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The map label for this gene is serA [H]

Identifier: 116249253

GI number: 116249253

Start: 638897

End: 639871

Strand: Direct

Name: serA [H]

Synonym: pRL120588

Alternate gene names: 116249253

Gene position: 638897-639871 (Clockwise)

Preceding gene: 116249252

Following gene: 116249260

Centisome position: 73.43

GC content: 66.46

Gene sequence:

>975_bases
ATGAGCTTCATCTTTTCCACACATCCCCTGCACCCTGCGGCCAAGTCCATGCTTGAGGCTGCGGGTGATCTGCGCGTCGC
TTCCGCGCCCGATCCCGAAACGTTGCTTAGAGAAGGCCGCGGCGCGGGCATCGTCGTCGTACGCGCGCCGATCCCGCCGG
CCTTCTTCGAGGATGCGCCGGCGCTTCGCGCTGCGATCCGCCATGGCGCCGGGCTCGATATGGTGCCGTTGGATGCGGCG
ACCCGCGCCGGCGTGCTTGTCGCCAACGTCCCGGGCGCCAATGCCTCGACTGTCGCCGAGCACGTCTTCCTCGTGACACT
GGCCCTGCTTCGGCGCTTTCGCGCGATGGACCGCGACCTGCGTCAGAGCGGCTGGGCGGCGGGCCGCGCCCAATCGGACA
CGGCCGTCGACCTCGCCGGCCGCACCATGGGCATCATCGGAATGGGCAATGTCGGCAAGGCGATCTTGAAGATCGCGAAG
TTCGGTTTCGGCCTGGAGGTGGTCGCCACGAGCCGGTCGCCGGAAAGCGTGCCGGACGGCGTGCGTTTCCTGAAGATCGA
TGAGCTTGTGGCGACGGCCGACATCGTGTTGCTCTGCTGCCCGCTGACGCCGGAGACGACCGGCTTGCTCAATGCCGGTC
GCATCGGGCGCATGAAGCCCACGGCCATTCTGGTCAACGTCTCGCGCGGCCCCGTCATCGACGATGCGGCGTTGATCGAG
GCGCTGCGCGATGGTCGCATCGGCGGAGCCGCGCTCGACGTCTTCGCAACGCAGCCGCTGCCGCTCGACCATCCCTATTT
CGGCTTTGACAACGTCATCGTCACGCCGCATCTCGCTGGTCTGACGGAAGAGAGCATGATGCGCATGGGAACAGGCGCGG
CGAGCGAAGCCCTGCGCGTCATCAAGGGCGACTTGCCCGTCAATTTGCGCAATCCCGAAGTGGTAGAACACTACCGCCGG
CGCTTTCCCGCATAG

Upstream 100 bases:

>100_bases
GCTGATGAGCGCACATCTTCAAGGTGCGGAAAGCTATTGGAAGGGTCTCATCGGTGGTCCAGCGACGTCAGCCGGATAGG
CGCAACCGGCGGGAGGGCCG

Downstream 100 bases:

>100_bases
CGCCTCGTCGCGACAACTCGAAATGCTCACTGCCCCTGCCGTGCCGCCGAGACCGCTGGCATCCTTCGGACCGATCAGGT
CAGCCCGCGTGCCGCAGGCT

Product: putative haloacid dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 324; Mature: 323

Protein sequence:

>324_residues
MSFIFSTHPLHPAAKSMLEAAGDLRVASAPDPETLLREGRGAGIVVVRAPIPPAFFEDAPALRAAIRHGAGLDMVPLDAA
TRAGVLVANVPGANASTVAEHVFLVTLALLRRFRAMDRDLRQSGWAAGRAQSDTAVDLAGRTMGIIGMGNVGKAILKIAK
FGFGLEVVATSRSPESVPDGVRFLKIDELVATADIVLLCCPLTPETTGLLNAGRIGRMKPTAILVNVSRGPVIDDAALIE
ALRDGRIGGAALDVFATQPLPLDHPYFGFDNVIVTPHLAGLTEESMMRMGTGAASEALRVIKGDLPVNLRNPEVVEHYRR
RFPA

Sequences:

>Translated_324_residues
MSFIFSTHPLHPAAKSMLEAAGDLRVASAPDPETLLREGRGAGIVVVRAPIPPAFFEDAPALRAAIRHGAGLDMVPLDAA
TRAGVLVANVPGANASTVAEHVFLVTLALLRRFRAMDRDLRQSGWAAGRAQSDTAVDLAGRTMGIIGMGNVGKAILKIAK
FGFGLEVVATSRSPESVPDGVRFLKIDELVATADIVLLCCPLTPETTGLLNAGRIGRMKPTAILVNVSRGPVIDDAALIE
ALRDGRIGGAALDVFATQPLPLDHPYFGFDNVIVTPHLAGLTEESMMRMGTGAASEALRVIKGDLPVNLRNPEVVEHYRR
RFPA
>Mature_323_residues
SFIFSTHPLHPAAKSMLEAAGDLRVASAPDPETLLREGRGAGIVVVRAPIPPAFFEDAPALRAAIRHGAGLDMVPLDAAT
RAGVLVANVPGANASTVAEHVFLVTLALLRRFRAMDRDLRQSGWAAGRAQSDTAVDLAGRTMGIIGMGNVGKAILKIAKF
GFGLEVVATSRSPESVPDGVRFLKIDELVATADIVLLCCPLTPETTGLLNAGRIGRMKPTAILVNVSRGPVIDDAALIEA
LRDGRIGGAALDVFATQPLPLDHPYFGFDNVIVTPHLAGLTEESMMRMGTGAASEALRVIKGDLPVNLRNPEVVEHYRRR
FPA

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=307, Percent_Identity=31.2703583061889, Blast_Score=142, Evalue=3e-34,
Organism=Homo sapiens, GI145580578, Length=268, Percent_Identity=33.955223880597, Blast_Score=136, Evalue=2e-32,
Organism=Homo sapiens, GI4557499, Length=268, Percent_Identity=33.955223880597, Blast_Score=136, Evalue=2e-32,
Organism=Homo sapiens, GI145580575, Length=268, Percent_Identity=33.955223880597, Blast_Score=135, Evalue=7e-32,
Organism=Homo sapiens, GI6912396, Length=245, Percent_Identity=32.2448979591837, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI61743967, Length=275, Percent_Identity=33.4545454545455, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI4557497, Length=275, Percent_Identity=33.4545454545455, Blast_Score=134, Evalue=2e-31,
Organism=Escherichia coli, GI87082289, Length=277, Percent_Identity=31.7689530685921, Blast_Score=158, Evalue=6e-40,
Organism=Escherichia coli, GI1787645, Length=268, Percent_Identity=30.9701492537313, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1789279, Length=300, Percent_Identity=31.3333333333333, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI87081824, Length=231, Percent_Identity=27.7056277056277, Blast_Score=80, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI25147481, Length=265, Percent_Identity=31.3207547169811, Blast_Score=109, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17532191, Length=247, Percent_Identity=27.5303643724696, Blast_Score=107, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6324964, Length=313, Percent_Identity=30.0319488817891, Blast_Score=125, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6324055, Length=248, Percent_Identity=33.0645161290323, Blast_Score=119, Evalue=5e-28,
Organism=Saccharomyces cerevisiae, GI6320925, Length=258, Percent_Identity=31.7829457364341, Blast_Score=114, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6322116, Length=258, Percent_Identity=31.0077519379845, Blast_Score=109, Evalue=6e-25,
Organism=Saccharomyces cerevisiae, GI6321253, Length=192, Percent_Identity=29.1666666666667, Blast_Score=81, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6324980, Length=119, Percent_Identity=33.6134453781513, Blast_Score=81, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24646446, Length=285, Percent_Identity=33.3333333333333, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24646448, Length=285, Percent_Identity=33.3333333333333, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24646452, Length=285, Percent_Identity=33.3333333333333, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24646450, Length=285, Percent_Identity=33.3333333333333, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI62472511, Length=285, Percent_Identity=33.3333333333333, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI28571528, Length=249, Percent_Identity=31.7269076305221, Blast_Score=128, Evalue=4e-30,
Organism=Drosophila melanogaster, GI28574286, Length=250, Percent_Identity=30.4, Blast_Score=118, Evalue=7e-27,
Organism=Drosophila melanogaster, GI24585514, Length=312, Percent_Identity=29.1666666666667, Blast_Score=115, Evalue=4e-26,
Organism=Drosophila melanogaster, GI28574282, Length=312, Percent_Identity=29.1666666666667, Blast_Score=115, Evalue=4e-26,
Organism=Drosophila melanogaster, GI45552429, Length=312, Percent_Identity=29.1666666666667, Blast_Score=115, Evalue=4e-26,
Organism=Drosophila melanogaster, GI28574284, Length=312, Percent_Identity=29.1666666666667, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI45551003, Length=312, Percent_Identity=29.1666666666667, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI19921140, Length=275, Percent_Identity=26.9090909090909, Blast_Score=108, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24585516, Length=245, Percent_Identity=26.1224489795918, Blast_Score=104, Evalue=9e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 34282; Mature: 34151

Theoretical pI: Translated: 7.71; Mature: 7.71

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFIFSTHPLHPAAKSMLEAAGDLRVASAPDPETLLREGRGAGIVVVRAPIPPAFFEDAP
CCCCCCCCCCCHHHHHHHHHHCCEEECCCCCHHHHHHCCCCCEEEEEECCCCCHHHCCCH
ALRAAIRHGAGLDMVPLDAATRAGVLVANVPGANASTVAEHVFLVTLALLRRFRAMDRDL
HHHHHHHCCCCCCEEECCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RQSGWAAGRAQSDTAVDLAGRTMGIIGMGNVGKAILKIAKFGFGLEVVATSRSPESVPDG
HHCCCCCCCCCCCCEEEECCCEEEEEECCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCC
VRFLKIDELVATADIVLLCCPLTPETTGLLNAGRIGRMKPTAILVNVSRGPVIDDAALIE
CEEEEHHHHHHHHCEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHH
ALRDGRIGGAALDVFATQPLPLDHPYFGFDNVIVTPHLAGLTEESMMRMGTGAASEALRV
HHHCCCCCCEEEEEEECCCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHCCCCHHHHHHH
IKGDLPVNLRNPEVVEHYRRRFPA
HHCCCCCCCCCCHHHHHHHHHCCC
>Mature Secondary Structure 
SFIFSTHPLHPAAKSMLEAAGDLRVASAPDPETLLREGRGAGIVVVRAPIPPAFFEDAP
CCCCCCCCCCHHHHHHHHHHCCEEECCCCCHHHHHHCCCCCEEEEEECCCCCHHHCCCH
ALRAAIRHGAGLDMVPLDAATRAGVLVANVPGANASTVAEHVFLVTLALLRRFRAMDRDL
HHHHHHHCCCCCCEEECCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RQSGWAAGRAQSDTAVDLAGRTMGIIGMGNVGKAILKIAKFGFGLEVVATSRSPESVPDG
HHCCCCCCCCCCCCEEEECCCEEEEEECCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCC
VRFLKIDELVATADIVLLCCPLTPETTGLLNAGRIGRMKPTAILVNVSRGPVIDDAALIE
CEEEEHHHHHHHHCEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHH
ALRDGRIGGAALDVFATQPLPLDHPYFGFDNVIVTPHLAGLTEESMMRMGTGAASEALRV
HHHCCCCCCEEEEEEECCCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHCCCCHHHHHHH
IKGDLPVNLRNPEVVEHYRRRFPA
HHCCCCCCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]