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The map label for this gene is pntAA [H]

Identifier: 114799994

GI number: 114799994

Start: 1151107

End: 1152222

Strand: Reverse

Name: pntAA [H]

Synonym: HNE_1140

Alternate gene names: 114799994

Gene position: 1152222-1151107 (Counterclockwise)

Preceding gene: 114800062

Following gene: 114799782

Centisome position: 31.1

GC content: 64.07

Gene sequence:

>1116_bases
GTGCTCAAAGAACGGCGATCCGGCGAAACCCGCGTGGCGGCAACTCCGGAGACAGTCAAGAAACTAATTGGCCTGGGCCA
CACGGTCACGGTCGAGGGAGGAGCGGGAACCGTTGCCGGTTTCCTGGATGCAGCTTTTACCGAAGCGGGGGCCAGCATTG
CGGGCTCTGCGGCCGAGGCGGCGAGCGGCGCGGACATTGTTTTCAAGGTCCGCCGTCCGGAGCCAGCAGAGATCGCGGCC
CTGCCCGAAGGCTCGGCGCTGATCGCGCTGATGGAGCCCTTCGCGTACCCGGCCGAGGAAATCGCGGCGCTCAATGCAAA
GAAGATCGCGGCGCTCTCGATGGAGTTCACCCCGCGAATCACGCGCGCCCAGTCGATGGACGCGCTCTCGTCCCAGTCCA
ACCTCTCAGGCTATCGCGCCATCATTGAAGGCGCCCAGATTTATGGCCGCGCCATGCCGATGATGATGACGGCGGCCGGC
ACCATTGCCCCGGCAAAAGTCTTCGTCATGGGCGCGGGCGTTGCCGGCCTCCAGGCCATCGCCACGGCCCGCCGCCTCGG
CGCAGTCGTCACGGCGAACGATGTGCGCCCCGCCGCCAAGGAACAGGTCGCCTCGCTCGGCGCCAAGTTCATTGCCGTAG
AGGATGATGAGTTCAAAGCGGCCGAAACCTCCGGCGGCTACGCCAAGGAAATGTCGGCTGAATACCAGGCCAAACAGGCC
GCGCTGACCGCCAGCCACATTGCCAAGCAGGACATCGTCGTGACCACGGCGCTTATCCCGGGGCGCCCCGCGCCCGTGCT
GATCACCGAGGAAATGGTGAAAAGCATGAAGCCCGGCTCGGTCATCATCGATATGGCCGTTGCACAGGGCGGCAACTGCC
CGCTCTCGAAGGCCGATGAGATTGTCGATGTCGGCGGCGTCAAAGTGGCCGGGTTCTCGAACCTGCCCGCGCGTCTGCCC
GCCGACTCCTCGTCGCTCTATGCCAAAAACCTGTTCGCCTTCATCCCGCTGATCACCGCCGAAAACGGCGCGATCAATCT
CGATACCGAGGATGAAGTCGTCGTTGCCATGCTGCTCACGCGCAATGGCGCAACCGTTAGTGAAAGGCTGAAGTGA

Upstream 100 bases:

>100_bases
GTCCTGTTAGCGAGACTAAACAAACTCATGCCCTAAACCCTCAAAATAACTATTGCACGGCGCAAAGTTTAACCTAATCC
AAGGCACCATGAAGATATCA

Downstream 100 bases:

>100_bases
TGAAACGCGCTACTGCCACTGCCCTCGCCCTCACCGCCTTCGCGCTTCCGGCTTTTGCGGACGCGGGCGGCATCGACTCG
ACCGTCTTCCTGGCGGCCAT

Product: NAD(P) transhydrogenase subunit alpha part 1

Products: NA

Alternate protein names: Nicotinamide nucleotide transhydrogenase subunit alpha 1; Proton-translocating transhydrogenase component 1; Pyridine nucleotide transhydrogenase subunit alpha 1; dI [H]

Number of amino acids: Translated: 371; Mature: 371

Protein sequence:

>371_residues
MLKERRSGETRVAATPETVKKLIGLGHTVTVEGGAGTVAGFLDAAFTEAGASIAGSAAEAASGADIVFKVRRPEPAEIAA
LPEGSALIALMEPFAYPAEEIAALNAKKIAALSMEFTPRITRAQSMDALSSQSNLSGYRAIIEGAQIYGRAMPMMMTAAG
TIAPAKVFVMGAGVAGLQAIATARRLGAVVTANDVRPAAKEQVASLGAKFIAVEDDEFKAAETSGGYAKEMSAEYQAKQA
ALTASHIAKQDIVVTTALIPGRPAPVLITEEMVKSMKPGSVIIDMAVAQGGNCPLSKADEIVDVGGVKVAGFSNLPARLP
ADSSSLYAKNLFAFIPLITAENGAINLDTEDEVVVAMLLTRNGATVSERLK

Sequences:

>Translated_371_residues
MLKERRSGETRVAATPETVKKLIGLGHTVTVEGGAGTVAGFLDAAFTEAGASIAGSAAEAASGADIVFKVRRPEPAEIAA
LPEGSALIALMEPFAYPAEEIAALNAKKIAALSMEFTPRITRAQSMDALSSQSNLSGYRAIIEGAQIYGRAMPMMMTAAG
TIAPAKVFVMGAGVAGLQAIATARRLGAVVTANDVRPAAKEQVASLGAKFIAVEDDEFKAAETSGGYAKEMSAEYQAKQA
ALTASHIAKQDIVVTTALIPGRPAPVLITEEMVKSMKPGSVIIDMAVAQGGNCPLSKADEIVDVGGVKVAGFSNLPARLP
ADSSSLYAKNLFAFIPLITAENGAINLDTEDEVVVAMLLTRNGATVSERLK
>Mature_371_residues
MLKERRSGETRVAATPETVKKLIGLGHTVTVEGGAGTVAGFLDAAFTEAGASIAGSAAEAASGADIVFKVRRPEPAEIAA
LPEGSALIALMEPFAYPAEEIAALNAKKIAALSMEFTPRITRAQSMDALSSQSNLSGYRAIIEGAQIYGRAMPMMMTAAG
TIAPAKVFVMGAGVAGLQAIATARRLGAVVTANDVRPAAKEQVASLGAKFIAVEDDEFKAAETSGGYAKEMSAEYQAKQA
ALTASHIAKQDIVVTTALIPGRPAPVLITEEMVKSMKPGSVIIDMAVAQGGNCPLSKADEIVDVGGVKVAGFSNLPARLP
ADSSSLYAKNLFAFIPLITAENGAINLDTEDEVVVAMLLTRNGATVSERLK

Specific function: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [H]

COG id: COG3288

COG function: function code C; NAD/NADP transhydrogenase alpha subunit

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=355, Percent_Identity=39.1549295774648, Blast_Score=234, Evalue=8e-62,
Organism=Homo sapiens, GI122939153, Length=355, Percent_Identity=39.1549295774648, Blast_Score=234, Evalue=8e-62,
Organism=Escherichia coli, GI1787887, Length=364, Percent_Identity=47.8021978021978, Blast_Score=306, Evalue=1e-84,
Organism=Caenorhabditis elegans, GI17550456, Length=364, Percent_Identity=43.6813186813187, Blast_Score=275, Evalue=3e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.6.1.2 [H]

Molecular weight: Translated: 38292; Mature: 38292

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS00837 ALADH_PNT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKERRSGETRVAATPETVKKLIGLGHTVTVEGGAGTVAGFLDAAFTEAGASIAGSAAEA
CCCCCCCCCCEEEECHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCCHHCCCHHHC
ASGADIVFKVRRPEPAEIAALPEGSALIALMEPFAYPAEEIAALNAKKIAALSMEFTPRI
CCCCEEEEEECCCCCCEEEECCCCCEEEEEECCCCCCHHHHHHCCHHHEEEEEEECCCCH
TRAQSMDALSSQSNLSGYRAIIEGAQIYGRAMPMMMTAAGTIAPAKVFVMGAGVAGLQAI
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCHHHHHHH
ATARRLGAVVTANDVRPAAKEQVASLGAKFIAVEDDEFKAAETSGGYAKEMSAEYQAKQA
HHHHHHCEEEEECCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHH
ALTASHIAKQDIVVTTALIPGRPAPVLITEEMVKSMKPGSVIIDMAVAQGGNCPLSKADE
HHHHHHHHHCCEEEEEEECCCCCCCEEEEHHHHHCCCCCCEEEEEEECCCCCCCCCCCCC
IVDVGGVKVAGFSNLPARLPADSSSLYAKNLFAFIPLITAENGAINLDTEDEVVVAMLLT
EEECCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHEEEEECCCEEECCCCCCEEEEEEEE
RNGATVSERLK
CCCCCHHHHCC
>Mature Secondary Structure
MLKERRSGETRVAATPETVKKLIGLGHTVTVEGGAGTVAGFLDAAFTEAGASIAGSAAEA
CCCCCCCCCCEEEECHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCCHHCCCHHHC
ASGADIVFKVRRPEPAEIAALPEGSALIALMEPFAYPAEEIAALNAKKIAALSMEFTPRI
CCCCEEEEEECCCCCCEEEECCCCCEEEEEECCCCCCHHHHHHCCHHHEEEEEEECCCCH
TRAQSMDALSSQSNLSGYRAIIEGAQIYGRAMPMMMTAAGTIAPAKVFVMGAGVAGLQAI
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCHHHHHHH
ATARRLGAVVTANDVRPAAKEQVASLGAKFIAVEDDEFKAAETSGGYAKEMSAEYQAKQA
HHHHHHCEEEEECCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHH
ALTASHIAKQDIVVTTALIPGRPAPVLITEEMVKSMKPGSVIIDMAVAQGGNCPLSKADE
HHHHHHHHHCCEEEEEEECCCCCCCEEEEHHHHHCCCCCCEEEEEEECCCCCCCCCCCCC
IVDVGGVKVAGFSNLPARLPADSSSLYAKNLFAFIPLITAENGAINLDTEDEVVVAMLLT
EEECCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHEEEEECCCEEECCCCCCEEEEEEEE
RNGATVSERLK
CCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8075801 [H]