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The map label for this gene is cocE [H]

Identifier: 116492807

GI number: 116492807

Start: 1036457

End: 1038217

Strand: Direct

Name: cocE [H]

Synonym: PEPE_1044

Alternate gene names: 116492807

Gene position: 1036457-1038217 (Clockwise)

Preceding gene: 116492803

Following gene: 116492808

Centisome position: 56.56

GC content: 40.49

Gene sequence:

>1761_bases
ATGACTGTTGATGTTACGAAAGAAATGCAATTTAGTGATGCTTTTGCATATATTGATGATGGTGTAGAACATGGTGTCCT
TAGCCCATTTGAAACCAAAGAATTAATCCTAAAGAAAGGCGAAAAAATCGCCGATGGATTTAAACCACTTGATACTGATA
TTAAAATGTTAAAAGATATCCCTGTTAAATTACGAGATGGAGTAACCATTTATACCGATATTTATTTACCAATTACAAAT
GACAAAGTTCCTACCTTAATTGCTTGGAGCCCTTATGGTAAAAGCGCTGGAACTGCACCAAGATATAAAAATCTTTTTAA
CATGCTTGGAATGGGTAATCAATGGAATTCTGGATTGACTAAATTTGAGGCACCTGATCCAGCCTACTGGACTCGTCATG
GATATGCAGTGGCTAACCCCGATATGCGTGGAATCGCTCATAGCGAAGGAAATACAACGATGCTTGGTTCACAAGAAGCT
CAGGATGGTTATGATTTAATTGAATGGATTGCCCAACAAGATTGGTCCAACGGTAAGACGGCCCTAACTGGTACTTCCTA
TTTAGCTTGGTCACAATGGTTTATTGCTGCTGAAAGACCACCACATTTAACTGCAATTAATCCTACCGAAGGTTTATCAG
ATGCATATCGTGACTTGGCCTTTATCGGAGGAATTCCTGACAAAAACTTTATTGAACGCTTAGCCGTAAATCATGTCAGT
GCAAATGATGCCAAACGTGAGGATTTAGCTAAAGAAATGGATGCTGATCCGTTAGTTACGGCTCCCGTTTGGCAAGACAA
AATTGCAGATACCAGCAAAATTGAAGTTCCCGCTTTTGTGATTGGCAGTTATTCCAACACATTGCATACCATGGGAACAT
TCCGAGCTTGGCGCACCTTAGGATCTAAAGATAAATGGCTCAGAATTCATGATCGTCAAGAATGGCCTTATTACTACGAT
AAAAATAATACGGAAGAACTTCGTCGTTTCTTTGACCACTATTTACTTGGCAAAGAAAATGGATGGGAAAATACAGCTCC
TGTTCGCTACACTACCATTGGTTTTCAAGGCAAAAATGAGACAGATATTCCAGCAACTAGCTTTCCACCAGCTGGTGTGA
ATAACCAACCATTTTATCTCAACCCCTTAACTCGGACTTTGCAAGAAAAGCCTTTGTCACAGGCTGCCACAGTGCAGTAT
GTAGCTAACGACAATCCTGGACGTGTCTCATTTTTAACTACTTTCGATGCGCCGGTCACGATGGTCGGTTATCCTAAGGC
AAAGCTATTCATGGAAGTCGACGGTTACGATGATATGGATATCTTTATCATGGTACAAAAATTAGACAAATACAGTAATG
TGTTAAGTGAGTTCGTTGTACCTAATCACGGTGCAGCCCTCCAAGACTTTACTCAAGAAAGTGCCTCGGCCCTACGTTAT
AAAGGAGTCTGGGGCCGTCTACGAGCTTCAATGCGTCATTTAGATGATAAGATGAGCACGGATGAGATTCCTGCATATTC
ATTTGATCGCGTTGAAAAGTTGGCACCAAAAGAAATTGTCCAATTAGATGTTGTTTTAAGCCCAATGGGGATGACTTTTG
CTCCTGGCGAATCGTTACGTTTTGTAATCAGTTCCAAGAATGAATTAGGTTCTGTTATGCCAGGGACTCCTGGTGCTACC
CCTGACAATCAAGGTATCCATATCCTTCATACCGGTGGCAAATATGATTCCTATTTACAATTACCTATCTTAAAAAAATA
G

Upstream 100 bases:

>100_bases
CCTTCTAAACTTGCAAATATGATAGTGTACAGAAGTTCTCCCCCCTCATATACTTTAGTTTGTTAAATCAAACTTACTAA
AAATATTTGGAGGTAAAGTT

Downstream 100 bases:

>100_bases
AAAAGAATTTAGTTGCTTAACTAAAGGATTTGTAGTATTAATGACTATAAATCCTTTTTTTGATTGGAGTCACAATGAAT
TTAACAACATTAGAATACTT

Product: acyl esterase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 586; Mature: 585

Protein sequence:

>586_residues
MTVDVTKEMQFSDAFAYIDDGVEHGVLSPFETKELILKKGEKIADGFKPLDTDIKMLKDIPVKLRDGVTIYTDIYLPITN
DKVPTLIAWSPYGKSAGTAPRYKNLFNMLGMGNQWNSGLTKFEAPDPAYWTRHGYAVANPDMRGIAHSEGNTTMLGSQEA
QDGYDLIEWIAQQDWSNGKTALTGTSYLAWSQWFIAAERPPHLTAINPTEGLSDAYRDLAFIGGIPDKNFIERLAVNHVS
ANDAKREDLAKEMDADPLVTAPVWQDKIADTSKIEVPAFVIGSYSNTLHTMGTFRAWRTLGSKDKWLRIHDRQEWPYYYD
KNNTEELRRFFDHYLLGKENGWENTAPVRYTTIGFQGKNETDIPATSFPPAGVNNQPFYLNPLTRTLQEKPLSQAATVQY
VANDNPGRVSFLTTFDAPVTMVGYPKAKLFMEVDGYDDMDIFIMVQKLDKYSNVLSEFVVPNHGAALQDFTQESASALRY
KGVWGRLRASMRHLDDKMSTDEIPAYSFDRVEKLAPKEIVQLDVVLSPMGMTFAPGESLRFVISSKNELGSVMPGTPGAT
PDNQGIHILHTGGKYDSYLQLPILKK

Sequences:

>Translated_586_residues
MTVDVTKEMQFSDAFAYIDDGVEHGVLSPFETKELILKKGEKIADGFKPLDTDIKMLKDIPVKLRDGVTIYTDIYLPITN
DKVPTLIAWSPYGKSAGTAPRYKNLFNMLGMGNQWNSGLTKFEAPDPAYWTRHGYAVANPDMRGIAHSEGNTTMLGSQEA
QDGYDLIEWIAQQDWSNGKTALTGTSYLAWSQWFIAAERPPHLTAINPTEGLSDAYRDLAFIGGIPDKNFIERLAVNHVS
ANDAKREDLAKEMDADPLVTAPVWQDKIADTSKIEVPAFVIGSYSNTLHTMGTFRAWRTLGSKDKWLRIHDRQEWPYYYD
KNNTEELRRFFDHYLLGKENGWENTAPVRYTTIGFQGKNETDIPATSFPPAGVNNQPFYLNPLTRTLQEKPLSQAATVQY
VANDNPGRVSFLTTFDAPVTMVGYPKAKLFMEVDGYDDMDIFIMVQKLDKYSNVLSEFVVPNHGAALQDFTQESASALRY
KGVWGRLRASMRHLDDKMSTDEIPAYSFDRVEKLAPKEIVQLDVVLSPMGMTFAPGESLRFVISSKNELGSVMPGTPGAT
PDNQGIHILHTGGKYDSYLQLPILKK
>Mature_585_residues
TVDVTKEMQFSDAFAYIDDGVEHGVLSPFETKELILKKGEKIADGFKPLDTDIKMLKDIPVKLRDGVTIYTDIYLPITND
KVPTLIAWSPYGKSAGTAPRYKNLFNMLGMGNQWNSGLTKFEAPDPAYWTRHGYAVANPDMRGIAHSEGNTTMLGSQEAQ
DGYDLIEWIAQQDWSNGKTALTGTSYLAWSQWFIAAERPPHLTAINPTEGLSDAYRDLAFIGGIPDKNFIERLAVNHVSA
NDAKREDLAKEMDADPLVTAPVWQDKIADTSKIEVPAFVIGSYSNTLHTMGTFRAWRTLGSKDKWLRIHDRQEWPYYYDK
NNTEELRRFFDHYLLGKENGWENTAPVRYTTIGFQGKNETDIPATSFPPAGVNNQPFYLNPLTRTLQEKPLSQAATVQYV
ANDNPGRVSFLTTFDAPVTMVGYPKAKLFMEVDGYDDMDIFIMVQKLDKYSNVLSEFVVPNHGAALQDFTQESASALRYK
GVWGRLRASMRHLDDKMSTDEIPAYSFDRVEKLAPKEIVQLDVVLSPMGMTFAPGESLRFVISSKNELGSVMPGTPGATP
DNQGIHILHTGGKYDSYLQLPILKK

Specific function: Hydrolyzes cocaine to benzoate and ecgonine methyl ester, endowing the bacteria with the ability to utilize cocaine as a sole source of carbon and energy for growth, as this bacterium lives in the rhizosphere of coca plants [H]

COG id: COG2936

COG function: function code R; Predicted acyl esterases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alpha/beta hydrolase family. Carboxylesterase subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005674
- InterPro:   IPR008979
- InterPro:   IPR013736
- InterPro:   IPR000383 [H]

Pfam domain/function: PF02129 Peptidase_S15; PF08530 PepX_C [H]

EC number: NA

Molecular weight: Translated: 65739; Mature: 65608

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVDVTKEMQFSDAFAYIDDGVEHGVLSPFETKELILKKGEKIADGFKPLDTDIKMLKDI
CCCCCCCCCCHHHHHHHHHCCHHCCCCCCCHHHHHHHHCCCHHHCCCCCCCHHHHHHHCC
PVKLRDGVTIYTDIYLPITNDKVPTLIAWSPYGKSAGTAPRYKNLFNMLGMGNQWNSGLT
CEEECCCEEEEEEEEEEECCCCCCEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCCC
KFEAPDPAYWTRHGYAVANPDMRGIAHSEGNTTMLGSQEAQDGYDLIEWIAQQDWSNGKT
CCCCCCCCCCCCCCEEEECCCCCCEEECCCCEEEECCCCCCCHHHHHHHHHHCCCCCCCE
ALTGTSYLAWSQWFIAAERPPHLTAINPTEGLSDAYRDLAFIGGIPDKNFIERLAVNHVS
EEECCCCCEEEEEEEEECCCCCEEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCC
ANDAKREDLAKEMDADPLVTAPVWQDKIADTSKIEVPAFVIGSYSNTLHTMGTFRAWRTL
CCCHHHHHHHHHCCCCCCEECCCCHHHCCCCCCEECCEEEEECCCCHHHHHHHHHHHHHC
GSKDKWLRIHDRQEWPYYYDKNNTEELRRFFDHYLLGKENGWENTAPVRYTTIGFQGKNE
CCCCCEEEEECCCCCCEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCCCC
TDIPATSFPPAGVNNQPFYLNPLTRTLQEKPLSQAATVQYVANDNPGRVSFLTTFDAPVT
CCCCCCCCCCCCCCCCCEEECHHHHHHHHCCCCCCEEEEEEECCCCCEEEEEEECCCCEE
MVGYPKAKLFMEVDGYDDMDIFIMVQKLDKYSNVLSEFVVPNHGAALQDFTQESASALRY
EEECCCEEEEEEECCCCCCEEEEHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
KGVWGRLRASMRHLDDKMSTDEIPAYSFDRVEKLAPKEIVQLDVVLSPMGMTFAPGESLR
HHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCHHHEEEEEEECCCCCEECCCCCEE
FVISSKNELGSVMPGTPGATPDNQGIHILHTGGKYDSYLQLPILKK
EEEECCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCEEECCCCCC
>Mature Secondary Structure 
TVDVTKEMQFSDAFAYIDDGVEHGVLSPFETKELILKKGEKIADGFKPLDTDIKMLKDI
CCCCCCCCCHHHHHHHHHCCHHCCCCCCCHHHHHHHHCCCHHHCCCCCCCHHHHHHHCC
PVKLRDGVTIYTDIYLPITNDKVPTLIAWSPYGKSAGTAPRYKNLFNMLGMGNQWNSGLT
CEEECCCEEEEEEEEEEECCCCCCEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCCC
KFEAPDPAYWTRHGYAVANPDMRGIAHSEGNTTMLGSQEAQDGYDLIEWIAQQDWSNGKT
CCCCCCCCCCCCCCEEEECCCCCCEEECCCCEEEECCCCCCCHHHHHHHHHHCCCCCCCE
ALTGTSYLAWSQWFIAAERPPHLTAINPTEGLSDAYRDLAFIGGIPDKNFIERLAVNHVS
EEECCCCCEEEEEEEEECCCCCEEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCC
ANDAKREDLAKEMDADPLVTAPVWQDKIADTSKIEVPAFVIGSYSNTLHTMGTFRAWRTL
CCCHHHHHHHHHCCCCCCEECCCCHHHCCCCCCEECCEEEEECCCCHHHHHHHHHHHHHC
GSKDKWLRIHDRQEWPYYYDKNNTEELRRFFDHYLLGKENGWENTAPVRYTTIGFQGKNE
CCCCCEEEEECCCCCCEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCCCC
TDIPATSFPPAGVNNQPFYLNPLTRTLQEKPLSQAATVQYVANDNPGRVSFLTTFDAPVT
CCCCCCCCCCCCCCCCCEEECHHHHHHHHCCCCCCEEEEEEECCCCCEEEEEEECCCCEE
MVGYPKAKLFMEVDGYDDMDIFIMVQKLDKYSNVLSEFVVPNHGAALQDFTQESASALRY
EEECCCEEEEEEECCCCCCEEEEHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
KGVWGRLRASMRHLDDKMSTDEIPAYSFDRVEKLAPKEIVQLDVVLSPMGMTFAPGESLR
HHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCHHHEEEEEEECCCCCEECCCCCEE
FVISSKNELGSVMPGTPGATPDNQGIHILHTGGKYDSYLQLPILKK
EEEECCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10698749; 11742345; 12369817 [H]