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The map label for this gene is proC [H]

Identifier: 116249087

GI number: 116249087

Start: 455842

End: 456624

Strand: Reverse

Name: proC [H]

Synonym: pRL120421

Alternate gene names: 116249087

Gene position: 456624-455842 (Counterclockwise)

Preceding gene: 116249089

Following gene: 116249085

Centisome position: 52.48

GC content: 62.58

Gene sequence:

>783_bases
ATGAAAATCGACAGTATCGGCTTCGTCGGCACCGGCGCGATTACCGAGGCCATGGTTCGCGGGCTTCTCACCGAGCCGGC
CTATGCCTCCCAAATTCACGTGTCTCCACGAAGCGCCCACATCGCCGCGACGCTGGCCGACGAATTCGCCACTGTGAGAA
TTGCCAAGGATAATCAGGACGTCGTCGAACGCAGCGACATGGTGTTCCTGGCGATACGGCCGCAGGTCGCCGAGGAGGTC
GTGCGTGCGCTATCGTTCAGGGATGGCCAAATGGTCGTCAGCCTCGTTGCGGCGACGGAGCGCCAGGCTCTCTCCGAATG
GATCGCCGCCGACGTGCATCTGGTGCAGGCGATCCCCCTGCCCTTCGTCGCCGGCCGGCAAGGCGTCACTGCCGTCTATC
CGCCTGATACCGCCGTCGCAGCGCTTTTCGATGCGCTCGGAACGGCTGTCCAATGCCAGTCGAGGAAGGAGTATGATCTT
CTCGCGGCAGCGAGCGCAATGATGTCGACCTATTTCGGCATCATGGAGCAGGTTGCCGTCTGGCTGGAAAGAGGCGGCCT
CGAAAAGGCGAAGGGACAGGCCTACATTGCCCCGCTCTTTGCAAGCCTCGCGCAGAAAGCGAACAGCCCCGGCAACGAAC
CGTTCAGCGCGCTGAGCCGCGAATTCGCGACCAAGGGCGGACTGAACGAGCAGGTTTTCTCAGACTTCGAGAAGAAGGGC
GGCCTTGCCGCGCTGACCGCTGCACTCGACGGGGTGCTTGCCCGCATCGAGGGCAAGAACTAG

Upstream 100 bases:

>100_bases
TTCTGGGTGAAGGCGGTAACCGCCGTCTTGCCGTTTGTAGGTGATGTAGTTCGGCACGGGGATGTCGCATTGGGCCCGCT
GCGGGCTGCGGAGTAATCAA

Downstream 100 bases:

>100_bases
AAAGTCGGCGGCGTGCAGGCGCTGATGACCTCGCAGGGCACCGGTCCGACGCAGCGGAAGCGGTGCGGGCGTCTGCTTTC
GAAATAGTAGGCGTCACCCG

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 260; Mature: 260

Protein sequence:

>260_residues
MKIDSIGFVGTGAITEAMVRGLLTEPAYASQIHVSPRSAHIAATLADEFATVRIAKDNQDVVERSDMVFLAIRPQVAEEV
VRALSFRDGQMVVSLVAATERQALSEWIAADVHLVQAIPLPFVAGRQGVTAVYPPDTAVAALFDALGTAVQCQSRKEYDL
LAAASAMMSTYFGIMEQVAVWLERGGLEKAKGQAYIAPLFASLAQKANSPGNEPFSALSREFATKGGLNEQVFSDFEKKG
GLAALTAALDGVLARIEGKN

Sequences:

>Translated_260_residues
MKIDSIGFVGTGAITEAMVRGLLTEPAYASQIHVSPRSAHIAATLADEFATVRIAKDNQDVVERSDMVFLAIRPQVAEEV
VRALSFRDGQMVVSLVAATERQALSEWIAADVHLVQAIPLPFVAGRQGVTAVYPPDTAVAALFDALGTAVQCQSRKEYDL
LAAASAMMSTYFGIMEQVAVWLERGGLEKAKGQAYIAPLFASLAQKANSPGNEPFSALSREFATKGGLNEQVFSDFEKKG
GLAALTAALDGVLARIEGKN
>Mature_260_residues
MKIDSIGFVGTGAITEAMVRGLLTEPAYASQIHVSPRSAHIAATLADEFATVRIAKDNQDVVERSDMVFLAIRPQVAEEV
VRALSFRDGQMVVSLVAATERQALSEWIAADVHLVQAIPLPFVAGRQGVTAVYPPDTAVAALFDALGTAVQCQSRKEYDL
LAAASAMMSTYFGIMEQVAVWLERGGLEKAKGQAYIAPLFASLAQKANSPGNEPFSALSREFATKGGLNEQVFSDFEKKG
GLAALTAALDGVLARIEGKN

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786585, Length=262, Percent_Identity=25.9541984732824, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 27659; Mature: 27659

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIDSIGFVGTGAITEAMVRGLLTEPAYASQIHVSPRSAHIAATLADEFATVRIAKDNQD
CCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHEEEEEECCCHH
VVERSDMVFLAIRPQVAEEVVRALSFRDGQMVVSLVAATERQALSEWIAADVHLVQAIPL
HHHCCCEEEEEECHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PFVAGRQGVTAVYPPDTAVAALFDALGTAVQCQSRKEYDLLAAASAMMSTYFGIMEQVAV
CCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
WLERGGLEKAKGQAYIAPLFASLAQKANSPGNEPFSALSREFATKGGLNEQVFSDFEKKG
HHHHCCCCHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHCC
GLAALTAALDGVLARIEGKN
CHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKIDSIGFVGTGAITEAMVRGLLTEPAYASQIHVSPRSAHIAATLADEFATVRIAKDNQD
CCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHEEEEEECCCHH
VVERSDMVFLAIRPQVAEEVVRALSFRDGQMVVSLVAATERQALSEWIAADVHLVQAIPL
HHHCCCEEEEEECHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PFVAGRQGVTAVYPPDTAVAALFDALGTAVQCQSRKEYDLLAAASAMMSTYFGIMEQVAV
CCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
WLERGGLEKAKGQAYIAPLFASLAQKANSPGNEPFSALSREFATKGGLNEQVFSDFEKKG
HHHHCCCCHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHCC
GLAALTAALDGVLARIEGKN
CHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2107123; 10984043; 1676385 [H]