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The map label for this gene is capI [H]

Identifier: 114798701

GI number: 114798701

Start: 2799146

End: 2800150

Strand: Direct

Name: capI [H]

Synonym: HNE_2639

Alternate gene names: 114798701

Gene position: 2799146-2800150 (Clockwise)

Preceding gene: 114799830

Following gene: 114799913

Centisome position: 75.55

GC content: 61.19

Gene sequence:

>1005_bases
ATGAAAATCCTCGTTACCGGCGCGGCCGGCTTCATCGGGAGCGAGATGGCGCTGCGGCTTCTCAAGGAGGGCCATAGCGT
GACGGGCGTGGACTGTTTCACGCCCTATTATGATCCCCAGCTGAAAGAAGACCGCGCCGCGCGCCTGACGGCGTTTGACG
ATTTTCGCCTGGAGCGCATCCGCATCGAGGACAGCGAGGCGATGGAGGCGGTGTTCCAGCGCGATACCCCCGAGATGGTG
CTCCATTTCGCCGCGCAGGCCGGCGTGCGCTACAGCCTCGACCATCCGCGCGACTTCATAGACGCCAACATCGTCGGCTC
GTTCAACATCATTGACCTTTCGCGCCGCCACGGCACGCAGCATCTGGTGATGGCCTCGACCAGCTCTGCCTATGGCGCCA
ACCAGAAATTCCCATTCGAGGAGCGCGATTCAGCGCCCTACCCGCTGACCATCTATGCGGCGACGAAGCTGGCCAGCGAG
TTGATCGCGCACAGCCATGCCCATCTTTATGGCGTGCCGACGACCGTGCTGCGCTTCTTCAGCGTGTATGGCCCGTGGGG
GCGGCCGGATATGGCGTTCTTTCTGTTCACGGACAAGATATTCAAGGGCCAGCCGATTGACGTGTTCAATCATGGCGACC
TGTTGCGCGACTTTACCTATATCGACGACCTGGTAGAGGCCATCCGCCGTCTGATGGATACCCCGCCGGTTGTCGGCAAT
CACATCATCCGGGGGGATTCGCTGTCACCGGTGGCGCCCTATCGCCTGGTGAATATCGGCAATGCCAGCCCTGTGCGCCT
GATGGACTATATCGAGGCCATCGAAGGCGCCATCGGGCGCAAGGCCGAGAAGAACATGATCGACATGCAGCCGGGCGACG
TGAAGCAGACCTTTGCCGATGTCCGCCTGCTGGACGCGCTGACCGGGTATACGCCGGACACGGATTATCGCACCGGCATT
GCCCGCTTTGTCGACTGGTATCGCGATTATTTCAAGCCGGCCTGA

Upstream 100 bases:

>100_bases
GCACCCTCGCCGAACTGGCGGGGGTGTTGCAGTTTAAGGGGAATTGATACCCTGCCCTTCACTCCGGCCTCCTCCCGGCC
TGCCAGCAGATGAGACTGAC

Downstream 100 bases:

>100_bases
AGGCCCGCCTTTTCGGCCGCCGCCCTGAAATCCTCCGGCACGGGCGCTTCCAGCGTGAGCGTGCCACCTTCGGGATGGGG
CACTTCCAGACGCGCGGCAT

Product: UDP-glucuronate 5'-epimerase

Products: UDP-L-iduronate

Alternate protein names: NA

Number of amino acids: Translated: 334; Mature: 334

Protein sequence:

>334_residues
MKILVTGAAGFIGSEMALRLLKEGHSVTGVDCFTPYYDPQLKEDRAARLTAFDDFRLERIRIEDSEAMEAVFQRDTPEMV
LHFAAQAGVRYSLDHPRDFIDANIVGSFNIIDLSRRHGTQHLVMASTSSAYGANQKFPFEERDSAPYPLTIYAATKLASE
LIAHSHAHLYGVPTTVLRFFSVYGPWGRPDMAFFLFTDKIFKGQPIDVFNHGDLLRDFTYIDDLVEAIRRLMDTPPVVGN
HIIRGDSLSPVAPYRLVNIGNASPVRLMDYIEAIEGAIGRKAEKNMIDMQPGDVKQTFADVRLLDALTGYTPDTDYRTGI
ARFVDWYRDYFKPA

Sequences:

>Translated_334_residues
MKILVTGAAGFIGSEMALRLLKEGHSVTGVDCFTPYYDPQLKEDRAARLTAFDDFRLERIRIEDSEAMEAVFQRDTPEMV
LHFAAQAGVRYSLDHPRDFIDANIVGSFNIIDLSRRHGTQHLVMASTSSAYGANQKFPFEERDSAPYPLTIYAATKLASE
LIAHSHAHLYGVPTTVLRFFSVYGPWGRPDMAFFLFTDKIFKGQPIDVFNHGDLLRDFTYIDDLVEAIRRLMDTPPVVGN
HIIRGDSLSPVAPYRLVNIGNASPVRLMDYIEAIEGAIGRKAEKNMIDMQPGDVKQTFADVRLLDALTGYTPDTDYRTGI
ARFVDWYRDYFKPA
>Mature_334_residues
MKILVTGAAGFIGSEMALRLLKEGHSVTGVDCFTPYYDPQLKEDRAARLTAFDDFRLERIRIEDSEAMEAVFQRDTPEMV
LHFAAQAGVRYSLDHPRDFIDANIVGSFNIIDLSRRHGTQHLVMASTSSAYGANQKFPFEERDSAPYPLTIYAATKLASE
LIAHSHAHLYGVPTTVLRFFSVYGPWGRPDMAFFLFTDKIFKGQPIDVFNHGDLLRDFTYIDDLVEAIRRLMDTPPVVGN
HIIRGDSLSPVAPYRLVNIGNASPVRLMDYIEAIEGAIGRKAEKNMIDMQPGDVKQTFADVRLLDALTGYTPDTDYRTGI
ARFVDWYRDYFKPA

Specific function: Required for the biosynthesis of type 1 capsular polysaccharide [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI42516563, Length=336, Percent_Identity=24.1071428571429, Blast_Score=104, Evalue=9e-23,
Organism=Homo sapiens, GI56237023, Length=332, Percent_Identity=25, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI56118217, Length=332, Percent_Identity=25, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI189083684, Length=332, Percent_Identity=25, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI7657641, Length=337, Percent_Identity=24.6290801186944, Blast_Score=100, Evalue=4e-21,
Organism=Escherichia coli, GI1788353, Length=349, Percent_Identity=24.9283667621776, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI48994969, Length=352, Percent_Identity=25.5681818181818, Blast_Score=105, Evalue=6e-24,
Organism=Escherichia coli, GI1786974, Length=327, Percent_Identity=21.7125382262997, Blast_Score=80, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71982038, Length=353, Percent_Identity=25.7790368271955, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI71982035, Length=351, Percent_Identity=25.6410256410256, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17539532, Length=338, Percent_Identity=23.0769230769231, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17568069, Length=240, Percent_Identity=27.5, Blast_Score=82, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6319493, Length=189, Percent_Identity=26.4550264550265, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI19923002, Length=338, Percent_Identity=24.8520710059172, Blast_Score=95, Evalue=6e-20,
Organism=Drosophila melanogaster, GI21356223, Length=337, Percent_Identity=24.6290801186944, Blast_Score=88, Evalue=9e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR016040
- InterPro:   IPR008089 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: 5.1.3.12

Molecular weight: Translated: 37673; Mature: 37673

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILVTGAAGFIGSEMALRLLKEGHSVTGVDCFTPYYDPQLKEDRAARLTAFDDFRLERI
CEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCHHHEEEEECCCEEEEE
RIEDSEAMEAVFQRDTPEMVLHFAAQAGVRYSLDHPRDFIDANIVGSFNIIDLSRRHGTQ
EECCHHHHHHHHHCCCHHHHHHHHHHCCCEEECCCCHHHHCCCEECCEEEEEEHHHCCCC
HLVMASTSSAYGANQKFPFEERDSAPYPLTIYAATKLASELIAHSHAHLYGVPTTVLRFF
EEEEEECCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHCCCCEEECHHHHHHHH
SVYGPWGRPDMAFFLFTDKIFKGQPIDVFNHGDLLRDFTYIDDLVEAIRRLMDTPPVVGN
HHCCCCCCCCEEEEEEEHHHHCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCC
HIIRGDSLSPVAPYRLVNIGNASPVRLMDYIEAIEGAIGRKAEKNMIDMQPGDVKQTFAD
EEECCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCHHCCCCCCCCCHHHHHHHH
VRLLDALTGYTPDTDYRTGIARFVDWYRDYFKPA
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKILVTGAAGFIGSEMALRLLKEGHSVTGVDCFTPYYDPQLKEDRAARLTAFDDFRLERI
CEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCHHHEEEEECCCEEEEE
RIEDSEAMEAVFQRDTPEMVLHFAAQAGVRYSLDHPRDFIDANIVGSFNIIDLSRRHGTQ
EECCHHHHHHHHHCCCHHHHHHHHHHCCCEEECCCCHHHHCCCEECCEEEEEEHHHCCCC
HLVMASTSSAYGANQKFPFEERDSAPYPLTIYAATKLASELIAHSHAHLYGVPTTVLRFF
EEEEEECCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHCCCCEEECHHHHHHHH
SVYGPWGRPDMAFFLFTDKIFKGQPIDVFNHGDLLRDFTYIDDLVEAIRRLMDTPPVVGN
HHCCCCCCCCEEEEEEEHHHHCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCC
HIIRGDSLSPVAPYRLVNIGNASPVRLMDYIEAIEGAIGRKAEKNMIDMQPGDVKQTFAD
EEECCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCHHCCCCCCCCCHHHHHHHH
VRLLDALTGYTPDTDYRTGIARFVDWYRDYFKPA
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-glucuronate

Specific reaction: UDP-glucuronate = UDP-L-iduronate

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7961465 [H]