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The map label for this gene is pkn1 [H]

Identifier: 114799422

GI number: 114799422

Start: 1708256

End: 1709026

Strand: Direct

Name: pkn1 [H]

Synonym: HNE_1666

Alternate gene names: 114799422

Gene position: 1708256-1709026 (Clockwise)

Preceding gene: 114798125

Following gene: 114800462

Centisome position: 46.11

GC content: 63.29

Gene sequence:

>771_bases
ATGGGCGCGTTTGTCGAGGTTCCAGGCGGGGTGCTTCAGAAAGGGCGCGGGGCGATCTATCCTGAGGAGCGGCCGGAAGT
GACGCTGCATGTGGATGGGTTCCGCATCCAGGCGCACGAAGTGACCAATGATCAGTTTGCAGAGTTTGTGACGGCGACGG
GATATGTGACCGATGCCGAGCGCGGCGTGATGGAGGACCGGCCGGGCGCAGGCTCTGCCGTGTTTCAGGGCGCACGCTGG
CATCTGATGCGCGAGGCGAGCTGGAAAACGCCAGAAGGCGCGGGGTCTTCCATTGAAGGCAAGGGCAATTGGCCGGTCAT
GCATGTGTCGCTGGCTGACGCGGAAGCCTATGCGGCCTGGGCCGGTGGGCGCCTTCCGAGCGAGGAAGAATGGGAGCATG
CCGCGCGCCTTGGCCTGCCAGACCCGGACCGCGAGACGTCGGGCGCCTTTGAAGACGATGGCAAGCCGCGCGCCAATACC
TGGCAGGGCATCTTCCCGGTTGCTAATGCGGGCGAGGACGGATTTGCGGGCGCCGCGCCTGTGGGATGCTTTCCGGCGGA
CCAGTTGGGCCTTTATGACATGATCGGCAATGTGTGGGAGTGGACGGATACGCCGTTTGCGCCGGGCAACAATACGATCA
AGGGCGGCAGCTATCTGTGTGCGGACAATTTCTGTCAGCGTTACCGGCCCGCGGCGCGCCACCCGCAGGAGATTGATTTC
TCCTCCAACCATATCGGCTTCCGGATCGTGAAAGAGCTGGAAGCCGAATAG

Upstream 100 bases:

>100_bases
CGGGAGACTTGCCCTTCTGTCTTTATGCGCGATTGCCGCGTGTGGCGCGTCTTCTTCTGACGATCCCGTCTCAGGGAGCT
GTGGCCTGAACAGCGCCGCG

Downstream 100 bases:

>100_bases
GCCGGGTCAATTGGGCCAGTAGACGTATTCCTCGCCTTCGACATACGGCGCGTCGATGGTGTGGTCGATCTTGATCGGGC
TTTCGATTGTATAGGGATAG

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 256; Mature: 255

Protein sequence:

>256_residues
MGAFVEVPGGVLQKGRGAIYPEERPEVTLHVDGFRIQAHEVTNDQFAEFVTATGYVTDAERGVMEDRPGAGSAVFQGARW
HLMREASWKTPEGAGSSIEGKGNWPVMHVSLADAEAYAAWAGGRLPSEEEWEHAARLGLPDPDRETSGAFEDDGKPRANT
WQGIFPVANAGEDGFAGAAPVGCFPADQLGLYDMIGNVWEWTDTPFAPGNNTIKGGSYLCADNFCQRYRPAARHPQEIDF
SSNHIGFRIVKELEAE

Sequences:

>Translated_256_residues
MGAFVEVPGGVLQKGRGAIYPEERPEVTLHVDGFRIQAHEVTNDQFAEFVTATGYVTDAERGVMEDRPGAGSAVFQGARW
HLMREASWKTPEGAGSSIEGKGNWPVMHVSLADAEAYAAWAGGRLPSEEEWEHAARLGLPDPDRETSGAFEDDGKPRANT
WQGIFPVANAGEDGFAGAAPVGCFPADQLGLYDMIGNVWEWTDTPFAPGNNTIKGGSYLCADNFCQRYRPAARHPQEIDF
SSNHIGFRIVKELEAE
>Mature_255_residues
GAFVEVPGGVLQKGRGAIYPEERPEVTLHVDGFRIQAHEVTNDQFAEFVTATGYVTDAERGVMEDRPGAGSAVFQGARWH
LMREASWKTPEGAGSSIEGKGNWPVMHVSLADAEAYAAWAGGRLPSEEEWEHAARLGLPDPDRETSGAFEDDGKPRANTW
QGIFPVANAGEDGFAGAAPVGCFPADQLGLYDMIGNVWEWTDTPFAPGNNTIKGGSYLCADNFCQRYRPAARHPQEIDFS
SNHIGFRIVKELEAE

Specific function: Together with the serine/threonine kinase pknD, may play a role in the specific interactions with host proteins during intracellular growth. Phosphorylates incG, a inclusion-membrane protein required for the modification of the nascent chlamydial inclusio

COG id: COG1262

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 protein kinase domain [H]

Homologues:

Organism=Homo sapiens, GI38202250, Length=278, Percent_Identity=37.410071942446, Blast_Score=179, Evalue=1e-45,
Organism=Homo sapiens, GI257470975, Length=268, Percent_Identity=37.3134328358209, Blast_Score=173, Evalue=1e-43,
Organism=Homo sapiens, GI257470977, Length=262, Percent_Identity=37.0229007633588, Blast_Score=166, Evalue=2e-41,
Organism=Homo sapiens, GI194248088, Length=270, Percent_Identity=37.037037037037, Blast_Score=139, Evalue=2e-33,
Organism=Homo sapiens, GI194248087, Length=262, Percent_Identity=36.6412213740458, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI226437577, Length=179, Percent_Identity=41.8994413407821, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI194248090, Length=199, Percent_Identity=38.1909547738693, Blast_Score=104, Evalue=7e-23,
Organism=Homo sapiens, GI194248084, Length=97, Percent_Identity=38.1443298969072, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI20130397, Length=266, Percent_Identity=37.593984962406, Blast_Score=160, Evalue=1e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016187
- InterPro:   IPR011009
- InterPro:   IPR000719
- InterPro:   IPR017442
- InterPro:   IPR005532 [H]

Pfam domain/function: PF03781 DUF323; PF00069 Pkinase [H]

EC number: =2.7.11.1 [H]

Molecular weight: Translated: 27841; Mature: 27710

Theoretical pI: Translated: 4.44; Mature: 4.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGAFVEVPGGVLQKGRGAIYPEERPEVTLHVDGFRIQAHEVTNDQFAEFVTATGYVTDAE
CCCEEECCCHHHHCCCCCCCCCCCCCEEEEECCEEEEEEECCCHHHHHHHHHCCEEECCC
RGVMEDRPGAGSAVFQGARWHLMREASWKTPEGAGSSIEGKGNWPVMHVSLADAEAYAAW
CCCCCCCCCCCHHHHCCCHHEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHH
AGGRLPSEEEWEHAARLGLPDPDRETSGAFEDDGKPRANTWQGIFPVANAGEDGFAGAAP
CCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
VGCFPADQLGLYDMIGNVWEWTDTPFAPGNNTIKGGSYLCADNFCQRYRPAARHPQEIDF
CCCCCCHHHHHHHHHCCCEECCCCCCCCCCCEECCCCEEHHHHHHHHCCHHHCCCCCCCC
SSNHIGFRIVKELEAE
CCCCCHHEEHHHHCCC
>Mature Secondary Structure 
GAFVEVPGGVLQKGRGAIYPEERPEVTLHVDGFRIQAHEVTNDQFAEFVTATGYVTDAE
CCEEECCCHHHHCCCCCCCCCCCCCEEEEECCEEEEEEECCCHHHHHHHHHCCEEECCC
RGVMEDRPGAGSAVFQGARWHLMREASWKTPEGAGSSIEGKGNWPVMHVSLADAEAYAAW
CCCCCCCCCCCHHHHCCCHHEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHH
AGGRLPSEEEWEHAARLGLPDPDRETSGAFEDDGKPRANTWQGIFPVANAGEDGFAGAAP
CCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
VGCFPADQLGLYDMIGNVWEWTDTPFAPGNNTIKGGSYLCADNFCQRYRPAARHPQEIDF
CCCCCCHHHHHHHHHCCCEECCCCCCCCCCCEECCCCEEHHHHHHHHCCHHHCCCCCCCC
SSNHIGFRIVKELEAE
CCCCCHHEEHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9784136; 14500499 [H]