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The map label for this gene is degP [H]

Identifier: 116327582

GI number: 116327582

Start: 939777

End: 940883

Strand: Direct

Name: degP [H]

Synonym: LBL_0813

Alternate gene names: 116327582

Gene position: 939777-940883 (Clockwise)

Preceding gene: 116327580

Following gene: 116327583

Centisome position: 26.0

GC content: 44.35

Gene sequence:

>1107_bases
ATGGAATTTATACGTTCACTCCCAAAGGTAGTCGTTTTCAACGGAATTCTTTTCGTTGTTCTAATGTTGGTTCTGATTTT
TCCGAAGGATTGTTCGTTGTCTTCACTTTTCTCCGATAGGAGGCCGATCAGCCCCGGAAAACAAAAATCCGCGATCGAAA
TTCAGAATTCGTTTCGAAACGTTTATCATTTCGCGAAGGATTCGGTGGTTTCCATACGAACGAAAAAAAGCGAATCGATA
ACCAGTCCGTATCATTACTTCGATTTTAAGAGCGAAAGACCGGCTTCTTTTGGGAGTGGATTTTTCGTTCACGAAAAAGG
TTATATCGTAACGAATTATCATGTGATTGAAGGTGCGGAAAGTATCGAAGTCATCACTTCCAACGGGGGTGTTCACGCCG
CAAAGTATGTCGGAAGTCATGAACGTGCCGATATTGCACTTTTGAAAATCAGAGAAGGATCGGGATTACACCCGGTCGTA
TTCGGAGATTCGGATCGGATCGAAGTCGGAGATTGGGCGATCGTAATTGGTTCGCCCTTCGGTTTGGAACGTTCGTTTAG
TGTGGGTGTAGTTTCCGCAAAATATAGGGAGGATTTGGACGAGACCGGACAAACCCACATTCAAATAGACAGCATGATTA
ATCCCGGAAGCAGCGGCGGACCGCTTTTAAACATTTATGGAGAGGTCATCGGAATCAATCGATTGATCCGAAGTGAAACG
GGAAAAAATTCAGGAATCGGATTTGCGATTCCAAGTAACTATGCGCTGAAAATCATCAGAATGATCGAGTCCAATCAGGG
TAGACATATTCGTTCTGCTATTCTCGGAGTGATGGCGACGACTCCGCTTCCGGATCACAGAATTGCGTTGGGGATTCCCG
ATTCTTGGATGGGAATACTTGTATATGATATGGATCCTGGTTCTTCGGCAGAACTCGGAGGAATCAAACGTTACGATTTT
ATTCTAGAGGCGAATGGAGTTCCGATCAAAAATATTAATGATCTGCGCGAACAGGTGGGAATAGTGGGACTTGGGGGCAA
ACTCAAGCTCCGTATCTATCGGGAAAAATCGACGCTGGAACTTCCGGTGAAGTTGATTCAAAAATAA

Upstream 100 bases:

>100_bases
AAAAGCAAAACAAAGAGTAATTAAGATTAAGGTGTGTTGGATTTTGATTTTCGATTTAGGCTTGTTCTTCGAACGAGTGG
AATTGAATTTAGGTTCTAAC

Downstream 100 bases:

>100_bases
CGAGTTGGAATTTTAAGGAAAAAAAGAGAGCGGTATGAGAAGAAACATCGTTCACAGCGGAGCGGACGCTCTGATCTATG
AAATCAGACAGATTGCAGCC

Product: trypsin-like serine protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 368; Mature: 368

Protein sequence:

>368_residues
MEFIRSLPKVVVFNGILFVVLMLVLIFPKDCSLSSLFSDRRPISPGKQKSAIEIQNSFRNVYHFAKDSVVSIRTKKSESI
TSPYHYFDFKSERPASFGSGFFVHEKGYIVTNYHVIEGAESIEVITSNGGVHAAKYVGSHERADIALLKIREGSGLHPVV
FGDSDRIEVGDWAIVIGSPFGLERSFSVGVVSAKYREDLDETGQTHIQIDSMINPGSSGGPLLNIYGEVIGINRLIRSET
GKNSGIGFAIPSNYALKIIRMIESNQGRHIRSAILGVMATTPLPDHRIALGIPDSWMGILVYDMDPGSSAELGGIKRYDF
ILEANGVPIKNINDLREQVGIVGLGGKLKLRIYREKSTLELPVKLIQK

Sequences:

>Translated_368_residues
MEFIRSLPKVVVFNGILFVVLMLVLIFPKDCSLSSLFSDRRPISPGKQKSAIEIQNSFRNVYHFAKDSVVSIRTKKSESI
TSPYHYFDFKSERPASFGSGFFVHEKGYIVTNYHVIEGAESIEVITSNGGVHAAKYVGSHERADIALLKIREGSGLHPVV
FGDSDRIEVGDWAIVIGSPFGLERSFSVGVVSAKYREDLDETGQTHIQIDSMINPGSSGGPLLNIYGEVIGINRLIRSET
GKNSGIGFAIPSNYALKIIRMIESNQGRHIRSAILGVMATTPLPDHRIALGIPDSWMGILVYDMDPGSSAELGGIKRYDF
ILEANGVPIKNINDLREQVGIVGLGGKLKLRIYREKSTLELPVKLIQK
>Mature_368_residues
MEFIRSLPKVVVFNGILFVVLMLVLIFPKDCSLSSLFSDRRPISPGKQKSAIEIQNSFRNVYHFAKDSVVSIRTKKSESI
TSPYHYFDFKSERPASFGSGFFVHEKGYIVTNYHVIEGAESIEVITSNGGVHAAKYVGSHERADIALLKIREGSGLHPVV
FGDSDRIEVGDWAIVIGSPFGLERSFSVGVVSAKYREDLDETGQTHIQIDSMINPGSSGGPLLNIYGEVIGINRLIRSET
GKNSGIGFAIPSNYALKIIRMIESNQGRHIRSAILGVMATTPLPDHRIALGIPDSWMGILVYDMDPGSSAELGGIKRYDF
ILEANGVPIKNINDLREQVGIVGLGGKLKLRIYREKSTLELPVKLIQK

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=307, Percent_Identity=34.2019543973941, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI22129776, Length=266, Percent_Identity=33.4586466165414, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI24308541, Length=288, Percent_Identity=31.5972222222222, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI7019477, Length=295, Percent_Identity=32.5423728813559, Blast_Score=113, Evalue=2e-25,
Organism=Escherichia coli, GI1786356, Length=275, Percent_Identity=40.3636363636364, Blast_Score=179, Evalue=3e-46,
Organism=Escherichia coli, GI1789629, Length=311, Percent_Identity=37.2990353697749, Blast_Score=176, Evalue=3e-45,
Organism=Escherichia coli, GI1789630, Length=371, Percent_Identity=31.8059299191375, Blast_Score=137, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24646839, Length=306, Percent_Identity=29.7385620915033, Blast_Score=108, Evalue=6e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 40506; Mature: 40506

Theoretical pI: Translated: 9.09; Mature: 9.09

Prosite motif: PS50106 PDZ ; PS00237 G_PROTEIN_RECEP_F1_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFIRSLPKVVVFNGILFVVLMLVLIFPKDCSLSSLFSDRRPISPGKQKSAIEIQNSFRN
CCHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHH
VYHFAKDSVVSIRTKKSESITSPYHYFDFKSERPASFGSGFFVHEKGYIVTNYHVIEGAE
HHHHHCCCEEEEEECCCCCCCCCEEEECCCCCCCCCCCCEEEEEECCEEEEEEEEECCCC
SIEVITSNGGVHAAKYVGSHERADIALLKIREGSGLHPVVFGDSDRIEVGDWAIVIGSPF
EEEEEECCCCEEEEHHCCCCCCCCEEEEEEECCCCCCEEEECCCCCEEECCEEEEEECCC
GLERSFSVGVVSAKYREDLDETGQTHIQIDSMINPGSSGGPLLNIYGEVIGINRLIRSET
CCCCCCEEEEEEHHHHHHHHHCCCEEEEEECEECCCCCCCCEEEEHHHHHHHHHHHHHCC
GKNSGIGFAIPSNYALKIIRMIESNQGRHIRSAILGVMATTPLPDHRIALGIPDSWMGIL
CCCCCEEEEECCHHHHHHEEEHHCCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCEEEE
VYDMDPGSSAELGGIKRYDFILEANGVPIKNINDLREQVGIVGLGGKLKLRIYREKSTLE
EEECCCCCCCCCCCEEEEEEEEECCCCCCCCHHHHHHHCCEEEECCEEEEEEEECCCCEE
LPVKLIQK
ECHHHHCC
>Mature Secondary Structure
MEFIRSLPKVVVFNGILFVVLMLVLIFPKDCSLSSLFSDRRPISPGKQKSAIEIQNSFRN
CCHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHH
VYHFAKDSVVSIRTKKSESITSPYHYFDFKSERPASFGSGFFVHEKGYIVTNYHVIEGAE
HHHHHCCCEEEEEECCCCCCCCCEEEECCCCCCCCCCCCEEEEEECCEEEEEEEEECCCC
SIEVITSNGGVHAAKYVGSHERADIALLKIREGSGLHPVVFGDSDRIEVGDWAIVIGSPF
EEEEEECCCCEEEEHHCCCCCCCCEEEEEEECCCCCCEEEECCCCCEEECCEEEEEECCC
GLERSFSVGVVSAKYREDLDETGQTHIQIDSMINPGSSGGPLLNIYGEVIGINRLIRSET
CCCCCCEEEEEEHHHHHHHHHCCCEEEEEECEECCCCCCCCEEEEHHHHHHHHHHHHHCC
GKNSGIGFAIPSNYALKIIRMIESNQGRHIRSAILGVMATTPLPDHRIALGIPDSWMGIL
CCCCCEEEEECCHHHHHHEEEHHCCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCEEEE
VYDMDPGSSAELGGIKRYDFILEANGVPIKNINDLREQVGIVGLGGKLKLRIYREKSTLE
EEECCCCCCCCCCCEEEEEEEEECCCCCCCCHHHHHHHCCEEEECCEEEEEEEECCCCEE
LPVKLIQK
ECHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10684935 [H]