Click here to switch to the map view.

The map label for this gene is pyrD [H]

Identifier: 116326969

GI number: 116326969

Start: 156482

End: 157636

Strand: Reverse

Name: pyrD [H]

Synonym: LBL_0135

Alternate gene names: 116326969

Gene position: 157636-156482 (Counterclockwise)

Preceding gene: 116326970

Following gene: 116326968

Centisome position: 4.36

GC content: 39.31

Gene sequence:

>1155_bases
TTGATCGACACGGATTCAATAGTTTTAGAGATGTTTTCCTCTACTTTGAAGCAAGCTGCATATTCCACTTTTTTGAAACC
GTTTTTCCTCTCTTTGGACCCGGAGACATCGCATGAACTTGCAAAAAACTTACTTAGCATCAGTGCAAAATTCCCTGGAA
TCTTAACTTTGGTGGAATCGATGACATCTTATCGAAGCGATCGTTTGAAAACGAGAGTTGCGGGAATCGAATTCGAAAAT
CCTTTAGGGATGGGCGCGGGCTTTGATAAAACGGGAGAACTTTATCCTTTTCTTTCTCGAATGGGTTTCGGCCATATCGA
AATAGGAACGATCACAGGAAAGTCGCAACCGGGAAATCTCAAACCTAGAGTGTTTCGTTACCCTGAAGATCAAGCTTTAA
TCAATCATATGGGTTTTAATAATCCAGGCGCCGATTCAGCGGAAAGAATCATTGCTCCCCAAAAAAAAAGAAAGATTCGC
GGGATCAACGCAGGTAAAACAAAAATCATTTCCGAAGAAAAAGCTGTCGAAGATTACATTTATACTCTCAAAAAACTTTC
ACCTTATGCGGACTATGCGGTTATCAATATAAGCTCTCCGAATACTCCGGGATTGAGGGATTTTCAAAAACAGAAAAATT
TCGTGTCTCTGATTCAAGGAATTAAAAACGGACTTGGAAAGAATTTTATAATTCCGCTATTCGTAAAATTCGCTCCCGAT
ATGGAGACAAAAGATCTTGAAGCTTTACTTGAATCCTCTTTGAGCTTAAAAATCGACGGCGTCGTTCTAACCAATACTAC
GATCGATAAATCTTCTTTGAAAGCATATCCGAACGTGGAAAAGGAAGGAGGACTTTCCGGAGTACCTTTGAAAAATCGTT
CCACTGAATTTGTTCGAGTCGCTTATCGAATTTTAAAACGAAGAATTCCGATTATCGGAGTCGGTGGAATCGATTCCGAA
AAAGCGGCCCTAGAAAAAATTCTTGCAGGGGCTGATTTAATTCAAATTTACACCGGTTATATTTATCAAGGACCTTTTTT
ACCTCTGAAGATTTTGGAGTTTTTGGATCGGTTCTTAAAAGAACAAGATCTAAAAACCGTGTCGGATTTGGTGGGCAAGG
AAAAGGAAATTCAATACGATCCGAAATGTTCGTAA

Upstream 100 bases:

>100_bases
TCGAAGGGGCGGGTTTCATTTCGGTGATTCCCGCCGTGATTACGTTATTTATATATGGAATCGTATTTCTTTTTGCAGGA
AATAAAATTTTTCGCTGGTC

Downstream 100 bases:

>100_bases
TCTTTTTTAGAAAAACGAATTTAGATCGCATAGGTTAAAAACAAAAAGTGTTTAATAAAAACAGGATATTTTAGAATATT
AATATAAAATATATATTAGG

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 384; Mature: 384

Protein sequence:

>384_residues
MIDTDSIVLEMFSSTLKQAAYSTFLKPFFLSLDPETSHELAKNLLSISAKFPGILTLVESMTSYRSDRLKTRVAGIEFEN
PLGMGAGFDKTGELYPFLSRMGFGHIEIGTITGKSQPGNLKPRVFRYPEDQALINHMGFNNPGADSAERIIAPQKKRKIR
GINAGKTKIISEEKAVEDYIYTLKKLSPYADYAVINISSPNTPGLRDFQKQKNFVSLIQGIKNGLGKNFIIPLFVKFAPD
METKDLEALLESSLSLKIDGVVLTNTTIDKSSLKAYPNVEKEGGLSGVPLKNRSTEFVRVAYRILKRRIPIIGVGGIDSE
KAALEKILAGADLIQIYTGYIYQGPFLPLKILEFLDRFLKEQDLKTVSDLVGKEKEIQYDPKCS

Sequences:

>Translated_384_residues
MIDTDSIVLEMFSSTLKQAAYSTFLKPFFLSLDPETSHELAKNLLSISAKFPGILTLVESMTSYRSDRLKTRVAGIEFEN
PLGMGAGFDKTGELYPFLSRMGFGHIEIGTITGKSQPGNLKPRVFRYPEDQALINHMGFNNPGADSAERIIAPQKKRKIR
GINAGKTKIISEEKAVEDYIYTLKKLSPYADYAVINISSPNTPGLRDFQKQKNFVSLIQGIKNGLGKNFIIPLFVKFAPD
METKDLEALLESSLSLKIDGVVLTNTTIDKSSLKAYPNVEKEGGLSGVPLKNRSTEFVRVAYRILKRRIPIIGVGGIDSE
KAALEKILAGADLIQIYTGYIYQGPFLPLKILEFLDRFLKEQDLKTVSDLVGKEKEIQYDPKCS
>Mature_384_residues
MIDTDSIVLEMFSSTLKQAAYSTFLKPFFLSLDPETSHELAKNLLSISAKFPGILTLVESMTSYRSDRLKTRVAGIEFEN
PLGMGAGFDKTGELYPFLSRMGFGHIEIGTITGKSQPGNLKPRVFRYPEDQALINHMGFNNPGADSAERIIAPQKKRKIR
GINAGKTKIISEEKAVEDYIYTLKKLSPYADYAVINISSPNTPGLRDFQKQKNFVSLIQGIKNGLGKNFIIPLFVKFAPD
METKDLEALLESSLSLKIDGVVLTNTTIDKSSLKAYPNVEKEGGLSGVPLKNRSTEFVRVAYRILKRRIPIIGVGGIDSE
KAALEKILAGADLIQIYTGYIYQGPFLPLKILEFLDRFLKEQDLKTVSDLVGKEKEIQYDPKCS

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI45006951, Length=366, Percent_Identity=39.8907103825137, Blast_Score=251, Evalue=6e-67,
Organism=Escherichia coli, GI1787177, Length=333, Percent_Identity=42.9429429429429, Blast_Score=255, Evalue=4e-69,
Organism=Caenorhabditis elegans, GI17509475, Length=356, Percent_Identity=36.5168539325843, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI281361352, Length=373, Percent_Identity=37.8016085790885, Blast_Score=231, Evalue=8e-61,
Organism=Drosophila melanogaster, GI17137316, Length=373, Percent_Identity=37.8016085790885, Blast_Score=231, Evalue=8e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.5.2 [H]

Molecular weight: Translated: 42704; Mature: 42704

Theoretical pI: Translated: 9.57; Mature: 9.57

Prosite motif: PS00911 DHODEHASE_1 ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDTDSIVLEMFSSTLKQAAYSTFLKPFFLSLDPETSHELAKNLLSISAKFPGILTLVES
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHCCCCHHHHHHHH
MTSYRSDRLKTRVAGIEFENPLGMGAGFDKTGELYPFLSRMGFGHIEIGTITGKSQPGNL
HHHHHHHHHHHHHCCCEECCCCCCCCCCCCCCCHHHHHHHCCCCCEEEEEEECCCCCCCC
KPRVFRYPEDQALINHMGFNNPGADSAERIIAPQKKRKIRGINAGKTKIISEEKAVEDYI
CCCEEECCCHHHHHHHCCCCCCCCCCHHHHCCCHHHHHHCCCCCCCHHHHHHHHHHHHHH
YTLKKLSPYADYAVINISSPNTPGLRDFQKQKNFVSLIQGIKNGLGKNFIIPLFVKFAPD
HHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHEECCCC
METKDLEALLESSLSLKIDGVVLTNTTIDKSSLKAYPNVEKEGGLSGVPLKNRSTEFVRV
CCHHHHHHHHHCCCCEEECCEEEECCCCCHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHH
AYRILKRRIPIIGVGGIDSEKAALEKILAGADLIQIYTGYIYQGPFLPLKILEFLDRFLK
HHHHHHHCCCEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
EQDLKTVSDLVGKEKEIQYDPKCS
HHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MIDTDSIVLEMFSSTLKQAAYSTFLKPFFLSLDPETSHELAKNLLSISAKFPGILTLVES
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHCCCCHHHHHHHH
MTSYRSDRLKTRVAGIEFENPLGMGAGFDKTGELYPFLSRMGFGHIEIGTITGKSQPGNL
HHHHHHHHHHHHHCCCEECCCCCCCCCCCCCCCHHHHHHHCCCCCEEEEEEECCCCCCCC
KPRVFRYPEDQALINHMGFNNPGADSAERIIAPQKKRKIRGINAGKTKIISEEKAVEDYI
CCCEEECCCHHHHHHHCCCCCCCCCCHHHHCCCHHHHHHCCCCCCCHHHHHHHHHHHHHH
YTLKKLSPYADYAVINISSPNTPGLRDFQKQKNFVSLIQGIKNGLGKNFIIPLFVKFAPD
HHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHEECCCC
METKDLEALLESSLSLKIDGVVLTNTTIDKSSLKAYPNVEKEGGLSGVPLKNRSTEFVRV
CCHHHHHHHHHCCCCEEECCEEEECCCCCHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHH
AYRILKRRIPIIGVGGIDSEKAALEKILAGADLIQIYTGYIYQGPFLPLKILEFLDRFLK
HHHHHHHCCCEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
EQDLKTVSDLVGKEKEIQYDPKCS
HHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]