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The map label for this gene is relA [H]

Identifier: 115351411

GI number: 115351411

Start: 1490457

End: 1492676

Strand: Direct

Name: relA [H]

Synonym: Bamb_1358

Alternate gene names: 115351411

Gene position: 1490457-1492676 (Clockwise)

Preceding gene: 115351410

Following gene: 115351412

Centisome position: 41.91

GC content: 67.75

Gene sequence:

>2220_bases
ATGACCGAGTCCGTTACCGCTTCTTCCGTCGCGGCGCCGTCGTTCGACGACGTGCTCGCGTTCGTGCGCGAGCGGGCCGG
CGACGCGCGCCTGTCGACGGGCGAACTGCTCGCCGATCACTCGGCGGGCACCGCATCGATCATGCGCACGTTGAACGTCG
ACCCGCACGCGATGCAGGCGGCCGCGCTGTTCGTGCTGACGCCGCATCTGAACGATCCCGAGCGGGAACTGACCGAACGG
TTCGGCGAAGAGGTCGCGCGGCTCGTGTCCGACGTGCGCAAGCTGCTGCGGCTCGGCACCGTCAGCCTGCGCGCCCAGAA
TGCGATGCCTGAAGCCGGGCGCGACGCGGCGGAAGAGCGGCGCACGCAGATCGAGGCGCTGCGCAAGATGCTGCTGGCGT
TCGCGCAGGACATCCGCGTGGTGCTGATCCGGCTGGCGTCGCGGTTGCAGTCGCTGCGGTATTACGCGGCGGCGAAGATC
GATCCGCCGCCCGACGTCGCGCGCGAGACACTCGAGATCTACGCGCCGCTCGCGAACCGTCTCGGCATCTGGCAACTGAA
GTGGGAACTCGAGGATCTCGCGTTCCGCTTCGAGGATCCGGTCACCTACAAGCGCATCGCCAAGCTGCTCGACGAGAAGC
GCATCGAGCGCGAGGCGTACGTCGCGCAGGCGATCGAGCGGCTCCAGCACGAACTGGCGGAAGCGCACATCCCGGCCGAC
GTGAGCGGGCGGCCGAAACATATCTACAGCATCTGGCGCAAGATGCGCGGCAAGGAGCTCGACTTCGCCGAGCTGTACGA
CGTGCGGGCGTTTCGCGTGATCGTGCCGGACATCAAGGATTGCTACGCGGTGCTCGGCATCGTGCATCACCTGTGGCAGC
CGGTGCCGAAGGAATTCGACGACTACATCTCGCGCCCGAAGCCGAACGGCTACAAGTCGCTGCATACGGTCGTGATCGGC
GACGACGGCCGCGCGTTCGAGGTGCAGATCCGCACGCAGGAAATGCACCGCTTCGCGGAGTACGGGATCGCCGCGCACTG
GCGCTACAAGGAAGCCGGCGCACGCGGCTATGGCGGCCAGTTCTCGGCGAGCGACAAGTACGACGAGAAGATCGCGTGGC
TGCGCCAGCTGCTCGCATGGAAGGACGACGTCGAAGTGTCGGGCGACCAGGCGTGGGCCCAGCTGCGCGAGACGTCGCTC
GACGACGACCACATCTACGTGCTGACGCCGCAGGCGCGCGTGATCGCGCTGCCGCAGGGGGCGACGCCGGTCGATTTCGC
GTACCACCTGCACAGCGAGCTCGGCCATCGCTGCCGCGGCGCGCGCGTCGACGGCGTGATGGTGCCGCTGAACACGTCGC
TCGCGAACGGCCAGACGGTCGAGATCGTCGCGGTGAAGGAGGGCGGCCCGTCGCGCGACTGGCTGAACCTGCAGCTCGGC
TACCTGAAGAGTTCGCGTGCGCGACAGAAGGTGCGCGCGTGGTTCAACTCGATCGAGCAGGAAGAGAACATCGCGCATGG
CCGCGCGCTCGTCGAAAAGACGCTGCAGCGCGAGGGCAAGACGTCGGTCAATCTCGACAACCTCGCCGCGAAGCTCGGCT
TCAAGTCGCCCGACGAACTGTTCTCGGTCGTGGGCAAGGAAGAATTCAGCCTGCGCCACGTCGAGCAGGCGCTGTCCGAT
GCGCCGCCGCCCGAGCATGCGCCCGAGGCGCCCGCCGATTTCGAGAAGCGCAGCAGCGGGGCGAGTGTCGCGCACGGCGC
GTCGACCGGCGTGCTGGTGGTCGGCGTCGATGCGCTGTTGACCCAGCTTGCGCGCTGCTGCCGTCCGGCGCCGCCCGACC
CGATCAGCGGTTTCGTCACGCGCGGCAAGGGAATGTCGATTCACCGCAGCGACTGCCCCACCTTCCGGCGGATGGCCGAA
CGGGCGCCGGAGCGCGTGCTGCAGACGACCTGGTCGGCCGATGTGCTGGGCGGACGCGGCGCGTCCGTCTATCCGGTCGA
CCTGATGATCGAGGCAAGCGACCGGCAAGGCTTGCTGCGTGACATCTCCGAAGTGTTCGCGCGCGAAAAAATGAACGTGG
TGGGCGTGAAGACGCAGAGCCGCCGCAATGCGGCGTTCATGCAGTTCACGGTCGAGGTGTCGAATTCCGCGCAGGTGCAG
CGTGCGTGCACGCTGCTTGGCGAAGTGGCGGGCGTCGTGCGGGCGGGGCGCAAGACGTGA

Upstream 100 bases:

>100_bases
GAAGCTCGCGGATCCAGCGCTGCTGGTCGAGATCGTCGTCGTCGCCGCGCAGCGGAGCTGAGCGAAGCATCACGATGACC
GCAATACGCCAGGCCGTGCG

Downstream 100 bases:

>100_bases
CGTCCCTGTAATGGGGCCGGAATACGAGCCTTTTGCTGCGGCCGCATAAAACACTTGCCAAGTCGGCGCTGGCTCCATAT
AATCTTAGCTTCTCTAGGCT

Product: (p)ppGpp synthetase I SpoT/RelA

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I [H]

Number of amino acids: Translated: 739; Mature: 738

Protein sequence:

>739_residues
MTESVTASSVAAPSFDDVLAFVRERAGDARLSTGELLADHSAGTASIMRTLNVDPHAMQAAALFVLTPHLNDPERELTER
FGEEVARLVSDVRKLLRLGTVSLRAQNAMPEAGRDAAEERRTQIEALRKMLLAFAQDIRVVLIRLASRLQSLRYYAAAKI
DPPPDVARETLEIYAPLANRLGIWQLKWELEDLAFRFEDPVTYKRIAKLLDEKRIEREAYVAQAIERLQHELAEAHIPAD
VSGRPKHIYSIWRKMRGKELDFAELYDVRAFRVIVPDIKDCYAVLGIVHHLWQPVPKEFDDYISRPKPNGYKSLHTVVIG
DDGRAFEVQIRTQEMHRFAEYGIAAHWRYKEAGARGYGGQFSASDKYDEKIAWLRQLLAWKDDVEVSGDQAWAQLRETSL
DDDHIYVLTPQARVIALPQGATPVDFAYHLHSELGHRCRGARVDGVMVPLNTSLANGQTVEIVAVKEGGPSRDWLNLQLG
YLKSSRARQKVRAWFNSIEQEENIAHGRALVEKTLQREGKTSVNLDNLAAKLGFKSPDELFSVVGKEEFSLRHVEQALSD
APPPEHAPEAPADFEKRSSGASVAHGASTGVLVVGVDALLTQLARCCRPAPPDPISGFVTRGKGMSIHRSDCPTFRRMAE
RAPERVLQTTWSADVLGGRGASVYPVDLMIEASDRQGLLRDISEVFAREKMNVVGVKTQSRRNAAFMQFTVEVSNSAQVQ
RACTLLGEVAGVVRAGRKT

Sequences:

>Translated_739_residues
MTESVTASSVAAPSFDDVLAFVRERAGDARLSTGELLADHSAGTASIMRTLNVDPHAMQAAALFVLTPHLNDPERELTER
FGEEVARLVSDVRKLLRLGTVSLRAQNAMPEAGRDAAEERRTQIEALRKMLLAFAQDIRVVLIRLASRLQSLRYYAAAKI
DPPPDVARETLEIYAPLANRLGIWQLKWELEDLAFRFEDPVTYKRIAKLLDEKRIEREAYVAQAIERLQHELAEAHIPAD
VSGRPKHIYSIWRKMRGKELDFAELYDVRAFRVIVPDIKDCYAVLGIVHHLWQPVPKEFDDYISRPKPNGYKSLHTVVIG
DDGRAFEVQIRTQEMHRFAEYGIAAHWRYKEAGARGYGGQFSASDKYDEKIAWLRQLLAWKDDVEVSGDQAWAQLRETSL
DDDHIYVLTPQARVIALPQGATPVDFAYHLHSELGHRCRGARVDGVMVPLNTSLANGQTVEIVAVKEGGPSRDWLNLQLG
YLKSSRARQKVRAWFNSIEQEENIAHGRALVEKTLQREGKTSVNLDNLAAKLGFKSPDELFSVVGKEEFSLRHVEQALSD
APPPEHAPEAPADFEKRSSGASVAHGASTGVLVVGVDALLTQLARCCRPAPPDPISGFVTRGKGMSIHRSDCPTFRRMAE
RAPERVLQTTWSADVLGGRGASVYPVDLMIEASDRQGLLRDISEVFAREKMNVVGVKTQSRRNAAFMQFTVEVSNSAQVQ
RACTLLGEVAGVVRAGRKT
>Mature_738_residues
TESVTASSVAAPSFDDVLAFVRERAGDARLSTGELLADHSAGTASIMRTLNVDPHAMQAAALFVLTPHLNDPERELTERF
GEEVARLVSDVRKLLRLGTVSLRAQNAMPEAGRDAAEERRTQIEALRKMLLAFAQDIRVVLIRLASRLQSLRYYAAAKID
PPPDVARETLEIYAPLANRLGIWQLKWELEDLAFRFEDPVTYKRIAKLLDEKRIEREAYVAQAIERLQHELAEAHIPADV
SGRPKHIYSIWRKMRGKELDFAELYDVRAFRVIVPDIKDCYAVLGIVHHLWQPVPKEFDDYISRPKPNGYKSLHTVVIGD
DGRAFEVQIRTQEMHRFAEYGIAAHWRYKEAGARGYGGQFSASDKYDEKIAWLRQLLAWKDDVEVSGDQAWAQLRETSLD
DDHIYVLTPQARVIALPQGATPVDFAYHLHSELGHRCRGARVDGVMVPLNTSLANGQTVEIVAVKEGGPSRDWLNLQLGY
LKSSRARQKVRAWFNSIEQEENIAHGRALVEKTLQREGKTSVNLDNLAAKLGFKSPDELFSVVGKEEFSLRHVEQALSDA
PPPEHAPEAPADFEKRSSGASVAHGASTGVLVVGVDALLTQLARCCRPAPPDPISGFVTRGKGMSIHRSDCPTFRRMAER
APERVLQTTWSADVLGGRGASVYPVDLMIEASDRQGLLRDISEVFAREKMNVVGVKTQSRRNAAFMQFTVEVSNSAQVQR
ACTLLGEVAGVVRAGRKT

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1789147, Length=698, Percent_Identity=40.4011461318052, Blast_Score=528, Evalue=1e-151,
Organism=Escherichia coli, GI1790082, Length=723, Percent_Identity=34.4398340248963, Blast_Score=390, Evalue=1e-109,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 82412; Mature: 82280

Theoretical pI: Translated: 7.36; Mature: 7.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTESVTASSVAAPSFDDVLAFVRERAGDARLSTGELLADHSAGTASIMRTLNVDPHAMQA
CCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHCCCCCHHHHHHHCCCCHHHHHH
AALFVLTPHLNDPERELTERFGEEVARLVSDVRKLLRLGTVSLRAQNAMPEAGRDAAEER
HEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCHHHHHH
RTQIEALRKMLLAFAQDIRVVLIRLASRLQSLRYYAAAKIDPPPDVARETLEIYAPLANR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHC
LGIWQLKWELEDLAFRFEDPVTYKRIAKLLDEKRIEREAYVAQAIERLQHELAEAHIPAD
CCEEEEEEEHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
VSGRPKHIYSIWRKMRGKELDFAELYDVRAFRVIVPDIKDCYAVLGIVHHLWQPVPKEFD
CCCCHHHHHHHHHHHCCCCCCHHHHHHHHEEEEECCCHHHHHHHHHHHHHHHCCCCHHHH
DYISRPKPNGYKSLHTVVIGDDGRAFEVQIRTQEMHRFAEYGIAAHWRYKEAGARGYGGQ
HHHCCCCCCCCCCEEEEEECCCCCEEEEEEEHHHHHHHHHCCCCEEEEEHHCCCCCCCCC
FSASDKYDEKIAWLRQLLAWKDDVEVSGDQAWAQLRETSLDDDHIYVLTPQARVIALPQG
CCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCEEEEECCC
ATPVDFAYHLHSELGHRCRGARVDGVMVPLNTSLANGQTVEIVAVKEGGPSRDWLNLQLG
CCCHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCEEEEEEEECCCCCCCEEEEEEH
YLKSSRARQKVRAWFNSIEQEENIAHGRALVEKTLQREGKTSVNLDNLAAKLGFKSPDEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCHHHH
FSVVGKEEFSLRHVEQALSDAPPPEHAPEAPADFEKRSSGASVAHGASTGVLVVGVDALL
HHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCCCCCEECCCCCCEEEEEHHHHH
TQLARCCRPAPPDPISGFVTRGKGMSIHRSDCPTFRRMAERAPERVLQTTWSADVLGGRG
HHHHHHCCCCCCCCCCHHHCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCC
ASVYPVDLMIEASDRQGLLRDISEVFAREKMNVVGVKTQSRRNAAFMQFTVEVSNSAQVQ
CEEEEEEEEEECCCCCCHHHHHHHHHHHHCCCEEEECCCCCCCCEEEEEEEEECCCHHHH
RACTLLGEVAGVVRAGRKT
HHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TESVTASSVAAPSFDDVLAFVRERAGDARLSTGELLADHSAGTASIMRTLNVDPHAMQA
CCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHCCCCCHHHHHHHCCCCHHHHHH
AALFVLTPHLNDPERELTERFGEEVARLVSDVRKLLRLGTVSLRAQNAMPEAGRDAAEER
HEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCHHHHHH
RTQIEALRKMLLAFAQDIRVVLIRLASRLQSLRYYAAAKIDPPPDVARETLEIYAPLANR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHC
LGIWQLKWELEDLAFRFEDPVTYKRIAKLLDEKRIEREAYVAQAIERLQHELAEAHIPAD
CCEEEEEEEHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
VSGRPKHIYSIWRKMRGKELDFAELYDVRAFRVIVPDIKDCYAVLGIVHHLWQPVPKEFD
CCCCHHHHHHHHHHHCCCCCCHHHHHHHHEEEEECCCHHHHHHHHHHHHHHHCCCCHHHH
DYISRPKPNGYKSLHTVVIGDDGRAFEVQIRTQEMHRFAEYGIAAHWRYKEAGARGYGGQ
HHHCCCCCCCCCCEEEEEECCCCCEEEEEEEHHHHHHHHHCCCCEEEEEHHCCCCCCCCC
FSASDKYDEKIAWLRQLLAWKDDVEVSGDQAWAQLRETSLDDDHIYVLTPQARVIALPQG
CCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCEEEEECCC
ATPVDFAYHLHSELGHRCRGARVDGVMVPLNTSLANGQTVEIVAVKEGGPSRDWLNLQLG
CCCHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCEEEEEEEECCCCCCCEEEEEEH
YLKSSRARQKVRAWFNSIEQEENIAHGRALVEKTLQREGKTSVNLDNLAAKLGFKSPDEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCHHHH
FSVVGKEEFSLRHVEQALSDAPPPEHAPEAPADFEKRSSGASVAHGASTGVLVVGVDALL
HHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCCCCCEECCCCCCEEEEEHHHHH
TQLARCCRPAPPDPISGFVTRGKGMSIHRSDCPTFRRMAERAPERVLQTTWSADVLGGRG
HHHHHHCCCCCCCCCCHHHCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCC
ASVYPVDLMIEASDRQGLLRDISEVFAREKMNVVGVKTQSRRNAAFMQFTVEVSNSAQVQ
CEEEEEEEEEECCCCCCHHHHHHHHHHHHCCCEEEECCCCCCCCEEEEEEEEECCCHHHH
RACTLLGEVAGVVRAGRKT
HHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7928955 [H]