Click here to switch to the map view.

The map label for this gene is accC [H]

Identifier: 116248826

GI number: 116248826

Start: 152041

End: 153426

Strand: Reverse

Name: accC [H]

Synonym: pRL120152

Alternate gene names: 116248826

Gene position: 153426-152041 (Counterclockwise)

Preceding gene: 116248827

Following gene: 116248825

Centisome position: 17.63

GC content: 65.37

Gene sequence:

>1386_bases
ATGACGATCCGCTCGGTGCTCGTCGCCAATCGCGGGGAAATCGCCGTTCGCGTCATCAAGGCGGCGAAGGCGCTCGGTAT
CCGGACCGTGCAGGTGCACAGCGCAGCAGATGCCGACATGCTGGCGGTGCGGCTCGCCGACGAGGCGGTGAACATCGGCC
CGCCGGCGCCGAAGAAATCCTATCTCGACATCGAGGCGGTGATCGCCGCCGCCAAGGCGGCCGGTGTCGATGCCGTGCAT
CCGGGCTACGGCTTTCTGTCCGAAAACGGCGATTTCGCCGATGCGGTGCGCGACGCCGGCATGATTTTCATCGGTCCTTC
CGGCGATGCGATCCGCACGCTCGGCGACAAGGTGGCGGCGCGGCAGGTGGCAAAACGCGCGGGCGTGCCGACGGTGCCCG
GCAGCGACGGGCGTGTGGCCGGGCTCGAAGAGGCGCGGTTGCTCGCAGGCGAGATCGGTTTTCCTGTGATGATCAAGGCG
GCGGCTGGCGGCGGCGGACGCGGCATCCGGATCGTCGACAGCATCGCCGAGCTCGAACAGCAGTTTCCGCTGGCTTCGGC
CGAGGCACTGGCCGCATTCGGCGACGGCGGACTTTATCTGGAAAAGGTCATCGCCCGCGCCCGGCACGTCGAGGTGCAGA
TCTTCGGCGACGGACAGAATTTCGTGCATTTCTTCGAACGCGAATGCTCCTTGCAGCGGCGGCGCCAGAAGGTGTGGGAG
GAGGCGCCCGCCTTCATGCTGCCTGCCGACATGCGCGAACGCCTCTGCGTCAGCGCCGTGGCGCTTGCGCGCGAGGTCGG
CTATCGCGGCGCCGGCACGGTCGAATATCTCTATGACGACGAAACGGGCGACTTCTACTTCATCGAAGTCAACACCCGCA
TCCAGGTCGAGCATCCTGTTACCGAGATGATCACCGGGTTCGACCTGGTGCAGGAGATGTTCAAGGTCGCCGGCGGTGCG
GCTCTTTCGGTCGCTCAGCGCGACATCGTGGCCAGCGGCCATGCGATCGAGTGTCGCATCAATGCCGAGGATCCGTTCAA
AGCCTTCCAGCCATCGCCAGGTACGATCGCGTCGCTGTCGGTCCCGGAAGGCGAGGGCATCCGGTTCGACACGATGCTCT
ACGAGGGCTACACGATCCCGCCCTTTTATGATTCCCTGCTCGGCAAGCTGATCGTGCACGCCGAAACACGCAAGGCCTGC
CTCGAAAAGCTTGCCGCGTCGCTGACGGCTCTCGCGATCGAAGGCGTGCCGACGACGGTGGCGCTGCATCTGGCGCTCGC
CCGCGATGCAAGCGTCGCCAAGGGCGCTTTCCATACCCGCTTTCTCGAACAATGGCTGGAGCACGATTTTCCCGCTCTGG
CCGGCCGGACCCAGGAGGTTGCCTGA

Upstream 100 bases:

>100_bases
TCCAGGAAGTTCCGGCTGGTGTTTCCGGCAAGGCGATCACCTTCCTCGTCGACAATGAGGAGCCTGTCATGGCAGGGCAG
GTCATCGCGGAGGTCGAGGC

Downstream 100 bases:

>100_bases
TGCCTGCGCGATATACCTTCGGAGGTGATGAACACCTCTTCGTCGAATGCAGCAGCGAGATGTCGCTGGAAGCCTTCTTC
AAGAGCTTGTCCATGGCGAC

Product: acetyl-CoA carboxylase biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 461; Mature: 460

Protein sequence:

>461_residues
MTIRSVLVANRGEIAVRVIKAAKALGIRTVQVHSAADADMLAVRLADEAVNIGPPAPKKSYLDIEAVIAAAKAAGVDAVH
PGYGFLSENGDFADAVRDAGMIFIGPSGDAIRTLGDKVAARQVAKRAGVPTVPGSDGRVAGLEEARLLAGEIGFPVMIKA
AAGGGGRGIRIVDSIAELEQQFPLASAEALAAFGDGGLYLEKVIARARHVEVQIFGDGQNFVHFFERECSLQRRRQKVWE
EAPAFMLPADMRERLCVSAVALAREVGYRGAGTVEYLYDDETGDFYFIEVNTRIQVEHPVTEMITGFDLVQEMFKVAGGA
ALSVAQRDIVASGHAIECRINAEDPFKAFQPSPGTIASLSVPEGEGIRFDTMLYEGYTIPPFYDSLLGKLIVHAETRKAC
LEKLAASLTALAIEGVPTTVALHLALARDASVAKGAFHTRFLEQWLEHDFPALAGRTQEVA

Sequences:

>Translated_461_residues
MTIRSVLVANRGEIAVRVIKAAKALGIRTVQVHSAADADMLAVRLADEAVNIGPPAPKKSYLDIEAVIAAAKAAGVDAVH
PGYGFLSENGDFADAVRDAGMIFIGPSGDAIRTLGDKVAARQVAKRAGVPTVPGSDGRVAGLEEARLLAGEIGFPVMIKA
AAGGGGRGIRIVDSIAELEQQFPLASAEALAAFGDGGLYLEKVIARARHVEVQIFGDGQNFVHFFERECSLQRRRQKVWE
EAPAFMLPADMRERLCVSAVALAREVGYRGAGTVEYLYDDETGDFYFIEVNTRIQVEHPVTEMITGFDLVQEMFKVAGGA
ALSVAQRDIVASGHAIECRINAEDPFKAFQPSPGTIASLSVPEGEGIRFDTMLYEGYTIPPFYDSLLGKLIVHAETRKAC
LEKLAASLTALAIEGVPTTVALHLALARDASVAKGAFHTRFLEQWLEHDFPALAGRTQEVA
>Mature_460_residues
TIRSVLVANRGEIAVRVIKAAKALGIRTVQVHSAADADMLAVRLADEAVNIGPPAPKKSYLDIEAVIAAAKAAGVDAVHP
GYGFLSENGDFADAVRDAGMIFIGPSGDAIRTLGDKVAARQVAKRAGVPTVPGSDGRVAGLEEARLLAGEIGFPVMIKAA
AGGGGRGIRIVDSIAELEQQFPLASAEALAAFGDGGLYLEKVIARARHVEVQIFGDGQNFVHFFERECSLQRRRQKVWEE
APAFMLPADMRERLCVSAVALAREVGYRGAGTVEYLYDDETGDFYFIEVNTRIQVEHPVTEMITGFDLVQEMFKVAGGAA
LSVAQRDIVASGHAIECRINAEDPFKAFQPSPGTIASLSVPEGEGIRFDTMLYEGYTIPPFYDSLLGKLIVHAETRKACL
EKLAASLTALAIEGVPTTVALHLALARDASVAKGAFHTRFLEQWLEHDFPALAGRTQEVA

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI189095269, Length=444, Percent_Identity=48.1981981981982, Blast_Score=390, Evalue=1e-108,
Organism=Homo sapiens, GI295821183, Length=444, Percent_Identity=48.1981981981982, Blast_Score=389, Evalue=1e-108,
Organism=Homo sapiens, GI65506442, Length=444, Percent_Identity=48.1981981981982, Blast_Score=389, Evalue=1e-108,
Organism=Homo sapiens, GI106049528, Length=451, Percent_Identity=48.1152993348115, Blast_Score=385, Evalue=1e-107,
Organism=Homo sapiens, GI106049295, Length=451, Percent_Identity=48.1152993348115, Blast_Score=385, Evalue=1e-107,
Organism=Homo sapiens, GI106049292, Length=451, Percent_Identity=48.1152993348115, Blast_Score=385, Evalue=1e-107,
Organism=Homo sapiens, GI116805327, Length=445, Percent_Identity=45.1685393258427, Blast_Score=379, Evalue=1e-105,
Organism=Homo sapiens, GI134142062, Length=504, Percent_Identity=32.1428571428571, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI38679960, Length=504, Percent_Identity=31.1507936507937, Blast_Score=222, Evalue=6e-58,
Organism=Homo sapiens, GI38679974, Length=504, Percent_Identity=31.1507936507937, Blast_Score=221, Evalue=8e-58,
Organism=Homo sapiens, GI38679977, Length=504, Percent_Identity=31.1507936507937, Blast_Score=221, Evalue=8e-58,
Organism=Homo sapiens, GI38679967, Length=504, Percent_Identity=31.1507936507937, Blast_Score=221, Evalue=8e-58,
Organism=Homo sapiens, GI38679971, Length=504, Percent_Identity=31.1507936507937, Blast_Score=221, Evalue=9e-58,
Organism=Escherichia coli, GI1789654, Length=444, Percent_Identity=50, Blast_Score=432, Evalue=1e-122,
Organism=Caenorhabditis elegans, GI17562816, Length=465, Percent_Identity=45.5913978494624, Blast_Score=366, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI17567343, Length=460, Percent_Identity=42.6086956521739, Blast_Score=363, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI71987519, Length=457, Percent_Identity=44.4201312910284, Blast_Score=355, Evalue=4e-98,
Organism=Caenorhabditis elegans, GI71997168, Length=506, Percent_Identity=30.0395256916996, Blast_Score=224, Evalue=5e-59,
Organism=Caenorhabditis elegans, GI71997163, Length=510, Percent_Identity=29.6078431372549, Blast_Score=221, Evalue=9e-58,
Organism=Caenorhabditis elegans, GI133931226, Length=490, Percent_Identity=30.8163265306122, Blast_Score=209, Evalue=3e-54,
Organism=Saccharomyces cerevisiae, GI6319685, Length=442, Percent_Identity=44.7963800904977, Blast_Score=372, Evalue=1e-104,
Organism=Saccharomyces cerevisiae, GI6319695, Length=448, Percent_Identity=43.3035714285714, Blast_Score=340, Evalue=4e-94,
Organism=Saccharomyces cerevisiae, GI6321376, Length=448, Percent_Identity=43.5267857142857, Blast_Score=331, Evalue=1e-91,
Organism=Saccharomyces cerevisiae, GI6324343, Length=519, Percent_Identity=31.9845857418112, Blast_Score=245, Evalue=1e-65,
Organism=Saccharomyces cerevisiae, GI6323863, Length=440, Percent_Identity=32.9545454545455, Blast_Score=223, Evalue=6e-59,
Organism=Drosophila melanogaster, GI24652212, Length=448, Percent_Identity=49.7767857142857, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24652210, Length=448, Percent_Identity=49.7767857142857, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24652214, Length=448, Percent_Identity=49.7767857142857, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI19921944, Length=448, Percent_Identity=49.7767857142857, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24652216, Length=448, Percent_Identity=49.7767857142857, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI281363050, Length=448, Percent_Identity=49.7767857142857, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24652224, Length=448, Percent_Identity=49.7767857142857, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24652222, Length=448, Percent_Identity=49.7767857142857, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24652220, Length=448, Percent_Identity=49.7767857142857, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24652218, Length=448, Percent_Identity=49.7767857142857, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24651757, Length=461, Percent_Identity=41.8655097613883, Blast_Score=356, Evalue=2e-98,
Organism=Drosophila melanogaster, GI24651759, Length=423, Percent_Identity=40.8983451536643, Blast_Score=318, Evalue=6e-87,
Organism=Drosophila melanogaster, GI161076407, Length=498, Percent_Identity=32.7309236947791, Blast_Score=228, Evalue=8e-60,
Organism=Drosophila melanogaster, GI24586460, Length=498, Percent_Identity=32.7309236947791, Blast_Score=228, Evalue=8e-60,
Organism=Drosophila melanogaster, GI24586458, Length=498, Percent_Identity=32.7309236947791, Blast_Score=228, Evalue=8e-60,
Organism=Drosophila melanogaster, GI161076409, Length=498, Percent_Identity=32.7309236947791, Blast_Score=228, Evalue=9e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 49313; Mature: 49182

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIRSVLVANRGEIAVRVIKAAKALGIRTVQVHSAADADMLAVRLADEAVNIGPPAPKKS
CCCHHEEEECCCCHHHHHHHHHHHHCEEEEEEECCCCCCEEEEEEHHHHCCCCCCCCCCC
YLDIEAVIAAAKAAGVDAVHPGYGFLSENGDFADAVRDAGMIFIGPSGDAIRTLGDKVAA
CCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHCCEEEECCCCCHHHHHHHHHHH
RQVAKRAGVPTVPGSDGRVAGLEEARLLAGEIGFPVMIKAAAGGGGRGIRIVDSIAELEQ
HHHHHHCCCCCCCCCCCCEECHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHHHHH
QFPLASAEALAAFGDGGLYLEKVIARARHVEVQIFGDGQNFVHFFERECSLQRRRQKVWE
HCCCCCHHHHHHCCCCCHHHHHHHHHHHEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHH
EAPAFMLPADMRERLCVSAVALAREVGYRGAGTVEYLYDDETGDFYFIEVNTRIQVEHPV
HCCCEECCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCEEEEEEECEEEECCCH
TEMITGFDLVQEMFKVAGGAALSVAQRDIVASGHAIECRINAEDPFKAFQPSPGTIASLS
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEECCCCCHHHCCCCCCCEEEEE
VPEGEGIRFDTMLYEGYTIPPFYDSLLGKLIVHAETRKACLEKLAASLTALAIEGVPTTV
CCCCCCEEEEEEEECCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCHHH
ALHLALARDASVAKGAFHTRFLEQWLEHDFPALAGRTQEVA
HHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCC
>Mature Secondary Structure 
TIRSVLVANRGEIAVRVIKAAKALGIRTVQVHSAADADMLAVRLADEAVNIGPPAPKKS
CCHHEEEECCCCHHHHHHHHHHHHCEEEEEEECCCCCCEEEEEEHHHHCCCCCCCCCCC
YLDIEAVIAAAKAAGVDAVHPGYGFLSENGDFADAVRDAGMIFIGPSGDAIRTLGDKVAA
CCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHCCEEEECCCCCHHHHHHHHHHH
RQVAKRAGVPTVPGSDGRVAGLEEARLLAGEIGFPVMIKAAAGGGGRGIRIVDSIAELEQ
HHHHHHCCCCCCCCCCCCEECHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHHHHH
QFPLASAEALAAFGDGGLYLEKVIARARHVEVQIFGDGQNFVHFFERECSLQRRRQKVWE
HCCCCCHHHHHHCCCCCHHHHHHHHHHHEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHH
EAPAFMLPADMRERLCVSAVALAREVGYRGAGTVEYLYDDETGDFYFIEVNTRIQVEHPV
HCCCEECCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCEEEEEEECEEEECCCH
TEMITGFDLVQEMFKVAGGAALSVAQRDIVASGHAIECRINAEDPFKAFQPSPGTIASLS
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEECCCCCHHHCCCCCCCEEEEE
VPEGEGIRFDTMLYEGYTIPPFYDSLLGKLIVHAETRKACLEKLAASLTALAIEGVPTTV
CCCCCCEEEEEEEECCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCHHH
ALHLALARDASVAKGAFHTRFLEQWLEHDFPALAGRTQEVA
HHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7693652; 10984043 [H]