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The map label for this gene is adh [H]

Identifier: 116491894

GI number: 116491894

Start: 84234

End: 85277

Strand: Direct

Name: adh [H]

Synonym: PEPE_0076

Alternate gene names: 116491894

Gene position: 84234-85277 (Clockwise)

Preceding gene: 116491893

Following gene: 116491895

Centisome position: 4.6

GC content: 42.82

Gene sequence:

>1044_bases
ATGAAAGCAGCAGTATTTATTGAACCAGGTAAAGTTGAAGTTAAAGAAGTACCTAAACCCCAAATTGATGGTGATAACCA
GGCAATCATCCGGATTGTACGGGCTAGTGTTTGTGGTTCAGATTTATGGTGGTATCGTGGAATTTCTGAACGTCAGACAG
ATACTTTTATCGGACATGAAGCCATTGGAGTTGTGGAAGAAACTAGTGCAGACGTTGATAACATTCAAGTTGGCGACTTC
GTGGTCGTGCCGTTTACGCATGGATGTGGTCATTGTGTAGCTTGTTTGAATGGTTTTGAAGGAGATTGTTTGAATCGTAA
ATCCGGCGATAACGGTGGCTACCAGGCTGAATACATGAAGTATGAACCAGCTAATTCAGGATTGGTTAAAATTCCGGGTA
AACCAGAAGATTATACCGATGCCCAATTAGCTTCATTCCAAACTCTTTCTGATGTTATGGCAACTGGCTATCATGCTGCC
CAAAATGCCGAAGTTAAGCCGGGTTCAACAGTTGCTGTCATCGGAGATGGAGCCGTTGGGTTATGTGGGGTGATCGGGGC
TAAGTTGCTTGGAGCAAGCAAGATTATCCTTTTAAGTCACCATGAAGACCGTGCTGAATTAGGTAAGGCCTTTGGTGCCA
CTGATATCGTAGATACACGCGGCGATGAAGCTATCCAAGATGTTTTGAAGTTAACGAAGGAAAATGCCGGAGCTGACGCA
ATTTTAGAATGTGTGGGTGCTACTAGTGCAATCGAACAAGCAGGTCAAATTGCTCGGCCAGGCGCCGTAATTGGAAGAGT
AGGGGTTCCTCAATCAGAACCTAAATCTAACCAATTATTCTGGAAAAATGTGGGTCTTCGTGGCGGGATTGCTTCAGTTA
CAAAACCTGATAAAGAAGTTCTTTTGCAAGCTGTTTTAGATGGTGAAATCAACCCTGGTCAAGTCTTTACAAAGAGTTTT
GATCTAGATCATATAGAAGATGCATACGAGGCAATGAGTAATCGTCAAGCTATCAAAGCATTGCTGGTAATTTCAGATAA
ATAA

Upstream 100 bases:

>100_bases
AAAGTCAGTTCTTTGATCACCGTGATCCAGAAGCCATTGTAAGTATTTTTGGTGAAAGCTTAAAAGCATTACGTAAATAA
TTTTAGGAGGAATTTAACAG

Downstream 100 bases:

>100_bases
AAGCATTTCTATAGCTTGCTTAACATTGTTAGCTCAAAAGGTGATTATACGAAGTTCAATAGAACGGTGGAAAGAGCTTC
TAGTTGGTAGCTCTCGTTTC

Product: threonine dehydrogenase related Zn-dependent dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MKAAVFIEPGKVEVKEVPKPQIDGDNQAIIRIVRASVCGSDLWWYRGISERQTDTFIGHEAIGVVEETSADVDNIQVGDF
VVVPFTHGCGHCVACLNGFEGDCLNRKSGDNGGYQAEYMKYEPANSGLVKIPGKPEDYTDAQLASFQTLSDVMATGYHAA
QNAEVKPGSTVAVIGDGAVGLCGVIGAKLLGASKIILLSHHEDRAELGKAFGATDIVDTRGDEAIQDVLKLTKENAGADA
ILECVGATSAIEQAGQIARPGAVIGRVGVPQSEPKSNQLFWKNVGLRGGIASVTKPDKEVLLQAVLDGEINPGQVFTKSF
DLDHIEDAYEAMSNRQAIKALLVISDK

Sequences:

>Translated_347_residues
MKAAVFIEPGKVEVKEVPKPQIDGDNQAIIRIVRASVCGSDLWWYRGISERQTDTFIGHEAIGVVEETSADVDNIQVGDF
VVVPFTHGCGHCVACLNGFEGDCLNRKSGDNGGYQAEYMKYEPANSGLVKIPGKPEDYTDAQLASFQTLSDVMATGYHAA
QNAEVKPGSTVAVIGDGAVGLCGVIGAKLLGASKIILLSHHEDRAELGKAFGATDIVDTRGDEAIQDVLKLTKENAGADA
ILECVGATSAIEQAGQIARPGAVIGRVGVPQSEPKSNQLFWKNVGLRGGIASVTKPDKEVLLQAVLDGEINPGQVFTKSF
DLDHIEDAYEAMSNRQAIKALLVISDK
>Mature_347_residues
MKAAVFIEPGKVEVKEVPKPQIDGDNQAIIRIVRASVCGSDLWWYRGISERQTDTFIGHEAIGVVEETSADVDNIQVGDF
VVVPFTHGCGHCVACLNGFEGDCLNRKSGDNGGYQAEYMKYEPANSGLVKIPGKPEDYTDAQLASFQTLSDVMATGYHAA
QNAEVKPGSTVAVIGDGAVGLCGVIGAKLLGASKIILLSHHEDRAELGKAFGATDIVDTRGDEAIQDVLKLTKENAGADA
ILECVGATSAIEQAGQIARPGAVIGRVGVPQSEPKSNQLFWKNVGLRGGIASVTKPDKEVLLQAVLDGEINPGQVFTKSF
DLDHIEDAYEAMSNRQAIKALLVISDK

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156523966, Length=373, Percent_Identity=25.7372654155496, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI71565154, Length=373, Percent_Identity=27.3458445040214, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI4501939, Length=363, Percent_Identity=25.8953168044077, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI71565152, Length=383, Percent_Identity=28.4595300261097, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI71743840, Length=374, Percent_Identity=27.2727272727273, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI262073058, Length=374, Percent_Identity=27.2727272727273, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI4501933, Length=265, Percent_Identity=31.6981132075472, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI4501929, Length=372, Percent_Identity=27.1505376344086, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI1786825, Length=272, Percent_Identity=35.6617647058824, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1788073, Length=359, Percent_Identity=24.7910863509749, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI1788075, Length=353, Percent_Identity=27.4787535410765, Blast_Score=98, Evalue=7e-22,
Organism=Escherichia coli, GI1790045, Length=341, Percent_Identity=26.099706744868, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1790718, Length=332, Percent_Identity=25.9036144578313, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1786552, Length=378, Percent_Identity=28.042328042328, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1788407, Length=273, Percent_Identity=28.9377289377289, Blast_Score=85, Evalue=6e-18,
Organism=Escherichia coli, GI87082125, Length=365, Percent_Identity=26.3013698630137, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1787863, Length=358, Percent_Identity=25.1396648044693, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI226510992, Length=339, Percent_Identity=23.598820058997, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI87081918, Length=333, Percent_Identity=27.9279279279279, Blast_Score=68, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI25146526, Length=367, Percent_Identity=26.9754768392371, Blast_Score=92, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17562876, Length=349, Percent_Identity=23.2091690544413, Blast_Score=91, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI71997431, Length=367, Percent_Identity=26.9754768392371, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17565904, Length=348, Percent_Identity=27.0114942528736, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17562878, Length=350, Percent_Identity=22.5714285714286, Blast_Score=76, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6323099, Length=290, Percent_Identity=27.2413793103448, Blast_Score=90, Evalue=7e-19,
Organism=Saccharomyces cerevisiae, GI6319258, Length=288, Percent_Identity=25.6944444444444, Blast_Score=87, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6320033, Length=378, Percent_Identity=25.9259259259259, Blast_Score=85, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6319955, Length=350, Percent_Identity=25.1428571428571, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6322619, Length=350, Percent_Identity=25.1428571428571, Blast_Score=74, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6323961, Length=285, Percent_Identity=27.0175438596491, Blast_Score=71, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6323729, Length=309, Percent_Identity=24.9190938511327, Blast_Score=69, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6319621, Length=285, Percent_Identity=26.6666666666667, Blast_Score=69, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6319257, Length=290, Percent_Identity=25.5172413793103, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324486, Length=285, Percent_Identity=26.3157894736842, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17737895, Length=373, Percent_Identity=29.2225201072386, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI17737897, Length=328, Percent_Identity=24.0853658536585, Blast_Score=92, Evalue=7e-19,
Organism=Drosophila melanogaster, GI17137530, Length=329, Percent_Identity=26.7477203647416, Blast_Score=91, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 36820; Mature: 36820

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAAVFIEPGKVEVKEVPKPQIDGDNQAIIRIVRASVCGSDLWWYRGISERQTDTFIGHE
CCEEEEECCCCEEHCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHCCCCCCCCHHHHCHH
AIGVVEETSADVDNIQVGDFVVVPFTHGCGHCVACLNGFEGDCLNRKSGDNGGYQAEYMK
HHCEEECCCCCCCCEEECCEEEEECCCCHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEE
YEPANSGLVKIPGKPEDYTDAQLASFQTLSDVMATGYHAAQNAEVKPGSTVAVIGDGAVG
ECCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHCCHHCCCCCCCCCCEEEEEECCCHH
LCGVIGAKLLGASKIILLSHHEDRAELGKAFGATDIVDTRGDEAIQDVLKLTKENAGADA
HHHHHHHHHHCCCEEEEEECCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCHHH
ILECVGATSAIEQAGQIARPGAVIGRVGVPQSEPKSNQLFWKNVGLRGGIASVTKPDKEV
HHHHHCCHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCEEEECCCCCCCCCCCCCCHHHH
LLQAVLDGEINPGQVFTKSFDLDHIEDAYEAMSNRQAIKALLVISDK
HHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHEEEEEEEECC
>Mature Secondary Structure
MKAAVFIEPGKVEVKEVPKPQIDGDNQAIIRIVRASVCGSDLWWYRGISERQTDTFIGHE
CCEEEEECCCCEEHCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHCCCCCCCCHHHHCHH
AIGVVEETSADVDNIQVGDFVVVPFTHGCGHCVACLNGFEGDCLNRKSGDNGGYQAEYMK
HHCEEECCCCCCCCEEECCEEEEECCCCHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEE
YEPANSGLVKIPGKPEDYTDAQLASFQTLSDVMATGYHAAQNAEVKPGSTVAVIGDGAVG
ECCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHCCHHCCCCCCCCCCEEEEEECCCHH
LCGVIGAKLLGASKIILLSHHEDRAELGKAFGATDIVDTRGDEAIQDVLKLTKENAGADA
HHHHHHHHHHCCCEEEEEECCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCHHH
ILECVGATSAIEQAGQIARPGAVIGRVGVPQSEPKSNQLFWKNVGLRGGIASVTKPDKEV
HHHHHCCHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCEEEECCCCCCCCCCCCCCHHHH
LLQAVLDGEINPGQVFTKSFDLDHIEDAYEAMSNRQAIKALLVISDK
HHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2846513 [H]