Click here to switch to the map view.

The map label for this gene is tkt [H]

Identifier: 114798491

GI number: 114798491

Start: 3591807

End: 3593780

Strand: Reverse

Name: tkt [H]

Synonym: HNE_3455

Alternate gene names: 114798491

Gene position: 3593780-3591807 (Counterclockwise)

Preceding gene: 114798378

Following gene: 114797906

Centisome position: 97.0

GC content: 62.46

Gene sequence:

>1974_bases
ATGGCTGTCACCAATCGCGACATGGCAAATGCCGTGCGGGCTCTGTCCATGGACGCCGTCGAAGCGGCCAAATCCGGCCA
TGTCGGCTTGCCTCTGGGCATGGCCGACGCCGCGACTGTCCTTTTCCGAAAATTCCTGAAGTTTGATCCGAAAGACCCCA
ACTGGGCGGACCGTGACCGGTTTGTGCTATCGGCAGGTCATGGATCGATGCTGATCTATTCGCTGCTGCACCTGACAGGT
TATGCCTCGGTCAGCCGCGACGACATCCGTAATTTCCGCCAGATGGGCGCCAGCACGCCGGGCCATCCGGAGAATTTCGT
GACCACCGGCGTTGAGACGACCACCGGCCCGCTGGGGCAGGGCATCGCCACCGCCGTCGGCATGGCAATTGCCGAGCGCC
ATCTCAATGCCCGGTTTGGCAATGATCTGGTAGATCACCGGACCTGGGTTGTTGCCGGGGATGGCTGCCTCATGGAAGGG
CTCAGCCAGGAAGCGATCACGCTGGCCGGGCATATGAAGCTGAACAAGCTCATCGTGCTGTTCGACGATAACGCCGTCAC
CATTGATGGTTCTACCGACCTTTCCGATTCGACCGATCAGTGCGCGCGCTTTGAAGCCTCTGGCTGGATCAGCCGCCGCG
TGGATGGCCATGACGAGAAAGACGTCGAAGCCGCGCTTAAGTGGGCGACCAAGCAGAAGAAGCCGGTTTTCCTGGCCGTG
AAGACCATCATCGGTTTCGGTGCGCCCAAGCTTGCCGGCACCGGCAAGGCCCATGGCGGCCCTTATGGCGCCGAAGAAAT
CGACGGTATTCGCAAGTCTCTGAACTGGCCGCATGCACCGTTTGAAGTACCAGAAGCGATCGAAAAAGCCTGGGCGAAAG
CTGGTGAGCGATCGGTTGCCGAGCATGCCGCCTGGAAGAAGCGCCTCGCAGCAAGCCCGCACAAGGGCGAATTCAACGCC
GCGATCGCTGGCCGTCTGCCGAAGAATCTCGGCAAGGCGATTATCAAGCACAAGAAGGCTGTGGCCGAAGGCGGCGCCTC
CAAGGCGACGCGCGTCTGGAGCGGGGAAGCGCTGGAAGTCATTACCGGTCTTGTGCCGGAGATGGTCGGCGGTTCGGCAG
ACCTTTCGGGATCGAACAACACCAAGACCAGCCACACCGCGCCGATGACACCCAAGAGCTGGAGTGGCCGCTACATCCAT
TACGGCGTGCGTGAGCATGCGATGGCGGCGGCGATGAACGGTATGGCGCTGCATGGCGGCATCATTCCGTATTCGGGCAC
GTTCCTGGTGTTTGCCGATTACAGCCGCGCGGCGATCCGGCTTGGCGCGTTGATGGGTACGCAGGTCATCCATGTGATGA
CGCACGACTCGATTGGCCTGGGCGAAGACGGCCCGACGCACCAGCCGGTGGAGCATGTCGCTTCGCTGCGCGCGATGCCG
AACATGGTGGTGTTCCGCCCGGCAGATGGCGTCGAGACCGCAGAGTGCTGGGAACTGGCTCTGCACCGCAATGATGGCCC
CGCCACGATGGCTCTGACCCGCCAGAATGTGGCGCCCGCCCGCAAGACGCATACGGATGAAAACCTCTCGGCCAAGGGCG
GTTATGTTCTTTCGCCCGCCGGCAAGGGCAAGGAGCGCGGTGTGCTCATCGCGACCGGCTCGGAAGTCGAGATTGCCCTG
AAGGCTCAGGCCATGCTGGCGGAAGAGGGGATCGCCGTGCGCGTCGTCTCGATGCCGTCGATGGAATTGTTTGGCCAGCA
GGACGCAGCCTACCGCGCCGAGACGCTCGGCAAGGAACTGCCCAAGGTCGCGATTGAAGCCGGAGTCCGCTTCGGCTGGG
ATCGCTGGATCGGCGCCGATGGCGGTTTCGTCGGCATGGACAGCTTCGGCGCCAGCGCGCCCTATCAGAAACTCTACCAG
CATTTCGGCATCACGGCGGAAGCCGCCGTTGCCGCGATCAAAGAGCGGGTCTGA

Upstream 100 bases:

>100_bases
ATCAAGTATCTGCATTGGTTTGCGCCGCCAAGCGCCTTGACGGAGGCCAGCAAGTCTGGCCTAGCAGCCTCGAACGCAAA
AACTCCGGGAGATCAGCAGA

Downstream 100 bases:

>100_bases
TTTAGTCCTCCATATAATTTGCCCGTGGGCGGATGGTCTTGCCGCTGGAGACTTGTTCTATGGCGTGGGCGATCCAGCCT
GCCATACGCCCGCTCGCAAA

Product: transketolase

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 657; Mature: 656

Protein sequence:

>657_residues
MAVTNRDMANAVRALSMDAVEAAKSGHVGLPLGMADAATVLFRKFLKFDPKDPNWADRDRFVLSAGHGSMLIYSLLHLTG
YASVSRDDIRNFRQMGASTPGHPENFVTTGVETTTGPLGQGIATAVGMAIAERHLNARFGNDLVDHRTWVVAGDGCLMEG
LSQEAITLAGHMKLNKLIVLFDDNAVTIDGSTDLSDSTDQCARFEASGWISRRVDGHDEKDVEAALKWATKQKKPVFLAV
KTIIGFGAPKLAGTGKAHGGPYGAEEIDGIRKSLNWPHAPFEVPEAIEKAWAKAGERSVAEHAAWKKRLAASPHKGEFNA
AIAGRLPKNLGKAIIKHKKAVAEGGASKATRVWSGEALEVITGLVPEMVGGSADLSGSNNTKTSHTAPMTPKSWSGRYIH
YGVREHAMAAAMNGMALHGGIIPYSGTFLVFADYSRAAIRLGALMGTQVIHVMTHDSIGLGEDGPTHQPVEHVASLRAMP
NMVVFRPADGVETAECWELALHRNDGPATMALTRQNVAPARKTHTDENLSAKGGYVLSPAGKGKERGVLIATGSEVEIAL
KAQAMLAEEGIAVRVVSMPSMELFGQQDAAYRAETLGKELPKVAIEAGVRFGWDRWIGADGGFVGMDSFGASAPYQKLYQ
HFGITAEAAVAAIKERV

Sequences:

>Translated_657_residues
MAVTNRDMANAVRALSMDAVEAAKSGHVGLPLGMADAATVLFRKFLKFDPKDPNWADRDRFVLSAGHGSMLIYSLLHLTG
YASVSRDDIRNFRQMGASTPGHPENFVTTGVETTTGPLGQGIATAVGMAIAERHLNARFGNDLVDHRTWVVAGDGCLMEG
LSQEAITLAGHMKLNKLIVLFDDNAVTIDGSTDLSDSTDQCARFEASGWISRRVDGHDEKDVEAALKWATKQKKPVFLAV
KTIIGFGAPKLAGTGKAHGGPYGAEEIDGIRKSLNWPHAPFEVPEAIEKAWAKAGERSVAEHAAWKKRLAASPHKGEFNA
AIAGRLPKNLGKAIIKHKKAVAEGGASKATRVWSGEALEVITGLVPEMVGGSADLSGSNNTKTSHTAPMTPKSWSGRYIH
YGVREHAMAAAMNGMALHGGIIPYSGTFLVFADYSRAAIRLGALMGTQVIHVMTHDSIGLGEDGPTHQPVEHVASLRAMP
NMVVFRPADGVETAECWELALHRNDGPATMALTRQNVAPARKTHTDENLSAKGGYVLSPAGKGKERGVLIATGSEVEIAL
KAQAMLAEEGIAVRVVSMPSMELFGQQDAAYRAETLGKELPKVAIEAGVRFGWDRWIGADGGFVGMDSFGASAPYQKLYQ
HFGITAEAAVAAIKERV
>Mature_656_residues
AVTNRDMANAVRALSMDAVEAAKSGHVGLPLGMADAATVLFRKFLKFDPKDPNWADRDRFVLSAGHGSMLIYSLLHLTGY
ASVSRDDIRNFRQMGASTPGHPENFVTTGVETTTGPLGQGIATAVGMAIAERHLNARFGNDLVDHRTWVVAGDGCLMEGL
SQEAITLAGHMKLNKLIVLFDDNAVTIDGSTDLSDSTDQCARFEASGWISRRVDGHDEKDVEAALKWATKQKKPVFLAVK
TIIGFGAPKLAGTGKAHGGPYGAEEIDGIRKSLNWPHAPFEVPEAIEKAWAKAGERSVAEHAAWKKRLAASPHKGEFNAA
IAGRLPKNLGKAIIKHKKAVAEGGASKATRVWSGEALEVITGLVPEMVGGSADLSGSNNTKTSHTAPMTPKSWSGRYIHY
GVREHAMAAAMNGMALHGGIIPYSGTFLVFADYSRAAIRLGALMGTQVIHVMTHDSIGLGEDGPTHQPVEHVASLRAMPN
MVVFRPADGVETAECWELALHRNDGPATMALTRQNVAPARKTHTDENLSAKGGYVLSPAGKGKERGVLIATGSEVEIALK
AQAMLAEEGIAVRVVSMPSMELFGQQDAAYRAETLGKELPKVAIEAGVRFGWDRWIGADGGFVGMDSFGASAPYQKLYQH
FGITAEAAVAAIKERV

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=579, Percent_Identity=27.1157167530225, Blast_Score=166, Evalue=5e-41,
Organism=Homo sapiens, GI4507521, Length=579, Percent_Identity=27.1157167530225, Blast_Score=166, Evalue=5e-41,
Organism=Homo sapiens, GI133778974, Length=576, Percent_Identity=27.0833333333333, Blast_Score=164, Evalue=3e-40,
Organism=Homo sapiens, GI225637459, Length=593, Percent_Identity=22.5969645868465, Blast_Score=115, Evalue=2e-25,
Organism=Homo sapiens, GI225637461, Length=516, Percent_Identity=23.6434108527132, Blast_Score=105, Evalue=2e-22,
Organism=Homo sapiens, GI225637463, Length=516, Percent_Identity=23.6434108527132, Blast_Score=104, Evalue=2e-22,
Organism=Escherichia coli, GI48994911, Length=663, Percent_Identity=49.9245852187029, Blast_Score=629, Evalue=0.0,
Organism=Escherichia coli, GI1788808, Length=662, Percent_Identity=49.2447129909366, Blast_Score=598, Evalue=1e-172,
Organism=Caenorhabditis elegans, GI17539652, Length=582, Percent_Identity=28.0068728522337, Blast_Score=162, Evalue=5e-40,
Organism=Saccharomyces cerevisiae, GI6325331, Length=657, Percent_Identity=41.5525114155251, Blast_Score=462, Evalue=1e-131,
Organism=Saccharomyces cerevisiae, GI6319593, Length=668, Percent_Identity=40.1197604790419, Blast_Score=444, Evalue=1e-125,
Organism=Drosophila melanogaster, GI45551847, Length=582, Percent_Identity=28.5223367697594, Blast_Score=188, Evalue=9e-48,
Organism=Drosophila melanogaster, GI45550715, Length=582, Percent_Identity=28.5223367697594, Blast_Score=188, Evalue=9e-48,
Organism=Drosophila melanogaster, GI24666278, Length=581, Percent_Identity=26.6781411359725, Blast_Score=170, Evalue=3e-42,
Organism=Drosophila melanogaster, GI24645119, Length=549, Percent_Identity=28.2331511839709, Blast_Score=169, Evalue=5e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 70061; Mature: 69929

Theoretical pI: Translated: 7.66; Mature: 7.66

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVTNRDMANAVRALSMDAVEAAKSGHVGLPLGMADAATVLFRKFLKFDPKDPNWADRDR
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCC
FVLSAGHGSMLIYSLLHLTGYASVSRDDIRNFRQMGASTPGHPENFVTTGVETTTGPLGQ
EEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCEECCCCCCCCCCCC
GIATAVGMAIAERHLNARFGNDLVDHRTWVVAGDGCLMEGLSQEAITLAGHMKLNKLIVL
HHHHHHHHHHHHHHHHHHCCCCHHHCCEEEEECCCHHHHCCCHHHEEHCCCEEEEEEEEE
FDDNAVTIDGSTDLSDSTDQCARFEASGWISRRVDGHDEKDVEAALKWATKQKKPVFLAV
ECCCEEEECCCCCCCCCHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHHHHCCCCCEEEEE
KTIIGFGAPKLAGTGKAHGGPYGAEEIDGIRKSLNWPHAPFEVPEAIEKAWAKAGERSVA
HHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCHHHHH
EHAAWKKRLAASPHKGEFNAAIAGRLPKNLGKAIIKHKKAVAEGGASKATRVWSGEALEV
HHHHHHHHHCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHCCCCCCCEEECCCCHHHH
ITGLVPEMVGGSADLSGSNNTKTSHTAPMTPKSWSGRYIHYGVREHAMAAAMNGMALHGG
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECHHHHHHHHHHCCEEEECC
IIPYSGTFLVFADYSRAAIRLGALMGTQVIHVMTHDSIGLGEDGPTHQPVEHVASLRAMP
CCCCCCCEEEEECCCHHHHHHHHHHHCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHCCC
NMVVFRPADGVETAECWELALHRNDGPATMALTRQNVAPARKTHTDENLSAKGGYVLSPA
CEEEEECCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCHHCCCCCCCCCCCCEEECCC
GKGKERGVLIATGSEVEIALKAQAMLAEEGIAVRVVSMPSMELFGQQDAAYRAETLGKEL
CCCCCCEEEEEECCCEEEEEEHHHHHHCCCCEEEEEECCCHHHHCCCHHHHHHHHHHHHH
PKVAIEAGVRFGWDRWIGADGGFVGMDSFGASAPYQKLYQHFGITAEAAVAAIKERV
HHHHHHHCCCCCHHHEECCCCCEECCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHCC
>Mature Secondary Structure 
AVTNRDMANAVRALSMDAVEAAKSGHVGLPLGMADAATVLFRKFLKFDPKDPNWADRDR
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCC
FVLSAGHGSMLIYSLLHLTGYASVSRDDIRNFRQMGASTPGHPENFVTTGVETTTGPLGQ
EEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCEECCCCCCCCCCCC
GIATAVGMAIAERHLNARFGNDLVDHRTWVVAGDGCLMEGLSQEAITLAGHMKLNKLIVL
HHHHHHHHHHHHHHHHHHCCCCHHHCCEEEEECCCHHHHCCCHHHEEHCCCEEEEEEEEE
FDDNAVTIDGSTDLSDSTDQCARFEASGWISRRVDGHDEKDVEAALKWATKQKKPVFLAV
ECCCEEEECCCCCCCCCHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHHHHCCCCCEEEEE
KTIIGFGAPKLAGTGKAHGGPYGAEEIDGIRKSLNWPHAPFEVPEAIEKAWAKAGERSVA
HHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCHHHHH
EHAAWKKRLAASPHKGEFNAAIAGRLPKNLGKAIIKHKKAVAEGGASKATRVWSGEALEV
HHHHHHHHHCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHCCCCCCCEEECCCCHHHH
ITGLVPEMVGGSADLSGSNNTKTSHTAPMTPKSWSGRYIHYGVREHAMAAAMNGMALHGG
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECHHHHHHHHHHCCEEEECC
IIPYSGTFLVFADYSRAAIRLGALMGTQVIHVMTHDSIGLGEDGPTHQPVEHVASLRAMP
CCCCCCCEEEEECCCHHHHHHHHHHHCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHCCC
NMVVFRPADGVETAECWELALHRNDGPATMALTRQNVAPARKTHTDENLSAKGGYVLSPA
CEEEEECCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCHHCCCCCCCCCCCCEEECCC
GKGKERGVLIATGSEVEIALKAQAMLAEEGIAVRVVSMPSMELFGQQDAAYRAETLGKEL
CCCCCCEEEEEECCCEEEEEEHHHHHHCCCCEEEEEECCCHHHHCCCHHHHHHHHHHHHH
PKVAIEAGVRFGWDRWIGADGGFVGMDSFGASAPYQKLYQHFGITAEAAVAAIKERV
HHHHHHHCCCCCHHHEECCCCCEECCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA