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The map label for this gene is galR [H]

Identifier: 116492009

GI number: 116492009

Start: 237847

End: 238842

Strand: Direct

Name: galR [H]

Synonym: PEPE_0201

Alternate gene names: 116492009

Gene position: 237847-238842 (Clockwise)

Preceding gene: 116492008

Following gene: 116492010

Centisome position: 12.98

GC content: 39.86

Gene sequence:

>996_bases
ATGGCAGCCACATTAAAAGATATTGCGGATAAAGTTGGCGTATCGTTAGCGACCGTATCACGCGTGCTGAATAAAGATGC
GTCTCTTTCAGTTGGCGATGAAACTAGACAAAAAATCCTAAAAACCGCCGAAGCCCTACACTATTCCAAAAGTAAACGAC
ATAATAATTTAACAACTAGAAAACGCTTGGCAATTGTTCAATGGTACTCAGAAACTGAAGAACAAGATGACTTGTATTAT
ATGTCGATTCGAATGGGAATTGAACAACGTGGACAAGACAATCAATTCGAAGTGACACGAATTTTTCAGAATAATTTACA
AGAATTAGGTCCAAATGTTGATGCAGTAATAGCAGTAGGAAAATTTAGTAAACCGCAAGTTGAAGAAATTGCAGCCGTTA
CTGATAATTTAGTTTTTGTGGACGATGATCAATTCGAAGCTGGCTTTGACAGTGTGATAACTGATTTTCAATTAGCCACC
GAAAAAGTAGTCGATTATTTCTGGCAACAGGGGATTGAAGATATTGGGATTATCCATGGGTTAGAAATGACGACAGATCA
CCAATTAACTGTTACAGATCGTCGAATGTTAGGATTTAAGGCCGCGATGACAAAGCGTAACGCCTTTAAACCGGAATTTG
TATTCGAGGGTGATTATACTAGCGAATCTGGTTCTAAAATGATGCAAAAGGCAATTGATGTGCTTGGAGATCAGTTACCT
AAAGCGTTTTTTGTGGCCAATGATCCCATGGCAGCTGGGGCATTGAAAGCACTTCAGACGAATGGCATTAAAGTACCAGA
CAGAGTTAAGTTATTCAGTTTTAACAATACTTCATTAGCTACTTTTGTTTATCCTGAATTAAGTGCAGTCAACGTTGATA
CGGAGTTGATGGGTGCCACAGCAGTCAATTTAGTAATGAGTCGTTTGGCCGGTCGCACCACCACGCAACGTGTGGAACTG
GGTACAAGGTTGGTAGAACGAGCTAGTACGAAATAG

Upstream 100 bases:

>100_bases
TAAAGTTTTACATGAGTGCTATCACGATTGTGTGCCAGTCGAGGTACATTAATAGAAAAATGAATTTATGCACAATTAAG
TAATTCAAAGGAGGCAGCTC

Downstream 100 bases:

>100_bases
AATAGAAGTGAATGACTCATAGTGGTCGGATTAAATTATCCAACCACTATGAGTCTTTTTATTTTAACTAAAATATTTAC
TCAATCCCATCCAAATTTGG

Product: LacI family transcription regulator

Products: NA

Alternate protein names: Galactose operon repressor [H]

Number of amino acids: Translated: 331; Mature: 330

Protein sequence:

>331_residues
MAATLKDIADKVGVSLATVSRVLNKDASLSVGDETRQKILKTAEALHYSKSKRHNNLTTRKRLAIVQWYSETEEQDDLYY
MSIRMGIEQRGQDNQFEVTRIFQNNLQELGPNVDAVIAVGKFSKPQVEEIAAVTDNLVFVDDDQFEAGFDSVITDFQLAT
EKVVDYFWQQGIEDIGIIHGLEMTTDHQLTVTDRRMLGFKAAMTKRNAFKPEFVFEGDYTSESGSKMMQKAIDVLGDQLP
KAFFVANDPMAAGALKALQTNGIKVPDRVKLFSFNNTSLATFVYPELSAVNVDTELMGATAVNLVMSRLAGRTTTQRVEL
GTRLVERASTK

Sequences:

>Translated_331_residues
MAATLKDIADKVGVSLATVSRVLNKDASLSVGDETRQKILKTAEALHYSKSKRHNNLTTRKRLAIVQWYSETEEQDDLYY
MSIRMGIEQRGQDNQFEVTRIFQNNLQELGPNVDAVIAVGKFSKPQVEEIAAVTDNLVFVDDDQFEAGFDSVITDFQLAT
EKVVDYFWQQGIEDIGIIHGLEMTTDHQLTVTDRRMLGFKAAMTKRNAFKPEFVFEGDYTSESGSKMMQKAIDVLGDQLP
KAFFVANDPMAAGALKALQTNGIKVPDRVKLFSFNNTSLATFVYPELSAVNVDTELMGATAVNLVMSRLAGRTTTQRVEL
GTRLVERASTK
>Mature_330_residues
AATLKDIADKVGVSLATVSRVLNKDASLSVGDETRQKILKTAEALHYSKSKRHNNLTTRKRLAIVQWYSETEEQDDLYYM
SIRMGIEQRGQDNQFEVTRIFQNNLQELGPNVDAVIAVGKFSKPQVEEIAAVTDNLVFVDDDQFEAGFDSVITDFQLATE
KVVDYFWQQGIEDIGIIHGLEMTTDHQLTVTDRRMLGFKAAMTKRNAFKPEFVFEGDYTSESGSKMMQKAIDVLGDQLPK
AFFVANDPMAAGALKALQTNGIKVPDRVKLFSFNNTSLATFVYPELSAVNVDTELMGATAVNLVMSRLAGRTTTQRVELG
TRLVERASTK

Specific function: Repressor of the galactose operon. Binds galactose as an inducer [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789456, Length=333, Percent_Identity=32.7327327327327, Blast_Score=184, Evalue=6e-48,
Organism=Escherichia coli, GI1787948, Length=346, Percent_Identity=28.9017341040462, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI1790369, Length=352, Percent_Identity=28.9772727272727, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1787580, Length=343, Percent_Identity=22.7405247813411, Blast_Score=85, Evalue=6e-18,
Organism=Escherichia coli, GI1790194, Length=341, Percent_Identity=24.9266862170088, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1786540, Length=343, Percent_Identity=25.0728862973761, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1789068, Length=312, Percent_Identity=24.3589743589744, Blast_Score=75, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 36898; Mature: 36767

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS00356 HTH_LACI_1 ; PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAATLKDIADKVGVSLATVSRVLNKDASLSVGDETRQKILKTAEALHYSKSKRHNNLTTR
CCCCHHHHHHHHCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHH
KRLAIVQWYSETEEQDDLYYMSIRMGIEQRGQDNQFEVTRIFQNNLQELGPNVDAVIAVG
HHHHHHHHHHCCCCCCCEEEEEEECCHHHCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEC
KFSKPQVEEIAAVTDNLVFVDDDQFEAGFDSVITDFQLATEKVVDYFWQQGIEDIGIIHG
CCCCCHHHHHHHHHCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCC
LEMTTDHQLTVTDRRMLGFKAAMTKRNAFKPEFVFEGDYTSESGSKMMQKAIDVLGDQLP
CEECCCCEEEEEHHHHHHHHHHHHHCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHCC
KAFFVANDPMAAGALKALQTNGIKVPDRVKLFSFNNTSLATFVYPELSAVNVDTELMGAT
CEEEEECCCHHHHHHHHHHCCCCCCCCCEEEEEECCCEEEEEECCCCEEECCCHHHHHHH
AVNLVMSRLAGRTTTQRVELGTRLVERASTK
HHHHHHHHHHCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AATLKDIADKVGVSLATVSRVLNKDASLSVGDETRQKILKTAEALHYSKSKRHNNLTTR
CCCHHHHHHHHCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHH
KRLAIVQWYSETEEQDDLYYMSIRMGIEQRGQDNQFEVTRIFQNNLQELGPNVDAVIAVG
HHHHHHHHHHCCCCCCCEEEEEEECCHHHCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEC
KFSKPQVEEIAAVTDNLVFVDDDQFEAGFDSVITDFQLATEKVVDYFWQQGIEDIGIIHG
CCCCCHHHHHHHHHCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCC
LEMTTDHQLTVTDRRMLGFKAAMTKRNAFKPEFVFEGDYTSESGSKMMQKAIDVLGDQLP
CEECCCCEEEEEHHHHHHHHHHHHHCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHCC
KAFFVANDPMAAGALKALQTNGIKVPDRVKLFSFNNTSLATFVYPELSAVNVDTELMGAT
CEEEEECCCHHHHHHHHHHCCCCCCCCCEEEEEECCCEEEEEECCCCEEECCCHHHHHHH
AVNLVMSRLAGRTTTQRVELGTRLVERASTK
HHHHHHHHHHCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11157930 [H]