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The map label for this gene is dxr [H]

Identifier: 114799124

GI number: 114799124

Start: 1816880

End: 1818073

Strand: Direct

Name: dxr [H]

Synonym: HNE_1774

Alternate gene names: 114799124

Gene position: 1816880-1818073 (Clockwise)

Preceding gene: 114798911

Following gene: 114800133

Centisome position: 49.04

GC content: 55.36

Gene sequence:

>1194_bases
ATGGTGCGCAAGGTTTCCATCTTCGGCTCAACAGGCTCAATCGGGCGGTCCGCGATCGACGTCATTTGCAATGCGAATGA
AACAGGCGCCGCCGAATTTTCTGTTGAGGCACTTGCAGCGGGCCGGGACGTGGAGGGCTTGGCGAGTCAGGCGCTGAAAC
TGAAGCCGAAAATTGCTGTAATTGCTGATGAAAGTCGCAAGGTGGAGCTCGCAGCCTTGCTGGCGGGGTCCGGCATCGAA
GTTGCTGCAGGCGAGGGGGCGTTAAATGAGGCCGCTGCGCGCCCCTGTGACCGTGTTTTGGCGGCAATTGTGGGCGCCGC
CGGCCTTGGTTCGACTTTGGCGGCCATAAAGGCTGGCAACGACATCGCGATCGCAAACAAGGAGAGCATTGTATGCGGCG
GTCAGCTTATGCTCGGCGAAGCCCGGCAGTCTGGAGCCCGCATTTTTCCCGTTGATTCGGAACATAGTGCCATTTTCCAA
TGCATCGGTGATGGGCGCAGCCTGGAAAACCTGACCATCACCGCATCTGGGGGGCCTTTCCGCAATTGGTCGCTGGAGCA
GATGGCAACGGCCACACCAGCTCAAGCGGCGGCCCATCCCGTCTGGTCCATGGGTATCAAAAATTCAATCGACAGCGCAT
CGTTGATGAATAAGGCCTTGGAATTCATAGAAGCGGCAGTCCTTTTTGACGTCGCCGCGGACCACATCAACGTATTGGTC
CACCCTCAGTCAATCATCCATGGCATGGCCCATTTCGACGATGGTTCGGTCATCGCTCAGCTTGGGTGTCCGGACATGAG
GACTCCGATTTCTTATGCTCTTGGATGGCCAGATCGAATTCCCACCACTGTCGACCGACTCAATCTTGCGCAGATTTCGA
ATCTGGAATTTTTTGAAGTCGATGAAGAGCGATTTGCTTCAATTCGGCTGGCTCGCGAGGCAATGGGCGCCGGCCCGGCT
GCCAGAGTGGTATTAAATTGCGCTAATGAAGCAGCTGTTTCAGCGTTCATAGCTGGTGAATGCGGCTTCCTTGACATCAG
CAGATTGGTCGAAGCCGCATTGGAGCGCTTTTCATCAGGTAATTTTGCCTCTAGCAAATGCGAAACGCTTGAAGAAATAG
CAGAAATAAGCCGGTACGGACGGTTCCTAGTGTCTCAATGGCTAAACAATGCCCCAAGCCGGGCGGGAGGATGA

Upstream 100 bases:

>100_bases
TTTGGATCGAGTTGATGGTTTGGGCGCTGTGGCTGTTGTAGGAAGCATTGCGTTGGCAGTTCACCCCGGTTTAGCAACTG
CGCTGGGGCTTTGAGGCTCC

Downstream 100 bases:

>100_bases
TCGAGTGGATCAGATTCTAAGCCAGGGGCCACTCTTCCTTTTCTGCCTGATCTTCATGATGGGCATTGTCGTTGTGATCC
ACGAATTTGGGCACTATCTG

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase [H]

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MVRKVSIFGSTGSIGRSAIDVICNANETGAAEFSVEALAAGRDVEGLASQALKLKPKIAVIADESRKVELAALLAGSGIE
VAAGEGALNEAAARPCDRVLAAIVGAAGLGSTLAAIKAGNDIAIANKESIVCGGQLMLGEARQSGARIFPVDSEHSAIFQ
CIGDGRSLENLTITASGGPFRNWSLEQMATATPAQAAAHPVWSMGIKNSIDSASLMNKALEFIEAAVLFDVAADHINVLV
HPQSIIHGMAHFDDGSVIAQLGCPDMRTPISYALGWPDRIPTTVDRLNLAQISNLEFFEVDEERFASIRLAREAMGAGPA
ARVVLNCANEAAVSAFIAGECGFLDISRLVEAALERFSSGNFASSKCETLEEIAEISRYGRFLVSQWLNNAPSRAGG

Sequences:

>Translated_397_residues
MVRKVSIFGSTGSIGRSAIDVICNANETGAAEFSVEALAAGRDVEGLASQALKLKPKIAVIADESRKVELAALLAGSGIE
VAAGEGALNEAAARPCDRVLAAIVGAAGLGSTLAAIKAGNDIAIANKESIVCGGQLMLGEARQSGARIFPVDSEHSAIFQ
CIGDGRSLENLTITASGGPFRNWSLEQMATATPAQAAAHPVWSMGIKNSIDSASLMNKALEFIEAAVLFDVAADHINVLV
HPQSIIHGMAHFDDGSVIAQLGCPDMRTPISYALGWPDRIPTTVDRLNLAQISNLEFFEVDEERFASIRLAREAMGAGPA
ARVVLNCANEAAVSAFIAGECGFLDISRLVEAALERFSSGNFASSKCETLEEIAEISRYGRFLVSQWLNNAPSRAGG
>Mature_397_residues
MVRKVSIFGSTGSIGRSAIDVICNANETGAAEFSVEALAAGRDVEGLASQALKLKPKIAVIADESRKVELAALLAGSGIE
VAAGEGALNEAAARPCDRVLAAIVGAAGLGSTLAAIKAGNDIAIANKESIVCGGQLMLGEARQSGARIFPVDSEHSAIFQ
CIGDGRSLENLTITASGGPFRNWSLEQMATATPAQAAAHPVWSMGIKNSIDSASLMNKALEFIEAAVLFDVAADHINVLV
HPQSIIHGMAHFDDGSVIAQLGCPDMRTPISYALGWPDRIPTTVDRLNLAQISNLEFFEVDEERFASIRLAREAMGAGPA
ARVVLNCANEAAVSAFIAGECGFLDISRLVEAALERFSSGNFASSKCETLEEIAEISRYGRFLVSQWLNNAPSRAGG

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) [H]

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family [H]

Homologues:

Organism=Escherichia coli, GI1786369, Length=371, Percent_Identity=45.2830188679245, Blast_Score=296, Evalue=2e-81,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom [H]

EC number: =1.1.1.267 [H]

Molecular weight: Translated: 41526; Mature: 41526

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRKVSIFGSTGSIGRSAIDVICNANETGAAEFSVEALAAGRDVEGLASQALKLKPKIAV
CCEEEEEECCCCCCCCHHHHEEECCCCCCCCCEEHHHHHCCCCHHHHHHHHHHCCCCEEE
IADESRKVELAALLAGSGIEVAAGEGALNEAAARPCDRVLAAIVGAAGLGSTLAAIKAGN
EECCCCCEEEEEEECCCCCEEECCCCCHHHHHCCHHHHHHHHHHHHCCCCHHHHHHCCCC
DIAIANKESIVCGGQLMLGEARQSGARIFPVDSEHSAIFQCIGDGRSLENLTITASGGPF
EEEEECCCCEEECCEEEECHHHHCCCEEEECCCCHHHHHHHHCCCCCCCEEEEEECCCCC
RNWSLEQMATATPAQAAAHPVWSMGIKNSIDSASLMNKALEFIEAAVLFDVAADHINVLV
CCCCHHHHHCCCCHHHHCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEE
HPQSIIHGMAHFDDGSVIAQLGCPDMRTPISYALGWPDRIPTTVDRLNLAQISNLEFFEV
CHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHCCCCCCCCCHHHHCCHHHHCCCEEEEC
DEERFASIRLAREAMGAGPAARVVLNCANEAAVSAFIAGECGFLDISRLVEAALERFSSG
CHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCC
NFASSKCETLEEIAEISRYGRFLVSQWLNNAPSRAGG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MVRKVSIFGSTGSIGRSAIDVICNANETGAAEFSVEALAAGRDVEGLASQALKLKPKIAV
CCEEEEEECCCCCCCCHHHHEEECCCCCCCCCEEHHHHHCCCCHHHHHHHHHHCCCCEEE
IADESRKVELAALLAGSGIEVAAGEGALNEAAARPCDRVLAAIVGAAGLGSTLAAIKAGN
EECCCCCEEEEEEECCCCCEEECCCCCHHHHHCCHHHHHHHHHHHHCCCCHHHHHHCCCC
DIAIANKESIVCGGQLMLGEARQSGARIFPVDSEHSAIFQCIGDGRSLENLTITASGGPF
EEEEECCCCEEECCEEEECHHHHCCCEEEECCCCHHHHHHHHCCCCCCCEEEEEECCCCC
RNWSLEQMATATPAQAAAHPVWSMGIKNSIDSASLMNKALEFIEAAVLFDVAADHINVLV
CCCCHHHHHCCCCHHHHCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEE
HPQSIIHGMAHFDDGSVIAQLGCPDMRTPISYALGWPDRIPTTVDRLNLAQISNLEFFEV
CHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHCCCCCCCCCHHHHCCHHHHCCCEEEEC
DEERFASIRLAREAMGAGPAARVVLNCANEAAVSAFIAGECGFLDISRLVEAALERFSSG
CHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCC
NFASSKCETLEEIAEISRYGRFLVSQWLNNAPSRAGG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA