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The map label for this gene is lig [H]

Identifier: 114799722

GI number: 114799722

Start: 1713609

End: 1715207

Strand: Direct

Name: lig [H]

Synonym: HNE_1670

Alternate gene names: 114799722

Gene position: 1713609-1715207 (Clockwise)

Preceding gene: 114800462

Following gene: 114799022

Centisome position: 46.25

GC content: 64.92

Gene sequence:

>1599_bases
ATGATCGCCGACTTTGCCCGCCTGCTGGACCGGCTGATCATTACGCGTTCCCGCAATGAAAAGTTGAGCCTGATTGCGCG
GTATCTGCGCGAGGCGGACCCCGGAGACCGGGGCTGGGCGCTGGCGGCGCTGGGCGGGTCACTGGACCTGCCGCAGCTGA
CCTCCAGCGTCATTCGCAAGATGGCGGCCGAGCGGGTGGATGAGGAGTTGTTGCGGCTGAGCCGGGAGTTTGTGGGGGAT
ACGGCTGAGACCGTCGCGTTGATCTGGCCCGCGATGGAGGGCGCTGAGCAAGGGCCGCCTCTGACGCTGCGCGGTGTTGT
TGAGGCGTTGCAGAACGCCCGGAAGGGCGATGCGCCGGGGCTGCTCGCGCGGTGGCTGGACCGGTCTACGGCGGAGGAGC
GGTTTGCGCTGTTGAAGCTGGTACTCGGCAATTTCCGCATTGGTGTTTCCGAGCGATTGGCAAAGACCGCTTTTGCCGAG
GCGTTTGGTGTGAGCCTCGCGGATGTCGAGGAATACTGGCATGCGAGCCCCGCGCCGCATGATGACCTTTTTGCCTGGGC
GACCGGGGTGGCGCCTGCGCCGGATGTGAGCGCGGTGGTGCGGTTCCGGCCGTTCATGCTGTCTGTGCCCGTCGAAAATA
CGCCGCCGGACCTGACGGACTTTGCGGCAGAATGGAAATGGGATGGCATTCGCGTTCAGCTGGCGCGGGCGGCAGGCGAG
GTGCGCCTCTACAGCCGGGGCGGGGAGGATATTACCGGCGCGTTTCCGGAATTCGCTGATGCCCTGCCAAAGGGCAGCGC
GGTGGATGGGGAGCTGCTGGTGGCAGACGAGGCGGCGCCTTACCGTGTGGCGCCATTTTCCGAGCTTCAGAAGCGCCTCG
GCCGCAAGGCGCCGCCGCGCAGCCTGCTGGAGGCGTCGCCCGCCTTCATTCGGCTCTATGATCTGCTGGAACATGAGGGG
GAAGACCTGCGGCCCCTGAGCTGGACCGAGCGCCGGGCGCGGCTGCAAGAATTTGCGGCGACACTTCCGGCAGACCGGTT
TGATCTCTCGCCTGTAATTGATGTGGCGGATGTGGGCGTGCTGGAACAGCTTCGCCGCGAGCCGCCCGCGCCCGCCATTG
AGGGCGTGATGCTGAAGCGGCGCGCCAGCCCCTATACCGCGGGGCGTATTTCGGGGCTGTGGTATAAATGGAAGCGTGAT
CCGCATACGGCCGATTGCGTGATGATGTACGCCCAGCGCGGATCGGGGAAGCGGTCCTCCTTCTACTCCGATTACACGTT
TGGCTGCTGGACGGAGGACGGCCAGCTTGTGCCGGTCGGCAAGGCGTATTCCGGCTTTACCGACGAGGAGCTTGTGCGTC
TCGACAAGTTTGTGCGGGGGAACATCACGGCGCGGTTCGGGCCGGTGCTGGAGGTACGCAAGGAACTTGTGCTGGAAGTG
GCGTTCGACTCGATTGCCGAAAGTAAGCGGCACAAATCCGGCGTGGCCATGCGCTTCCCGCGTATCAATCGCATCCGCTG
GGACAAGCCTGCGGCGGAAGCCGATACGGTCGCCAATCTGCGTGCCTTGATGGGGCAGGCTTCTTCCGCCGCAGAGTGA

Upstream 100 bases:

>100_bases
TGACACATGGCAGCGAGGCGGGGTTGTTGCGCTGGTGCGAGCTGAACCAGATTCGCGCGCGGGCGCTGCATATGGTGGGG
CGGACGGATGAGGGCGAGGC

Downstream 100 bases:

>100_bases
AGGGCGGGGTTGGCAAGGTGCTCGAGGGGCGATAGCTGTTCTAACACGAGACGTGCCAATACAGACACGCCGAGAACTTC
CGGGAGGACACTCATGCGCC

Product: putative DNA ligase, ATP-dependent

Products: NA

Alternate protein names: Polydeoxyribonucleotide synthase [ATP] [H]

Number of amino acids: Translated: 532; Mature: 532

Protein sequence:

>532_residues
MIADFARLLDRLIITRSRNEKLSLIARYLREADPGDRGWALAALGGSLDLPQLTSSVIRKMAAERVDEELLRLSREFVGD
TAETVALIWPAMEGAEQGPPLTLRGVVEALQNARKGDAPGLLARWLDRSTAEERFALLKLVLGNFRIGVSERLAKTAFAE
AFGVSLADVEEYWHASPAPHDDLFAWATGVAPAPDVSAVVRFRPFMLSVPVENTPPDLTDFAAEWKWDGIRVQLARAAGE
VRLYSRGGEDITGAFPEFADALPKGSAVDGELLVADEAAPYRVAPFSELQKRLGRKAPPRSLLEASPAFIRLYDLLEHEG
EDLRPLSWTERRARLQEFAATLPADRFDLSPVIDVADVGVLEQLRREPPAPAIEGVMLKRRASPYTAGRISGLWYKWKRD
PHTADCVMMYAQRGSGKRSSFYSDYTFGCWTEDGQLVPVGKAYSGFTDEELVRLDKFVRGNITARFGPVLEVRKELVLEV
AFDSIAESKRHKSGVAMRFPRINRIRWDKPAAEADTVANLRALMGQASSAAE

Sequences:

>Translated_532_residues
MIADFARLLDRLIITRSRNEKLSLIARYLREADPGDRGWALAALGGSLDLPQLTSSVIRKMAAERVDEELLRLSREFVGD
TAETVALIWPAMEGAEQGPPLTLRGVVEALQNARKGDAPGLLARWLDRSTAEERFALLKLVLGNFRIGVSERLAKTAFAE
AFGVSLADVEEYWHASPAPHDDLFAWATGVAPAPDVSAVVRFRPFMLSVPVENTPPDLTDFAAEWKWDGIRVQLARAAGE
VRLYSRGGEDITGAFPEFADALPKGSAVDGELLVADEAAPYRVAPFSELQKRLGRKAPPRSLLEASPAFIRLYDLLEHEG
EDLRPLSWTERRARLQEFAATLPADRFDLSPVIDVADVGVLEQLRREPPAPAIEGVMLKRRASPYTAGRISGLWYKWKRD
PHTADCVMMYAQRGSGKRSSFYSDYTFGCWTEDGQLVPVGKAYSGFTDEELVRLDKFVRGNITARFGPVLEVRKELVLEV
AFDSIAESKRHKSGVAMRFPRINRIRWDKPAAEADTVANLRALMGQASSAAE
>Mature_532_residues
MIADFARLLDRLIITRSRNEKLSLIARYLREADPGDRGWALAALGGSLDLPQLTSSVIRKMAAERVDEELLRLSREFVGD
TAETVALIWPAMEGAEQGPPLTLRGVVEALQNARKGDAPGLLARWLDRSTAEERFALLKLVLGNFRIGVSERLAKTAFAE
AFGVSLADVEEYWHASPAPHDDLFAWATGVAPAPDVSAVVRFRPFMLSVPVENTPPDLTDFAAEWKWDGIRVQLARAAGE
VRLYSRGGEDITGAFPEFADALPKGSAVDGELLVADEAAPYRVAPFSELQKRLGRKAPPRSLLEASPAFIRLYDLLEHEG
EDLRPLSWTERRARLQEFAATLPADRFDLSPVIDVADVGVLEQLRREPPAPAIEGVMLKRRASPYTAGRISGLWYKWKRD
PHTADCVMMYAQRGSGKRSSFYSDYTFGCWTEDGQLVPVGKAYSGFTDEELVRLDKFVRGNITARFGPVLEVRKELVLEV
AFDSIAESKRHKSGVAMRFPRINRIRWDKPAAEADTVANLRALMGQASSAAE

Specific function: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair [H]

COG id: COG1793

COG function: function code L; ATP-dependent DNA ligase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent DNA ligase family [H]

Homologues:

Organism=Homo sapiens, GI4557719, Length=347, Percent_Identity=25.6484149855908, Blast_Score=91, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71985269, Length=451, Percent_Identity=27.2727272727273, Blast_Score=105, Evalue=8e-23,
Organism=Saccharomyces cerevisiae, GI6320038, Length=334, Percent_Identity=27.8443113772455, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24762424, Length=503, Percent_Identity=25.4473161033797, Blast_Score=112, Evalue=7e-25,
Organism=Drosophila melanogaster, GI85815841, Length=522, Percent_Identity=23.7547892720307, Blast_Score=92, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022865
- InterPro:   IPR000977
- InterPro:   IPR012309
- InterPro:   IPR012310
- InterPro:   IPR016059
- InterPro:   IPR012308
- InterPro:   IPR012340
- InterPro:   IPR016027 [H]

Pfam domain/function: PF04679 DNA_ligase_A_C; PF01068 DNA_ligase_A_M; PF04675 DNA_ligase_A_N [H]

EC number: =6.5.1.1 [H]

Molecular weight: Translated: 58946; Mature: 58946

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: PS00697 DNA_LIGASE_A1 ; PS50160 DNA_LIGASE_A3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIADFARLLDRLIITRSRNEKLSLIARYLREADPGDRGWALAALGGSLDLPQLTSSVIRK
CCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHH
MAAERVDEELLRLSREFVGDTAETVALIWPAMEGAEQGPPLTLRGVVEALQNARKGDAPG
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHCCCCCCCH
LLARWLDRSTAEERFALLKLVLGNFRIGVSERLAKTAFAEAFGVSLADVEEYWHASPAPH
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCC
DDLFAWATGVAPAPDVSAVVRFRPFMLSVPVENTPPDLTDFAAEWKWDGIRVQLARAAGE
CCHHHHHCCCCCCCCHHHHHHHCCEEEECCCCCCCCCHHHHHHHCCCCCEEEEEECCCCC
VRLYSRGGEDITGAFPEFADALPKGSAVDGELLVADEAAPYRVAPFSELQKRLGRKAPPR
EEEEECCCCCCCCCCHHHHHHCCCCCCCCCCEEEECCCCCCEECCHHHHHHHHCCCCCCH
SLLEASPAFIRLYDLLEHEGEDLRPLSWTERRARLQEFAATLPADRFDLSPVIDVADVGV
HHHHCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
LEQLRREPPAPAIEGVMLKRRASPYTAGRISGLWYKWKRDPHTADCVMMYAQRGSGKRSS
HHHHHCCCCCCHHHHHHHHHCCCCCCCHHHCCEEEEECCCCCCHHHHHHHHHCCCCCCCC
FYSDYTFGCWTEDGQLVPVGKAYSGFTDEELVRLDKFVRGNITARFGPVLEVRKELVLEV
CCCCCCEEEECCCCEEEECCCCCCCCCHHHHHHHHHHHHCCCCCHHCHHHHHHHHHHHHH
AFDSIAESKRHKSGVAMRFPRINRIRWDKPAAEADTVANLRALMGQASSAAE
HHHHHHHHHHHHCCCEEECCCCCCEECCCCCCHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MIADFARLLDRLIITRSRNEKLSLIARYLREADPGDRGWALAALGGSLDLPQLTSSVIRK
CCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHH
MAAERVDEELLRLSREFVGDTAETVALIWPAMEGAEQGPPLTLRGVVEALQNARKGDAPG
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHCCCCCCCH
LLARWLDRSTAEERFALLKLVLGNFRIGVSERLAKTAFAEAFGVSLADVEEYWHASPAPH
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCC
DDLFAWATGVAPAPDVSAVVRFRPFMLSVPVENTPPDLTDFAAEWKWDGIRVQLARAAGE
CCHHHHHCCCCCCCCHHHHHHHCCEEEECCCCCCCCCHHHHHHHCCCCCEEEEEECCCCC
VRLYSRGGEDITGAFPEFADALPKGSAVDGELLVADEAAPYRVAPFSELQKRLGRKAPPR
EEEEECCCCCCCCCCHHHHHHCCCCCCCCCCEEEECCCCCCEECCHHHHHHHHCCCCCCH
SLLEASPAFIRLYDLLEHEGEDLRPLSWTERRARLQEFAATLPADRFDLSPVIDVADVGV
HHHHCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
LEQLRREPPAPAIEGVMLKRRASPYTAGRISGLWYKWKRDPHTADCVMMYAQRGSGKRSS
HHHHHCCCCCCHHHHHHHHHCCCCCCCHHHCCEEEEECCCCCCHHHHHHHHHCCCCCCCC
FYSDYTFGCWTEDGQLVPVGKAYSGFTDEELVRLDKFVRGNITARFGPVLEVRKELVLEV
CCCCCCEEEECCCCEEEECCCCCCCCCHHHHHHHHHHHHCCCCCHHCHHHHHHHHHHHHH
AFDSIAESKRHKSGVAMRFPRINRIRWDKPAAEADTVANLRALMGQASSAAE
HHHHHHHHHHHHCCCEEECCCCCCEECCCCCCHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA