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The map label for this gene is galM [H]

Identifier: 116492010

GI number: 116492010

Start: 238990

End: 240018

Strand: Direct

Name: galM [H]

Synonym: PEPE_0202

Alternate gene names: 116492010

Gene position: 238990-240018 (Clockwise)

Preceding gene: 116492009

Following gene: 116492011

Centisome position: 13.04

GC content: 38.68

Gene sequence:

>1029_bases
TTGGAAACTAAAAAAGAAGTATTTGATCAAATAGATGGTCAGGATGTCATACGTTATACATTGGTTAATGACCAACAAAC
TAGAATTTCAGTTTTGAGCTATGGAGGAACATGGCAAGAATTCGTAGTTAATGAGGATGGGGTGGAACGCTCATTAATTT
GGGGACTTGACAGCATGGCTGATTATCAACGCGTAGGCTATTGCCTTTGTCAATCAATTGGGCGAGTTGCTGGACGAATC
GGCGGAGCTAAATTTAAGATTGATGATCAAGAATACCAAGTTGAGATGAACGAACAAACTCATTCATTGCACGGTGGTGA
CCACGGTTTTAATACCTTAAATTTCGATGGTAAATTTAGTGAAGATGATGATCAAGTTAGCGTGATTTTATCGAAACATA
TTAAGGCGAGTGATGATAATTACCCTGGAAACCTTGATGTAGAAATTAAATTTACCCTAGACAATCAAAATCAAGTTTCG
ATTTCATTTATGGGTGATACGGACGCTGCGACGCTCTTTAACCCAACGAATCATGTTTATTGGAATACAACGGATGATCG
AACAAGTTTGGCTAAACAATGGTTGCAAATTAGCAGTACAGCTCACCTTGAATTCGATGAAGAAAAAGTTCCCACTGGCA
AGAAGCTTTCGGTTAAAGCAACCGCCTATGATTTTAATCAAGAACAACCTATTGAGGACGCCTTGAAACAGTTAAACGCT
GAAAATGGTGGGATTGAATTTGATGATGCTTACGAAGTTAATCCGAGTGAAACTACTCCTATTGCAATGGTAGGTGATAC
TGATGGTAAACGTCGAGTAAAGCTTTATTCAGATCGCAACGGACTAGTTGTATTCACGGCGAACCCATTTGATCCCGACC
AAGAAGCAGCTCATGAGTACAATGCTTTAGCTACTGAGGCACAAACATTACCTGATGCAATCAATCATTCTGATTTTGGT
GATATTGTTTTACGTCCAGGTAAGCCAGTTACAAATACTATTCGTTATCAATATGAACGTTTAAACTAA

Upstream 100 bases:

>100_bases
TATGAGTCTTTTTATTTTAACTAAAATATTTACTCAATCCCATCCAAATTTGGTATACTAAAAATGAAAACGGTTTAATT
AATACGGAGGTGTCATAATA

Downstream 100 bases:

>100_bases
ATCTAAATTAAGCGTAAGGTGTAAAAACCGAGCGCTTTTTTAATGGTTAAATAATTTAAAAAGTAGGTAGTAAAACTACA
TCGAGTGGCCTAAAACACCA

Product: aldose 1-epimerase

Products: NA

Alternate protein names: Galactose mutarotase; Type-1 mutarotase [H]

Number of amino acids: Translated: 342; Mature: 342

Protein sequence:

>342_residues
METKKEVFDQIDGQDVIRYTLVNDQQTRISVLSYGGTWQEFVVNEDGVERSLIWGLDSMADYQRVGYCLCQSIGRVAGRI
GGAKFKIDDQEYQVEMNEQTHSLHGGDHGFNTLNFDGKFSEDDDQVSVILSKHIKASDDNYPGNLDVEIKFTLDNQNQVS
ISFMGDTDAATLFNPTNHVYWNTTDDRTSLAKQWLQISSTAHLEFDEEKVPTGKKLSVKATAYDFNQEQPIEDALKQLNA
ENGGIEFDDAYEVNPSETTPIAMVGDTDGKRRVKLYSDRNGLVVFTANPFDPDQEAAHEYNALATEAQTLPDAINHSDFG
DIVLRPGKPVTNTIRYQYERLN

Sequences:

>Translated_342_residues
METKKEVFDQIDGQDVIRYTLVNDQQTRISVLSYGGTWQEFVVNEDGVERSLIWGLDSMADYQRVGYCLCQSIGRVAGRI
GGAKFKIDDQEYQVEMNEQTHSLHGGDHGFNTLNFDGKFSEDDDQVSVILSKHIKASDDNYPGNLDVEIKFTLDNQNQVS
ISFMGDTDAATLFNPTNHVYWNTTDDRTSLAKQWLQISSTAHLEFDEEKVPTGKKLSVKATAYDFNQEQPIEDALKQLNA
ENGGIEFDDAYEVNPSETTPIAMVGDTDGKRRVKLYSDRNGLVVFTANPFDPDQEAAHEYNALATEAQTLPDAINHSDFG
DIVLRPGKPVTNTIRYQYERLN
>Mature_342_residues
METKKEVFDQIDGQDVIRYTLVNDQQTRISVLSYGGTWQEFVVNEDGVERSLIWGLDSMADYQRVGYCLCQSIGRVAGRI
GGAKFKIDDQEYQVEMNEQTHSLHGGDHGFNTLNFDGKFSEDDDQVSVILSKHIKASDDNYPGNLDVEIKFTLDNQNQVS
ISFMGDTDAATLFNPTNHVYWNTTDDRTSLAKQWLQISSTAHLEFDEEKVPTGKKLSVKATAYDFNQEQPIEDALKQLNA
ENGGIEFDDAYEVNPSETTPIAMVGDTDGKRRVKLYSDRNGLVVFTANPFDPDQEAAHEYNALATEAQTLPDAINHSDFG
DIVLRPGKPVTNTIRYQYERLN

Specific function: Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose [H]

COG id: COG2017

COG function: function code G; Galactose mutarotase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldose epimerase family [H]

Homologues:

Organism=Homo sapiens, GI20270355, Length=344, Percent_Identity=26.453488372093, Blast_Score=118, Evalue=8e-27,
Organism=Escherichia coli, GI1786971, Length=336, Percent_Identity=27.3809523809524, Blast_Score=121, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI17557428, Length=337, Percent_Identity=25.2225519287834, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI115533334, Length=337, Percent_Identity=25.2225519287834, Blast_Score=110, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6324399, Length=346, Percent_Identity=21.9653179190751, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24583720, Length=343, Percent_Identity=29.1545189504373, Blast_Score=128, Evalue=7e-30,
Organism=Drosophila melanogaster, GI24668282, Length=343, Percent_Identity=27.6967930029155, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24668278, Length=340, Percent_Identity=26.4705882352941, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24659048, Length=345, Percent_Identity=27.536231884058, Blast_Score=118, Evalue=5e-27,
Organism=Drosophila melanogaster, GI24641876, Length=338, Percent_Identity=23.6686390532544, Blast_Score=89, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018052
- InterPro:   IPR013458
- InterPro:   IPR008183
- InterPro:   IPR015443
- InterPro:   IPR011013
- InterPro:   IPR014718 [H]

Pfam domain/function: PF01263 Aldose_epim [H]

EC number: =5.1.3.3 [H]

Molecular weight: Translated: 38490; Mature: 38490

Theoretical pI: Translated: 4.27; Mature: 4.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METKKEVFDQIDGQDVIRYTLVNDQQTRISVLSYGGTWQEFVVNEDGVERSLIWGLDSMA
CCCHHHHHHHCCCCCEEEEEEECCCCEEEEEEECCCCHHHEEECCCCCCHHHHHCCHHHH
DYQRVGYCLCQSIGRVAGRIGGAKFKIDDQEYQVEMNEQTHSLHGGDHGFNTLNFDGKFS
HHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEEEEECCCCCCCCCCCCCCEEECCCCCCC
EDDDQVSVILSKHIKASDDNYPGNLDVEIKFTLDNQNQVSISFMGDTDAATLFNPTNHVY
CCCCHHEEEEHHCCCCCCCCCCCCEEEEEEEEECCCCEEEEEEECCCCCEEEECCCCCEE
WNTTDDRTSLAKQWLQISSTAHLEFDEEKVPTGKKLSVKATAYDFNQEQPIEDALKQLNA
ECCCCHHHHHHHHHHHHCCEEEEEECHHHCCCCCEEEEEEEEECCCCCCCHHHHHHHHCC
ENGGIEFDDAYEVNPSETTPIAMVGDTDGKRRVKLYSDRNGLVVFTANPFDPDQEAAHEY
CCCCCCCCCCEECCCCCCCCEEEEECCCCCEEEEEEECCCCEEEEECCCCCCCHHHHHHH
NALATEAQTLPDAINHSDFGDIVLRPGKPVTNTIRYQYERLN
HHHHHHHHHHHHHCCCCCCCCEEECCCCCCCHHEEEEEEECC
>Mature Secondary Structure
METKKEVFDQIDGQDVIRYTLVNDQQTRISVLSYGGTWQEFVVNEDGVERSLIWGLDSMA
CCCHHHHHHHCCCCCEEEEEEECCCCEEEEEEECCCCHHHEEECCCCCCHHHHHCCHHHH
DYQRVGYCLCQSIGRVAGRIGGAKFKIDDQEYQVEMNEQTHSLHGGDHGFNTLNFDGKFS
HHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEEEEECCCCCCCCCCCCCCEEECCCCCCC
EDDDQVSVILSKHIKASDDNYPGNLDVEIKFTLDNQNQVSISFMGDTDAATLFNPTNHVY
CCCCHHEEEEHHCCCCCCCCCCCCEEEEEEEEECCCCEEEEEEECCCCCEEEECCCCCEE
WNTTDDRTSLAKQWLQISSTAHLEFDEEKVPTGKKLSVKATAYDFNQEQPIEDALKQLNA
ECCCCHHHHHHHHHHHHCCEEEEEECHHHCCCCCEEEEEEEEECCCCCCCHHHHHHHHCC
ENGGIEFDDAYEVNPSETTPIAMVGDTDGKRRVKLYSDRNGLVVFTANPFDPDQEAAHEY
CCCCCCCCCCEECCCCCCCCEEEEECCCCCEEEEEEECCCCEEEEECCCCCCCHHHHHHH
NALATEAQTLPDAINHSDFGDIVLRPGKPVTNTIRYQYERLN
HHHHHHHHHHHHHCCCCCCCCEEECCCCCCCHHEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1694527 [H]