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The map label for this gene is budC [H]

Identifier: 114798485

GI number: 114798485

Start: 698604

End: 699413

Strand: Reverse

Name: budC [H]

Synonym: HNE_0688

Alternate gene names: 114798485

Gene position: 699413-698604 (Counterclockwise)

Preceding gene: 114797685

Following gene: 114798232

Centisome position: 18.88

GC content: 64.2

Gene sequence:

>810_bases
ATGGCAGGCGCAAACGGCCGCAAGGCGATTTTCATCACGGGAGCCGCCTCGGGCATCGGCGCAGAAACGGCGCGCCATTT
TGCGCGGAAGGGCTGGTTCTGCGGGCTCTATGACGTCAACGAGATGGGGCTGAAGGCCGTTGCCGGTGAGATCGGCGCGG
AGAATTGCCATGTCGCAAAACTGGATGTGACCAGGCGGGCCGACTGGGCCGCCGCCATGGACGGCTTCAGCGCCGCAACC
GGCGGCAAGATGAACGCCCTTTTCAACAATGCCGGCATCGGGCGCCATGGCTGGTTTGAAGAGATCCCCGCCGAAGAGGC
CGACCTCATCATCGACATCAATGTGAAGGGCGTGGTGAACGGGGTCTATGCCGCCCTGCCCTTGCTGAAGGCCACGCCGG
GCGCGCGGATCGTGAATACGGCCTCGTCCGCCGGGATTGTCGGGGCGCCTCAGCTTTCGGTTTATTCGGCCTCCAAATGG
GCCGTGCGGGGGCTGACCGAGGCGCTCGACGCAGAATTCCGGGATCTGGGCATTCGGGTCACCACGCTGATGCCGTGGTT
TGTCGACACGCCGATCCTGGAGATGGGCAAGACGGCCGGCGCCAATGAGAAGATGTCCGATCAGATGAAAGCGAATGGCG
CGAAGGTTTATCCCGTGTCGATGGCTGCCGAGAAGGTGTGGGACGCCGTGCACGGCGATGACATCTATTACATGGTGGGC
GCAGAGGCCGACCGGGCGCGCTTCATGACGCGCTGGCTGCCGGGCGTGGTGCGCAAGGCGATCCGCAAGAACGTGCCCGC
GCGGGATTAG

Upstream 100 bases:

>100_bases
ACCCATTCGGCGCCCAATCTTGACCTTGGCCTCGATGTGGTCTGACAGTCTCTGCCAGAGACGCTGACACAGTCAGTGAA
AGATACTGGCGGAGGAAAAC

Downstream 100 bases:

>100_bases
GCTGGCAGGTCAATTGAGGGAAACAAAAAGGCCGCTGATGCGTTTCATCAGCGGCCTTGAAATTTTTGAACCGTGACCTG
GCGCTTACTCGGCGGCGGCG

Product: short chain dehydrogenase

Products: NA

Alternate protein names: Acetoin(diacetyl) reductase; AR; Meso-2,3-butanediol dehydrogenase [H]

Number of amino acids: Translated: 269; Mature: 268

Protein sequence:

>269_residues
MAGANGRKAIFITGAASGIGAETARHFARKGWFCGLYDVNEMGLKAVAGEIGAENCHVAKLDVTRRADWAAAMDGFSAAT
GGKMNALFNNAGIGRHGWFEEIPAEEADLIIDINVKGVVNGVYAALPLLKATPGARIVNTASSAGIVGAPQLSVYSASKW
AVRGLTEALDAEFRDLGIRVTTLMPWFVDTPILEMGKTAGANEKMSDQMKANGAKVYPVSMAAEKVWDAVHGDDIYYMVG
AEADRARFMTRWLPGVVRKAIRKNVPARD

Sequences:

>Translated_269_residues
MAGANGRKAIFITGAASGIGAETARHFARKGWFCGLYDVNEMGLKAVAGEIGAENCHVAKLDVTRRADWAAAMDGFSAAT
GGKMNALFNNAGIGRHGWFEEIPAEEADLIIDINVKGVVNGVYAALPLLKATPGARIVNTASSAGIVGAPQLSVYSASKW
AVRGLTEALDAEFRDLGIRVTTLMPWFVDTPILEMGKTAGANEKMSDQMKANGAKVYPVSMAAEKVWDAVHGDDIYYMVG
AEADRARFMTRWLPGVVRKAIRKNVPARD
>Mature_268_residues
AGANGRKAIFITGAASGIGAETARHFARKGWFCGLYDVNEMGLKAVAGEIGAENCHVAKLDVTRRADWAAAMDGFSAATG
GKMNALFNNAGIGRHGWFEEIPAEEADLIIDINVKGVVNGVYAALPLLKATPGARIVNTASSAGIVGAPQLSVYSASKWA
VRGLTEALDAEFRDLGIRVTTLMPWFVDTPILEMGKTAGANEKMSDQMKANGAKVYPVSMAAEKVWDAVHGDDIYYMVGA
EADRARFMTRWLPGVVRKAIRKNVPARD

Specific function: Catalyzes the irreversible reduction of 2,3-butanediol to (S)-acetoin in the presence of NADH [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI40807363, Length=251, Percent_Identity=29.0836653386454, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI4503817, Length=231, Percent_Identity=27.7056277056277, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI40254992, Length=186, Percent_Identity=32.7956989247312, Blast_Score=78, Evalue=7e-15,
Organism=Homo sapiens, GI223718074, Length=212, Percent_Identity=30.188679245283, Blast_Score=78, Evalue=7e-15,
Organism=Homo sapiens, GI66933014, Length=188, Percent_Identity=34.5744680851064, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI142976729, Length=211, Percent_Identity=30.3317535545024, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI31542939, Length=227, Percent_Identity=30.3964757709251, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI40548397, Length=243, Percent_Identity=29.6296296296296, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI214010158, Length=243, Percent_Identity=29.6296296296296, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI214010156, Length=243, Percent_Identity=29.6296296296296, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI22758144, Length=243, Percent_Identity=29.6296296296296, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI210032110, Length=187, Percent_Identity=29.4117647058824, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI7657478, Length=189, Percent_Identity=30.6878306878307, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI44680136, Length=187, Percent_Identity=27.2727272727273, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI44680133, Length=187, Percent_Identity=27.2727272727273, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI17738292, Length=187, Percent_Identity=27.2727272727273, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI4758504, Length=196, Percent_Identity=31.6326530612245, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI87082100, Length=190, Percent_Identity=37.3684210526316, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1786701, Length=280, Percent_Identity=27.8571428571429, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1788459, Length=186, Percent_Identity=29.5698924731183, Blast_Score=64, Evalue=7e-12,
Organism=Escherichia coli, GI1790717, Length=206, Percent_Identity=27.6699029126214, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1787335, Length=185, Percent_Identity=28.6486486486486, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1787820, Length=227, Percent_Identity=28.1938325991189, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17567345, Length=196, Percent_Identity=32.1428571428571, Blast_Score=85, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17508895, Length=192, Percent_Identity=29.6875, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71994600, Length=188, Percent_Identity=31.9148936170213, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17538182, Length=200, Percent_Identity=33.5, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71994604, Length=202, Percent_Identity=30.1980198019802, Blast_Score=71, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17507613, Length=203, Percent_Identity=31.5270935960591, Blast_Score=70, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI32563809, Length=202, Percent_Identity=31.6831683168317, Blast_Score=70, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI115534660, Length=267, Percent_Identity=23.5955056179775, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323882, Length=202, Percent_Identity=30.6930693069307, Blast_Score=77, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6322067, Length=178, Percent_Identity=30.3370786516854, Blast_Score=67, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6322861, Length=194, Percent_Identity=29.3814432989691, Blast_Score=65, Evalue=8e-12,
Organism=Drosophila melanogaster, GI281364892, Length=196, Percent_Identity=33.6734693877551, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI23397609, Length=185, Percent_Identity=35.1351351351351, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI28571526, Length=193, Percent_Identity=33.6787564766839, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24644339, Length=185, Percent_Identity=33.5135135135135, Blast_Score=84, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24639444, Length=192, Percent_Identity=30.2083333333333, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI21356301, Length=242, Percent_Identity=28.099173553719, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21357041, Length=201, Percent_Identity=30.8457711442786, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24651139, Length=226, Percent_Identity=26.5486725663717, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24640442, Length=198, Percent_Identity=28.2828282828283, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17737361, Length=199, Percent_Identity=32.1608040201005, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24643142, Length=183, Percent_Identity=30.6010928961749, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24641388, Length=198, Percent_Identity=31.8181818181818, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014007
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.304 [H]

Molecular weight: Translated: 28704; Mature: 28573

Theoretical pI: Translated: 8.66; Mature: 8.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGANGRKAIFITGAASGIGAETARHFARKGWFCGLYDVNEMGLKAVAGEIGAENCHVAK
CCCCCCCEEEEEEECCCCCCHHHHHHHHHCCCEEEEECCCHHHHHHHHHHCCCCCCEEEE
LDVTRRADWAAAMDGFSAATGGKMNALFNNAGIGRHGWFEEIPAEEADLIIDINVKGVVN
EECCCCCHHHHHHCCCCCCCCCCCCEEECCCCCCCCCCHHHCCCCCCCEEEEEECHHHHH
GVYAALPLLKATPGARIVNTASSAGIVGAPQLSVYSASKWAVRGLTEALDAEFRDLGIRV
HHHHHHHHHHCCCCCEEEECCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHCCEEE
TTLMPWFVDTPILEMGKTAGANEKMSDQMKANGAKVYPVSMAAEKVWDAVHGDDIYYMVG
EEECCHHHCCCHHHHCCCCCCCCHHHHHHHCCCCEEEEHHHHHHHHHHHHCCCCEEEEEC
AEADRARFMTRWLPGVVRKAIRKNVPARD
CCCHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
AGANGRKAIFITGAASGIGAETARHFARKGWFCGLYDVNEMGLKAVAGEIGAENCHVAK
CCCCCCEEEEEEECCCCCCHHHHHHHHHCCCEEEEECCCHHHHHHHHHHCCCCCCEEEE
LDVTRRADWAAAMDGFSAATGGKMNALFNNAGIGRHGWFEEIPAEEADLIIDINVKGVVN
EECCCCCHHHHHHCCCCCCCCCCCCEEECCCCCCCCCCHHHCCCCCCCEEEEEECHHHHH
GVYAALPLLKATPGARIVNTASSAGIVGAPQLSVYSASKWAVRGLTEALDAEFRDLGIRV
HHHHHHHHHHCCCCCEEEECCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHCCEEE
TTLMPWFVDTPILEMGKTAGANEKMSDQMKANGAKVYPVSMAAEKVWDAVHGDDIYYMVG
EEECCHHHCCCHHHHCCCCCCCCHHHHHHHCCCCEEEEHHHHHHHHHHHHCCCCEEEEEC
AEADRARFMTRWLPGVVRKAIRKNVPARD
CCCHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8444801 [H]