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The map label for this gene is lacR [H]

Identifier: 116248869

GI number: 116248869

Start: 207191

End: 208033

Strand: Reverse

Name: lacR [H]

Synonym: pRL120199

Alternate gene names: 116248869

Gene position: 208033-207191 (Counterclockwise)

Preceding gene: 116248870

Following gene: 116248868

Centisome position: 23.91

GC content: 59.79

Gene sequence:

>843_bases
GTGACACAGAAGACCAGCCGGGACGACGATCTGTTGGACCAGCTCACCAGCGACAGCCGGCAGACGCGCCAGATCGCGCG
CCGCCGCATGATTGCAGAGGCCGTGATGGGTGAAGGCTCGATGCGGATTGAAGACCTGACCGACCGCTTTGGGATCAGCC
TGATGACGGCTCACCGCGACGTCGATGAACTCGTCAGCCGCGGCCTCTTCAGGAAGACGCGCGGTATCGTCACTGCGGCG
GCGACCAATCTCATCGAATCCAGCGACGTCTATCGCTCGAACCGTCAGTCCGCCGAAAAGAAGCTGATTGCCGAGGCGGC
AATGCAGTTCGTCGAACCGGGACAGGCGATCTTTTTCGATGACTCGACCACGGTTCTTCAGATGGCGGCACATCTGCCTT
CGAAGGCGCCGGTCACCGCAATTACCAATTCCCTGACGCTGATGAATGCGCTGACGGGCCTGCACGACGTGACGCTGCTC
GCCCTCGGCGGCCAGTATTACAATTGGTGCAACGCCTTCATGGGTCGCATGACCATCAACGAGATCAACGCTCTCAGGGC
AGATGTCGCGTTCATCTCGATGTCGGCGATCAGCGATGGCACGGTGCTGCACCAGTCTCCTGAAACAGTCGATACCAAGC
GCGCCATGTTCGACTGTTCCGTAAAACGCATCCTGCTTGCCGATCATACCAAGTTCGAACGGCGCGCACTCCACAGTTTC
GCAGCACTGGATGAGTTCGACGTCGTTATCGTCGACGACAAGACCCAGCCGGTGCACATAGACCGTATGCGGTCCAGAGA
TATCAACGTGGTCATCGCCAGGGGCGCCGGAGGGCGCTCCTGA

Upstream 100 bases:

>100_bases
TGGCCGACGGCCCAACCGCCGGTTGCGCTTCGCCTTTTTGCCTTGGCGCGGCAATCACTGTACGAAGCTGGGATCCATAA
TTCAGCGACAGGGGTGACCC

Downstream 100 bases:

>100_bases
CGGCGCCGGCCGTTGCCCCTCATGAGGTAAATTTAAATGCCGACACTGCTCGGGATCGATAGTGGTTTGACAGTCACCAA
GGCGGTCATCTTCGATATCG

Product: DeoR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 280; Mature: 279

Protein sequence:

>280_residues
MTQKTSRDDDLLDQLTSDSRQTRQIARRRMIAEAVMGEGSMRIEDLTDRFGISLMTAHRDVDELVSRGLFRKTRGIVTAA
ATNLIESSDVYRSNRQSAEKKLIAEAAMQFVEPGQAIFFDDSTTVLQMAAHLPSKAPVTAITNSLTLMNALTGLHDVTLL
ALGGQYYNWCNAFMGRMTINEINALRADVAFISMSAISDGTVLHQSPETVDTKRAMFDCSVKRILLADHTKFERRALHSF
AALDEFDVVIVDDKTQPVHIDRMRSRDINVVIARGAGGRS

Sequences:

>Translated_280_residues
MTQKTSRDDDLLDQLTSDSRQTRQIARRRMIAEAVMGEGSMRIEDLTDRFGISLMTAHRDVDELVSRGLFRKTRGIVTAA
ATNLIESSDVYRSNRQSAEKKLIAEAAMQFVEPGQAIFFDDSTTVLQMAAHLPSKAPVTAITNSLTLMNALTGLHDVTLL
ALGGQYYNWCNAFMGRMTINEINALRADVAFISMSAISDGTVLHQSPETVDTKRAMFDCSVKRILLADHTKFERRALHSF
AALDEFDVVIVDDKTQPVHIDRMRSRDINVVIARGAGGRS
>Mature_279_residues
TQKTSRDDDLLDQLTSDSRQTRQIARRRMIAEAVMGEGSMRIEDLTDRFGISLMTAHRDVDELVSRGLFRKTRGIVTAAA
TNLIESSDVYRSNRQSAEKKLIAEAAMQFVEPGQAIFFDDSTTVLQMAAHLPSKAPVTAITNSLTLMNALTGLHDVTLLA
LGGQYYNWCNAFMGRMTINEINALRADVAFISMSAISDGTVLHQSPETVDTKRAMFDCSVKRILLADHTKFERRALHSFA
ALDEFDVVIVDDKTQPVHIDRMRSRDINVVIARGAGGRS

Specific function: Repressor of the lactose catabolism operon. Galactose-6- phosphate is the inducer [H]

COG id: COG1349

COG function: function code KG; Transcriptional regulators of sugar metabolism

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH deoR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI226510968, Length=250, Percent_Identity=28.8, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1789519, Length=261, Percent_Identity=25.6704980842912, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1789829, Length=231, Percent_Identity=28.5714285714286, Blast_Score=94, Evalue=7e-21,
Organism=Escherichia coli, GI1789059, Length=250, Percent_Identity=28.4, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1790635, Length=246, Percent_Identity=23.9837398373984, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1788069, Length=247, Percent_Identity=23.4817813765182, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1789170, Length=232, Percent_Identity=25, Blast_Score=74, Evalue=8e-15,
Organism=Escherichia coli, GI87082344, Length=264, Percent_Identity=25, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI1787540, Length=239, Percent_Identity=25.5230125523013, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1787063, Length=254, Percent_Identity=22.8346456692913, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014036
- InterPro:   IPR001034
- InterPro:   IPR018356
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00455 DeoR; PF08220 HTH_DeoR [H]

EC number: NA

Molecular weight: Translated: 31097; Mature: 30966

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: PS00894 HTH_DEOR_1 ; PS51000 HTH_DEOR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQKTSRDDDLLDQLTSDSRQTRQIARRRMIAEAVMGEGSMRIEDLTDRFGISLMTAHRD
CCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHCC
VDELVSRGLFRKTRGIVTAAATNLIESSDVYRSNRQSAEKKLIAEAAMQFVEPGQAIFFD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEC
DSTTVLQMAAHLPSKAPVTAITNSLTLMNALTGLHDVTLLALGGQYYNWCNAFMGRMTIN
CCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEECCHHHHHHHHHHHCCHHH
EINALRADVAFISMSAISDGTVLHQSPETVDTKRAMFDCSVKRILLADHTKFERRALHSF
HHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
AALDEFDVVIVDDKTQPVHIDRMRSRDINVVIARGAGGRS
HHHCCCCEEEECCCCCCEEHHHHCCCCCEEEEEECCCCCC
>Mature Secondary Structure 
TQKTSRDDDLLDQLTSDSRQTRQIARRRMIAEAVMGEGSMRIEDLTDRFGISLMTAHRD
CCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHCC
VDELVSRGLFRKTRGIVTAAATNLIESSDVYRSNRQSAEKKLIAEAAMQFVEPGQAIFFD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEC
DSTTVLQMAAHLPSKAPVTAITNSLTLMNALTGLHDVTLLALGGQYYNWCNAFMGRMTIN
CCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEECCHHHHHHHHHHHCCHHH
EINALRADVAFISMSAISDGTVLHQSPETVDTKRAMFDCSVKRILLADHTKFERRALHSF
HHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
AALDEFDVVIVDDKTQPVHIDRMRSRDINVVIARGAGGRS
HHHCCCCEEEECCCCCCEEHHHHCCCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2120234; 1901863 [H]