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The map label for this gene is zwf [H]

Identifier: 116249225

GI number: 116249225

Start: 611772

End: 613238

Strand: Reverse

Name: zwf [H]

Synonym: pRL120561

Alternate gene names: 116249225

Gene position: 613238-611772 (Counterclockwise)

Preceding gene: 116249226

Following gene: 116249216

Centisome position: 70.49

GC content: 60.87

Gene sequence:

>1467_bases
ATGAGTGTTTTGCGCAAGAATTCAACTCGGGTTGGCCCTGGCTATCCACAGGTCGTTGTGCTCGTCGGCGCAACAGGCGA
TCTCTCACGGCGCAAGCTACTGACCGGGCTGTTCCACCTCACCAATGCGGGCTTCATCCCAGGCTGCCGCATTATCGGCG
TCTCGCTCGACGATATCGACGCGGATGCCTTCCGCACCATCGCCCGTGACTCGCTTGACAAGTTCTTGACTCGCAAGTTC
TCGCAGTCCGAATGGGAAGCGTTTGCCGCATCGCTCGACTATGTCCCGCTCGCAGCAGGCGCCAATGCTCTCAAGGAAGC
GGTCGACAGGGCCGAGGAAGCACTGGGCGCCGAGACGCGGCGCGTGCATTATTTATCCGTGCCACCAAGTGCCGCCCTTC
TAGCCGTGCAACTCCTCGCCCAGGCTGAGCTGACTGAACGCTCCCGTATCATCATGGAAAAGCCCTTCGGTACGGACCTT
GCTAGTGCCGTTGCACTGAACAAGAAGCTGCACGAGGTGTTCGACGAGAAGCAGATCTTCCGCATCGACCATTTCCTCGG
CAAGGAGCCGGCGCAAAACATCCTGGCCTTCCGATTTGCCAATGGCCTGTTCGAACCAATCTGGAACCGCAACTTCATCG
ACCATGTGCAGATCGACGTCCCGGAGACGCTCGGCCTTTCCACTCGCGCCGCCTTTTACGAGACCACCGGCGCCTATCGT
GACATGGTGGTGACCCACCTCTTCCAGATCCTCGCCTTCATGGCGATGGAGCCGCCCACTGCGCTTGAGCCTGCGCCAAT
CTCGGAAGAGAAGAACAAGGTGTTCCGCTCCATGTTGCCGATTGAGCCGCGCGACGTGGTGCGCGGCCAATACATTGGCT
ACCGTAATGAGCCTGGCGTCGATCCCGAAAGCGACACTGACACCTTCATCGCCCTAAAATGCGCGATCGACAACTGGCGC
TGGGCCGGAGTGCCCTTCTACCTGCGTACAGGCAAGCGCATGGCCGAGGGGCAGCGCATTATTTCGATCGCATTCCGCGA
GCCCCCGAAATCGATGTTCCCTGCGGGATCTGGCGTGGGGGCACAGGGCCCTGACCACCTCACCTTCGACCTCGCTGATT
CCTCCAAGGTCTCGCTTTCCTTCTATGGCAAGCGCCCTGGCCCGGGCTTCCGGCTCGACAAGCTCTCGCTGCAATTCGCC
ATGAGCGAAACCGGCCTGATTGGCGAAGTTCTGGAGGCTTATGAGCGTCTGATCCTCGACGCCATGCGCGGTGACCACAC
GCTGTTCACTACGGCCGAGGGTATTGAGCGGCTCTGGGAGGTTTCCCAACCTCTCCTCGATAACCCACCGCCCGTACGCC
TCTACGACCAGGGCGGCTGGGGGCCGAAGTCGATCCACCAACTCATTGCCCCGCACGCCTGGCGCCTGCCGTTCGAGCGC
GCCTGGAGGGATGCGGCAAAAGGATGA

Upstream 100 bases:

>100_bases
GAGCTTCAACGTCATGCCATCACGCACGAAGATAGCCGCTTCGCGGCAGCGCGGAGCTGGGGTCGACCTCCATCCCCAAG
GGACAACGGAAGACTTGAGG

Downstream 100 bases:

>100_bases
TTGACGGTCAAAAGTTGGAGCGATGCCGGCGGTCGGAATGGCGCCGACCAATTGCGAACAATCCCAATAAAATGACGTTG
GCAGAGATGTGCAGGAAACG

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 488; Mature: 487

Protein sequence:

>488_residues
MSVLRKNSTRVGPGYPQVVVLVGATGDLSRRKLLTGLFHLTNAGFIPGCRIIGVSLDDIDADAFRTIARDSLDKFLTRKF
SQSEWEAFAASLDYVPLAAGANALKEAVDRAEEALGAETRRVHYLSVPPSAALLAVQLLAQAELTERSRIIMEKPFGTDL
ASAVALNKKLHEVFDEKQIFRIDHFLGKEPAQNILAFRFANGLFEPIWNRNFIDHVQIDVPETLGLSTRAAFYETTGAYR
DMVVTHLFQILAFMAMEPPTALEPAPISEEKNKVFRSMLPIEPRDVVRGQYIGYRNEPGVDPESDTDTFIALKCAIDNWR
WAGVPFYLRTGKRMAEGQRIISIAFREPPKSMFPAGSGVGAQGPDHLTFDLADSSKVSLSFYGKRPGPGFRLDKLSLQFA
MSETGLIGEVLEAYERLILDAMRGDHTLFTTAEGIERLWEVSQPLLDNPPPVRLYDQGGWGPKSIHQLIAPHAWRLPFER
AWRDAAKG

Sequences:

>Translated_488_residues
MSVLRKNSTRVGPGYPQVVVLVGATGDLSRRKLLTGLFHLTNAGFIPGCRIIGVSLDDIDADAFRTIARDSLDKFLTRKF
SQSEWEAFAASLDYVPLAAGANALKEAVDRAEEALGAETRRVHYLSVPPSAALLAVQLLAQAELTERSRIIMEKPFGTDL
ASAVALNKKLHEVFDEKQIFRIDHFLGKEPAQNILAFRFANGLFEPIWNRNFIDHVQIDVPETLGLSTRAAFYETTGAYR
DMVVTHLFQILAFMAMEPPTALEPAPISEEKNKVFRSMLPIEPRDVVRGQYIGYRNEPGVDPESDTDTFIALKCAIDNWR
WAGVPFYLRTGKRMAEGQRIISIAFREPPKSMFPAGSGVGAQGPDHLTFDLADSSKVSLSFYGKRPGPGFRLDKLSLQFA
MSETGLIGEVLEAYERLILDAMRGDHTLFTTAEGIERLWEVSQPLLDNPPPVRLYDQGGWGPKSIHQLIAPHAWRLPFER
AWRDAAKG
>Mature_487_residues
SVLRKNSTRVGPGYPQVVVLVGATGDLSRRKLLTGLFHLTNAGFIPGCRIIGVSLDDIDADAFRTIARDSLDKFLTRKFS
QSEWEAFAASLDYVPLAAGANALKEAVDRAEEALGAETRRVHYLSVPPSAALLAVQLLAQAELTERSRIIMEKPFGTDLA
SAVALNKKLHEVFDEKQIFRIDHFLGKEPAQNILAFRFANGLFEPIWNRNFIDHVQIDVPETLGLSTRAAFYETTGAYRD
MVVTHLFQILAFMAMEPPTALEPAPISEEKNKVFRSMLPIEPRDVVRGQYIGYRNEPGVDPESDTDTFIALKCAIDNWRW
AGVPFYLRTGKRMAEGQRIISIAFREPPKSMFPAGSGVGAQGPDHLTFDLADSSKVSLSFYGKRPGPGFRLDKLSLQFAM
SETGLIGEVLEAYERLILDAMRGDHTLFTTAEGIERLWEVSQPLLDNPPPVRLYDQGGWGPKSIHQLIAPHAWRLPFERA
WRDAAKG

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI108773793, Length=501, Percent_Identity=28.7425149700599, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI109389365, Length=501, Percent_Identity=28.7425149700599, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI52145310, Length=480, Percent_Identity=28.75, Blast_Score=149, Evalue=5e-36,
Organism=Escherichia coli, GI1788158, Length=468, Percent_Identity=37.6068376068376, Blast_Score=302, Evalue=3e-83,
Organism=Caenorhabditis elegans, GI17538218, Length=493, Percent_Identity=30.6288032454361, Blast_Score=241, Evalue=9e-64,
Organism=Saccharomyces cerevisiae, GI6324088, Length=491, Percent_Identity=31.1608961303462, Blast_Score=234, Evalue=3e-62,
Organism=Drosophila melanogaster, GI24643352, Length=489, Percent_Identity=28.8343558282209, Blast_Score=215, Evalue=5e-56,
Organism=Drosophila melanogaster, GI24643350, Length=489, Percent_Identity=28.8343558282209, Blast_Score=215, Evalue=6e-56,
Organism=Drosophila melanogaster, GI221513548, Length=468, Percent_Identity=27.5641025641026, Blast_Score=155, Evalue=8e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 54326; Mature: 54195

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVLRKNSTRVGPGYPQVVVLVGATGDLSRRKLLTGLFHLTNAGFIPGCRIIGVSLDDID
CCCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCC
ADAFRTIARDSLDKFLTRKFSQSEWEAFAASLDYVPLAAGANALKEAVDRAEEALGAETR
HHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCC
RVHYLSVPPSAALLAVQLLAQAELTERSRIIMEKPFGTDLASAVALNKKLHEVFDEKQIF
EEEEEECCCHHHHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHCHHHHH
RIDHFLGKEPAQNILAFRFANGLFEPIWNRNFIDHVQIDVPETLGLSTRAAFYETTGAYR
HHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCHHCCCCHHHHHHHHCCHHH
DMVVTHLFQILAFMAMEPPTALEPAPISEEKNKVFRSMLPIEPRDVVRGQYIGYRNEPGV
HHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCC
DPESDTDTFIALKCAIDNWRWAGVPFYLRTGKRMAEGQRIISIAFREPPKSMFPAGSGVG
CCCCCCCCEEEEEEEECCCEECCCCEEECCCCHHHCCCEEEEEEECCCCHHHCCCCCCCC
AQGPDHLTFDLADSSKVSLSFYGKRPGPGFRLDKLSLQFAMSETGLIGEVLEAYERLILD
CCCCCCEEEEECCCCEEEEEEECCCCCCCCEEHHHEEEEHHCCCCHHHHHHHHHHHHHHH
AMRGDHTLFTTAEGIERLWEVSQPLLDNPPPVRLYDQGGWGPKSIHQLIAPHAWRLPFER
HHCCCCEEEECHHHHHHHHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHCCCCCCCCHHH
AWRDAAKG
HHHHHCCC
>Mature Secondary Structure 
SVLRKNSTRVGPGYPQVVVLVGATGDLSRRKLLTGLFHLTNAGFIPGCRIIGVSLDDID
CCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCC
ADAFRTIARDSLDKFLTRKFSQSEWEAFAASLDYVPLAAGANALKEAVDRAEEALGAETR
HHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCC
RVHYLSVPPSAALLAVQLLAQAELTERSRIIMEKPFGTDLASAVALNKKLHEVFDEKQIF
EEEEEECCCHHHHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHCHHHHH
RIDHFLGKEPAQNILAFRFANGLFEPIWNRNFIDHVQIDVPETLGLSTRAAFYETTGAYR
HHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCHHCCCCHHHHHHHHCCHHH
DMVVTHLFQILAFMAMEPPTALEPAPISEEKNKVFRSMLPIEPRDVVRGQYIGYRNEPGV
HHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCC
DPESDTDTFIALKCAIDNWRWAGVPFYLRTGKRMAEGQRIISIAFREPPKSMFPAGSGVG
CCCCCCCCEEEEEEEECCCEECCCCEEECCCCHHHCCCEEEEEEECCCCHHHCCCCCCCC
AQGPDHLTFDLADSSKVSLSFYGKRPGPGFRLDKLSLQFAMSETGLIGEVLEAYERLILD
CCCCCCEEEEECCCCEEEEEEECCCCCCCCEEHHHEEEEHHCCCCHHHHHHHHHHHHHHH
AMRGDHTLFTTAEGIERLWEVSQPLLDNPPPVRLYDQGGWGPKSIHQLIAPHAWRLPFER
HHCCCCEEEECHHHHHHHHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHCCCCCCCCHHH
AWRDAAKG
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7870816 [H]