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The map label for this gene is proC [H]

Identifier: 116328681

GI number: 116328681

Start: 2404535

End: 2405308

Strand: Reverse

Name: proC [H]

Synonym: LBL_2052

Alternate gene names: 116328681

Gene position: 2405308-2404535 (Counterclockwise)

Preceding gene: 116328682

Following gene: 116328680

Centisome position: 66.55

GC content: 45.74

Gene sequence:

>774_bases
ATGAAACAGACAATTGGAATCGCAGGTTGCGGAAACATGGGTGGAGCGATTTACATTTCTCTTAAGAAACGTTATCCGAC
ACAGATTTTTGGGTATGATCCCTACATGACCTCGAATCAAAAAATTGAACTGATATCTTCTTGGGACGAATTCGTTACCA
AGTCCGATTTGATCGTTGTCTGTGTAAAACCCGGAAAGGTATCCGAACTTTTAAAACAGATCACGGTTCCTAAAAAAATA
ATTTCCGTCGCGGCCGGGATCCATACGGAAGCGATTCGAAAGGATCTTCCTTCCGGCTCCAAGGTAGTGCGCGTAATGCC
CAATCTTCCCTTGCTGATTTCCGAAGGAGCGATGGGATACTTCGGAGATGAGGAGTTGTACGAAATCGTTTCCGAAATTT
TTCAAACTCTAGGTCATTCTGTACAGTTGAGTTCCGAGTCGTTGATAGACGCGGTTACGGGACTTTCCGGATCGGGACCT
GCGTATGTGTTTCAATTTATACAAGCCTTAGCCGAAGGAGGGGTATTTTCCGGTTTGGGGTATCAAGAAGCCTTAGATCT
CAGCATACAAACCGTGATCGGCTCCGCGGAACTTCTTAGAAAGGAAAGGCGGAACGATCCCACAACTCATCCTTCGGTGT
GGAAGAATAAAGTCACTTCCCCGGGAGGAACTACAATTGCGGGACTTGCGGAATTGGAAAGGAATGGATTCACTAATGCA
ATCTTAGAGGCGGTGAAAGCCGCTACAAAACGTTCTCGGGAATTAGGATCTTAA

Upstream 100 bases:

>100_bases
AAACTTTCCATGGGCATGTCGGGGGATTATAAAATTGCGATCGAAGAGGGAAGCGATTTCGTCAGAATCGGGAGCGCAAT
TTTTGGGGAAAGGAATTAAG

Downstream 100 bases:

>100_bases
ATTTATCGGAGCCTATTCAGAAGTAGATAATAGAAAGGTTTTCCAAAATTTTAATTTCCTTTTTGTGCATTGAAAATTTG
AGTTTAAACTTGTCCTAAAA

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 257; Mature: 257

Protein sequence:

>257_residues
MKQTIGIAGCGNMGGAIYISLKKRYPTQIFGYDPYMTSNQKIELISSWDEFVTKSDLIVVCVKPGKVSELLKQITVPKKI
ISVAAGIHTEAIRKDLPSGSKVVRVMPNLPLLISEGAMGYFGDEELYEIVSEIFQTLGHSVQLSSESLIDAVTGLSGSGP
AYVFQFIQALAEGGVFSGLGYQEALDLSIQTVIGSAELLRKERRNDPTTHPSVWKNKVTSPGGTTIAGLAELERNGFTNA
ILEAVKAATKRSRELGS

Sequences:

>Translated_257_residues
MKQTIGIAGCGNMGGAIYISLKKRYPTQIFGYDPYMTSNQKIELISSWDEFVTKSDLIVVCVKPGKVSELLKQITVPKKI
ISVAAGIHTEAIRKDLPSGSKVVRVMPNLPLLISEGAMGYFGDEELYEIVSEIFQTLGHSVQLSSESLIDAVTGLSGSGP
AYVFQFIQALAEGGVFSGLGYQEALDLSIQTVIGSAELLRKERRNDPTTHPSVWKNKVTSPGGTTIAGLAELERNGFTNA
ILEAVKAATKRSRELGS
>Mature_257_residues
MKQTIGIAGCGNMGGAIYISLKKRYPTQIFGYDPYMTSNQKIELISSWDEFVTKSDLIVVCVKPGKVSELLKQITVPKKI
ISVAAGIHTEAIRKDLPSGSKVVRVMPNLPLLISEGAMGYFGDEELYEIVSEIFQTLGHSVQLSSESLIDAVTGLSGSGP
AYVFQFIQALAEGGVFSGLGYQEALDLSIQTVIGSAELLRKERRNDPTTHPSVWKNKVTSPGGTTIAGLAELERNGFTNA
ILEAVKAATKRSRELGS

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI21361454, Length=227, Percent_Identity=37.8854625550661, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI24797097, Length=227, Percent_Identity=36.1233480176211, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI24797095, Length=227, Percent_Identity=36.1233480176211, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI198041662, Length=270, Percent_Identity=32.5925925925926, Blast_Score=127, Evalue=1e-29,
Organism=Escherichia coli, GI1786585, Length=273, Percent_Identity=32.967032967033, Blast_Score=139, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17569021, Length=270, Percent_Identity=35.5555555555556, Blast_Score=137, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI17540664, Length=216, Percent_Identity=35.6481481481481, Blast_Score=119, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6320861, Length=291, Percent_Identity=30.2405498281787, Blast_Score=107, Evalue=2e-24,
Organism=Drosophila melanogaster, GI21358587, Length=267, Percent_Identity=36.7041198501873, Blast_Score=133, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24648116, Length=284, Percent_Identity=32.7464788732394, Blast_Score=133, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24647700, Length=173, Percent_Identity=40.4624277456647, Blast_Score=117, Evalue=8e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 27684; Mature: 27684

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQTIGIAGCGNMGGAIYISLKKRYPTQIFGYDPYMTSNQKIELISSWDEFVTKSDLIVV
CCCCEEEECCCCCCCEEEEEEECCCCCEEECCCCCCCCCCCEEHHHHHHHHHCCCCEEEE
CVKPGKVSELLKQITVPKKIISVAAGIHTEAIRKDLPSGSKVVRVMPNLPLLISEGAMGY
EECCCHHHHHHHHHCCHHHHHHHHHCHHHHHHHHHCCCCCCEEEECCCCCEEEECCCCCC
FGDEELYEIVSEIFQTLGHSVQLSSESLIDAVTGLSGSGPAYVFQFIQALAEGGVFSGLG
CCCHHHHHHHHHHHHHHCCEEEECHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCC
YQEALDLSIQTVIGSAELLRKERRNDPTTHPSVWKNKVTSPGGTTIAGLAELERNGFTNA
HHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHCCCHHH
ILEAVKAATKRSRELGS
HHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKQTIGIAGCGNMGGAIYISLKKRYPTQIFGYDPYMTSNQKIELISSWDEFVTKSDLIVV
CCCCEEEECCCCCCCEEEEEEECCCCCEEECCCCCCCCCCCEEHHHHHHHHHCCCCEEEE
CVKPGKVSELLKQITVPKKIISVAAGIHTEAIRKDLPSGSKVVRVMPNLPLLISEGAMGY
EECCCHHHHHHHHHCCHHHHHHHHHCHHHHHHHHHCCCCCCEEEECCCCCEEEECCCCCC
FGDEELYEIVSEIFQTLGHSVQLSSESLIDAVTGLSGSGPAYVFQFIQALAEGGVFSGLG
CCCHHHHHHHHHHHHHHCCEEEECHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCC
YQEALDLSIQTVIGSAELLRKERRNDPTTHPSVWKNKVTSPGGTTIAGLAELERNGFTNA
HHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHCCCHHH
ILEAVKAATKRSRELGS
HHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11844777; 11932238 [H]