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The map label for this gene is trpE [H]

Identifier: 114799062

GI number: 114799062

Start: 1833607

End: 1835031

Strand: Reverse

Name: trpE [H]

Synonym: HNE_1790

Alternate gene names: 114799062

Gene position: 1835031-1833607 (Counterclockwise)

Preceding gene: 114799881

Following gene: 114798771

Centisome position: 49.53

GC content: 58.39

Gene sequence:

>1425_bases
ATGACGGCGCGACTGATCGTAAGACGGTGCATCGGCGATATTGAAACGCCGGTTGGCGCCATGATGAAGCTCGGAGCAGA
CGAGCCGGGCAGTTTTCTGTTTGAGTCGATTGCCGGTGGCGAGCGCCTTGGGCGGTATTCGTTTATCGGGCTCAAGCCAG
AAATCTGGTTCCGCATCAAGGATGGCGTCGCCGAGACGAGCCGGTCCGCTGACTTTTCGGACGCTCATCAGCTGGCGGAG
CGTCCCGTAGACGCCCTGCGCAGTTTTGCTGAAGCGGCACGCGCCGAGACCAGTGATCCCCTGCCCCCCATGGCGTCCGG
CGCATTCGGCTATGTCGGGTACGACATGATCCAGCATGTCGAGCCGGTGTCGATCACGAAACCAGATCAGCTGGACGTGC
CCGAAGCGCTGTTAGTTGTCCCGCGGGTGATGGTGATCTTTGATCACATCTATCAGGAGCTGCTTCTGATTGGCCGGGTG
AATGGCGCCGATGAGACAGAGATCGATGCGCTCCTCGATGAGGTGGAGGCGCGGCTGGAAAGCCTGCCCTCGCTGCCTCC
GAAAAACGGCACTGCCCAACAAGTAGACCTGGTGTCGAACACATCCCAAGAACGCTATTTCGAGATTGTAGAGACCTGCC
GTGAGTACATCAAAGCTGGCGATATATTCCAGGTCGTGCCTAGCCAGCGTTTCTCTGCCGTGTTCAAGCAGAAGTCGATA
AGCCTCTATCGCGCCCTTCGGCGGCTGAACCCCTCCGCTTTCATGTTCCATATCAATCTGGGTGATGTACGGCTTGTTGG
GTCAAGCCCGGAAATTCTCGTCCGCCTGCGCGAAGGCCGGGTCGCAATCCGTCCTATTGCCGGAACCCGTCCGCGCAGCG
GCAATCCGGCGGAAGATGCTCTGCGTGCAGAAGACCTTCTGAACGATCCCAAGGAACGCGCCGAGCACCTCATGCTACTT
GATCTGGGGCGCAACGATGTGGGCCGGGTTGCGGCCTATGGTTCTGTGGAGGTCACAGAACAGTTCATCGTCGAACGCTA
CAGCCATGTGATGCACATCGTCAGCCATGTCGAAGGCAATCTGAGACCCGGCCTTGATGCTGTAGACGCATTATTCGCAG
GATTTCCGGCCGGAACAGTCTCTGGCGCCCCAAAGATTCGCGCCATGCAGATCATCAATGAAGTCGAAACACACAGCCGG
GGTATCTACGGTGGCGCCGTGGGTTATTTCGGCTGGAACGGCGACCTCGACACCTGCATCGCGCTGCGCACCGCCGTGCT
GAAAGACGGTATGGTGCACATACAGGCAGGGGGCGGTGTCGTGCTCGATTCCAATGCTCAGTATGAATATGATGAAACGG
TTCACAAATCCGGCGCCCTGAAGCGTGCTGCCGAATTGGCCGCAGCTTATGAGCACGACCAATGA

Upstream 100 bases:

>100_bases
ATCTGGAAGCCGCTGTGGATGACGAAATTCGCCGGGCGGTCAAGGTCAAGGAGAATGCTTCGGCGATCGCCTCTTACAAG
CGAACGATAACGGCTGCCCA

Downstream 100 bases:

>100_bases
TCCTCGTTATCGACAATTATGACAGCTTCACCTGGAACCTCGTCCATTATCTGGAAGAACTCGGCGCCAAAACACACGTT
GTCCGCAATGATCAGCTCAC

Product: anthranilate synthase component I

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 474; Mature: 473

Protein sequence:

>474_residues
MTARLIVRRCIGDIETPVGAMMKLGADEPGSFLFESIAGGERLGRYSFIGLKPEIWFRIKDGVAETSRSADFSDAHQLAE
RPVDALRSFAEAARAETSDPLPPMASGAFGYVGYDMIQHVEPVSITKPDQLDVPEALLVVPRVMVIFDHIYQELLLIGRV
NGADETEIDALLDEVEARLESLPSLPPKNGTAQQVDLVSNTSQERYFEIVETCREYIKAGDIFQVVPSQRFSAVFKQKSI
SLYRALRRLNPSAFMFHINLGDVRLVGSSPEILVRLREGRVAIRPIAGTRPRSGNPAEDALRAEDLLNDPKERAEHLMLL
DLGRNDVGRVAAYGSVEVTEQFIVERYSHVMHIVSHVEGNLRPGLDAVDALFAGFPAGTVSGAPKIRAMQIINEVETHSR
GIYGGAVGYFGWNGDLDTCIALRTAVLKDGMVHIQAGGGVVLDSNAQYEYDETVHKSGALKRAAELAAAYEHDQ

Sequences:

>Translated_474_residues
MTARLIVRRCIGDIETPVGAMMKLGADEPGSFLFESIAGGERLGRYSFIGLKPEIWFRIKDGVAETSRSADFSDAHQLAE
RPVDALRSFAEAARAETSDPLPPMASGAFGYVGYDMIQHVEPVSITKPDQLDVPEALLVVPRVMVIFDHIYQELLLIGRV
NGADETEIDALLDEVEARLESLPSLPPKNGTAQQVDLVSNTSQERYFEIVETCREYIKAGDIFQVVPSQRFSAVFKQKSI
SLYRALRRLNPSAFMFHINLGDVRLVGSSPEILVRLREGRVAIRPIAGTRPRSGNPAEDALRAEDLLNDPKERAEHLMLL
DLGRNDVGRVAAYGSVEVTEQFIVERYSHVMHIVSHVEGNLRPGLDAVDALFAGFPAGTVSGAPKIRAMQIINEVETHSR
GIYGGAVGYFGWNGDLDTCIALRTAVLKDGMVHIQAGGGVVLDSNAQYEYDETVHKSGALKRAAELAAAYEHDQ
>Mature_473_residues
TARLIVRRCIGDIETPVGAMMKLGADEPGSFLFESIAGGERLGRYSFIGLKPEIWFRIKDGVAETSRSADFSDAHQLAER
PVDALRSFAEAARAETSDPLPPMASGAFGYVGYDMIQHVEPVSITKPDQLDVPEALLVVPRVMVIFDHIYQELLLIGRVN
GADETEIDALLDEVEARLESLPSLPPKNGTAQQVDLVSNTSQERYFEIVETCREYIKAGDIFQVVPSQRFSAVFKQKSIS
LYRALRRLNPSAFMFHINLGDVRLVGSSPEILVRLREGRVAIRPIAGTRPRSGNPAEDALRAEDLLNDPKERAEHLMLLD
LGRNDVGRVAAYGSVEVTEQFIVERYSHVMHIVSHVEGNLRPGLDAVDALFAGFPAGTVSGAPKIRAMQIINEVETHSRG
IYGGAVGYFGWNGDLDTCIALRTAVLKDGMVHIQAGGGVVLDSNAQYEYDETVHKSGALKRAAELAAAYEHDQ

Specific function: Tryptophan biosynthesis; first step. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1787518, Length=367, Percent_Identity=40.3269754768392, Blast_Score=237, Evalue=1e-63,
Organism=Escherichia coli, GI1788114, Length=365, Percent_Identity=34.5205479452055, Blast_Score=219, Evalue=4e-58,
Organism=Escherichia coli, GI1786809, Length=205, Percent_Identity=28.780487804878, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI87082077, Length=259, Percent_Identity=25.4826254826255, Blast_Score=77, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6320935, Length=467, Percent_Identity=38.1156316916488, Blast_Score=290, Evalue=3e-79,
Organism=Saccharomyces cerevisiae, GI6324361, Length=386, Percent_Identity=24.0932642487047, Blast_Score=104, Evalue=3e-23,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005256
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 51984; Mature: 51853

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTARLIVRRCIGDIETPVGAMMKLGADEPGSFLFESIAGGERLGRYSFIGLKPEIWFRIK
CCHHHHHHHHHHHCCCCHHHHHHCCCCCCHHHHHHHHCCCHHCCCEEEEECCCEEEEEEC
DGVAETSRSADFSDAHQLAERPVDALRSFAEAARAETSDPLPPMASGAFGYVGYDMIQHV
CCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCC
EPVSITKPDQLDVPEALLVVPRVMVIFDHIYQELLLIGRVNGADETEIDALLDEVEARLE
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
SLPSLPPKNGTAQQVDLVSNTSQERYFEIVETCREYIKAGDIFQVVPSQRFSAVFKQKSI
HCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHH
SLYRALRRLNPSAFMFHINLGDVRLVGSSPEILVRLREGRVAIRPIAGTRPRSGNPAEDA
HHHHHHHHCCCCEEEEEEECCCEEEECCCCCEEEEEECCCEEEEECCCCCCCCCCCHHHH
LRAEDLLNDPKERAEHLMLLDLGRNDVGRVAAYGSVEVTEQFIVERYSHVMHIVSHVEGN
HHHHHHHCCHHHHHCEEEEEECCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHCCC
LRPGLDAVDALFAGFPAGTVSGAPKIRAMQIINEVETHSRGIYGGAVGYFGWNGDLDTCI
CCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCHHHHH
ALRTAVLKDGMVHIQAGGGVVLDSNAQYEYDETVHKSGALKRAAELAAAYEHDQ
HHHHHHHHCCEEEEEECCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TARLIVRRCIGDIETPVGAMMKLGADEPGSFLFESIAGGERLGRYSFIGLKPEIWFRIK
CHHHHHHHHHHHCCCCHHHHHHCCCCCCHHHHHHHHCCCHHCCCEEEEECCCEEEEEEC
DGVAETSRSADFSDAHQLAERPVDALRSFAEAARAETSDPLPPMASGAFGYVGYDMIQHV
CCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCC
EPVSITKPDQLDVPEALLVVPRVMVIFDHIYQELLLIGRVNGADETEIDALLDEVEARLE
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
SLPSLPPKNGTAQQVDLVSNTSQERYFEIVETCREYIKAGDIFQVVPSQRFSAVFKQKSI
HCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHH
SLYRALRRLNPSAFMFHINLGDVRLVGSSPEILVRLREGRVAIRPIAGTRPRSGNPAEDA
HHHHHHHHCCCCEEEEEEECCCEEEECCCCCEEEEEECCCEEEEECCCCCCCCCCCHHHH
LRAEDLLNDPKERAEHLMLLDLGRNDVGRVAAYGSVEVTEQFIVERYSHVMHIVSHVEGN
HHHHHHHCCHHHHHCEEEEEECCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHCCC
LRPGLDAVDALFAGFPAGTVSGAPKIRAMQIINEVETHSRGIYGGAVGYFGWNGDLDTCI
CCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCHHHHH
ALRTAVLKDGMVHIQAGGGVVLDSNAQYEYDETVHKSGALKRAAELAAAYEHDQ
HHHHHHHHCCEEEEEECCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA