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The map label for this gene is lgrC [H]

Identifier: 116248984

GI number: 116248984

Start: 334150

End: 338151

Strand: Reverse

Name: lgrC [H]

Synonym: pRL120315

Alternate gene names: 116248984

Gene position: 338151-334150 (Counterclockwise)

Preceding gene: 116248988

Following gene: 116248983

Centisome position: 38.87

GC content: 62.07

Gene sequence:

>4002_bases
ATGGCACGGATGAACAAACAGATCACAAATTTCGCAGATGCCTACCCGACCGATGTCGCAACGGATGCGATCTTCGAGAG
CTTCCCGCTGACGATCGCGCAGAAGCGTATCTGGTCGCTGGAGCAGATCGGCAATGAGACGGTATTTCCCGACCAGGTCA
TTTCGCTGCGATTAAGCCCGGCGGTCGACGTCAAGACCATTGCCGGCGCCTGCCGGACGCTCGTGGCGCAGCATCCGTCG
CTTGCCACCCGGTTCCGCCGGCTGGCGGGCGGCCGCGTCGAGCAATACTGCGGCGCATTGAACGCAGTACCGATCGAGAT
TGTCGGCGAAGGCGCGGCTCTTGCTGAGGCCGATGCGTTGGCCGCCCAGAAAGCCTTCCGCGACGGGCGCTTCGATCTCC
TTGCTGGTCCACCGGCGCGTGTTCAGATTATCTTGCTTGCCGATGGGCAGTCGCTTCTGACGATCGTGCTTCATCCCGTG
ATCTCGGACGATCGCGAGAAGTCTATTCTCTCCGGCTCCCTGACGCGAATTCTCGACGGCGCAGCCGCCGGCGACACACA
GCTGACCGAAATCTTGGCCGGAACGCGGGAGGCTGAATGGCTGCAGACCGAGCAGGCGCAGGAATCCCTCTCCTATTGGC
GGAACACGATCGGTCTCGACTACGCCGCCTCGACCTTTCCCACCCGCTTCAACAGTGGCGGGCTGGCAGGTGTGGCGCGC
GCTCAACATCGATTTTCGATCGAGCCCGATCTCTGGGGCAAGCTCGGTCGACATGCGCAGCATAAGGGTTATCAGGTCGA
GCGCGTGCTTCATGCGGCCTTTTGCGCGATGCTGGCACGTTACAGCGGCAACTATGCTTTGCTGACCGGGCTCCTGGTCG
CGCGGCCGCAGAAGGAACATCTTGCGAACCGCGGCCGTGCCGAACAGGTCCTTCCCCTCGTCCTGTCGCTGACATCAAGA
AGCTCTCTCGACGATGTCATCGCAGCGATCTCATCGGCAACGGAGGAGGGGCTTGCCCGGCTCGTTCCGCTGGAGCGCAT
CACGCAGGAACTGGTCGTCGACGAAGCGGCCGCCCAGGAAGCCGTGGTCAAGGCGCTGTTCGAATTCCGCGAGCCGTATC
CGGTCCCAAGACACGCAACAAATCTGGAACCACTGGGCGCGCGCGCCGATAGCGAGCTTTCCCTGGTGGTCGAGGCACGT
CTGGATGGGGCCGCAGCTGGGCTGATCGATTATGCGCAGGATCTCTATGACGGCGCGCTGATTGCCCGTGTCTCCCGGCA
TTTCACCCTCGTGCTCGAGCAGATCGTTGCGCGGCCGAAGGTGCGGATCAAGGACATCGAACTCGTGGGGTGCGACGAGC
TCGACCAGTTGTCGGCGCCCTACGAAGACGAGGTCGTCAACGACGACAGACCGGTCCACGAGCTGATATCGGCCCATTCG
CGCCAGACGCCGAAGAAGACGGCGATTGTCTACGGTGACGAGGAATGGAGCCATGGCTGGCTGGAGGCCAGTACCAACCG
TCTCGCACATCGGTTGCGGCAACTGGGCGTTCGTGCCGAGGTGACGGTCGCCATCTTCATCAAGCGATCGCCGGAGGCCA
TCGTCGGGATCCTCGCGACGCTGAAGGCGGGCGGCGCCTATATCCCGGTCGAGCCCGACCATCCGCCGGTCCGCAACCAT
CACATTCTGCGCGACGGCGGCGTCAAAATCGTCCTGACCCATAGCTGGCTTCGCCATCGGCTGCCGGAAGAGCTCGACAC
CATTATCCTCGAACTCGACAAGATCGACCTCGACGGCGAGCCGGATACGCCGCTTGATATTCCCACTCACAAGGATCAGC
TCGCCTATGTCATGTACACCTCCGGATCGACCGGACTACCGAAGGGTGTGGCCGTCGAGCACGGTCCGCTGACGCACCAT
CTGCAGAACACCTCGCGTGTCTATGGCATGAGCTCGGCATCCCGCGAGCTGCCGTTCCTGCCTTTCAGTTCGGATGGCGG
GCACGAGCGGTGGATGAACCCGCTGATGGAAGGCGGCAGCATCATTCTTCCCGACCAGCCGCTGTGGACACCGGAAGAGA
CATTGACGGCCATGCGCAAGCATGGCGCCAACAATGCGAGCATTCCGACCACCTATCTGCAGCAACTGGCGGAATGGGCC
GATATTTCAGACGGCGCGCCGCCGATGCGGCTTTACTCTTTCGGTGGCGAGGGGCTGGCGCAACCGACCTTCGATCTTCT
GTCGCGGGCGCTGAAATCGGAATGGCTGATCAACGGCTACGGGCCGACCGAAACCATCATGACGCCGATGGTCTGGAAGG
TGAGGGCCGGCACGAAATTTCAGGGTGTCTATGCTCCGCTCGGTCGCGCTGTCGGGTTAAGGCGCATCTATGTGCTCGAC
CCTGACCTCAATCCGTGCCCGATCGGCGTGACTGGCGAGCTCTATATCGGCGGCGAGGGCATCGCACGCGGCTATCTCGG
CAAGCCGGATACGACTGCGGACCGCTTCATCCCCGATCCGTTCTTCACGGAAGGCGGCCGGCTTTATCGCTCCGGTGATC
TGACGCGTTGGCGTGATGACGGAACCGTCGAATTCGTCGGTCGTGTCGACCATCAGGTGAAGCTCCGTGGCTACCGGATC
GAGCTCGGCGAGATCGAAGCGGCCCTGCTCCAGCAGCCAGGCGTCGGCGAGGCCCTGGTCGTCCTGCGCGATGACGATGC
CGGCGGCGACAAGGCGCTCGTTGCCTACGTCGTTCCGAAGAAAGACGAGACGTTGAACGTCGAGACGATCCGCGCCGGCC
TCGAGCGCAGCCTGCCGTCCTATATGGTGCCGGCTGCCGTGGTCGAACTGGAAAAAATGCCGACCAATCCGAACAGCAAG
CTCGATCGATTTGCGCTGCCGGCGCCACAACCGGTCAAACGCACAATCGTCCAGCCGTCAACCGTGCTCGAAGAAGAGGT
GCTGGATGTCTGGCGGCAGATTCTCAAGCTGGAAGCAATCAGCGTCGAGGACAATTTCTTCGCGATCGGCGGCAATTCGC
TTGGCGCGATCCGCATCCTTTCGCAGTTGCGGCAGCGCCGGCCGAAAACCCCGCTCACCGTCGCCGATATCTTCAACAAT
CCGACCGTGCGCTCATTTGCCGGCGTAATCGAGCAGGGAGACCAACGGGATCTGTCGGAGGTGATCGTGCTGCGTGCTTC
CGGCGTCAAGCCGCGGCTCTATTGCTTCCCAGGCCTTCTCGTCAGTACCCGTGAATACGTCAAGCTCGTCGACTATCTCG
GAGCCGATCAGCCGGCAACCGGCTTTATCTGCCACTCGCTTTCCGAGAAAAAGGCAGTCGGCGCTCCGGTCGAAGAGATC
ATCGAGAGCTATGTCGACTATATCAGGACGCACAGCCAGGGAGCGCCCTGCTATTTCCTCGGCTGGTCCTGGGGCGGGCT
TCTGGCCTATGAGGCTGCCCGCGCCCTCGGTGATGAGGTCGACGTCAGGATGATGGCGATGGTCGACGTTTGCGATCTCG
GATCGGAATTCGCGATCGGCGCAAAGCCGAGGTTCCGGCCCGGCGAGCGCGATGAGCTTCACCGAGACGTGCAGGCATGG
CTTGGAAGAACGGCGATGCGTCCCGAATGGGACCGGCTGCTGTCGACGATGGACGCGGATACCTACGATCAGTTCCTGCG
CTTTGTCGGCGACGAAAAGGATCCGCTTCCAAACGACGGGCCCGATATCAGCAGTCGCGAGCATACGTTTTGGGTGCTGA
TCGACAATGCCCTGATCTTCCGCAAGCACCGGCTCGTTCCTCACGATGTGCCGATCTATCCCTGGGCTGCTGACGACAGC
CTCAACCGCGGCCTCAACCTGATCGACTGGCGCCGCCTGTCGCCGCGGGCGCGTGCGGCCGAAATCATCACCGGCACCAA
CCATCTGCACATGATCGGGTCTCCCGCCTTCCACTCAAGGCTTGCCCTGCGTCTCAAGGAAACAGAGAAGGATATCGCAT
GA

Upstream 100 bases:

>100_bases
CAGCAATGCCTGGCGCATATCGCTGACGTCTGGGCGGATCCGCGCCCCCTCTCCTTGCGCTCGGCAATCGCCGGCGATGC
GCGTCTCTGAAAACGGCTGG

Downstream 100 bases:

>100_bases
CCGTCGCTTTTGCCCGCAGGGATGCCGAGCCGCTGGATATTGCCGGCATCGGCATCGGCCCCTCCAATCTGAGCCTCGCC
TGCCTGTTCGAGTCGGTGCC

Product: putative non-ribosomal peptide synthetase

Products: pyrophosphate; AMP; enterobactin; pyrophosphate; L-Seryl-AMP [C]

Alternate protein names: ATP-dependent valine adenylase; ValA; Valine activase; ATP-dependent D-valine adenylase; D-ValA; D-valine activase; Valine racemase [ATP-hydrolyzing]; ATP-dependent tryptophan adenylase; TrpA; Tryptophan activase; ATP-dependent D-leucine adenylase; D-LeuA; D-leucine activase; Leucine racemase [ATP-hydrolyzing]; ATP-dependent tryptophan/phenylalanine/tyrosine adenylase; Trp/Phe/TyrA; Tryptophan/phenylalanine/tyrosine activase; ATP-dependent D-leucine adenylase; D-LeuA; D-leucine activase; Leucine racemase [ATP-hydrolyzing] [H]

Number of amino acids: Translated: 1333; Mature: 1332

Protein sequence:

>1333_residues
MARMNKQITNFADAYPTDVATDAIFESFPLTIAQKRIWSLEQIGNETVFPDQVISLRLSPAVDVKTIAGACRTLVAQHPS
LATRFRRLAGGRVEQYCGALNAVPIEIVGEGAALAEADALAAQKAFRDGRFDLLAGPPARVQIILLADGQSLLTIVLHPV
ISDDREKSILSGSLTRILDGAAAGDTQLTEILAGTREAEWLQTEQAQESLSYWRNTIGLDYAASTFPTRFNSGGLAGVAR
AQHRFSIEPDLWGKLGRHAQHKGYQVERVLHAAFCAMLARYSGNYALLTGLLVARPQKEHLANRGRAEQVLPLVLSLTSR
SSLDDVIAAISSATEEGLARLVPLERITQELVVDEAAAQEAVVKALFEFREPYPVPRHATNLEPLGARADSELSLVVEAR
LDGAAAGLIDYAQDLYDGALIARVSRHFTLVLEQIVARPKVRIKDIELVGCDELDQLSAPYEDEVVNDDRPVHELISAHS
RQTPKKTAIVYGDEEWSHGWLEASTNRLAHRLRQLGVRAEVTVAIFIKRSPEAIVGILATLKAGGAYIPVEPDHPPVRNH
HILRDGGVKIVLTHSWLRHRLPEELDTIILELDKIDLDGEPDTPLDIPTHKDQLAYVMYTSGSTGLPKGVAVEHGPLTHH
LQNTSRVYGMSSASRELPFLPFSSDGGHERWMNPLMEGGSIILPDQPLWTPEETLTAMRKHGANNASIPTTYLQQLAEWA
DISDGAPPMRLYSFGGEGLAQPTFDLLSRALKSEWLINGYGPTETIMTPMVWKVRAGTKFQGVYAPLGRAVGLRRIYVLD
PDLNPCPIGVTGELYIGGEGIARGYLGKPDTTADRFIPDPFFTEGGRLYRSGDLTRWRDDGTVEFVGRVDHQVKLRGYRI
ELGEIEAALLQQPGVGEALVVLRDDDAGGDKALVAYVVPKKDETLNVETIRAGLERSLPSYMVPAAVVELEKMPTNPNSK
LDRFALPAPQPVKRTIVQPSTVLEEEVLDVWRQILKLEAISVEDNFFAIGGNSLGAIRILSQLRQRRPKTPLTVADIFNN
PTVRSFAGVIEQGDQRDLSEVIVLRASGVKPRLYCFPGLLVSTREYVKLVDYLGADQPATGFICHSLSEKKAVGAPVEEI
IESYVDYIRTHSQGAPCYFLGWSWGGLLAYEAARALGDEVDVRMMAMVDVCDLGSEFAIGAKPRFRPGERDELHRDVQAW
LGRTAMRPEWDRLLSTMDADTYDQFLRFVGDEKDPLPNDGPDISSREHTFWVLIDNALIFRKHRLVPHDVPIYPWAADDS
LNRGLNLIDWRRLSPRARAAEIITGTNHLHMIGSPAFHSRLALRLKETEKDIA

Sequences:

>Translated_1333_residues
MARMNKQITNFADAYPTDVATDAIFESFPLTIAQKRIWSLEQIGNETVFPDQVISLRLSPAVDVKTIAGACRTLVAQHPS
LATRFRRLAGGRVEQYCGALNAVPIEIVGEGAALAEADALAAQKAFRDGRFDLLAGPPARVQIILLADGQSLLTIVLHPV
ISDDREKSILSGSLTRILDGAAAGDTQLTEILAGTREAEWLQTEQAQESLSYWRNTIGLDYAASTFPTRFNSGGLAGVAR
AQHRFSIEPDLWGKLGRHAQHKGYQVERVLHAAFCAMLARYSGNYALLTGLLVARPQKEHLANRGRAEQVLPLVLSLTSR
SSLDDVIAAISSATEEGLARLVPLERITQELVVDEAAAQEAVVKALFEFREPYPVPRHATNLEPLGARADSELSLVVEAR
LDGAAAGLIDYAQDLYDGALIARVSRHFTLVLEQIVARPKVRIKDIELVGCDELDQLSAPYEDEVVNDDRPVHELISAHS
RQTPKKTAIVYGDEEWSHGWLEASTNRLAHRLRQLGVRAEVTVAIFIKRSPEAIVGILATLKAGGAYIPVEPDHPPVRNH
HILRDGGVKIVLTHSWLRHRLPEELDTIILELDKIDLDGEPDTPLDIPTHKDQLAYVMYTSGSTGLPKGVAVEHGPLTHH
LQNTSRVYGMSSASRELPFLPFSSDGGHERWMNPLMEGGSIILPDQPLWTPEETLTAMRKHGANNASIPTTYLQQLAEWA
DISDGAPPMRLYSFGGEGLAQPTFDLLSRALKSEWLINGYGPTETIMTPMVWKVRAGTKFQGVYAPLGRAVGLRRIYVLD
PDLNPCPIGVTGELYIGGEGIARGYLGKPDTTADRFIPDPFFTEGGRLYRSGDLTRWRDDGTVEFVGRVDHQVKLRGYRI
ELGEIEAALLQQPGVGEALVVLRDDDAGGDKALVAYVVPKKDETLNVETIRAGLERSLPSYMVPAAVVELEKMPTNPNSK
LDRFALPAPQPVKRTIVQPSTVLEEEVLDVWRQILKLEAISVEDNFFAIGGNSLGAIRILSQLRQRRPKTPLTVADIFNN
PTVRSFAGVIEQGDQRDLSEVIVLRASGVKPRLYCFPGLLVSTREYVKLVDYLGADQPATGFICHSLSEKKAVGAPVEEI
IESYVDYIRTHSQGAPCYFLGWSWGGLLAYEAARALGDEVDVRMMAMVDVCDLGSEFAIGAKPRFRPGERDELHRDVQAW
LGRTAMRPEWDRLLSTMDADTYDQFLRFVGDEKDPLPNDGPDISSREHTFWVLIDNALIFRKHRLVPHDVPIYPWAADDS
LNRGLNLIDWRRLSPRARAAEIITGTNHLHMIGSPAFHSRLALRLKETEKDIA
>Mature_1332_residues
ARMNKQITNFADAYPTDVATDAIFESFPLTIAQKRIWSLEQIGNETVFPDQVISLRLSPAVDVKTIAGACRTLVAQHPSL
ATRFRRLAGGRVEQYCGALNAVPIEIVGEGAALAEADALAAQKAFRDGRFDLLAGPPARVQIILLADGQSLLTIVLHPVI
SDDREKSILSGSLTRILDGAAAGDTQLTEILAGTREAEWLQTEQAQESLSYWRNTIGLDYAASTFPTRFNSGGLAGVARA
QHRFSIEPDLWGKLGRHAQHKGYQVERVLHAAFCAMLARYSGNYALLTGLLVARPQKEHLANRGRAEQVLPLVLSLTSRS
SLDDVIAAISSATEEGLARLVPLERITQELVVDEAAAQEAVVKALFEFREPYPVPRHATNLEPLGARADSELSLVVEARL
DGAAAGLIDYAQDLYDGALIARVSRHFTLVLEQIVARPKVRIKDIELVGCDELDQLSAPYEDEVVNDDRPVHELISAHSR
QTPKKTAIVYGDEEWSHGWLEASTNRLAHRLRQLGVRAEVTVAIFIKRSPEAIVGILATLKAGGAYIPVEPDHPPVRNHH
ILRDGGVKIVLTHSWLRHRLPEELDTIILELDKIDLDGEPDTPLDIPTHKDQLAYVMYTSGSTGLPKGVAVEHGPLTHHL
QNTSRVYGMSSASRELPFLPFSSDGGHERWMNPLMEGGSIILPDQPLWTPEETLTAMRKHGANNASIPTTYLQQLAEWAD
ISDGAPPMRLYSFGGEGLAQPTFDLLSRALKSEWLINGYGPTETIMTPMVWKVRAGTKFQGVYAPLGRAVGLRRIYVLDP
DLNPCPIGVTGELYIGGEGIARGYLGKPDTTADRFIPDPFFTEGGRLYRSGDLTRWRDDGTVEFVGRVDHQVKLRGYRIE
LGEIEAALLQQPGVGEALVVLRDDDAGGDKALVAYVVPKKDETLNVETIRAGLERSLPSYMVPAAVVELEKMPTNPNSKL
DRFALPAPQPVKRTIVQPSTVLEEEVLDVWRQILKLEAISVEDNFFAIGGNSLGAIRILSQLRQRRPKTPLTVADIFNNP
TVRSFAGVIEQGDQRDLSEVIVLRASGVKPRLYCFPGLLVSTREYVKLVDYLGADQPATGFICHSLSEKKAVGAPVEEII
ESYVDYIRTHSQGAPCYFLGWSWGGLLAYEAARALGDEVDVRMMAMVDVCDLGSEFAIGAKPRFRPGERDELHRDVQAWL
GRTAMRPEWDRLLSTMDADTYDQFLRFVGDEKDPLPNDGPDISSREHTFWVLIDNALIFRKHRLVPHDVPIYPWAADDSL
NRGLNLIDWRRLSPRARAAEIITGTNHLHMIGSPAFHSRLALRLKETEKDIA

Specific function: Activates the 7th to 12th amino acids (Val, D-Val, Trp, D-Leu, Xaa and D-Leu) in linear gramicidin and catalyzes the formation of the peptide bond between them. This enzyme is also responsible for the epimerization of the 8th (D-Val), the 10th (D- Leu) an

COG id: COG1020

COG function: function code Q; Non-ribosomal peptide synthetase modules and related proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 6 acyl carrier domains [H]

Homologues:

Organism=Homo sapiens, GI45580730, Length=553, Percent_Identity=24.2314647377938, Blast_Score=89, Evalue=2e-17,
Organism=Homo sapiens, GI187761345, Length=497, Percent_Identity=23.5412474849095, Blast_Score=89, Evalue=2e-17,
Organism=Homo sapiens, GI187761343, Length=497, Percent_Identity=23.5412474849095, Blast_Score=89, Evalue=2e-17,
Organism=Homo sapiens, GI156151445, Length=559, Percent_Identity=21.824686940966, Blast_Score=84, Evalue=9e-16,
Organism=Homo sapiens, GI42544132, Length=388, Percent_Identity=23.4536082474227, Blast_Score=72, Evalue=5e-12,
Organism=Homo sapiens, GI157311624, Length=478, Percent_Identity=23.0125523012552, Blast_Score=69, Evalue=3e-11,
Organism=Homo sapiens, GI157311622, Length=478, Percent_Identity=23.0125523012552, Blast_Score=69, Evalue=3e-11,
Organism=Homo sapiens, GI58082049, Length=482, Percent_Identity=23.0290456431535, Blast_Score=69, Evalue=4e-11,
Organism=Escherichia coli, GI1786801, Length=896, Percent_Identity=27.1205357142857, Blast_Score=250, Evalue=4e-67,
Organism=Escherichia coli, GI145693145, Length=547, Percent_Identity=23.5831809872029, Blast_Score=107, Evalue=7e-24,
Organism=Escherichia coli, GI1786810, Length=543, Percent_Identity=23.7569060773481, Blast_Score=90, Evalue=1e-18,
Organism=Escherichia coli, GI1788107, Length=531, Percent_Identity=24.105461393597, Blast_Score=86, Evalue=2e-17,
Organism=Escherichia coli, GI1790505, Length=563, Percent_Identity=23.4458259325044, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17556356, Length=708, Percent_Identity=25.2824858757062, Blast_Score=145, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17550940, Length=551, Percent_Identity=23.2304900181488, Blast_Score=133, Evalue=6e-31,
Organism=Caenorhabditis elegans, GI32563687, Length=505, Percent_Identity=24.1584158415842, Blast_Score=108, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17538037, Length=543, Percent_Identity=23.3885819521179, Blast_Score=103, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI17558820, Length=453, Percent_Identity=25.8278145695364, Blast_Score=99, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17559526, Length=383, Percent_Identity=24.2819843342037, Blast_Score=79, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17560308, Length=385, Percent_Identity=22.5974025974026, Blast_Score=73, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6319591, Length=749, Percent_Identity=25.6341789052069, Blast_Score=214, Evalue=8e-56,
Organism=Saccharomyces cerevisiae, GI6319699, Length=352, Percent_Identity=24.1477272727273, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24648676, Length=623, Percent_Identity=27.4478330658106, Blast_Score=169, Evalue=1e-41,
Organism=Drosophila melanogaster, GI18859661, Length=542, Percent_Identity=23.6162361623616, Blast_Score=95, Evalue=3e-19,
Organism=Drosophila melanogaster, GI21355181, Length=542, Percent_Identity=22.6937269372694, Blast_Score=91, Evalue=8e-18,
Organism=Drosophila melanogaster, GI19922652, Length=510, Percent_Identity=23.5294117647059, Blast_Score=86, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24581924, Length=366, Percent_Identity=23.7704918032787, Blast_Score=71, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010071
- InterPro:   IPR009081
- InterPro:   IPR020845
- InterPro:   IPR000873
- InterPro:   IPR023213
- InterPro:   IPR001242
- InterPro:   IPR010060
- InterPro:   IPR006163
- InterPro:   IPR020806
- InterPro:   IPR006162 [H]

Pfam domain/function: PF00501 AMP-binding; PF00668 Condensation; PF00550 PP-binding [H]

EC number: 2.7.7.- [C]

Molecular weight: Translated: 147240; Mature: 147109

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: PS00012 PHOSPHOPANTETHEINE ; PS50075 ACP_DOMAIN ; PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARMNKQITNFADAYPTDVATDAIFESFPLTIAQKRIWSLEQIGNETVFPDQVISLRLSP
CCCCHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCEEEEECCC
AVDVKTIAGACRTLVAQHPSLATRFRRLAGGRVEQYCGALNAVPIEIVGEGAALAEADAL
CCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHCCCCCCEEEEECCCCHHHHHHHH
AAQKAFRDGRFDLLAGPPARVQIILLADGQSLLTIVLHPVISDDREKSILSGSLTRILDG
HHHHHHCCCCEEEEECCCCEEEEEEEECCCCEEHHHHHHHHCCCHHHHHHHHHHHHHHCC
AAAGDTQLTEILAGTREAEWLQTEQAQESLSYWRNTIGLDYAASTFPTRFNSGGLAGVAR
CCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHH
AQHRFSIEPDLWGKLGRHAQHKGYQVERVLHAAFCAMLARYSGNYALLTGLLVARPQKEH
HHHCCCCCHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHH
LANRGRAEQVLPLVLSLTSRSSLDDVIAAISSATEEGLARLVPLERITQELVVDEAAAQE
HHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
AVVKALFEFREPYPVPRHATNLEPLGARADSELSLVVEARLDGAAAGLIDYAQDLYDGAL
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHCHHH
IARVSRHFTLVLEQIVARPKVRIKDIELVGCDELDQLSAPYEDEVVNDDRPVHELISAHS
HHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHCCCCCCCCCCCCCCHHHHHHHHHC
RQTPKKTAIVYGDEEWSHGWLEASTNRLAHRLRQLGVRAEVTVAIFIKRSPEAIVGILAT
CCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEEEEECCCHHHHHHHHH
LKAGGAYIPVEPDHPPVRNHHILRDGGVKIVLTHSWLRHRLPEELDTIILELDKIDLDGE
HHCCCEEECCCCCCCCCCCCEEEECCCEEEEEECHHHHHHCHHHHHHHHHHHEEECCCCC
PDTPLDIPTHKDQLAYVMYTSGSTGLPKGVAVEHGPLTHHLQNTSRVYGMSSASRELPFL
CCCCCCCCCCCCCEEEEEEECCCCCCCCCCEECCCCCHHHHCCCHHEEECCCCCCCCCCC
PFSSDGGHERWMNPLMEGGSIILPDQPLWTPEETLTAMRKHGANNASIPTTYLQQLAEWA
CCCCCCCHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
DISDGAPPMRLYSFGGEGLAQPTFDLLSRALKSEWLINGYGPTETIMTPMVWKVRAGTKF
CCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHCCEEECCCCHHHHHCCCEEEEECCCEE
QGVYAPLGRAVGLRRIYVLDPDLNPCPIGVTGELYIGGEGIARGYLGKPDTTADRFIPDP
CCHHHHHHHHCCCEEEEEECCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCHHHCCCCC
FFTEGGRLYRSGDLTRWRDDGTVEFVGRVDHQVKLRGYRIELGEIEAALLQQPGVGEALV
CCCCCCCEEECCCCCEECCCCCEEEEECCCCEEEEEEEEEEHHHHHHHHHCCCCCCCEEE
VLRDDDAGGDKALVAYVVPKKDETLNVETIRAGLERSLPSYMVPAAVVELEKMPTNPNSK
EEECCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCC
LDRFALPAPQPVKRTIVQPSTVLEEEVLDVWRQILKLEAISVEDNFFAIGGNSLGAIRIL
CHHCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHEEEECCCEEEECCCCCHHHHHH
SQLRQRRPKTPLTVADIFNNPTVRSFAGVIEQGDQRDLSEVIVLRASGVKPRLYCFPGLL
HHHHHHCCCCCEEHHHHCCCCCHHHHHHHHHCCCCCCHHHEEEEEECCCCCEEEECCCHH
VSTREYVKLVDYLGADQPATGFICHSLSEKKAVGAPVEEIIESYVDYIRTHSQGAPCYFL
HHHHHHHHHHHHHCCCCCCCCHHHHCCCHHHCCCCCHHHHHHHHHHHHHHCCCCCCEEEE
GWSWGGLLAYEAARALGDEVDVRMMAMVDVCDLGSEFAIGAKPRFRPGERDELHRDVQAW
ECCCCHHHHHHHHHHCCCHHCCHHHHHHHHHHCCCCCEECCCCCCCCCCHHHHHHHHHHH
LGRTAMRPEWDRLLSTMDADTYDQFLRFVGDEKDPLPNDGPDISSREHTFWVLIDNALIF
HCCCCCCCHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEECCEEEE
RKHRLVPHDVPIYPWAADDSLNRGLNLIDWRRLSPRARAAEIITGTNHLHMIGSPAFHSR
HHCCCCCCCCCCCCCCCCCHHHCCCCCEECCCCCCHHHHHHEEECCCCEEEECCCHHHHH
LALRLKETEKDIA
HHHHHHHHHCCCC
>Mature Secondary Structure 
ARMNKQITNFADAYPTDVATDAIFESFPLTIAQKRIWSLEQIGNETVFPDQVISLRLSP
CCCHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCEEEEECCC
AVDVKTIAGACRTLVAQHPSLATRFRRLAGGRVEQYCGALNAVPIEIVGEGAALAEADAL
CCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHCCCCCCEEEEECCCCHHHHHHHH
AAQKAFRDGRFDLLAGPPARVQIILLADGQSLLTIVLHPVISDDREKSILSGSLTRILDG
HHHHHHCCCCEEEEECCCCEEEEEEEECCCCEEHHHHHHHHCCCHHHHHHHHHHHHHHCC
AAAGDTQLTEILAGTREAEWLQTEQAQESLSYWRNTIGLDYAASTFPTRFNSGGLAGVAR
CCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHH
AQHRFSIEPDLWGKLGRHAQHKGYQVERVLHAAFCAMLARYSGNYALLTGLLVARPQKEH
HHHCCCCCHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHH
LANRGRAEQVLPLVLSLTSRSSLDDVIAAISSATEEGLARLVPLERITQELVVDEAAAQE
HHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
AVVKALFEFREPYPVPRHATNLEPLGARADSELSLVVEARLDGAAAGLIDYAQDLYDGAL
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHCHHH
IARVSRHFTLVLEQIVARPKVRIKDIELVGCDELDQLSAPYEDEVVNDDRPVHELISAHS
HHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHCCCCCCCCCCCCCCHHHHHHHHHC
RQTPKKTAIVYGDEEWSHGWLEASTNRLAHRLRQLGVRAEVTVAIFIKRSPEAIVGILAT
CCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEEEEECCCHHHHHHHHH
LKAGGAYIPVEPDHPPVRNHHILRDGGVKIVLTHSWLRHRLPEELDTIILELDKIDLDGE
HHCCCEEECCCCCCCCCCCCEEEECCCEEEEEECHHHHHHCHHHHHHHHHHHEEECCCCC
PDTPLDIPTHKDQLAYVMYTSGSTGLPKGVAVEHGPLTHHLQNTSRVYGMSSASRELPFL
CCCCCCCCCCCCCEEEEEEECCCCCCCCCCEECCCCCHHHHCCCHHEEECCCCCCCCCCC
PFSSDGGHERWMNPLMEGGSIILPDQPLWTPEETLTAMRKHGANNASIPTTYLQQLAEWA
CCCCCCCHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
DISDGAPPMRLYSFGGEGLAQPTFDLLSRALKSEWLINGYGPTETIMTPMVWKVRAGTKF
CCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHCCEEECCCCHHHHHCCCEEEEECCCEE
QGVYAPLGRAVGLRRIYVLDPDLNPCPIGVTGELYIGGEGIARGYLGKPDTTADRFIPDP
CCHHHHHHHHCCCEEEEEECCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCHHHCCCCC
FFTEGGRLYRSGDLTRWRDDGTVEFVGRVDHQVKLRGYRIELGEIEAALLQQPGVGEALV
CCCCCCCEEECCCCCEECCCCCEEEEECCCCEEEEEEEEEEHHHHHHHHHCCCCCCCEEE
VLRDDDAGGDKALVAYVVPKKDETLNVETIRAGLERSLPSYMVPAAVVELEKMPTNPNSK
EEECCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCC
LDRFALPAPQPVKRTIVQPSTVLEEEVLDVWRQILKLEAISVEDNFFAIGGNSLGAIRIL
CHHCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHEEEECCCEEEECCCCCHHHHHH
SQLRQRRPKTPLTVADIFNNPTVRSFAGVIEQGDQRDLSEVIVLRASGVKPRLYCFPGLL
HHHHHHCCCCCEEHHHHCCCCCHHHHHHHHHCCCCCCHHHEEEEEECCCCCEEEECCCHH
VSTREYVKLVDYLGADQPATGFICHSLSEKKAVGAPVEEIIESYVDYIRTHSQGAPCYFL
HHHHHHHHHHHHHCCCCCCCCHHHHCCCHHHCCCCCHHHHHHHHHHHHHHCCCCCCEEEE
GWSWGGLLAYEAARALGDEVDVRMMAMVDVCDLGSEFAIGAKPRFRPGERDELHRDVQAW
ECCCCHHHHHHHHHHCCCHHCCHHHHHHHHHHCCCCCEECCCCCCCCCCHHHHHHHHHHH
LGRTAMRPEWDRLLSTMDADTYDQFLRFVGDEKDPLPNDGPDISSREHTFWVLIDNALIF
HCCCCCCCHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEECCEEEE
RKHRLVPHDVPIYPWAADDSLNRGLNLIDWRRLSPRARAAEIITGTNHLHMIGSPAFHSR
HHCCCCCCCCCCCCCCCCCHHHCCCCCEECCCCCCHHHHHHEEECCCCEEEECCCHHHHH
LALRLKETEKDIA
HHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Phosphopantetheine. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 6 ATP; L-serine; 2,3-dihydroxybenzoate [C]

Specific reaction: 6 ATP + 3 L-serine + 3 2,3-dihydroxybenzoate = 6 pyrophosphate + 6 AMP + enterobactin ATP + L-serine = pyrophosphate + L-Seryl-AMP 6 ATP + 3 L-serine + 3 2,3-dihydroxybenzoate = 6 pyrophosphate + 6 AMP + enterobactin ATP + L-serine = pyrophosphate + L-Ser

General reaction: Transferases; Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA