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The map label for this gene is pyrH [H]

Identifier: 116327675

GI number: 116327675

Start: 1064087

End: 1064827

Strand: Direct

Name: pyrH [H]

Synonym: LBL_0921

Alternate gene names: 116327675

Gene position: 1064087-1064827 (Clockwise)

Preceding gene: 116327674

Following gene: 116327676

Centisome position: 29.44

GC content: 46.29

Gene sequence:

>741_bases
TTGGGATCAAAGTATAAGAGAATTCTGATCAAACTTTCCGGGGAAGCACTTGCCGGAGAGGGAGAATTCGGGATCGATAC
CAATAAGGCTCATTCTCTCGCGGAGGAAATCAAGGAAGTTCATGATCTGGGAGTGGAAATCGCTCTTGTAGTCGGGGGTG
GTAATATCATCCGGGGCACCAATCTCGCCAAGGTGGGAATTGATCGAGCGACCGCGGATTATATGGGAATGCTCGCTACG
ATCCAGAACGCTCTCGCGCTTCAGGATGCTTGCGAAAAGAAAGGACTCTACACAAGAGTTCAATCGGCGATTGAAATTAA
TTCCATCGCCGAAAGTTACATTCGTCGTCGTGCCGTTAGACATCTTGAAAAAAGAAGAATCGTAATCTTTGCGGGAGGAA
CCGGAAACCCTTATTTTACGACTGATACGACCGCCAGTCTTCGAGCCGTAGAAGTGGGTTGCGACGTGATTCTCAAGGCT
ACGAAAGTGGACGGAGTTTATACCGCCGATCCTAAAAAAGACAACGGCGCCAAGCGTTATTCTCAAATTTCCTTTATGGA
GTCGATCAATCGTCGTTTGAAGGTGATGGATTCAACCGCACTCAGTTTGTGTATGGAAAACAACATGCCGATCATTGTCT
TCGATATCTTCAAACAAGGAAACCTTAAGGACTTAGTCACAGGAAAAAATATCGGGACCTTGATCTCTAACTCGGAGGAT
ATTCAAATCGATGGCAAGTGA

Upstream 100 bases:

>100_bases
CAAAACCATAGACGATTTGGTAAAGGAAGCGATCGCGAAATTCGGCGAGAACATCACGATCGCCCATTTTGTCCGCTTTC
AGGTGGGTGGACTCTAAATT

Downstream 100 bases:

>100_bases
AGAAATCATTTCGGGAATGAAGACTAAAATGGATAAAACCATCGACCTGGTAAAAAAGGATTTTGGAACTGTTCGTACCG
GACGCGCAAATCCCTCTCTT

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK [H]

Number of amino acids: Translated: 246; Mature: 245

Protein sequence:

>246_residues
MGSKYKRILIKLSGEALAGEGEFGIDTNKAHSLAEEIKEVHDLGVEIALVVGGGNIIRGTNLAKVGIDRATADYMGMLAT
IQNALALQDACEKKGLYTRVQSAIEINSIAESYIRRRAVRHLEKRRIVIFAGGTGNPYFTTDTTASLRAVEVGCDVILKA
TKVDGVYTADPKKDNGAKRYSQISFMESINRRLKVMDSTALSLCMENNMPIIVFDIFKQGNLKDLVTGKNIGTLISNSED
IQIDGK

Sequences:

>Translated_246_residues
MGSKYKRILIKLSGEALAGEGEFGIDTNKAHSLAEEIKEVHDLGVEIALVVGGGNIIRGTNLAKVGIDRATADYMGMLAT
IQNALALQDACEKKGLYTRVQSAIEINSIAESYIRRRAVRHLEKRRIVIFAGGTGNPYFTTDTTASLRAVEVGCDVILKA
TKVDGVYTADPKKDNGAKRYSQISFMESINRRLKVMDSTALSLCMENNMPIIVFDIFKQGNLKDLVTGKNIGTLISNSED
IQIDGK
>Mature_245_residues
GSKYKRILIKLSGEALAGEGEFGIDTNKAHSLAEEIKEVHDLGVEIALVVGGGNIIRGTNLAKVGIDRATADYMGMLATI
QNALALQDACEKKGLYTRVQSAIEINSIAESYIRRRAVRHLEKRRIVIFAGGTGNPYFTTDTTASLRAVEVGCDVILKAT
KVDGVYTADPKKDNGAKRYSQISFMESINRRLKVMDSTALSLCMENNMPIIVFDIFKQGNLKDLVTGKNIGTLISNSEDI
QIDGK

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP [H]

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family [H]

Homologues:

Organism=Escherichia coli, GI1786367, Length=232, Percent_Identity=49.1379310344828, Blast_Score=239, Evalue=1e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963 [H]

Pfam domain/function: PF00696 AA_kinase [H]

EC number: =2.7.4.22 [H]

Molecular weight: Translated: 26801; Mature: 26670

Theoretical pI: Translated: 8.76; Mature: 8.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSKYKRILIKLSGEALAGEGEFGIDTNKAHSLAEEIKEVHDLGVEIALVVGGGNIIRGT
CCCCEEEEEEEECCCEEECCCCCCCCCCHHHHHHHHHHHHHHCCEEEEEEEECCCEEECC
NLAKVGIDRATADYMGMLATIQNALALQDACEKKGLYTRVQSAIEINSIAESYIRRRAVR
CEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
HLEKRRIVIFAGGTGNPYFTTDTTASLRAVEVGCDVILKATKVDGVYTADPKKDNGAKRY
HHHHCEEEEEECCCCCCCEECCCCCCEEEEEECCEEEEEEEEECCEEECCCCCCCCHHHH
SQISFMESINRRLKVMDSTALSLCMENNMPIIVFDIFKQGNLKDLVTGKNIGTLISNSED
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHCCCCCHHEECCCCC
IQIDGK
EEECCC
>Mature Secondary Structure 
GSKYKRILIKLSGEALAGEGEFGIDTNKAHSLAEEIKEVHDLGVEIALVVGGGNIIRGT
CCCEEEEEEEECCCEEECCCCCCCCCCHHHHHHHHHHHHHHCCEEEEEEEECCCEEECC
NLAKVGIDRATADYMGMLATIQNALALQDACEKKGLYTRVQSAIEINSIAESYIRRRAVR
CEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
HLEKRRIVIFAGGTGNPYFTTDTTASLRAVEVGCDVILKATKVDGVYTADPKKDNGAKRY
HHHHCEEEEEECCCCCCCEECCCCCCEEEEEECCEEEEEEEEECCEEECCCCCCCCHHHH
SQISFMESINRRLKVMDSTALSLCMENNMPIIVFDIFKQGNLKDLVTGKNIGTLISNSED
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHCCCCCHHEECCCCC
IQIDGK
EEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA