEIKVETNGSEGVKHRLTNEDIERADGVIITADKKVE
MARFDGKPLLNRPVIDGINKADELIDLVEANQATTFHSTGNEASESESSNGGFWNEIYKDLMNGISHMLPFVVGGGIIMA
LSFFIERYTSATSLWFTFPNGIGNYAFSFLIPILAGFIAQSIGDLPALMPGVVGGYMATQSAASVMHTTSVSGFIGGLIA
GFAAGLIVNGLKKLFKFVPKTLEGLKPMLIYPILSLLLVGALMFFAVNPVFAAVNAWVTGVLEGMGTGNAVLLGAVLAAM
MSIDMGGPFNKAAYAFAIAAFTSTKNGDLMAAVMVGGMIPPLATAIATTFWPKKFTAQEREAGISNWVLGLSFITEGAIP
FATADPLRVIGSSIIGSAIGGGLSQLWKVSVPAPHGGIWVIALADHKLFYVLSVVIGAVIAGVIMGLWKPVKNSKNA
>Mature_637_residues
MEIKDLLKKNLMIMDLKADSKSDAINEMIDKYVSEGIVADRATYLKGILDREAESTTGIGDEIAMPHAKTNAVNEAAVLF
AKSSNGVDFDALDGKPVKLFFMIAAPEGANNAHLQALAKLSSLLIDPELVGKLKNAETPADVLALFEAAEAAKDVEDSHD
AETTEPVDSDKKSFIVAVSACPNGIAHTYMAEAALKKAAKEKGIEIKVETNGSEGVKHRLTNEDIERADGVIITADKKVE
MARFDGKPLLNRPVIDGINKADELIDLVEANQATTFHSTGNEASESESSNGGFWNEIYKDLMNGISHMLPFVVGGGIIMA
LSFFIERYTSATSLWFTFPNGIGNYAFSFLIPILAGFIAQSIGDLPALMPGVVGGYMATQSAASVMHTTSVSGFIGGLIA
GFAAGLIVNGLKKLFKFVPKTLEGLKPMLIYPILSLLLVGALMFFAVNPVFAAVNAWVTGVLEGMGTGNAVLLGAVLAAM
MSIDMGGPFNKAAYAFAIAAFTSTKNGDLMAAVMVGGMIPPLATAIATTFWPKKFTAQEREAGISNWVLGLSFITEGAIP
FATADPLRVIGSSIIGSAIGGGLSQLWKVSVPAPHGGIWVIALADHKLFYVLSVVIGAVIAGVIMGLWKPVKNSKNA

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This

COG id: COG1299

COG function: function code G; Phosphotransferase system, fructose-specific IIC component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-2 domain [H]

Homologues:

Organism=Escherichia coli, GI1788492, Length=463, Percent_Identity=40.8207343412527, Blast_Score=326, Evalue=3e-90,
Organism=Escherichia coli, GI1786951, Length=652, Percent_Identity=31.1349693251534, Blast_Score=301, Evalue=7e-83,
Organism=Escherichia coli, GI87082348, Length=470, Percent_Identity=33.1914893617021, Blast_Score=215, Evalue=9e-57,
Organism=Escherichia coli, GI1790386, Length=318, Percent_Identity=36.7924528301887, Blast_Score=172, Evalue=5e-44,
Organism=Escherichia coli, GI1788729, Length=384, Percent_Identity=29.9479166666667, Blast_Score=124, Evalue=3e-29,
Organism=Escherichia coli, GI1790387, Length=102, Percent_Identity=48.0392156862745, Blast_Score=95, Evalue=2e-20,
Organism=Escherichia coli, GI1788730, Length=96, Percent_Identity=38.5416666666667, Blast_Score=69, Evalue=9e-13,
Organism=Escherichia coli, GI2367327, Length=133, Percent_Identity=24.812030075188, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1789597, Length=155, Percent_Identity=25.8064516129032, Blast_Score=67, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016152
- InterPro:   IPR002178
- InterPro:   IPR013011
- InterPro:   IPR003501
- InterPro:   IPR003352
- InterPro:   IPR013014
- InterPro:   IPR004715
- InterPro:   IPR003353
- InterPro:   IPR006327 [H]

Pfam domain/function: PF00359 PTS_EIIA_2; PF02378 PTS_EIIC; PF02302 PTS_IIB [H]

EC number: =2.7.1.69 [H]

Molecular weight: Translated: 67238; Mature: 67238

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS00372 PTS_EIIA_TYPE_2_HIS ; PS51094 PTS_EIIA_TYPE_2 ; PS51099 PTS_EIIB_TYPE_2 ; PS51104 PTS_EIIC_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIKDLLKKNLMIMDLKADSKSDAINEMIDKYVSEGIVADRATYLKGILDREAESTTGIG
CCHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCC
DEIAMPHAKTNAVNEAAVLFAKSSNGVDFDALDGKPVKLFFMIAAPEGANNAHLQALAKL
CHHCCCCCCCCCCCCEEEEEEECCCCCCEECCCCCCEEEEEEEECCCCCCHHHHHHHHHH
SSLLIDPELVGKLKNAETPADVLALFEAAEAAKDVEDSHDAETTEPVDSDKKSFIVAVSA
HHHHCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEEC
CPNGIAHTYMAEAALKKAAKEKGIEIKVETNGSEGVKHRLTNEDIERADGVIITADKKVE
CCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHCCCHHHHHHCCEEEEECCCEE
MARFDGKPLLNRPVIDGINKADELIDLVEANQATTFHSTGNEASESESSNGGFWNEIYKD
HHHCCCCCCCCCCHHHCCCHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCHHHHHHHH
LMNGISHMLPFVVGGGIIMALSFFIERYTSATSLWFTFPNGIGNYAFSFLIPILAGFIAQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHH
SIGDLPALMPGVVGGYMATQSAASVMHTTSVSGFIGGLIAGFAAGLIVNGLKKLFKFVPK
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLEGLKPMLIYPILSLLLVGALMFFAVNPVFAAVNAWVTGVLEGMGTGNAVLLGAVLAAM
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
MSIDMGGPFNKAAYAFAIAAFTSTKNGDLMAAVMVGGMIPPLATAIATTFWPKKFTAQER
HHHCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHCCCCHHHHHHHHHHHCCCHHCCHHH
EAGISNWVLGLSFITEGAIPFATADPLRVIGSSIIGSAIGGGLSQLWKVSVPAPHGGIWV
HCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHEECCCCCCCCEEE
IALADHKLFYVLSVVIGAVIAGVIMGLWKPVKNSKNA
EEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MEIKDLLKKNLMIMDLKADSKSDAINEMIDKYVSEGIVADRATYLKGILDREAESTTGIG
CCHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCC
DEIAMPHAKTNAVNEAAVLFAKSSNGVDFDALDGKPVKLFFMIAAPEGANNAHLQALAKL
CHHCCCCCCCCCCCCEEEEEEECCCCCCEECCCCCCEEEEEEEECCCCCCHHHHHHHHHH
SSLLIDPELVGKLKNAETPADVLALFEAAEAAKDVEDSHDAETTEPVDSDKKSFIVAVSA
HHHHCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEEC
CPNGIAHTYMAEAALKKAAKEKGIEIKVETNGSEGVKHRLTNEDIERADGVIITADKKVE
CCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHCCCHHHHHHCCEEEEECCCEE
MARFDGKPLLNRPVIDGINKADELIDLVEANQATTFHSTGNEASESESSNGGFWNEIYKD
HHHCCCCCCCCCCHHHCCCHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCHHHHHHHH
LMNGISHMLPFVVGGGIIMALSFFIERYTSATSLWFTFPNGIGNYAFSFLIPILAGFIAQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHH
SIGDLPALMPGVVGGYMATQSAASVMHTTSVSGFIGGLIAGFAAGLIVNGLKKLFKFVPK
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLEGLKPMLIYPILSLLLVGALMFFAVNPVFAAVNAWVTGVLEGMGTGNAVLLGAVLAAM
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
MSIDMGGPFNKAAYAFAIAAFTSTKNGDLMAAVMVGGMIPPLATAIATTFWPKKFTAQER
HHHCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHCCCCHHHHHHHHHHHCCCHHCCHHH
EAGISNWVLGLSFITEGAIPFATADPLRVIGSSIIGSAIGGGLSQLWKVSVPAPHGGIWV
HCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHEECCCCCCCCEEE
IALADHKLFYVLSVVIGAVIAGVIMGLWKPVKNSKNA
EEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]