| Definition | Pediococcus pentosaceus ATCC 25745, complete genome. |
|---|---|
| Accession | NC_008525 |
| Length | 1,832,387 |
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The map label for this gene is dkgA [H]
Identifier: 116491893
GI number: 116491893
Start: 83353
End: 84213
Strand: Direct
Name: dkgA [H]
Synonym: PEPE_0075
Alternate gene names: 116491893
Gene position: 83353-84213 (Clockwise)
Preceding gene: 116491891
Following gene: 116491894
Centisome position: 4.55
GC content: 40.19
Gene sequence:
>861_bases ATGGAATATGTAAAGTTAAATGATGGCAACCAAATGCCTCAACTTGGATTTGGTGTTTTCCAAGTTTCCGATTTGAGCCA AGCCGAACAAGCCGTGAGTGATGCACTTGATACAGGTTATCGTCTAATTGATACGGCTGCTGCTTATGACAACGAAGAGG CGGTGGGTGCCGCGATCAAGAAGAGCGGTATTAATCGCAGTGAGATTTTTGTGACTTCTAAGCTTTGGGTGGATCACTTC ACCTATGAAAAAGCGCAACAAGGAATTGAAGATTCACTAAATAAATTAGGATTGGACTATATTGATTTATACTTGCTTCA CCAACCTTATGGTGACACAGCAGGTGCATGGCGAGCTTTGATTGAAGCTCAAAAGGCGGGTAAAATTAAGTCAATCGGTG TATCTAATTTTGCTCCAGATCAATTGATGAATCTGGAATTAATGTCAGATGTTAAGCCAGCACTTAATCAAATCGAAGTT TCACCTTGGTACCAAGAAGGCGAAGCGGTTGGTTTTGCTCAAAGTCAAGATGTTCAAGTTGAAGCATGGGCTCCCTTTGC GGAAGGTAAGCATAATATTTTCTCAAATGAGACGATTGCTGAAATTGGTCAGAAATATGGAAAAGCGAACGGACAAGTTA TCCTACGTTGGCTCCTCCAACGCGGAATTGTGGTAATCCCCAAGTCAGTTCATAAGACGCGCATGGCTGAAAACTTAGAT GTTTTTGATTTTGAATTGAGTGATGATGATATGCAAAAGATGAGTAGTTTAGATAAAAACGAAAGTCAGTTCTTTGATCA CCGTGATCCAGAAGCCATTGTAAGTATTTTTGGTGAAAGCTTAAAAGCATTACGTAAATAA
Upstream 100 bases:
>100_bases TGATTGGTAATTTTTATATGGTAATTAACCCCCTATACTAGAAAGTACTTAAAGATAGTGTAAATAAATAGGATATATAA ATTTAAAGGGGTACAAAGTT
Downstream 100 bases:
>100_bases TTTTAGGAGGAATTTAACAGATGAAAGCAGCAGTATTTATTGAACCAGGTAAAGTTGAAGTTAAAGAAGTACCTAAACCC CAAATTGATGGTGATAACCA
Product: aldo/keto reductase
Products: NA
Alternate protein names: 2,5-DKG reductase A; 2,5-DKGR A; 25DKGR-A; AKR5C [H]
Number of amino acids: Translated: 286; Mature: 286
Protein sequence:
>286_residues MEYVKLNDGNQMPQLGFGVFQVSDLSQAEQAVSDALDTGYRLIDTAAAYDNEEAVGAAIKKSGINRSEIFVTSKLWVDHF TYEKAQQGIEDSLNKLGLDYIDLYLLHQPYGDTAGAWRALIEAQKAGKIKSIGVSNFAPDQLMNLELMSDVKPALNQIEV SPWYQEGEAVGFAQSQDVQVEAWAPFAEGKHNIFSNETIAEIGQKYGKANGQVILRWLLQRGIVVIPKSVHKTRMAENLD VFDFELSDDDMQKMSSLDKNESQFFDHRDPEAIVSIFGESLKALRK
Sequences:
>Translated_286_residues MEYVKLNDGNQMPQLGFGVFQVSDLSQAEQAVSDALDTGYRLIDTAAAYDNEEAVGAAIKKSGINRSEIFVTSKLWVDHF TYEKAQQGIEDSLNKLGLDYIDLYLLHQPYGDTAGAWRALIEAQKAGKIKSIGVSNFAPDQLMNLELMSDVKPALNQIEV SPWYQEGEAVGFAQSQDVQVEAWAPFAEGKHNIFSNETIAEIGQKYGKANGQVILRWLLQRGIVVIPKSVHKTRMAENLD VFDFELSDDDMQKMSSLDKNESQFFDHRDPEAIVSIFGESLKALRK >Mature_286_residues MEYVKLNDGNQMPQLGFGVFQVSDLSQAEQAVSDALDTGYRLIDTAAAYDNEEAVGAAIKKSGINRSEIFVTSKLWVDHF TYEKAQQGIEDSLNKLGLDYIDLYLLHQPYGDTAGAWRALIEAQKAGKIKSIGVSNFAPDQLMNLELMSDVKPALNQIEV SPWYQEGEAVGFAQSQDVQVEAWAPFAEGKHNIFSNETIAEIGQKYGKANGQVILRWLLQRGIVVIPKSVHKTRMAENLD VFDFELSDDDMQKMSSLDKNESQFFDHRDPEAIVSIFGESLKALRK
Specific function: Catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG) [H]
COG id: COG0656
COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase
Gene ontology:
Cell location: Cytoplasm [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the aldo/keto reductase family [H]
Homologues:
Organism=Homo sapiens, GI24497577, Length=291, Percent_Identity=31.6151202749141, Blast_Score=176, Evalue=2e-44, Organism=Homo sapiens, GI5174391, Length=291, Percent_Identity=31.6151202749141, Blast_Score=176, Evalue=2e-44, Organism=Homo sapiens, GI24497585, Length=298, Percent_Identity=33.2214765100671, Blast_Score=176, Evalue=3e-44, Organism=Homo sapiens, GI5453543, Length=302, Percent_Identity=33.112582781457, Blast_Score=173, Evalue=1e-43, Organism=Homo sapiens, GI24497583, Length=304, Percent_Identity=32.5657894736842, Blast_Score=173, Evalue=2e-43, Organism=Homo sapiens, GI310109920, Length=300, Percent_Identity=33, Blast_Score=172, Evalue=3e-43, Organism=Homo sapiens, GI310109922, Length=279, Percent_Identity=34.7670250896057, Blast_Score=172, Evalue=3e-43, Organism=Homo sapiens, GI45446745, Length=300, Percent_Identity=33, Blast_Score=171, Evalue=5e-43, Organism=Homo sapiens, GI4503285, Length=300, Percent_Identity=33, Blast_Score=171, Evalue=5e-43, Organism=Homo sapiens, GI5174695, Length=299, Percent_Identity=31.7725752508361, Blast_Score=171, Evalue=6e-43, Organism=Homo sapiens, GI223468663, Length=293, Percent_Identity=32.7645051194539, Blast_Score=170, Evalue=1e-42, Organism=Homo sapiens, GI93277124, Length=298, Percent_Identity=31.5436241610738, Blast_Score=158, Evalue=6e-39, Organism=Homo sapiens, GI300116273, Length=280, Percent_Identity=31.4285714285714, Blast_Score=151, Evalue=6e-37, Organism=Homo sapiens, GI4502049, Length=293, Percent_Identity=34.8122866894198, Blast_Score=150, Evalue=1e-36, Organism=Homo sapiens, GI291291012, Length=280, Percent_Identity=30.7142857142857, Blast_Score=149, Evalue=4e-36, Organism=Homo sapiens, GI300116271, Length=273, Percent_Identity=30.03663003663, Blast_Score=142, Evalue=4e-34, Organism=Homo sapiens, GI310109926, Length=114, Percent_Identity=44.7368421052632, Blast_Score=97, Evalue=2e-20, Organism=Homo sapiens, GI207028673, Length=114, Percent_Identity=44.7368421052632, Blast_Score=97, Evalue=2e-20, Organism=Homo sapiens, GI310109924, Length=153, Percent_Identity=29.4117647058824, Blast_Score=85, Evalue=8e-17, Organism=Escherichia coli, GI87082198, Length=261, Percent_Identity=45.5938697318008, Blast_Score=238, Evalue=3e-64, Organism=Escherichia coli, GI1786400, Length=255, Percent_Identity=35.2941176470588, Blast_Score=160, Evalue=9e-41, Organism=Escherichia coli, GI1788081, Length=266, Percent_Identity=30.4511278195489, Blast_Score=89, Evalue=4e-19, Organism=Escherichia coli, GI1787674, Length=279, Percent_Identity=25.089605734767, Blast_Score=71, Evalue=6e-14, Organism=Caenorhabditis elegans, GI17537077, Length=294, Percent_Identity=34.3537414965986, Blast_Score=178, Evalue=3e-45, Organism=Caenorhabditis elegans, GI17564128, Length=300, Percent_Identity=35.3333333333333, Blast_Score=178, Evalue=3e-45, Organism=Caenorhabditis elegans, GI17537075, Length=293, Percent_Identity=33.4470989761092, Blast_Score=171, Evalue=3e-43, Organism=Caenorhabditis elegans, GI17561298, Length=274, Percent_Identity=32.4817518248175, Blast_Score=166, Evalue=1e-41, Organism=Caenorhabditis elegans, GI17550248, Length=295, Percent_Identity=33.2203389830508, Blast_Score=164, Evalue=4e-41, Organism=Caenorhabditis elegans, GI71998625, Length=271, Percent_Identity=30.6273062730627, Blast_Score=156, Evalue=1e-38, Organism=Caenorhabditis elegans, GI17561300, Length=272, Percent_Identity=31.6176470588235, Blast_Score=150, Evalue=9e-37, Organism=Caenorhabditis elegans, GI17537079, Length=294, Percent_Identity=29.2517006802721, Blast_Score=144, Evalue=4e-35, Organism=Caenorhabditis elegans, GI17552492, Length=284, Percent_Identity=29.2253521126761, Blast_Score=143, Evalue=1e-34, Organism=Caenorhabditis elegans, GI17562292, Length=278, Percent_Identity=27.6978417266187, Blast_Score=142, Evalue=2e-34, Organism=Caenorhabditis elegans, GI17538386, Length=276, Percent_Identity=31.1594202898551, Blast_Score=140, Evalue=9e-34, Organism=Caenorhabditis elegans, GI17566692, Length=292, Percent_Identity=27.0547945205479, Blast_Score=132, Evalue=3e-31, Organism=Saccharomyces cerevisiae, GI6324694, Length=291, Percent_Identity=36.426116838488, Blast_Score=179, Evalue=3e-46, Organism=Saccharomyces cerevisiae, GI6320576, Length=287, Percent_Identity=36.2369337979094, Blast_Score=175, Evalue=6e-45, Organism=Saccharomyces cerevisiae, GI6322556, Length=281, Percent_Identity=35.5871886120996, Blast_Score=168, Evalue=8e-43, Organism=Saccharomyces cerevisiae, GI6321896, Length=306, Percent_Identity=33.3333333333333, Blast_Score=156, Evalue=3e-39, Organism=Saccharomyces cerevisiae, GI6320079, Length=282, Percent_Identity=31.2056737588652, Blast_Score=134, Evalue=2e-32, Organism=Saccharomyces cerevisiae, GI6319625, Length=303, Percent_Identity=27.0627062706271, Blast_Score=125, Evalue=6e-30, Organism=Drosophila melanogaster, GI24663317, Length=281, Percent_Identity=36.6548042704626, Blast_Score=186, Evalue=2e-47, Organism=Drosophila melanogaster, GI24644950, Length=300, Percent_Identity=34.3333333333333, Blast_Score=181, Evalue=7e-46, Organism=Drosophila melanogaster, GI21356425, Length=293, Percent_Identity=33.4470989761092, Blast_Score=174, Evalue=7e-44, Organism=Drosophila melanogaster, GI221378297, Length=320, Percent_Identity=32.1875, Blast_Score=173, Evalue=1e-43, Organism=Drosophila melanogaster, GI20129731, Length=278, Percent_Identity=34.5323741007194, Blast_Score=171, Evalue=5e-43, Organism=Drosophila melanogaster, GI24657054, Length=293, Percent_Identity=33.7883959044369, Blast_Score=171, Evalue=5e-43, Organism=Drosophila melanogaster, GI45553081, Length=286, Percent_Identity=31.8181818181818, Blast_Score=167, Evalue=1e-41, Organism=Drosophila melanogaster, GI24662789, Length=291, Percent_Identity=33.6769759450172, Blast_Score=166, Evalue=1e-41, Organism=Drosophila melanogaster, GI24662785, Length=286, Percent_Identity=34.6153846153846, Blast_Score=145, Evalue=4e-35, Organism=Drosophila melanogaster, GI24662781, Length=290, Percent_Identity=34.1379310344828, Blast_Score=142, Evalue=2e-34, Organism=Drosophila melanogaster, GI281366140, Length=251, Percent_Identity=29.8804780876494, Blast_Score=137, Evalue=7e-33,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR001395 - InterPro: IPR018170 - InterPro: IPR020471 - InterPro: IPR023210 [H]
Pfam domain/function: PF00248 Aldo_ket_red [H]
EC number: =1.1.1.274 [H]
Molecular weight: Translated: 31945; Mature: 31945
Theoretical pI: Translated: 4.47; Mature: 4.47
Prosite motif: PS00798 ALDOKETO_REDUCTASE_1 ; PS00062 ALDOKETO_REDUCTASE_2 ; PS00063 ALDOKETO_REDUCTASE_3
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.0 %Cys (Translated Protein) 2.4 %Met (Translated Protein) 2.4 %Cys+Met (Translated Protein) 0.0 %Cys (Mature Protein) 2.4 %Met (Mature Protein) 2.4 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MEYVKLNDGNQMPQLGFGVFQVSDLSQAEQAVSDALDTGYRLIDTAAAYDNEEAVGAAIK CCEEEECCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHH KSGINRSEIFVTSKLWVDHFTYEKAQQGIEDSLNKLGLDYIDLYLLHQPYGDTAGAWRAL HCCCCHHHEEEEHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHEECCCCCCHHHHHHH IEAQKAGKIKSIGVSNFAPDQLMNLELMSDVKPALNQIEVSPWYQEGEAVGFAQSQDVQV HHHHHCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHEECCCCHHCCCEECCCCCCCEEE EAWAPFAEGKHNIFSNETIAEIGQKYGKANGQVILRWLLQRGIVVIPKSVHKTRMAENLD EEECCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCEEEECCHHHHHHHHCCCC VFDFELSDDDMQKMSSLDKNESQFFDHRDPEAIVSIFGESLKALRK EEEEECCCHHHHHHHHCCCCHHHHCCCCCHHHHHHHHHHHHHHHCC >Mature Secondary Structure MEYVKLNDGNQMPQLGFGVFQVSDLSQAEQAVSDALDTGYRLIDTAAAYDNEEAVGAAIK CCEEEECCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHH KSGINRSEIFVTSKLWVDHFTYEKAQQGIEDSLNKLGLDYIDLYLLHQPYGDTAGAWRAL HCCCCHHHEEEEHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHEECCCCCCHHHHHHH IEAQKAGKIKSIGVSNFAPDQLMNLELMSDVKPALNQIEVSPWYQEGEAVGFAQSQDVQV HHHHHCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHEECCCCHHCCCEECCCCCCCEEE EAWAPFAEGKHNIFSNETIAEIGQKYGKANGQVILRWLLQRGIVVIPKSVHKTRMAENLD EEECCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCEEEECCHHHHHHHHCCCC VFDFELSDDDMQKMSSLDKNESQFFDHRDPEAIVSIFGESLKALRK EEEEECCCHHHHHHHHCCCCHHHHCCCCCHHHHHHHHHHHHHHHCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 11206551; 11258796 [H]