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The map label for this gene is lig [H]

Identifier: 114800462

GI number: 114800462

Start: 1712611

End: 1713612

Strand: Direct

Name: lig [H]

Synonym: HNE_1669

Alternate gene names: 114800462

Gene position: 1712611-1713612 (Clockwise)

Preceding gene: 114799422

Following gene: 114799722

Centisome position: 46.22

GC content: 66.47

Gene sequence:

>1002_bases
ATGAGTTTGCCAATCGACTGGATAAAGCCCGGCGCAGGCGGAATTGAGGTGGCCGGCGGGGCGGCATTTGTCGACCCGTC
GCTGCCCAAGCCGCTCGCTATCGTCACGCATGGTCATGCCGACCATGCGCGCGCCGGCCATGGGAGAGTGATCGCTACGC
CCGAAACACTGGCCATCATGGAGGCGCGCTACGGGCCGACGGAAGGTTGGCCGGTTGCGTATGGCGAGACGGTTGAGGTG
GGCGATGTACGGGTGACGCTATATCCCGCCGGGCATGTGCTGGGCTCGGCGCAGGTGTTGCTGGAGCGGGCGGGGGAGCG
TGTGATCGTGACGGGCGATTTCAAGCGCGCGGCGGACCCGACGTGCCCGCCTTTTGTGCCTATTGCTTGCGATGTGTTGA
TCACCGAGGCGACGTTTGGGCTGCCGGTGTTCCGGCATCCGCCGGCTTCCGATGAAATAGCCAAGGTGATGGAGCGCCTG
GCCGAGAGCCCGGAGCGGTGTGTGCTGGTAGGCGCGTATGCGCTGGGCAAGGCGCAGCGGGTGATCTGCCATCTGCGCGA
GGCGGGGTATGACAAGCCGATCTATCTGCATGGCGCGATGGAGAAGCTGTGCGCACTGTATGAGGCGCATGGGGTGGCGC
TGGGGGAGCTACGCTCTGCGACCGGGGCGGAGGCGGCTGAGATGGCCGGACATGTTGTGGTGGCGCCGCCGAGCGCGCTG
CGGGACCGCTGGGCGCGGCGGTTGCCTGATCCTGTGCTGGCGATGGCGTCGGGCTGGTTGCAGGTGCGCCAGCGTGTGCG
GCAGAACAATATCGATCTGCCGCTGGTGATCTCCGATCATGCCGACTGGGAGGAACTGACCCGGACGATCCGCGAGGTGG
CGCCGTCGGAAGTGTGGGTGACACATGGCAGCGAGGCGGGGTTGTTGCGCTGGTGCGAGCTGAACCAGATTCGCGCGCGG
GCGCTGCATATGGTGGGGCGGACGGATGAGGGCGAGGCATGA

Upstream 100 bases:

>100_bases
GGCACGATCCGCGTCAATTGAATCCTGAGCGTCTGCTTGCCTGCCAGCCGGAAAGGGCCAGATTGAACCTTCAGGGACGC
CGGTGCGTTCTGCTGTGAGG

Downstream 100 bases:

>100_bases
TCGCCGACTTTGCCCGCCTGCTGGACCGGCTGATCATTACGCGTTCCCGCAATGAAAAGTTGAGCCTGATTGCGCGGTAT
CTGCGCGAGGCGGACCCCGG

Product: hypothetical protein

Products: NA

Alternate protein names: Polydeoxyribonucleotide synthase [ATP] [H]

Number of amino acids: Translated: 333; Mature: 332

Protein sequence:

>333_residues
MSLPIDWIKPGAGGIEVAGGAAFVDPSLPKPLAIVTHGHADHARAGHGRVIATPETLAIMEARYGPTEGWPVAYGETVEV
GDVRVTLYPAGHVLGSAQVLLERAGERVIVTGDFKRAADPTCPPFVPIACDVLITEATFGLPVFRHPPASDEIAKVMERL
AESPERCVLVGAYALGKAQRVICHLREAGYDKPIYLHGAMEKLCALYEAHGVALGELRSATGAEAAEMAGHVVVAPPSAL
RDRWARRLPDPVLAMASGWLQVRQRVRQNNIDLPLVISDHADWEELTRTIREVAPSEVWVTHGSEAGLLRWCELNQIRAR
ALHMVGRTDEGEA

Sequences:

>Translated_333_residues
MSLPIDWIKPGAGGIEVAGGAAFVDPSLPKPLAIVTHGHADHARAGHGRVIATPETLAIMEARYGPTEGWPVAYGETVEV
GDVRVTLYPAGHVLGSAQVLLERAGERVIVTGDFKRAADPTCPPFVPIACDVLITEATFGLPVFRHPPASDEIAKVMERL
AESPERCVLVGAYALGKAQRVICHLREAGYDKPIYLHGAMEKLCALYEAHGVALGELRSATGAEAAEMAGHVVVAPPSAL
RDRWARRLPDPVLAMASGWLQVRQRVRQNNIDLPLVISDHADWEELTRTIREVAPSEVWVTHGSEAGLLRWCELNQIRAR
ALHMVGRTDEGEA
>Mature_332_residues
SLPIDWIKPGAGGIEVAGGAAFVDPSLPKPLAIVTHGHADHARAGHGRVIATPETLAIMEARYGPTEGWPVAYGETVEVG
DVRVTLYPAGHVLGSAQVLLERAGERVIVTGDFKRAADPTCPPFVPIACDVLITEATFGLPVFRHPPASDEIAKVMERLA
ESPERCVLVGAYALGKAQRVICHLREAGYDKPIYLHGAMEKLCALYEAHGVALGELRSATGAEAAEMAGHVVVAPPSALR
DRWARRLPDPVLAMASGWLQVRQRVRQNNIDLPLVISDHADWEELTRTIREVAPSEVWVTHGSEAGLLRWCELNQIRARA
LHMVGRTDEGEA

Specific function: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair [H]

COG id: COG1236

COG function: function code J; Predicted exonuclease of the beta-lactamase fold involved in RNA processing

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the ATP- dependent DNA ligase family [H]

Homologues:

Organism=Caenorhabditis elegans, GI32566029, Length=390, Percent_Identity=22.8205128205128, Blast_Score=71, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6323307, Length=146, Percent_Identity=33.5616438356164, Blast_Score=71, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24648013, Length=391, Percent_Identity=24.2966751918159, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000977
- InterPro:   IPR012309
- InterPro:   IPR012310
- InterPro:   IPR016059
- InterPro:   IPR012308
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR011108 [H]

Pfam domain/function: PF04679 DNA_ligase_A_C; PF01068 DNA_ligase_A_M; PF04675 DNA_ligase_A_N; PF07521 RMMBL [H]

EC number: =6.5.1.1 [H]

Molecular weight: Translated: 35966; Mature: 35834

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLPIDWIKPGAGGIEVAGGAAFVDPSLPKPLAIVTHGHADHARAGHGRVIATPETLAIM
CCCCCCCCCCCCCCEEECCCEEEECCCCCCCEEEEECCCCCCCCCCCCEEEECCHHEEEE
EARYGPTEGWPVAYGETVEVGDVRVTLYPAGHVLGSAQVLLERAGERVIVTGDFKRAADP
ECCCCCCCCCCCCCCCEEEECCEEEEEEECCHHHHHHHHHHHHCCCEEEEEECCHHCCCC
TCPPFVPIACDVLITEATFGLPVFRHPPASDEIAKVMERLAESPERCVLVGAYALGKAQR
CCCCCCHHHHEEEEEHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEHHHHHHHHH
VICHLREAGYDKPIYLHGAMEKLCALYEAHGVALGELRSATGAEAAEMAGHVVVAPPSAL
HHHHHHHCCCCCCEEEHHHHHHHHHHHHHCCCHHHHHHCCCCCCHHHHCCEEEECCCHHH
RDRWARRLPDPVLAMASGWLQVRQRVRQNNIDLPLVISDHADWEELTRTIREVAPSEVWV
HHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHCCCCEEEE
THGSEAGLLRWCELNQIRARALHMVGRTDEGEA
ECCCCCCEEEEHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SLPIDWIKPGAGGIEVAGGAAFVDPSLPKPLAIVTHGHADHARAGHGRVIATPETLAIM
CCCCCCCCCCCCCEEECCCEEEECCCCCCCEEEEECCCCCCCCCCCCEEEECCHHEEEE
EARYGPTEGWPVAYGETVEVGDVRVTLYPAGHVLGSAQVLLERAGERVIVTGDFKRAADP
ECCCCCCCCCCCCCCCEEEECCEEEEEEECCHHHHHHHHHHHHCCCEEEEEECCHHCCCC
TCPPFVPIACDVLITEATFGLPVFRHPPASDEIAKVMERLAESPERCVLVGAYALGKAQR
CCCCCCHHHHEEEEEHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEHHHHHHHHH
VICHLREAGYDKPIYLHGAMEKLCALYEAHGVALGELRSATGAEAAEMAGHVVVAPPSAL
HHHHHHHCCCCCCEEEHHHHHHHHHHHHHCCCHHHHHHCCCCCCHHHHCCEEEECCCHHH
RDRWARRLPDPVLAMASGWLQVRQRVRQNNIDLPLVISDHADWEELTRTIREVAPSEVWV
HHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHCCCCEEEE
THGSEAGLLRWCELNQIRARALHMVGRTDEGEA
ECCCCCCEEEEHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA