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The map label for this gene is aroE

Identifier: 114799600

GI number: 114799600

Start: 1690

End: 2502

Strand: Direct

Name: aroE

Synonym: HNE_0003

Alternate gene names: 114799600

Gene position: 1690-2502 (Clockwise)

Preceding gene: 114798603

Following gene: 114797191

Centisome position: 0.05

GC content: 61.13

Gene sequence:

>813_bases
ATGACCCATCTTCTTGGCGTTGTGGGCGATCCTGTCGCCCATTCGCTTTCGCCTTTCATCCATAATGGATGGCTTCGCGC
GCATCAGATTGACGCGGTTTATTCCGCCTTTGAAGTAAAAGCCGGAGAGCTTGTGTCTGGCCTTCAGTCCCTGTCCAGCC
AGGGGGTCATCGGGCTGAACGTTACCCTTCCGCACAAGGAAGAGGCGATGCGGCTCGCAACCTCTGTCAGCGGCACAGCC
CACCGGCTGGGTGCCGTGAATTTTCTGGTTCGCCGGGAAGATGGATGGATCGGCGACAATACAGACGCTCCCGGCTTCGG
GCTGACGCTCGACTTTGGTGACATTGAAGTCTCTGGGAGGAATGTCTTTCTGCTCGGGGCAGGGGGCTCTGCCCGCGCGG
TGGCTTCGGTTCTCGCAGATCGCGGCGCACGCCTCACAATCTGTAACCGGACGGTCGGCCGCGCAGAAGACCTCGCGCGC
GACCTTGCGCCCGGCGCGCGGGTTCGCTCCCTGGACGAAGGCCTGCGTAAGCTCTCTTCTGCTGCGCTCGTCGTAAACAC
GCTCAGCCTTGGCCATTCTGGCGGACGTCTGGAATTACCGCCATCCGCCGGGGGCATCTTCTATGACATCAGCTATGGCA
AAGGCGCAGAGGCTGCCTTGAAGGAAGCCCGCGAAAAAGGCTGGCGCGCGCTCGACGGTCTCGGCATGCTGGTTGCTCAG
GCAGCTATCAGCTTCGAACACTGGTTTGGTATCAAGCCGGACATGGCCGAGGCGCATGCCCGGTGCCGTAAGCTTGTGGA
GGCCACATCATGA

Upstream 100 bases:

>100_bases
CGCAGCTGTTTACGCGGATCGAGGGAGATTATTTCTCCATTCTCGGCCTGCCGCTGCTGCCGCTTCTGGATTACCTCCGT
ATCCGGAAAGTGCTTCCTAC

Downstream 100 bases:

>100_bases
TCATCCTTGGGCTGACTGGCTCTATAGGCATGGGAAAATCTGCCACCGCGAACCTTTTCAAGGACGCGGGCATACCGGTT
TATGATGCCGACGCGGCCGT

Product: shikimate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 270; Mature: 269

Protein sequence:

>270_residues
MTHLLGVVGDPVAHSLSPFIHNGWLRAHQIDAVYSAFEVKAGELVSGLQSLSSQGVIGLNVTLPHKEEAMRLATSVSGTA
HRLGAVNFLVRREDGWIGDNTDAPGFGLTLDFGDIEVSGRNVFLLGAGGSARAVASVLADRGARLTICNRTVGRAEDLAR
DLAPGARVRSLDEGLRKLSSAALVVNTLSLGHSGGRLELPPSAGGIFYDISYGKGAEAALKEAREKGWRALDGLGMLVAQ
AAISFEHWFGIKPDMAEAHARCRKLVEATS

Sequences:

>Translated_270_residues
MTHLLGVVGDPVAHSLSPFIHNGWLRAHQIDAVYSAFEVKAGELVSGLQSLSSQGVIGLNVTLPHKEEAMRLATSVSGTA
HRLGAVNFLVRREDGWIGDNTDAPGFGLTLDFGDIEVSGRNVFLLGAGGSARAVASVLADRGARLTICNRTVGRAEDLAR
DLAPGARVRSLDEGLRKLSSAALVVNTLSLGHSGGRLELPPSAGGIFYDISYGKGAEAALKEAREKGWRALDGLGMLVAQ
AAISFEHWFGIKPDMAEAHARCRKLVEATS
>Mature_269_residues
THLLGVVGDPVAHSLSPFIHNGWLRAHQIDAVYSAFEVKAGELVSGLQSLSSQGVIGLNVTLPHKEEAMRLATSVSGTAH
RLGAVNFLVRREDGWIGDNTDAPGFGLTLDFGDIEVSGRNVFLLGAGGSARAVASVLADRGARLTICNRTVGRAEDLARD
LAPGARVRSLDEGLRKLSSAALVVNTLSLGHSGGRLELPPSAGGIFYDISYGKGAEAALKEAREKGWRALDGLGMLVAQA
AISFEHWFGIKPDMAEAHARCRKLVEATS

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1789675, Length=256, Percent_Identity=39.453125, Blast_Score=143, Evalue=1e-35,
Organism=Escherichia coli, GI1787983, Length=275, Percent_Identity=26.9090909090909, Blast_Score=87, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6320332, Length=271, Percent_Identity=25.0922509225092, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROE_HYPNA (Q0C6A6)

Other databases:

- EMBL:   CP000158
- RefSeq:   YP_758737.1
- ProteinModelPortal:   Q0C6A6
- SMR:   Q0C6A6
- STRING:   Q0C6A6
- GeneID:   4289096
- GenomeReviews:   CP000158_GR
- KEGG:   hne:HNE_0003
- NMPDR:   fig|228405.5.peg.3
- TIGR:   HNE_0003
- eggNOG:   COG0169
- HOGENOM:   HBG553408
- OMA:   RIVIANR
- PhylomeDB:   Q0C6A6
- ProtClustDB:   CLSK2532021
- BioCyc:   HNEP81032:HNE_0003-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00222
- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR00507

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N

EC number: =1.1.1.25

Molecular weight: Translated: 28486; Mature: 28355

Theoretical pI: Translated: 7.33; Mature: 7.33

Prosite motif: NA

Important sites: ACT_SITE 66-66

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHLLGVVGDPVAHSLSPFIHNGWLRAHQIDAVYSAFEVKAGELVSGLQSLSSQGVIGLN
CCCCCCCCCCHHHHHHCHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCEEEEE
VTLPHKEEAMRLATSVSGTAHRLGAVNFLVRREDGWIGDNTDAPGFGLTLDFGDIEVSGR
EECCCHHHHHHHHHHCCCHHHHHHHEEEEEEECCCCCCCCCCCCCCEEEEECCCEEECCC
NVFLLGAGGSARAVASVLADRGARLTICNRTVGRAEDLARDLAPGARVRSLDEGLRKLSS
EEEEEECCCCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHH
AALVVNTLSLGHSGGRLELPPSAGGIFYDISYGKGAEAALKEAREKGWRALDGLGMLVAQ
HHHEEEHHHCCCCCCEEECCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AAISFEHWFGIKPDMAEAHARCRKLVEATS
HHHHHHHHCCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
THLLGVVGDPVAHSLSPFIHNGWLRAHQIDAVYSAFEVKAGELVSGLQSLSSQGVIGLN
CCCCCCCCCHHHHHHCHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCEEEEE
VTLPHKEEAMRLATSVSGTAHRLGAVNFLVRREDGWIGDNTDAPGFGLTLDFGDIEVSGR
EECCCHHHHHHHHHHCCCHHHHHHHEEEEEEECCCCCCCCCCCCCCEEEEECCCEEECCC
NVFLLGAGGSARAVASVLADRGARLTICNRTVGRAEDLARDLAPGARVRSLDEGLRKLSS
EEEEEECCCCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHH
AALVVNTLSLGHSGGRLELPPSAGGIFYDISYGKGAEAALKEAREKGWRALDGLGMLVAQ
HHHEEEHHHCCCCCCEEECCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AAISFEHWFGIKPDMAEAHARCRKLVEATS
HHHHHHHHCCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA