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The map label for this gene is aptA [C]

Identifier: 116249085

GI number: 116249085

Start: 453819

End: 455153

Strand: Reverse

Name: aptA [C]

Synonym: pRL120419

Alternate gene names: 116249085

Gene position: 455153-453819 (Counterclockwise)

Preceding gene: 116249087

Following gene: 116249081

Centisome position: 52.32

GC content: 62.25

Gene sequence:

>1335_bases
ATGGACCAGATCAGCAAAACGAACGCGCCCGTACTCGAAAATTTCTGGATGCCATTCACCGCGAACCGGCAATTCAAGGC
CACGCCGCGGCTTCTCGCAGCCGCGGAGGGAATGTACTACACCGACGTCGATGGACATCAGGTGCTTGACGGCACCGCCG
GGCTCTGGTGCTGCAATGCCGGCCACGGCCGCAAGAAGATCGCCCATGCCGTCGAGCGACAGCTTGCAACGCTGGACTAT
GCGCCGACCTTTCAGATGGGGCATCCGATCGCCTTCGACTTCGCCTCAAAACTGGCTGCGAACGCGCCGGGCGGCCCGGA
AGCCAAGCTCGACAGGATATTCTTCACCGGCTCAGGCTCGGAATCGGTCGATACGGCGCTGAAGATCGCCATCGCCTATC
AGCGGGCGATCGGCCAGGGCACCCGCACGCGGATCATCGGGCGCGAGAAGGGATATCATGGCGTCGGGTTCGGCGGCATT
TCCGTCGGCGGTCTCGTCAACAACCGGCGGGTCTTCCCGCAAATACCGGCCGACCATATGCGCCACACGCTCGACATCGA
GCGCAATGCGTTCTCAAAGGGTCTTCCCGCTCACGGCGTGGAACTGGCGGACGATCTCGAGCGCCTGGTGCAACTGCACG
GCGCCGAAACCATCGCAGCGGTCATCGTCGAGCCGATGTCGGGATCGGCAGGCGTGGTTCTGCCTGCGAAGGGCTATCTG
GAGAAACTGCGCGCAACCGCCGACAAGCACGGAATCCTGCTGATCTTCGACGAGGTCATCACCGGCTTCGGACGTCTCGG
CACTCCTTTCGCGGCCGACTACTTCGGCGTCGTGCCCGACCTGATCACCACGGCAAAAGGCATCACCAACGGCTCGATCC
CCATGGGCGCGGTCTTTGCCAGCAGGAAGGTCTATGACGGCCTGATGGTCGGACCCGATAACGCGATCGAACTCTTCCAT
GGCTACACCTATTCCGGCCATCCGGTCGCCTGTGCGGCCGGGCTCGCTACTCTGGAGATCTACGAGGAGGAAGGCCTGCT
GACCCGCGCAGCCGATTTGGCCGAGTACTGGCAGGAGGCCCTCCATTCACTGAAAGGCCTGCCTCATGTCGTCGACATCC
GCAATCTCGGACTGGTCGGCGCAGTCGAACTGGCTTCTCGTGACGGGGCGCCTGGAACCCGCGCCTATGACATCTTCGTT
GACTGCTTCAACAAGGGCCTGTTGATCCGGGTAACCGGCGACATTATCGCCCTCTCCCCGCCGCTCATTATCGAGAAAAG
CCAGATCGACACGATCGTTTCGATCCTCGGTGATGCCCTGAAGCGCGCGGCATAG

Upstream 100 bases:

>100_bases
CCAAATCCATTGAATTTCAATAGCTTGCAACAGCAAAGAAAAGGACTTGTTTGTCAGAGGGAAACTGACATTCTCGGCGC
CATCCCCAAAGGAGGCCAGG

Downstream 100 bases:

>100_bases
ATCCGTATCCCGCGTGCCGCTCCCGTCGGCGATCGGACGCCTGGTCCATCGTCGACGGAATCATCCACGCCGAGATAGAG
CTCAGCGCCTCAAGGTCTGT

Product: beta alanine--pyruvate transaminase

Products: NA

Alternate protein names: Omega-APT; Beta-alanine--pyruvate aminotransferase [H]

Number of amino acids: Translated: 444; Mature: 444

Protein sequence:

>444_residues
MDQISKTNAPVLENFWMPFTANRQFKATPRLLAAAEGMYYTDVDGHQVLDGTAGLWCCNAGHGRKKIAHAVERQLATLDY
APTFQMGHPIAFDFASKLAANAPGGPEAKLDRIFFTGSGSESVDTALKIAIAYQRAIGQGTRTRIIGREKGYHGVGFGGI
SVGGLVNNRRVFPQIPADHMRHTLDIERNAFSKGLPAHGVELADDLERLVQLHGAETIAAVIVEPMSGSAGVVLPAKGYL
EKLRATADKHGILLIFDEVITGFGRLGTPFAADYFGVVPDLITTAKGITNGSIPMGAVFASRKVYDGLMVGPDNAIELFH
GYTYSGHPVACAAGLATLEIYEEEGLLTRAADLAEYWQEALHSLKGLPHVVDIRNLGLVGAVELASRDGAPGTRAYDIFV
DCFNKGLLIRVTGDIIALSPPLIIEKSQIDTIVSILGDALKRAA

Sequences:

>Translated_444_residues
MDQISKTNAPVLENFWMPFTANRQFKATPRLLAAAEGMYYTDVDGHQVLDGTAGLWCCNAGHGRKKIAHAVERQLATLDY
APTFQMGHPIAFDFASKLAANAPGGPEAKLDRIFFTGSGSESVDTALKIAIAYQRAIGQGTRTRIIGREKGYHGVGFGGI
SVGGLVNNRRVFPQIPADHMRHTLDIERNAFSKGLPAHGVELADDLERLVQLHGAETIAAVIVEPMSGSAGVVLPAKGYL
EKLRATADKHGILLIFDEVITGFGRLGTPFAADYFGVVPDLITTAKGITNGSIPMGAVFASRKVYDGLMVGPDNAIELFH
GYTYSGHPVACAAGLATLEIYEEEGLLTRAADLAEYWQEALHSLKGLPHVVDIRNLGLVGAVELASRDGAPGTRAYDIFV
DCFNKGLLIRVTGDIIALSPPLIIEKSQIDTIVSILGDALKRAA
>Mature_444_residues
MDQISKTNAPVLENFWMPFTANRQFKATPRLLAAAEGMYYTDVDGHQVLDGTAGLWCCNAGHGRKKIAHAVERQLATLDY
APTFQMGHPIAFDFASKLAANAPGGPEAKLDRIFFTGSGSESVDTALKIAIAYQRAIGQGTRTRIIGREKGYHGVGFGGI
SVGGLVNNRRVFPQIPADHMRHTLDIERNAFSKGLPAHGVELADDLERLVQLHGAETIAAVIVEPMSGSAGVVLPAKGYL
EKLRATADKHGILLIFDEVITGFGRLGTPFAADYFGVVPDLITTAKGITNGSIPMGAVFASRKVYDGLMVGPDNAIELFH
GYTYSGHPVACAAGLATLEIYEEEGLLTRAADLAEYWQEALHSLKGLPHVVDIRNLGLVGAVELASRDGAPGTRAYDIFV
DCFNKGLLIRVTGDIIALSPPLIIEKSQIDTIVSILGDALKRAA

Specific function: Catalyzes transamination between a variety of omega- amino acids, mono and diamines, and pyruvate. Plays a pivotal role in the metabolism of the omega amino acids [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI13994255, Length=441, Percent_Identity=29.7052154195011, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI4557809, Length=429, Percent_Identity=26.3403263403263, Blast_Score=137, Evalue=3e-32,
Organism=Homo sapiens, GI37574042, Length=435, Percent_Identity=26.8965517241379, Blast_Score=132, Evalue=9e-31,
Organism=Homo sapiens, GI226442705, Length=435, Percent_Identity=27.1264367816092, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI284507298, Length=256, Percent_Identity=31.640625, Blast_Score=122, Evalue=6e-28,
Organism=Homo sapiens, GI226442709, Length=399, Percent_Identity=27.0676691729323, Blast_Score=122, Evalue=8e-28,
Organism=Homo sapiens, GI24119277, Length=447, Percent_Identity=25.0559284116331, Blast_Score=113, Evalue=3e-25,
Organism=Escherichia coli, GI145693181, Length=409, Percent_Identity=30.8068459657702, Blast_Score=166, Evalue=2e-42,
Organism=Escherichia coli, GI1789016, Length=420, Percent_Identity=30.2380952380952, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI1786991, Length=442, Percent_Identity=29.4117647058824, Blast_Score=162, Evalue=5e-41,
Organism=Escherichia coli, GI1787560, Length=441, Percent_Identity=30.6122448979592, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1788044, Length=428, Percent_Identity=28.7383177570093, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI1789759, Length=436, Percent_Identity=27.0642201834862, Blast_Score=129, Evalue=4e-31,
Organism=Escherichia coli, GI1786349, Length=376, Percent_Identity=31.1170212765957, Blast_Score=116, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI32564660, Length=440, Percent_Identity=31.1363636363636, Blast_Score=165, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI25144271, Length=424, Percent_Identity=27.8301886792453, Blast_Score=143, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI71992977, Length=441, Percent_Identity=26.984126984127, Blast_Score=127, Evalue=8e-30,
Organism=Caenorhabditis elegans, GI25144274, Length=227, Percent_Identity=34.8017621145374, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17541228, Length=438, Percent_Identity=22.8310502283105, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323470, Length=437, Percent_Identity=26.3157894736842, Blast_Score=150, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6324386, Length=431, Percent_Identity=26.2180974477958, Blast_Score=122, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6324432, Length=410, Percent_Identity=26.3414634146341, Blast_Score=111, Evalue=2e-25,
Organism=Drosophila melanogaster, GI21357415, Length=421, Percent_Identity=27.0783847980998, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI161085790, Length=460, Percent_Identity=27.3913043478261, Blast_Score=132, Evalue=6e-31,
Organism=Drosophila melanogaster, GI28574759, Length=459, Percent_Identity=27.4509803921569, Blast_Score=128, Evalue=7e-30,
Organism=Drosophila melanogaster, GI21356575, Length=447, Percent_Identity=26.3982102908277, Blast_Score=124, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.18 [H]

Molecular weight: Translated: 47502; Mature: 47502

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDQISKTNAPVLENFWMPFTANRQFKATPRLLAAAEGMYYTDVDGHQVLDGTAGLWCCNA
CCCCCCCCCCHHHHCCCCCCCCCCCCCCHHHHHHHCCCEEECCCCCEEECCCCCEEEECC
GHGRKKIAHAVERQLATLDYAPTFQMGHPIAFDFASKLAANAPGGPEAKLDRIFFTGSGS
CCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCEEEEEEEECCCC
ESVDTALKIAIAYQRAIGQGTRTRIIGREKGYHGVGFGGISVGGLVNNRRVFPQIPADHM
CHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCEEECCEECCCEECCCCCHHHH
RHTLDIERNAFSKGLPAHGVELADDLERLVQLHGAETIAAVIVEPMSGSAGVVLPAKGYL
HHHHCCCHHHHHCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCEEECCHHHH
EKLRATADKHGILLIFDEVITGFGRLGTPFAADYFGVVPDLITTAKGITNGSIPMGAVFA
HHHHHHHCCCCEEEEEHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHH
SRKVYDGLMVGPDNAIELFHGYTYSGHPVACAAGLATLEIYEEEGLLTRAADLAEYWQEA
HHHHHCCEEECCCCCEEHEECCCCCCCCHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHH
LHSLKGLPHVVDIRNLGLVGAVELASRDGAPGTRAYDIFVDCFNKGLLIRVTGDIIALSP
HHHHCCCCEEEEHHCCCCEEEEEHHCCCCCCCCEEHEEEEEHHCCCEEEEEECCEEEECC
PLIIEKSQIDTIVSILGDALKRAA
CCEEEHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDQISKTNAPVLENFWMPFTANRQFKATPRLLAAAEGMYYTDVDGHQVLDGTAGLWCCNA
CCCCCCCCCCHHHHCCCCCCCCCCCCCCHHHHHHHCCCEEECCCCCEEECCCCCEEEECC
GHGRKKIAHAVERQLATLDYAPTFQMGHPIAFDFASKLAANAPGGPEAKLDRIFFTGSGS
CCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCEEEEEEEECCCC
ESVDTALKIAIAYQRAIGQGTRTRIIGREKGYHGVGFGGISVGGLVNNRRVFPQIPADHM
CHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCEEECCEECCCEECCCCCHHHH
RHTLDIERNAFSKGLPAHGVELADDLERLVQLHGAETIAAVIVEPMSGSAGVVLPAKGYL
HHHHCCCHHHHHCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCEEECCHHHH
EKLRATADKHGILLIFDEVITGFGRLGTPFAADYFGVVPDLITTAKGITNGSIPMGAVFA
HHHHHHHCCCCEEEEEHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHH
SRKVYDGLMVGPDNAIELFHGYTYSGHPVACAAGLATLEIYEEEGLLTRAADLAEYWQEA
HHHHHCCEEECCCCCEEHEECCCCCCCCHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHH
LHSLKGLPHVVDIRNLGLVGAVELASRDGAPGTRAYDIFVDCFNKGLLIRVTGDIIALSP
HHHHCCCCEEEEHHCCCCEEEEEHHCCCCCCCCEEHEEEEEHHCCCEEEEEECCEEEECC
PLIIEKSQIDTIVSILGDALKRAA
CCEEEHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1618757; 6822556; 2500426 [H]