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The map label for this gene is mmpA [H]

Identifier: 114800133

GI number: 114800133

Start: 1818078

End: 1819241

Strand: Direct

Name: mmpA [H]

Synonym: HNE_1775

Alternate gene names: 114800133

Gene position: 1818078-1819241 (Clockwise)

Preceding gene: 114799124

Following gene: 114797815

Centisome position: 49.07

GC content: 54.38

Gene sequence:

>1164_bases
GTGGATCAGATTCTAAGCCAGGGGCCACTCTTCCTTTTCTGCCTGATCTTCATGATGGGCATTGTCGTTGTGATCCACGA
ATTTGGGCACTATCTGGCTGCCCGGCTCTATGGTGTGGCCATCGAGTCTTTTTCAGTTGGATTTGGCAAGCCGCTTTTCG
AGCGCCGCGACAGGCGCGGCACCAGATGGCGCGTCAACTGGATTCCGCTGGGTGGGTTTGTCAGTTTTCTTCCTGCCAGC
GCCAAAGCTGATGATGAAACTGCCCAAGGCATTGCGGGCATATCATTCGACGAGCTGAAGCCGATTCCGAAAATTGTGGT
CAGTTTGGCTGGGCCGTTTGCCAACTTCGTGCTTGCGACACTGATCTTCGCGTTGGCTTATGGTGTATTTGGATCACCGA
AGTTTGAGGTTCAAATCACGCATATAGGTGAGGGAATGCCCGCTGAAGAAGCGGGGCTCCTGCCAGGCGACATCATCCGT
GAAATCAATGGGCGGCCGATCCTGACGGGCGCGGACGCAACGATGATGGTGTTGGTCAGTCCGAATAAGGCAATGCGGTT
CAATGTTGACAGAAATGGACAGGAATTGAACCTGGACGTAATTCCGCGAGAAATTGTGCGCCCGAACGAGTTCGGCCAGG
TCGTTCCTCAGAGCACCGCAGGCTTCAGTTTGGTGCATTCCAAGTTCATCGAGCGCGTAACATATGGCCCTATTGGCTCG
CTGGTTGAGGGCACCGCCCAGACCGGGCGAACAATAGATCAGACCGTTAAGATGTTGAGCCGGATCGCAACCGGAAACAT
GTCAGTTCATGCGATGTCTGGGCCCGTTGGGGTCGGCGATATATCTCGCCGCGCGGTCAATCGCGTAATGGAACAGACGC
AACTGACGTCTTGGCAAAAGACTGAGCAGCTGTTCTGGATGCTCATGAGTGTTTGCGCTGCGGTTTCAGTGGGCGTGGGC
TTTTTCAACCTTTTGCCACTGCCTGTTCTGGATGGCGGTCGTGTGGTCTTTCATGCATACGAAGCGTTCACGGGTTCAAA
AATGCCCAGCCAAGTGGAAGCGTTCGCATTGAGAGCGAGCGTCTTTCTTCTGCTGCTTATGGTGGTGGTTATCACATGGG
GAGATGTGATTGAAACGGGCGTGTTTGGACGGGGAGGCGGCTGA

Upstream 100 bases:

>100_bases
TGCGAAACGCTTGAAGAAATAGCAGAAATAAGCCGGTACGGACGGTTCCTAGTGTCTCAATGGCTAAACAATGCCCCAAG
CCGGGCGGGAGGATGATCGA

Downstream 100 bases:

>100_bases
CAATCTGTCAGCCCGGTACGGAGAGTGATATCCATAATGCTTAAGTTCCTCGCGGCCACTATTCTTGCGACGAGTGCTCT
TGGTTTGGGAGTGAGCGGCT

Product: M50 family peptidase

Products: NA

Alternate protein names: Membrane metalloprotease A [H]

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MDQILSQGPLFLFCLIFMMGIVVVIHEFGHYLAARLYGVAIESFSVGFGKPLFERRDRRGTRWRVNWIPLGGFVSFLPAS
AKADDETAQGIAGISFDELKPIPKIVVSLAGPFANFVLATLIFALAYGVFGSPKFEVQITHIGEGMPAEEAGLLPGDIIR
EINGRPILTGADATMMVLVSPNKAMRFNVDRNGQELNLDVIPREIVRPNEFGQVVPQSTAGFSLVHSKFIERVTYGPIGS
LVEGTAQTGRTIDQTVKMLSRIATGNMSVHAMSGPVGVGDISRRAVNRVMEQTQLTSWQKTEQLFWMLMSVCAAVSVGVG
FFNLLPLPVLDGGRVVFHAYEAFTGSKMPSQVEAFALRASVFLLLLMVVVITWGDVIETGVFGRGGG

Sequences:

>Translated_387_residues
MDQILSQGPLFLFCLIFMMGIVVVIHEFGHYLAARLYGVAIESFSVGFGKPLFERRDRRGTRWRVNWIPLGGFVSFLPAS
AKADDETAQGIAGISFDELKPIPKIVVSLAGPFANFVLATLIFALAYGVFGSPKFEVQITHIGEGMPAEEAGLLPGDIIR
EINGRPILTGADATMMVLVSPNKAMRFNVDRNGQELNLDVIPREIVRPNEFGQVVPQSTAGFSLVHSKFIERVTYGPIGS
LVEGTAQTGRTIDQTVKMLSRIATGNMSVHAMSGPVGVGDISRRAVNRVMEQTQLTSWQKTEQLFWMLMSVCAAVSVGVG
FFNLLPLPVLDGGRVVFHAYEAFTGSKMPSQVEAFALRASVFLLLLMVVVITWGDVIETGVFGRGGG
>Mature_387_residues
MDQILSQGPLFLFCLIFMMGIVVVIHEFGHYLAARLYGVAIESFSVGFGKPLFERRDRRGTRWRVNWIPLGGFVSFLPAS
AKADDETAQGIAGISFDELKPIPKIVVSLAGPFANFVLATLIFALAYGVFGSPKFEVQITHIGEGMPAEEAGLLPGDIIR
EINGRPILTGADATMMVLVSPNKAMRFNVDRNGQELNLDVIPREIVRPNEFGQVVPQSTAGFSLVHSKFIERVTYGPIGS
LVEGTAQTGRTIDQTVKMLSRIATGNMSVHAMSGPVGVGDISRRAVNRVMEQTQLTSWQKTEQLFWMLMSVCAAVSVGVG
FFNLLPLPVLDGGRVVFHAYEAFTGSKMPSQVEAFALRASVFLLLLMVVVITWGDVIETGVFGRGGG

Specific function: Involved in the regulated intramembrane proteolysis (RIP) of the short isoform of podJ protein (podJS), during the swarmer-to-stalked transition. The cleavage occurs near or within the single transmembrane of podJS thereby releasing the N-terminal segment

COG id: COG0750

COG function: function code M; Predicted membrane-associated Zn-dependent proteases 1

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Escherichia coli, GI1786373, Length=233, Percent_Identity=28.3261802575107, Blast_Score=94, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR004387
- InterPro:   IPR008915 [H]

Pfam domain/function: PF00595 PDZ; PF02163 Peptidase_M50 [H]

EC number: NA

Molecular weight: Translated: 42043; Mature: 42043

Theoretical pI: Translated: 7.15; Mature: 7.15

Prosite motif: PS50106 PDZ ; PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDQILSQGPLFLFCLIFMMGIVVVIHEFGHYLAARLYGVAIESFSVGFGKPLFERRDRRG
CCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCC
TRWRVNWIPLGGFVSFLPASAKADDETAQGIAGISFDELKPIPKIVVSLAGPFANFVLAT
CEEEEEEEECCHHHHHCCCCCCCCCHHHCCCCCCCHHHHCHHHHHHHHHHCHHHHHHHHH
LIFALAYGVFGSPKFEVQITHIGEGMPAEEAGLLPGDIIREINGRPILTGADATMMVLVS
HHHHHHHHCCCCCEEEEEEEECCCCCCHHHCCCCCHHHHHHCCCCEEEECCCCEEEEEEC
PNKAMRFNVDRNGQELNLDVIPREIVRPNEFGQVVPQSTAGFSLVHSKFIERVTYGPIGS
CCCEEEEEECCCCCEEEEEECCHHHCCCCHHCCCCCCCCCHHHHHHHHHHHHHCCCCHHH
LVEGTAQTGRTIDQTVKMLSRIATGNMSVHAMSGPVGVGDISRRAVNRVMEQTQLTSWQK
HHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHH
TEQLFWMLMSVCAAVSVGVGFFNLLPLPVLDGGRVVFHAYEAFTGSKMPSQVEAFALRAS
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCEEEEEEHHHHCCCCCCHHHHHHHHHHH
VFLLLLMVVVITWGDVIETGVFGRGGG
HHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MDQILSQGPLFLFCLIFMMGIVVVIHEFGHYLAARLYGVAIESFSVGFGKPLFERRDRRG
CCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCC
TRWRVNWIPLGGFVSFLPASAKADDETAQGIAGISFDELKPIPKIVVSLAGPFANFVLAT
CEEEEEEEECCHHHHHCCCCCCCCCHHHCCCCCCCHHHHCHHHHHHHHHHCHHHHHHHHH
LIFALAYGVFGSPKFEVQITHIGEGMPAEEAGLLPGDIIREINGRPILTGADATMMVLVS
HHHHHHHHCCCCCEEEEEEEECCCCCCHHHCCCCCHHHHHHCCCCEEEECCCCEEEEEEC
PNKAMRFNVDRNGQELNLDVIPREIVRPNEFGQVVPQSTAGFSLVHSKFIERVTYGPIGS
CCCEEEEEECCCCCEEEEEECCHHHCCCCHHCCCCCCCCCHHHHHHHHHHHHHCCCCHHH
LVEGTAQTGRTIDQTVKMLSRIATGNMSVHAMSGPVGVGDISRRAVNRVMEQTQLTSWQK
HHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHH
TEQLFWMLMSVCAAVSVGVGFFNLLPLPVLDGGRVVFHAYEAFTGSKMPSQVEAFALRAS
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCEEEEEEHHHHCCCCCCHHHHHHHHHHH
VFLLLLMVVVITWGDVIETGVFGRGGG
HHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11259647 [H]