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The map label for this gene is lyx [H]

Identifier: 116248868

GI number: 116248868

Start: 205625

End: 207154

Strand: Reverse

Name: lyx [H]

Synonym: pRL120198

Alternate gene names: 116248868

Gene position: 207154-205625 (Counterclockwise)

Preceding gene: 116248869

Following gene: 116248867

Centisome position: 23.81

GC content: 64.31

Gene sequence:

>1530_bases
ATGCCGACACTGCTCGGGATCGATAGTGGTTTGACAGTCACCAAGGCGGTCATCTTCGATATCGACGGCACGCCGCTTGC
AGCCGCGCGTCGCCGTGTCACGCAGTTCATTCCGAAGGCCCGCCATATCGAGCGCGACATGGATGAATTATGGAGCGCGA
CGGCCGATGCCATCCGCGAGGCGATTTCGCTCAGCGGGCGGCCAGCAAGCGACATAGAGGGCATTGCCGCTACCGCGCAC
GGAGACGGTATCTACCTGCTCGATCACGCCCAACAGCCGCTCGGCCGGGCCATTCTCTCGCTGGACAGCCGGGCAGGGGC
GATCGTCGACCGGTGGACGCAGAGCGATGTCGCCGACCTGGCGATCGAGCTGACGGGACAGATCCCGCACGTCTCCGCGC
CATCGGCATTGCTTGCCTGGATCCGCGAAATGGAGCCTGAGCGCTACAAGCGCATCGGCCATTTCTGCAGCTGCAAGGAC
TGGCTGCGGTTCTGCCTGACCGGGATCATCGGTACGGACCGCACCGAAGCGAGTACCTCCTTCACCAATGTCAAAACGCA
GAACTACAGTGAGGATGCCCTGCAGCTGTTTGGCTTACAGGATCTCGTCCACGCCCTGCCGCCAGCCTCGCGCTCCGACC
AGATCGTTGGACGCGTGACTCGTGAAGCCGCGCAGCTGACGGGCCTTGCCGAAGGAACGCCTGTCGTTGCCGGTCTGCAC
GACGTCACGGCCTCGGCGCTCGGGGCAGGGGGTTATGCCAAGGGCGTTGTCGCGGTCATTGCCGGGACCTATTCGATCAA
CGAGACGCTTTCGTCGGAACCGCGTGTCGACCGACGCTGGTTCTGCCGCAACGGGATTGCGCCCGGCATCTGGAACAGCA
TGTCGATCTCCCCTGCGTCGACAGCCAATTACGACTGGTTTCTGGCCACGCTCTGCGCTGCCGAGCGAACGAATGGCGAG
GTGCGAGGCAACTCGATCCACGCCCTGCTGGCGCCCGAGATCGACGCCGCCTTCGAACGCCCCTCGACGGCGCTCTTCCA
TCCCTATCTGTTCGGCTCGCCTTATGGCGCAGCCGCCAGCGCCGGCTTCTTCGGGCTCGGTGGATGGCACGACCGCGGCG
ACATGCTGCGCGCCGTGCTTGAGGGCATCGCCTTCAATCATCGCATCCATGTCGATGCGCTTCGCGACGGCTTTGCCTTC
GATCAGGCGCGGCTCGCCGGTGGCGTCTCGCGCAATCCTGCCGTCGTGCAGATGTTTGCCGATGTGCTTGGCATGCCGGT
CACGGTAACCGAGACGGATGAGGCAGCCGCCTGGGGTGCTGCGCTTTGTGCCGGCTCGGGCGCCGGTATCTTTGCCGATC
CGCAGAGCGATCCGCGCGACACGGCCTCCATCGCAAAGACTTGCCGGCCCGATGCGGCGCGCAGCGCGGATTATGAAAAG
CGTTACCAGGTGTTCCGCGACATTGCCGACGCGATGATCTCCCTTTGGCCTAGGATTGCCGCGCTTGCGCCGGAGCAATC
GGCAAACTGA

Upstream 100 bases:

>100_bases
AGACCGTATGCGGTCCAGAGATATCAACGTGGTCATCGCCAGGGGCGCCGGAGGGCGCTCCTGACGGCGCCGGCCGTTGC
CCCTCATGAGGTAAATTTAA

Downstream 100 bases:

>100_bases
AAAGACAAATGCCTGCTGCGGCGGGCGATTTAGGACGATGAGCATGACCCCCGATTTGCAGCAGCGCTTCTCGAACCTCG
GCGAGAACGATATCGACGTT

Product: putative L-xylulose kinase

Products: NA

Alternate protein names: L-xylulokinase; 3-dehydro-L-gulonate kinase [H]

Number of amino acids: Translated: 509; Mature: 508

Protein sequence:

>509_residues
MPTLLGIDSGLTVTKAVIFDIDGTPLAAARRRVTQFIPKARHIERDMDELWSATADAIREAISLSGRPASDIEGIAATAH
GDGIYLLDHAQQPLGRAILSLDSRAGAIVDRWTQSDVADLAIELTGQIPHVSAPSALLAWIREMEPERYKRIGHFCSCKD
WLRFCLTGIIGTDRTEASTSFTNVKTQNYSEDALQLFGLQDLVHALPPASRSDQIVGRVTREAAQLTGLAEGTPVVAGLH
DVTASALGAGGYAKGVVAVIAGTYSINETLSSEPRVDRRWFCRNGIAPGIWNSMSISPASTANYDWFLATLCAAERTNGE
VRGNSIHALLAPEIDAAFERPSTALFHPYLFGSPYGAAASAGFFGLGGWHDRGDMLRAVLEGIAFNHRIHVDALRDGFAF
DQARLAGGVSRNPAVVQMFADVLGMPVTVTETDEAAAWGAALCAGSGAGIFADPQSDPRDTASIAKTCRPDAARSADYEK
RYQVFRDIADAMISLWPRIAALAPEQSAN

Sequences:

>Translated_509_residues
MPTLLGIDSGLTVTKAVIFDIDGTPLAAARRRVTQFIPKARHIERDMDELWSATADAIREAISLSGRPASDIEGIAATAH
GDGIYLLDHAQQPLGRAILSLDSRAGAIVDRWTQSDVADLAIELTGQIPHVSAPSALLAWIREMEPERYKRIGHFCSCKD
WLRFCLTGIIGTDRTEASTSFTNVKTQNYSEDALQLFGLQDLVHALPPASRSDQIVGRVTREAAQLTGLAEGTPVVAGLH
DVTASALGAGGYAKGVVAVIAGTYSINETLSSEPRVDRRWFCRNGIAPGIWNSMSISPASTANYDWFLATLCAAERTNGE
VRGNSIHALLAPEIDAAFERPSTALFHPYLFGSPYGAAASAGFFGLGGWHDRGDMLRAVLEGIAFNHRIHVDALRDGFAF
DQARLAGGVSRNPAVVQMFADVLGMPVTVTETDEAAAWGAALCAGSGAGIFADPQSDPRDTASIAKTCRPDAARSADYEK
RYQVFRDIADAMISLWPRIAALAPEQSAN
>Mature_508_residues
PTLLGIDSGLTVTKAVIFDIDGTPLAAARRRVTQFIPKARHIERDMDELWSATADAIREAISLSGRPASDIEGIAATAHG
DGIYLLDHAQQPLGRAILSLDSRAGAIVDRWTQSDVADLAIELTGQIPHVSAPSALLAWIREMEPERYKRIGHFCSCKDW
LRFCLTGIIGTDRTEASTSFTNVKTQNYSEDALQLFGLQDLVHALPPASRSDQIVGRVTREAAQLTGLAEGTPVVAGLHD
VTASALGAGGYAKGVVAVIAGTYSINETLSSEPRVDRRWFCRNGIAPGIWNSMSISPASTANYDWFLATLCAAERTNGEV
RGNSIHALLAPEIDAAFERPSTALFHPYLFGSPYGAAASAGFFGLGGWHDRGDMLRAVLEGIAFNHRIHVDALRDGFAFD
QARLAGGVSRNPAVVQMFADVLGMPVTVTETDEAAAWGAALCAGSGAGIFADPQSDPRDTASIAKTCRPDAARSADYEKR
YQVFRDIADAMISLWPRIAALAPEQSAN

Specific function: Catalyzes the phosphorylation of L-xylulose and 3-keto- L-gulonate. Is involved in L-lyxose utilization via xylulose, and may also be involved in the utilization of 2,3-diketo-L-gulonate [H]

COG id: COG1070

COG function: function code G; Sugar (pentulose and hexulose) kinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family [H]

Homologues:

Organism=Homo sapiens, GI164663828, Length=535, Percent_Identity=24.8598130841122, Blast_Score=121, Evalue=2e-27,
Organism=Homo sapiens, GI164663830, Length=560, Percent_Identity=24.1071428571429, Blast_Score=115, Evalue=1e-25,
Organism=Escherichia coli, GI1790005, Length=504, Percent_Identity=32.9365079365079, Blast_Score=272, Evalue=3e-74,
Organism=Escherichia coli, GI1787789, Length=508, Percent_Identity=27.5590551181102, Blast_Score=141, Evalue=9e-35,
Organism=Escherichia coli, GI1789987, Length=509, Percent_Identity=28.4872298624754, Blast_Score=119, Evalue=5e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018483
- InterPro:   IPR018484 [H]

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N [H]

EC number: =2.7.1.53 [H]

Molecular weight: Translated: 54490; Mature: 54359

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: PS00445 FGGY_KINASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTLLGIDSGLTVTKAVIFDIDGTPLAAARRRVTQFIPKARHIERDMDELWSATADAIRE
CCCEEECCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AISLSGRPASDIEGIAATAHGDGIYLLDHAQQPLGRAILSLDSRAGAIVDRWTQSDVADL
HHHCCCCCCCCCCCCEEEECCCCEEEECCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHH
AIELTGQIPHVSAPSALLAWIREMEPERYKRIGHFCSCKDWLRFCLTGIIGTDRTEASTS
HHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCC
FTNVKTQNYSEDALQLFGLQDLVHALPPASRSDQIVGRVTREAAQLTGLAEGTPVVAGLH
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEECHH
DVTASALGAGGYAKGVVAVIAGTYSINETLSSEPRVDRRWFCRNGIAPGIWNSMSISPAS
HHHHHHHCCCCHHHHHHHHHCCCCHHHHHHCCCCCCCHHHHHHCCCCCCCCCCCCCCCCC
TANYDWFLATLCAAERTNGEVRGNSIHALLAPEIDAAFERPSTALFHPYLFGSPYGAAAS
CCCCHHHHHHHHHHHHCCCCCCCCCEEEEECCCHHHHHCCCCCCEECCHHCCCCCCCHHC
AGFFGLGGWHDRGDMLRAVLEGIAFNHRIHVDALRDGFAFDQARLAGGVSRNPAVVQMFA
CCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEHHHHCCCHHHHHHHHCCCCCCHHHHHHHH
DVLGMPVTVTETDEAAAWGAALCAGSGAGIFADPQSDPRDTASIAKTCRPDAARSADYEK
HHHCCCEEEECCCCHHHHHHHHHCCCCCCEECCCCCCCHHHHHHHHHCCCCHHCCCCHHH
RYQVFRDIADAMISLWPRIAALAPEQSAN
HHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
PTLLGIDSGLTVTKAVIFDIDGTPLAAARRRVTQFIPKARHIERDMDELWSATADAIRE
CCEEECCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AISLSGRPASDIEGIAATAHGDGIYLLDHAQQPLGRAILSLDSRAGAIVDRWTQSDVADL
HHHCCCCCCCCCCCCEEEECCCCEEEECCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHH
AIELTGQIPHVSAPSALLAWIREMEPERYKRIGHFCSCKDWLRFCLTGIIGTDRTEASTS
HHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCC
FTNVKTQNYSEDALQLFGLQDLVHALPPASRSDQIVGRVTREAAQLTGLAEGTPVVAGLH
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEECHH
DVTASALGAGGYAKGVVAVIAGTYSINETLSSEPRVDRRWFCRNGIAPGIWNSMSISPAS
HHHHHHHCCCCHHHHHHHHHCCCCHHHHHHCCCCCCCHHHHHHCCCCCCCCCCCCCCCCC
TANYDWFLATLCAAERTNGEVRGNSIHALLAPEIDAAFERPSTALFHPYLFGSPYGAAAS
CCCCHHHHHHHHHHHHCCCCCCCCCEEEEECCCHHHHHCCCCCCEECCHHCCCCCCCHHC
AGFFGLGGWHDRGDMLRAVLEGIAFNHRIHVDALRDGFAFDQARLAGGVSRNPAVVQMFA
CCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEHHHHCCCHHHHHHHHCCCCCCHHHHHHHH
DVLGMPVTVTETDEAAAWGAALCAGSGAGIFADPQSDPRDTASIAKTCRPDAARSADYEK
HHHCCCEEEECCCCHHHHHHHHHCCCCCCEECCCCCCCHHHHHHHHHCCCCHHCCCCHHH
RYQVFRDIADAMISLWPRIAALAPEQSAN
HHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8041620; 9278503; 7961955; 11741871 [H]