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The map label for this gene is sdh [H]

Identifier: 116329453

GI number: 116329453

Start: 3473798

End: 3474550

Strand: Direct

Name: sdh [H]

Synonym: LBL_2922

Alternate gene names: 116329453

Gene position: 3473798-3474550 (Clockwise)

Preceding gene: 116329452

Following gene: 116329454

Centisome position: 96.11

GC content: 40.5

Gene sequence:

>753_bases
ATGAAAACGAATTCGGAACCAAACAACTTGTTGGCGATCGTCACAGGTTCTTCCAAAGGAATCGGAAAAGCGATTTCAGA
ATTTTTAATTTCCGAAGGTTACAGAGTAATCGGGATTTCCAGAACGAAGCCAAAATCCACTCTTTTGGAAAATTCGCCTT
TGTATCGCCACGTTGTACTTGATCTTTCTGATACGAAAGAGATCAGACTTCGATTGTCAAATATTCTCAAGGAAGAACCT
CCCTTGAAAATCTTAGTAAACAATGCCGGCCTTGGAAATTTTTCTCCTCATGAAGAAATCCCTTTCGAAGAATTGGAAAA
AATGCTCACCGTCAATTTTGTCTCTCCGATTCTAATCACTAAATTATTTTTAAGAGATCTAAAAAAAAATGGAGGTTGGA
TCATTCAAATTCACTCGATCGCGGCATTGAAAGAATCAGCTCGAGGAGCGGCTTACGCCGGGACCAAGGCCGGACTTAGG
CACTTCGGATTAAATTTATTCGAAGAAACTCGAAAATCGGGAGTCAAATTTATGAGCATCAATCCAGATATTTCGGATAC
CGAGTTTTATGACTTTTTGGATTTCGAAAAGGATTCCGATCCCGCTTCTTATTTGAACGTTTCCGAAATTTTGAGCGCCT
TCGGGCACGCTCTTTCAAGCCCGGAGAATCTGGGTTTTATCGAAATTACGATCCGCCCGAAATACCATCGAGTTTCGAAA
AAATCAATCCGAAACGTTTCTTCGGAAGAATGA

Upstream 100 bases:

>100_bases
TATTAGAAAAAGAAATGTTTACAGTCCTTGAAAAAGAATTGGAAACATTTGTCCCTCGAGAAAAAATCCACAGACTCGTC
GCCGACCAAACGGAATACAA

Downstream 100 bases:

>100_bases
AGACGATATGAAATTGTTCGAGGAGGAAAAACAAAATTGAACCTAGGTGAACTGAATATTGCTCTTGTACAATGTGATCT
TTCCTGGGAAAACCGGGAAA

Product: Short chain dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 250; Mature: 250

Protein sequence:

>250_residues
MKTNSEPNNLLAIVTGSSKGIGKAISEFLISEGYRVIGISRTKPKSTLLENSPLYRHVVLDLSDTKEIRLRLSNILKEEP
PLKILVNNAGLGNFSPHEEIPFEELEKMLTVNFVSPILITKLFLRDLKKNGGWIIQIHSIAALKESARGAAYAGTKAGLR
HFGLNLFEETRKSGVKFMSINPDISDTEFYDFLDFEKDSDPASYLNVSEILSAFGHALSSPENLGFIEITIRPKYHRVSK
KSIRNVSSEE

Sequences:

>Translated_250_residues
MKTNSEPNNLLAIVTGSSKGIGKAISEFLISEGYRVIGISRTKPKSTLLENSPLYRHVVLDLSDTKEIRLRLSNILKEEP
PLKILVNNAGLGNFSPHEEIPFEELEKMLTVNFVSPILITKLFLRDLKKNGGWIIQIHSIAALKESARGAAYAGTKAGLR
HFGLNLFEETRKSGVKFMSINPDISDTEFYDFLDFEKDSDPASYLNVSEILSAFGHALSSPENLGFIEITIRPKYHRVSK
KSIRNVSSEE
>Mature_250_residues
MKTNSEPNNLLAIVTGSSKGIGKAISEFLISEGYRVIGISRTKPKSTLLENSPLYRHVVLDLSDTKEIRLRLSNILKEEP
PLKILVNNAGLGNFSPHEEIPFEELEKMLTVNFVSPILITKLFLRDLKKNGGWIIQIHSIAALKESARGAAYAGTKAGLR
HFGLNLFEETRKSGVKFMSINPDISDTEFYDFLDFEKDSDPASYLNVSEILSAFGHALSSPENLGFIEITIRPKYHRVSK
KSIRNVSSEE

Specific function: Catalyzes the oxidation of the hydroxyl group of serine to form 2-aminomalonate semialdehyde which is spontaneously converted into 2-aminoacetaldehyde and CO(2). Also acts on D- serine, L-glycerate, D-glycerate and 2-methyl-DL-serine. Does not act on O-me

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI7705925, Length=180, Percent_Identity=26.1111111111111, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI31542939, Length=211, Percent_Identity=28.9099526066351, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI226371731, Length=182, Percent_Identity=30.7692307692308, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1787820, Length=199, Percent_Identity=30.6532663316583, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1787335, Length=190, Percent_Identity=29.4736842105263, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1786812, Length=188, Percent_Identity=25.531914893617, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1786701, Length=191, Percent_Identity=27.2251308900524, Blast_Score=64, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI115534694, Length=184, Percent_Identity=28.2608695652174, Blast_Score=72, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6322226, Length=184, Percent_Identity=30.4347826086957, Blast_Score=71, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6322227, Length=191, Percent_Identity=27.2251308900524, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24643142, Length=223, Percent_Identity=30.4932735426009, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI23397609, Length=226, Percent_Identity=27.8761061946903, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI116007236, Length=243, Percent_Identity=26.7489711934156, Blast_Score=71, Evalue=8e-13,
Organism=Drosophila melanogaster, GI28571387, Length=249, Percent_Identity=25.7028112449799, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24639444, Length=185, Percent_Identity=28.1081081081081, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI116007234, Length=244, Percent_Identity=27.0491803278689, Blast_Score=64, Evalue=9e-11,

Paralogues:

None

Copy number: 1300 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.276 [H]

Molecular weight: Translated: 27907; Mature: 27907

Theoretical pI: Translated: 8.76; Mature: 8.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTNSEPNNLLAIVTGSSKGIGKAISEFLISEGYRVIGISRTKPKSTLLENSPLYRHVVL
CCCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCEEEEEECCCCHHHHHCCCCCEEEEEE
DLSDTKEIRLRLSNILKEEPPLKILVNNAGLGNFSPHEEIPFEELEKMLTVNFVSPILIT
ECCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
KLFLRDLKKNGGWIIQIHSIAALKESARGAAYAGTKAGLRHFGLNLFEETRKSGVKFMSI
HHHHHHHHCCCCEEEEEHHHHHHHHHCCCCCCCCHHHHHHHHCCHHHHHHHHCCCEEEEE
NPDISDTEFYDFLDFEKDSDPASYLNVSEILSAFGHALSSPENLGFIEITIRPKYHRVSK
CCCCCCCHHHHHHCCCCCCCCHHHCCHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHH
KSIRNVSSEE
HHHHCCCCCC
>Mature Secondary Structure
MKTNSEPNNLLAIVTGSSKGIGKAISEFLISEGYRVIGISRTKPKSTLLENSPLYRHVVL
CCCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCEEEEEECCCCHHHHHCCCCCEEEEEE
DLSDTKEIRLRLSNILKEEPPLKILVNNAGLGNFSPHEEIPFEELEKMLTVNFVSPILIT
ECCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
KLFLRDLKKNGGWIIQIHSIAALKESARGAAYAGTKAGLRHFGLNLFEETRKSGVKFMSI
HHHHHHHHCCCCEEEEEHHHHHHHHHCCCCCCCCHHHHHHHHCCHHHHHHHHCCCEEEEE
NPDISDTEFYDFLDFEKDSDPASYLNVSEILSAFGHALSSPENLGFIEITIRPKYHRVSK
CCCCCCCHHHHHHCCCCCCCCHHHCCHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHH
KSIRNVSSEE
HHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194 [H]